The role of non-coding RNAs in neuroprotection and angiogenesis following ischemic stroke

The Regulatory Role of Long Noncoding RNAs in Different Brain Cell Types Involved in Ischemic Stroke

(2019) Runsen Chen et al.   Frontiers in Molecular Neuroscience

The expression and functional roles of miRNAs in embryonic and lineage-specific stem cells

(2019) Maryam Farzaneh et al.   Current Stem Cell Research & Therapy

NLRP3 inflammasome in ischemic stroke: As possible therapeutic target

(2019) Masoumeh Alishahi et al.   International Journal of Stroke

Long non-coding RNAs and cell death following ischemic stroke

(2019) Masoumeh Alishahi et al.   METABOLIC BRAIN DISEASE

Profiling neuron-autonomous lncRNA changes upon ischemia/reperfusion injury

(2018) Haiying Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of microRNA-210 suppresses pro-inflammatory response and reduces acute brain injury of ischemic stroke in mice

(2018) Lei Huang et al.   EXPERIMENTAL NEUROLOGY

Long Non-Coding RNA Malat1 Regulates Angiogenesis in Hindlimb Ischemia

(2018) Xuejing Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

microRNA-137 promotes endothelial progenitor cell proliferation and angiogenesis in cerebral ischemic stroke mice by targeting NR4A2 through the Notch pathway

(2018) Xing-Li Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Vanillic acid attenuates cerebral hyperemia, blood-brain barrier disruption and anxiety-like behaviors in rats following transient bilateral common carotid occlusion and reperfusion

(2018) Seyed Esmaeil Khoshnam et al.   METABOLIC BRAIN DISEASE

Upregulation of miR-215 exerts neuroprotection effects against ischemic injury via negative regulation of Act1/IL-17RA signaling

(2018) Hongxue Sun et al.   NEUROSCIENCE LETTERS

Noncoding RNAs and Stroke

(2018) Xuejing Zhang et al.   NEUROSCIENTIST

Long non-coding RNAs in ischemic stroke

(2018) Mei-Hua Bao et al.   Cell Death & Disease

Pathophysiology of Long Non-coding RNAs in Ischemic Stroke

(2018) Weimin Ren et al.   Frontiers in Molecular Neuroscience

Memory deficits and hippocampal inflammation in cerebral hypoperfusion and reperfusion in male rats: Neuroprotective role of vanillic acid

(2018) Seyed Esmaeil Khoshnam et al.   LIFE SCIENCES

Non-Coding RNA in Acute Ischemic Stroke: Mechanisms, Biomarkers and Therapeutic Targets

(2018) Sheng-Wen Wang et al.   CELL TRANSPLANTATION

MiR-377 Regulates Inflammation and Angiogenesis in Rats After Cerebral Ischemic Injury

(2017) Yiling Fan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Interplay of MicroRNAs in the Inflammatory Mechanisms Following Ischemic Stroke

(2017) Seyed Esmaeil Khoshnam et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Long Noncoding RNA Malat1 Regulates Cerebrovascular Pathologies in Ischemic Stroke

(2017) Xuejing Zhang et al.   JOURNAL OF NEUROSCIENCE

Discovery of novel stroke-responsive lncRNAs in the mouse cortex using genome-wide RNA-seq

(2017) Sunil Bhattarai et al.   NEUROBIOLOGY OF DISEASE

Pathogenic mechanisms following ischemic stroke

(2017) Seyed Esmaeil Khoshnam et al.   NEUROLOGICAL SCIENCES

Long Noncoding RNA H19 Promotes Neuroinflammation in Ischemic Stroke by Driving Histone Deacetylase 1–Dependent M1 Microglial Polarization

(2017) Jue Wang et al.   STROKE

MicroRNA-17–92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats

(2017) Hongqi Xin et al.   STROKE

Circular RNA Expression Profiles Alter Significantly in Mouse Brain After Transient Focal Ischemia

(2017) Suresh L. Mehta et al.   STROKE

MicroRNA Changes in Preconditioning-Induced Neuroprotection

(2017) Josh D. Bell et al.   Translational Stroke Research

Emerging Roles of microRNAs in Ischemic Stroke: As Possible Therapeutic Agents

(2017) Seyed Esmaeil Khoshnam et al.   Journal of Stroke

MiR-150 Regulates Poststroke Cerebral Angiogenesis via Vascular Endothelial Growth Factor in Rats

(2016) Quan-Wei He et al.   CNS Neuroscience & Therapeutics

Altered long non-coding RNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia

(2016) J. Zhang et al.   EXPERIMENTAL NEUROLOGY

Lithium-induced neuroprotection in stroke involves increased miR-124 expression, reduced RE1-silencing transcription factor abundance and decreased protein deubiquitination by GSK3β inhibition-independent pathways

(2016) Thorsten R Doeppner et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

miR-140-5p regulates angiogenesis following ischemic stroke by targeting VEGFA

(2016) JIJUN SUN et al.   Molecular Medicine Reports

LncRNA-N1LR Enhances Neuroprotection Against Ischemic Stroke Probably by Inhibiting p53 Phosphorylation

(2016) Zhuomin Wu et al.   MOLECULAR NEUROBIOLOGY

An Antagomir to MicroRNA-106b-5p Ameliorates Cerebral Ischemia and Reperfusion Injury in Rats Via Inhibiting Apoptosis and Oxidative Stress

(2016) Pengfei Li et al.   MOLECULAR NEUROBIOLOGY

Downregulation of the Long Non-Coding RNA Meg3 Promotes Angiogenesis After Ischemic Brain Injury by Activating Notch Signaling

(2016) Juan Liu et al.   MOLECULAR NEUROBIOLOGY

Long noncoding RNA MEG3 activation of p53 mediates ischemic neuronal death in stroke

(2016) Honglin Yan et al.   NEUROSCIENCE

Altered Expression of Long Noncoding RNAs in Blood After Ischemic Stroke and Proximity to Putative Stroke Risk Loci

(2016) Cheryl Dykstra-Aiello et al.   STROKE

Angiogenesis-regulating microRNAs and Ischemic Stroke

(2015) Ke-Jie Yin et al.   Current Vascular Pharmacology

Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia

(2015) Li-Jun Xu et al.   EXPERIMENTAL NEUROLOGY

miR-210 mediates vagus nerve stimulation-induced antioxidant stress and anti-apoptosis reactions following cerebral ischemia/reperfusion injury in rats

(2015) Ying Jiang et al.   JOURNAL OF NEUROCHEMISTRY

MicroRNA-181c negatively regulates the inflammatory response in oxygen-glucose-deprived microglia by targeting Toll-like receptor 4

(2015) Li Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Long Noncoding RNA FosDT Promotes Ischemic Brain Injury by Interacting with REST-Associated Chromatin-Modifying Proteins

(2015) S. L. Mehta et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective effect of microRNA-99a against focal cerebral ischemia–reperfusion injury in mice

(2015) Zhen Tao et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

MicroRNA-200c Contributes to Injury From Transient Focal Cerebral Ischemia by Targeting Reelin

(2015) Creed M. Stary et al.   STROKE

MicroRNA-107 contributes to post-stroke angiogenesis by targeting Dicer-1

(2015) Yanan Li et al.   Scientific Reports

MicroRNA-23a-3p attenuates oxidative stress injury in a mouse model of focal cerebral ischemia-reperfusion

(2014) Haiping Zhao et al.   BRAIN RESEARCH

Impact of microRNA-134 on neural cell survival against ischemic injury in primary cultured neuronal cells and mouse brain with ischemic stroke by targeting HSPA12B

(2014) Wenying Chi et al.   BRAIN RESEARCH

Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth

(2014) Katharina M. Michalik et al.   CIRCULATION RESEARCH

Combination treatment of r-tPA and an optimized human apyrase reduces mortality rate and hemorrhagic transformation 6h after ischemic stroke in aged female rats

(2014) Zhenjun Tan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation

(2014) Shruti Kabadi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA miR-124 Controls the Choice between Neuronal and Astrocyte Differentiation by Fine-tuning Ezh2 Expression

(2014) Wen Hao Neo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CpG Preconditioning Regulates Mirna Expression That Modulates Genomic Reprogramming Associated with Neuroprotection against Ischemic Injury

(2014) Keri B Vartanian et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

miR-134 Regulates Ischemia/Reperfusion Injury-Induced Neuronal Cell Death by Regulating CREB Signaling

(2014) Weidong Huang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

microRNA-200b modulates microglia-mediated neuroinflammationviathe cJun/MAPK pathway

(2014) Shweta P. Jadhav et al.   JOURNAL OF NEUROCHEMISTRY

Therapeutic targeting of microRNAs: current status and future challenges

(2014) Zhonghan Li et al.   NATURE REVIEWS DRUG DISCOVERY

Non-coding RNAs in cerebral endothelial pathophysiology: Emerging roles in stroke

(2014) Ke-Jie Yin et al.   NEUROCHEMISTRY INTERNATIONAL

MicroRNAs and synaptic plasticity--a mutual relationship

(2014) A. Aksoy-Aksel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Blood Brain Barrier and Neuroinflammation Are Critical Targets of IGF-1-Mediated Neuroprotection in Stroke for Middle-Aged Female Rats

(2014) Shameena Bake et al.   PLoS One

Non-coding RNA interact to regulate neuronal development and function

(2014) Bharat R. Iyengar et al.   Frontiers in Cellular Neuroscience

MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis

(2014) Q Chen et al.   Cell Death & Disease

Exosomes function in cell–cell communication during brain circuit development

(2013) Pranav Sharma et al.   CURRENT OPINION IN NEUROBIOLOGY

miRNAs in brain development

(2013) Rebecca Petri et al.   EXPERIMENTAL CELL RESEARCH

MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain

(2013) L Zeng et al.   GENE THERAPY

Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis

(2013) Zhen Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Progress in microRNA delivery

(2013) Yu Zhang et al.   JOURNAL OF CONTROLLED RELEASE

MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart

(2013) Zoltán V. Varga et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Comprehensive Expression Analyses of Neural Cell-Type-Specific miRNAs Identify New Determinants of the Specification and Maintenance of Neuronal Phenotypes

(2013) A. Jovicic et al.   JOURNAL OF NEUROSCIENCE

Downregulation of miR-181b in mouse brain following ischemic stroke induces neuroprotection against ischemic injury through targeting heat shock protein A5 and ubiquitin carboxyl-terminal hydrolase isozyme L1

(2013) Zhifeng Peng et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Structure and function of long noncoding RNAs in epigenetic regulation

(2013) Tim R Mercer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

All’s well that transcribes well: Non-coding RNAs and post-stroke brain damage

(2013) Raghu Vemuganti   NEUROCHEMISTRY INTERNATIONAL

Emerging epigenetic mechanisms of long non-coding RNAs

(2013) K. Schaukowitch et al.   NEUROSCIENCE

Long Non-coding RNAs: Novel Targets for Nervous System Disease Diagnosis and Therapy

(2013) Irfan A. Qureshi et al.   Neurotherapeutics

MicroRNA miR-29c Down-Regulation Leading to De-Repression of Its Target DNA Methyltransferase 3a Promotes Ischemic Brain Damage

(2013) Gopal Pandi et al.   PLoS One

A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes

(2013) S. Carpenter et al.   SCIENCE

MiRNA-424 Protects Against Permanent Focal Cerebral Ischemia Injury in Mice Involving Suppressing Microglia Activation

(2013) Haiping Zhao et al.   STROKE

Extracellular vesicles as mediators of neuron-glia communication

(2013) Carsten Frühbeis et al.   Frontiers in Cellular Neuroscience

MicroRNA let-7d regulates the TLX/microRNA-9 cascade to control neural cell fate and neurogenesis

(2013) Chunnian Zhao et al.   Scientific Reports

Approaches to manipulating microRNAs in neurogenesis

(2013) Haijun Zhang et al.   Frontiers in Neuroscience

Neuroprotective role of ATP-sensitive potassium channels in cerebral ischemia

(2012) Hong-shuo Sun et al.   ACTA PHARMACOLOGICA SINICA

Regulation of mammalian cell differentiation by long non-coding RNAs

(2012) Wenqian Hu et al.   EMBO REPORTS

Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells

(2012) Feng Yang et al.   FEBS Journal

Vascular Endothelial Cell-specificMicroRNA-15aInhibits Angiogenesis in Hindlimb Ischemia

(2012) Ke-Jie Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia

(2012) Yuan-Lei Lou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

LincRNA-p21 Suppresses Target mRNA Translation

(2012) Je-Hyun Yoon et al.   MOLECULAR CELL

Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease

(2012) Irfan A. Qureshi et al.   NATURE REVIEWS NEUROSCIENCE

miRNA Regulons Associated with Synaptic Function

(2012) Maria Paschou et al.   PLoS One

MicroRNA-223 is neuroprotective by targeting glutamate receptors

(2012) M. M. Harraz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiogenesis

(2012) Adviye Ergul et al.   STROKE

Effect of Focal Ischemia on Long Noncoding RNAs

(2012) Ashutosh Dharap et al.   STROKE

Pentoxifylline attenuates TNF-α protein levels and brain edema following temporary focal cerebral ischemia in rats

(2011) Abedin Vakili et al.   BRAIN RESEARCH

A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA

(2011) Marcella Cesana et al.   CELL

In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma

(2011) Florian A. Karreth et al.   CELL

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

(2011) Leonardo Salmena et al.   CELL

MicroRNA networks direct neuronal development and plasticity

(2011) N. F. M. Olde Loohuis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

microRNAs in Stroke Pathogenesis

(2011) J. R. Tan et al.   CURRENT MOLECULAR MEDICINE

Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors

(2011) Shi-Yan Ng et al.   EMBO JOURNAL

Intranasal delivery of stem cells to the brain

(2011) Yongjun Jiang et al.   Expert Opinion on Drug Delivery

lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3′ UTRs via Alu elements

(2011) Chenguang Gong et al.   NATURE

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Stroke research at a crossroad: asking the brain for directions

(2011) Costantino Iadecola et al.   NATURE NEUROSCIENCE

Natural Vitamin E α-Tocotrienol Protects Against Ischemic Stroke by Induction of Multidrug Resistance-Associated Protein 1

(2011) Han-A Park et al.   STROKE

Long non-coding RNAs in nervous system function and disease

(2010) Irfan A. Qureshi et al.   BRAIN RESEARCH

MicroRNAs as Effectors of Brain Function with Roles in Ischemia and Injury, Neuroprotection, and Neurodegeneration

(2010) Julie A Saugstad   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The magic and mystery of miR-21

(2010) Edward E. Morrisey   JOURNAL OF CLINICAL INVESTIGATION

Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice

(2010) David M. Patrick et al.   JOURNAL OF CLINICAL INVESTIGATION

Gender and Stroke Symptoms

(2010) Claudia C. Beal   JOURNAL OF NEUROSCIENCE NURSING

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation

(2010) Vidisha Tripathi et al.   MOLECULAR CELL

miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia

(2010) Ke-Jie Yin et al.   NEUROBIOLOGY OF DISEASE

Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132

(2010) Dieter Edbauer et al.   NEURON

Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats

(2010) Y. Jiang et al.   NEUROSCIENCE

MicroRNA in ischemic stroke etiology and pathology

(2010) Cameron Rink et al.   PHYSIOLOGICAL GENOMICS

microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus

(2010) S. T. Magill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of specific microRNAs for endothelial function and angiogenesis

(2009) Fusheng Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Emerging Roles of microRNAs in the Molecular Responses to Hypoxia

(2009) Meredith Crosby et al.   CURRENT PHARMACEUTICAL DESIGN

Mef2-mediated transcription of the miR379–410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels

(2009) Roberto Fiore et al.   EMBO JOURNAL

Long noncoding RNAs: functional surprises from the RNA world

(2009) J. E. Wilusz et al.   GENES & DEVELOPMENT

Transient Focal Ischemia Induces Extensive Temporal Changes in Rat Cerebral MicroRNAome

(2009) Ashuthosh Dharap et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Penumbra, the basis of neuroimaging in acute stroke treatment: Current evidence

(2009) Gyanendra Kumar et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

(2009) Zheng Gang Zhang et al.   LANCET NEUROLOGY

miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche

(2009) Li-Chun Cheng et al.   NATURE NEUROSCIENCE

Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia

(2009) Hong-Shuo Sun et al.   NATURE NEUROSCIENCE

Long non-coding RNAs: insights into functions

(2009) Tim R. Mercer et al.   NATURE REVIEWS GENETICS

Dual response of BDNF to sublethal concentrations of β-amyloid peptides in cultured cortical neurons

(2009) E. Aliaga et al.   NEUROBIOLOGY OF DISEASE

microRNA involvement in developmental and functional aspects of the nervous system and in neurological diseases

(2009) Mette Christensen et al.   NEUROSCIENCE LETTERS

microRNA: Emerging therapeutic targets in acute ischemic diseases

(2009) Pasquale Fasanaro et al.   PHARMACOLOGY & THERAPEUTICS

Expression Profile of MicroRNAs in Young Stroke Patients

(2009) Kay Sin Tan et al.   PLoS One

A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex

(2008) Nikolaos Mellios et al.   HUMAN MOLECULAR GENETICS

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

MicroRNA expression in the adult mouse central nervous system

(2008) M. Bak et al.   RNA

Effectiveness of PSD95 Inhibitors in Permanent and Transient Focal Ischemia in the Rat

(2008) Hong-Shuo Sun et al.   STROKE