Artificial High Density Lipoprotein Nanoparticles in Cardiovascular Research

Jak -ing Up the Plaque’s Lipid Core…and Even More

(2019) Peter Libby et al.   CIRCULATION RESEARCH

Distinct phospholipid and sphingolipid species are linked to altered HDL function in apolipoprotein A-I deficiency

(2019) Emile Zakiev et al.   Journal of Clinical Lipidology

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

(2019) Emelia J. Benjamin et al.   CIRCULATION

Novel Antiatherosclerotic Therapies

(2019) Peter Libby et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CSL112 (Apolipoprotein A-I [Human]) Enhances Cholesterol Efflux Similarly in Healthy Individuals and Stable Atherosclerotic Disease PatientsHighlights

(2018) Andreas Gille et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tertiary structure of apolipoprotein A-I in nascent high-density lipoproteins

(2018) Mohsen Pourmousa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural properties of apolipoprotein A-I mimetic peptides that promote ABCA1-dependent cholesterol efflux

(2018) Rafique M. Islam et al.   Scientific Reports

Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization

(2018) Susan Hua et al.   Frontiers in Pharmacology

Recent Advances in Single Particle Cryo-electron Microscopy and Cryo-electron Tomography to Determine the Structures of Biological Macromolecules

(2018) Moumita Dutta   JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE

Reconstituted high-density lipoproteins: novel biomimetic nanocarriers for drug delivery

(2018) Xinyi Ma et al.   Acta Pharmaceutica Sinica B

Imaging Atherosclerotic Plaque Inflammation via Folate Receptor Targeting Using a Novel 18 F-Folate Radiotracer

(2018) Adrienne Müller et al.   Molecular Imaging

Effect of Serial Infusions of CER-001, a Pre-β High-Density Lipoprotein Mimetic, on Coronary Atherosclerosis in Patients Following Acute Coronary Syndromes in the CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial

(2018) Stephen J. Nicholls et al.   JAMA Cardiology

Reconstituted Discoidal High-Density Lipoproteins: Bioinspired Nanodiscs with Many Unexpected Applications

(2018) Maki Tsujita et al.   Current Atherosclerosis Reports

Reconstituted HDL: Drug Delivery Platform for Overcoming Biological Barriers to Cancer Therapy

(2018) Sangram Raut et al.   Frontiers in Pharmacology

Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum

(2017) Pallavi Mukherjee et al.   JOURNAL OF LIPID RESEARCH

A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state

(2017) John T Melchior et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state

(2017) John T Melchior et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Potential Therapeutic Application of Peptides and Peptidomimetics in Cardiovascular Disease

(2017) Carlota Recio et al.   Frontiers in Pharmacology

High-Density Lipoproteins: Nature’s Multifunctional Nanoparticles

(2016) Rui Kuai et al.   ACS Nano

Lipoproteins and lipoprotein mimetics for imaging and drug delivery

(2016) C. Shad Thaxton et al.   ADVANCED DRUG DELIVERY REVIEWS

Properties of Native High-Density Lipoproteins Inspire Synthesis of Actively Targeted In Vivo siRNA Delivery Vehicles

(2016) Kaylin M. McMahon et al.   ADVANCED FUNCTIONAL MATERIALS

HDL mimetic CER-001 targets atherosclerotic plaques in patients

(2016) Kang He Zheng et al.   ATHEROSCLEROSIS

Direct Measurement of the Structure of Reconstituted High-Density Lipoproteins by Cryo-EM

(2016) Stephen C. Murray et al.   BIOPHYSICAL JOURNAL

Phosphatidylserine in atherosclerosis

(2016) Maryam Darabi et al.   CURRENT OPINION IN LIPIDOLOGY

Influence of route of administration and lipidation of apolipoprotein A-I peptide on pharmacokinetics and cholesterol mobilization

(2016) Jie Tang et al.   JOURNAL OF LIPID RESEARCH

Evaluation of reconstituted high-density lipoprotein (rHDL) as a drug delivery platform – a detailed survey of rHDL particles ranging from biophysical properties to clinical implications

(2016) Jens B. Simonsen   Nanomedicine-Nanotechnology Biology and Medicine

Therapeutic applications of reconstituted HDL: When structure meets function

(2016) Maryam Darabi et al.   PHARMACOLOGY & THERAPEUTICS

HDL and microRNA therapeutics in cardiovascular disease

(2016) Danielle L. Michell et al.   PHARMACOLOGY & THERAPEUTICS

Immune cell screening of a nanoparticle library improves atherosclerosis therapy

(2016) Jun Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-density lipoproteins for therapeutic delivery systems

(2016) R. Kannan Mutharasan et al.   Journal of Materials Chemistry B

Single-Particle Tracking of Human Lipoproteins

(2015) Michel de Messieres et al.   ANALYTICAL CHEMISTRY

High-density lipoprotein mimetics: promises and challenges

(2015) D. Sviridov et al.   BIOCHEMICAL JOURNAL

HDL-Mimetic PLGA Nanoparticle To Target Atherosclerosis Plaque Macrophages

(2015) Brenda L. Sanchez-Gaytan et al.   BIOCONJUGATE CHEMISTRY

HDL Particle Size Is a Critical Determinant of ABCA1-Mediated Macrophage Cellular Cholesterol ExportNovelty and Significance

(2015) Xian-Ming Du et al.   CIRCULATION RESEARCH

Lipoprotein-Related and Apolipoprotein-Mediated Delivery Systems for Drug Targeting and Imaging

(2015) Gunter Almer et al.   CURRENT MEDICINAL CHEMISTRY

Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein

(2015) Andrea J. Luthi et al.   JOURNAL OF LIPID RESEARCH

The effect of phospholipid composition of reconstituted HDL on its cholesterol efflux and anti-inflammatory properties

(2015) Anna Schwendeman et al.   JOURNAL OF LIPID RESEARCH

Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA

(2015) Ruud S. Kootte et al.   JOURNAL OF LIPID RESEARCH

Infusion of Reconstituted High‐Density Lipoprotein, CSL112, in Patients With Atherosclerosis: Safety and Pharmacokinetic Results From a Phase 2a Randomized Clinical Trial

(2015) Pierluigi Tricoci et al.   Journal of the American Heart Association

HDL as a drug and nucleic acid delivery vehicle

(2015) Andras G. Lacko et al.   Frontiers in Pharmacology

Antioxidant properties of HDL

(2015) Handrean Soran et al.   Frontiers in Pharmacology

Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation

(2015) J. Tang et al.   Science Advances

Nanomedicines: addressing the scientific and regulatory gap

(2014) Sally Tinkle et al.   Annals of the New York Academy of Sciences

Phosphatidylserine: A key player in multiple biological activities of HDL

(2014) A. Kontush et al.   ATHEROSCLEROSIS

Nature-inspired nanoformulations for contrast-enhancedin vivoMR imaging of macrophages

(2014) Alexander B. Sigalov   Contrast Media & Molecular Imaging

Apolipoprotein A-I mimetics

(2014) Srinivasa T. Reddy et al.   CURRENT OPINION IN LIPIDOLOGY

In vivo efficacy of HDL-like nanolipid particles containing multivalent peptide mimetics of apolipoprotein A-I

(2014) Yannan Zhao et al.   JOURNAL OF LIPID RESEARCH

Anti-inflammatory and cholesterol-reducing properties of apolipoprotein mimetics: a review

(2014) C. Roger White et al.   JOURNAL OF LIPID RESEARCH

HDL-targeted therapies: progress, failures and future

(2014) Bronwyn A. Kingwell et al.   NATURE REVIEWS DRUG DISCOVERY

A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation

(2014) Raphaël Duivenvoorden et al.   Nature Communications

Single Step Reconstitution of Multifunctional High-Density Lipoprotein-Derived Nanomaterials Using Microfluidics

(2013) YongTae Kim et al.   ACS Nano

Novel Formulation of a Reconstituted High-Density Lipoprotein (CSL112) Dramatically Enhances ABCA1-Dependent Cholesterol Efflux

(2013) Svetlana Diditchenko et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Apolipoprotein A–I binding to anionic vesicles and lipopolysaccharides: Role for lysine residues in antimicrobial properties

(2013) Wendy H.J. Beck et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effect of phospholipid composition on discoidal HDL formation

(2013) Masakazu Miyazaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

High-density lipoproteins for the systemic delivery of short interfering RNA

(2013) Kaylin Marie McMahon et al.   Expert Opinion on Drug Delivery

A novel approach to oral apoA-I mimetic therapy

(2013) Arnab Chattopadhyay et al.   JOURNAL OF LIPID RESEARCH

Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid

(2013) Mohamad Navab et al.   JOURNAL OF LIPID RESEARCH

Unraveling the complexities of the HDL lipidome

(2013) Anatol Kontush et al.   JOURNAL OF LIPID RESEARCH

Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond

(2013) Amy S. Shah et al.   JOURNAL OF LIPID RESEARCH

Molecules That Mimic Apolipoprotein A-I: Potential Agents for Treating Atherosclerosis

(2013) Luke J. Leman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biomimetic, synthetic HDL nanostructures for lymphoma

(2013) S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Templated high density lipoprotein nanoparticles as potential therapies and for molecular delivery

(2012) Marina G. Damiano et al.   ADVANCED DRUG DELIVERY REVIEWS

High-Density Lipoprotein and 4F Peptide Reduce Systemic Inflammation by Modulating Intestinal Oxidized Lipid Metabolism

(2012) Mohamad Navab et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation in Atherosclerosis

(2012) Peter Libby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pharmacokinetics and atherosclerotic lesions targeting effects of tanshinone IIA discoidal and spherical biomimetic high density lipoproteins

(2012) Wenli Zhang et al.   BIOMATERIALS

HDL drug carriers for targeted therapy

(2012) Xing Liu et al.   CLINICA CHIMICA ACTA

Lipid-based carriers of microRNAs and intercellular communication

(2012) Kasey C. Vickers et al.   CURRENT OPINION IN LIPIDOLOGY

Near-infrared fluorescent imaging of metastatic ovarian cancer using folate receptor-targeted high-density lipoprotein nanocarriers

(2012) Ian R Corbin et al.   Nanomedicine

Lipoprotein-Inspired Nanoparticles for Cancer Theranostics

(2011) Kenneth K. Ng et al.   ACCOUNTS OF CHEMICAL RESEARCH

The apolipoprotein A-I mimetic peptide ETC-642 exhibits anti-inflammatory properties that are comparable to high density lipoproteins

(2011) Belinda A. Di Bartolo et al.   ATHEROSCLEROSIS

HDL Measures, Particle Heterogeneity, Proposed Nomenclature, and Relation to Atherosclerotic Cardiovascular Events

(2011) R. S. Rosenson et al.   CLINICAL CHEMISTRY

Structure and remodeling behavior of drug-loaded high density lipoproteins and their atherosclerotic plaque targeting mechanism in foam cell model

(2011) Wen-Li Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The Low Resolution Structure of ApoA1 in Spherical High Density Lipoprotein Revealed by Small Angle Neutron Scattering

(2011) Zhiping Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intestine may be a major site of action for the apoA-I mimetic peptide 4F whether administered subcutaneously or orally

(2011) Mohamad Navab et al.   JOURNAL OF LIPID RESEARCH

The apolipoprotein A-I mimetic peptide, ETC-642, reduces chronic vascular inflammation in the rabbit

(2011) Belinda A Di Bartolo et al.   Lipids in Health and Disease

Biomimetic High Density Lipoprotein Nanoparticles For Nucleic Acid Delivery

(2011) Kaylin M. McMahon et al.   NANO LETTERS

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

Perspectives and opportunities for nanomedicine in the management of atherosclerosis

(2011) Mark E. Lobatto et al.   NATURE REVIEWS DRUG DISCOVERY

Reconstituted Lipoprotein: A Versatile Class of Biologically-Inspired Nanostructures

(2010) Daniel A. Bricarello et al.   ACS Nano

The biological properties of iron oxide core high-density lipoprotein in experimental atherosclerosis

(2010) Torjus Skajaa et al.   BIOMATERIALS

Structure/Function Relationships of Apolipoprotein A-I Mimetic Peptides

(2010) Wilissa D'Souza et al.   CIRCULATION RESEARCH

Apolipoprotein A-I mimetic peptides

(2010) GK Hovingh et al.   CURRENT OPINION IN LIPIDOLOGY

Antiatherogenic function of HDL particle subpopulations: focus on antioxidative activities

(2010) Anatol Kontush et al.   CURRENT OPINION IN LIPIDOLOGY

High-Density Lipoprotein-Mediated Anti-Atherosclerotic and Endothelial-Protective Effects: A Potential Novel Therapeutic Target in Cardiovascular Disease

(2010) Christian Besler et al.   CURRENT PHARMACEUTICAL DESIGN

Apolipoprotein A-I possesses an anti-obesity effect associated with increase of energy expenditure and up-regulation of UCP1 in brown fat

(2010) Xiangbo Ruan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Treatment of patients with cardiovascular disease with L-4F, an apo-A1 mimetic, did not improve select biomarkers of HDL function

(2010) Catherine E. Watson et al.   JOURNAL OF LIPID RESEARCH

Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy

(2010) Lei Zhang et al.   JOURNAL OF LIPID RESEARCH

5A Apolipoprotein Mimetic Peptide Promotes Cholesterol Efflux and Reduces Atherosclerosis in Mice

(2010) M. J. A. Amar et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the Measurement of Nanoparticles and Protein Aggregates

(2010) Vasco Filipe et al.   PHARMACEUTICAL RESEARCH

Apolipoprotein mimetic peptides: Mechanisms of action as anti-atherogenic agents

(2010) David O. Osei-Hwedieh et al.   PHARMACOLOGY & THERAPEUTICS

Nanotechnology for synthetic high-density lipoproteins

(2010) Andrea J. Luthi et al.   TRENDS IN MOLECULAR MEDICINE

Nanoparticles for detection and diagnosis

(2009) Sarit S. Agasti et al.   ADVANCED DRUG DELIVERY REVIEWS

Modified natural nanoparticles as contrast agents for medical imaging

(2009) David P. Cormode et al.   ADVANCED DRUG DELIVERY REVIEWS

Biomimetic Nanocarrier for Direct Cytosolic Drug Delivery

(2009) Zhihong Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proteomic Analysis of Defined HDL Subpopulations Reveals Particle-Specific Protein Clusters

(2009) W. Sean Davidson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Structure and Function of HDL Mimetics

(2009) Mohamad Navab et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High-Density Lipoprotein–Based Contrast Agents for Multimodal Imaging of Atherosclerosis

(2009) Torjus Skajaa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Anti-inflammatory peptides grab on to the whiskers of atherogenic oxidized lipids

(2009) Raquel F. Epand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Comparison of Synthetic High Density Lipoprotein (HDL) Contrast Agents for MR Imaging of Atherosclerosis

(2009) David P. Cormode et al.   BIOCONJUGATE CHEMISTRY

HDL as a contrast agent for medical imaging

(2009) David P Cormode et al.   Clinical Lipidology

Reconstituted HDL: a therapy for atherosclerosis and beyond

(2009) Andrew J Murphy et al.   Clinical Lipidology

HDL as a Biomarker, Potential Therapeutic Target, and Therapy: FIG. 1.

(2009) Mohamad Navab et al.   DIABETES

Double Superhelix Model of High Density Lipoprotein

(2009) Zhiping Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Relaxivity Gadolinium-Modified High-Density Lipoproteins as Magnetic Resonance Imaging Contrast Agents

(2009) Karen C. Briley-Saebo et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Brefeldin A inhibits cholesterol efflux without affecting the rate of cellular uptake and re-secretion of apolipoprotein A-I in adipocytes

(2008) Philip B. Verghese et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cholesterol is a determinant of the structures of discoidal high density lipoproteins formed by the solubilization of phospholipid membranes by apolipoprotein A-I

(2008) John B. Massey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

HELIQUEST: a web server to screen sequences with specific  -helical properties

(2008) R. Gautier et al.   BIOINFORMATICS

Incorporation of an apoE-derived lipopeptide in high-density lipoprotein MRI contrast agents for enhanced imaging of macrophages in atherosclerosis

(2008) Wei Chen et al.   Contrast Media & Molecular Imaging

Apolipoprotein A-I mimetic peptides

(2008) Brian J. Van Lenten et al.   Current Atherosclerosis Reports

Asymmetry in the Lipid Affinity of Bihelical Amphipathic Peptides

(2008) Amar A. Sethi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of dysfunctional HDL in atherosclerosis

(2008) Mohamad Navab et al.   JOURNAL OF LIPID RESEARCH

Apolipoprotein A-I mimetic peptide helix number and helix linker influence potentially anti-atherogenic properties

(2008) Geoffrey D. Wool et al.   JOURNAL OF LIPID RESEARCH

L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice

(2008) Stephen J. Peterson et al.   JOURNAL OF LIPID RESEARCH

Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I

(2008) Brian J. Van Lenten et al.   JOURNAL OF LIPID RESEARCH

Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients

(2008) LeAnne T. Bloedon et al.   JOURNAL OF LIPID RESEARCH

Nanocrystal Core High-Density Lipoproteins: A Multimodality Contrast Agent Platform

(2008) David P. Cormode et al.   NANO LETTERS

Form to function: current and future roles for atherosclerosis imaging in drug development

(2008) Alistair C. Lindsay et al.   NATURE REVIEWS DRUG DISCOVERY

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes

(2008) R. A. G. D. Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ApoA-I Mimetic Peptide High-Density-Lipoprotein-Based MRI Contrast Agent for Atherosclerotic Plaque Composition Detection

(2008) David P. Cormode et al.   Small