Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid

Diesel Exhaust Induces Systemic Lipid Peroxidation and Development of Dysfunctional Pro-Oxidant and Pro-Inflammatory High-Density Lipoprotein

(2013) Fen Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Increased lysophosphatidic acid levels in culprit coronary arteries of patients with acute coronary syndrome

(2013) Tomotaka Dohi et al.   ATHEROSCLEROSIS

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

(2013) Brian J. Bennett et al.   Cell Metabolism

A novel approach to oral apoA-I mimetic therapy

(2013) Arnab Chattopadhyay et al.   JOURNAL OF LIPID RESEARCH

ApoA-I mimetics: tomatoes to the rescue

(2013) Godfrey S. Getz et al.   JOURNAL OF LIPID RESEARCH

Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation

(2013) Martine Bot et al.   JOURNAL OF LIPID RESEARCH

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-Density Lipoprotein and 4F Peptide Reduce Systemic Inflammation by Modulating Intestinal Oxidized Lipid Metabolism

(2012) Mohamad Navab et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lipid Phosphate Phosphatase 3 Negatively Regulates Smooth Muscle Cell Phenotypic Modulation to Limit Intimal Hyperplasia

(2012) Manikandan Panchatcharam et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lysophosphatidic acid causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells

(2012) Chanygi Chen et al.   ATHEROSCLEROSIS

Identification of genes affecting apolipoprotein B secretion following siRNA-mediated gene knockdown in primary human hepatocytes

(2012) Xun Shen et al.   ATHEROSCLEROSIS

Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice

(2012) Wilma T Steegenga et al.   BMC Medical Genomics

Lysophosphatidic acid in atherosclerotic diseases

(2012) Andreas Schober et al.   BRITISH JOURNAL OF PHARMACOLOGY

Quantification of Phosphatidic Acid in Foodstuffs Using a Thin-Layer-Chromatography-Imaging Technique

(2012) Tamotsu Tanaka et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Fatty Acids Bind Tightly to the N-terminal Domain of Angiopoietin-like Protein 4 and Modulate Its Interaction with Lipoprotein Lipase

(2012) Terje Robal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angptl4 deficiency decreases serum triglyceride levels in low-density lipoprotein receptor knockout mice and streptozotocin-induced diabetic mice

(2011) Hironori Adachi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Angiopoietin-like 4: a decade of research

(2011) Pengcheng Zhu et al.   BIOSCIENCE REPORTS

Lipoprotein-Derived Lysophosphatidic Acid Promotes Atherosclerosis by Releasing CXCL1 from the Endothelium

(2011) Zhe Zhou et al.   Cell Metabolism

Comparison of Lysophospholipid Levels in Rat Feces with Those in a Standard Chow

(2011) Manami Inoue et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

D-4F-mediated reduction in metabolites of arachidonic and linoleic acids in the small intestine is associated with decreased inflammation in low-density lipoprotein receptor-null mice

(2011) Mohamad Navab et al.   JOURNAL OF LIPID RESEARCH

Intestine may be a major site of action for the apoA-I mimetic peptide 4F whether administered subcutaneously or orally

(2011) Mohamad Navab et al.   JOURNAL OF LIPID RESEARCH

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

(2011) Heribert Schunkert et al.   NATURE GENETICS

Atherosclerotic Lesion Progression Changes Lysophosphatidic Acid Homeostasis to Favor its Accumulation

(2010) Martine Bot et al.   AMERICAN JOURNAL OF PATHOLOGY

Absence of intestinal microbiota does not protect mice from diet-induced obesity

(2010) Christine K. Fleissner et al.   BRITISH JOURNAL OF NUTRITION

Treatment of patients with cardiovascular disease with L-4F, an apo-A1 mimetic, did not improve select biomarkers of HDL function

(2010) Catherine E. Watson et al.   JOURNAL OF LIPID RESEARCH

Formation of Lysophosphatidic Acid, a Wound-Healing Lipid, during Digestion of Cabbage Leaves

(2009) Tamotsu TANAKA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis

(2008) Hironori Adachi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Two pathways for lysophosphatidic acid production

(2008) J AOKI   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice

(2008) Nicole JW de Wit et al.   BMC Medical Genomics

Safety, pharmacokinetics, and pharmacodynamics of oral apoA-I mimetic peptide D-4F in high-risk cardiovascular patients

(2008) LeAnne T. Bloedon et al.   JOURNAL OF LIPID RESEARCH