Neuroprotective Strategies for Traumatic Brain Injury: Improving Clinical Translation

Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness

(2014) Robert S.B. Clark et al.   Autophagy

CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury, a nested randomised, placebo-controlled trial.

(2014) P Perel et al.   HEALTH TECHNOLOGY ASSESSMENT

Neuroprotective Effects of Geranylgeranylacetone in Experimental Traumatic Brain Injury

(2013) Zaorui Zhao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Late exercise reduces neuroinflammation and cognitive dysfunction after traumatic brain injury

(2013) Chun-Shu Piao et al.   NEUROBIOLOGY OF DISEASE

Traumatic Brain Injury, Shell Shock, and Posttraumatic Stress Disorder in the Military—Past, Present, and Future

(2012) Sharon B. Shively et al.   JOURNAL OF HEAD TRAUMA REHABILITATION

Over-expression of HSP70 attenuates caspase-dependent and caspase-independent pathways and inhibits neuronal apoptosis

(2012) Boris Sabirzhanov et al.   JOURNAL OF NEUROCHEMISTRY

Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury

(2012) Kimberly R Byrnes et al.   Journal of Neuroinflammation

Are There Gender Differences in Cognitive Function, Chronic Stress, and Neurobehavioral Symptoms After Mild-to-Moderate Traumatic Brain Injury?

(2012) Tracey Covassin et al.   JOURNAL OF NEUROSCIENCE NURSING

Activation of mGluR5 and Inhibition of NADPH Oxidase Improves Functional Recovery after Traumatic Brain Injury

(2012) David J. Loane et al.   JOURNAL OF NEUROTRAUMA

Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury

(2012) Chun-Shu Piao et al.   NEUROBIOLOGY OF DISEASE

The Neuropathology and Neurobiology of Traumatic Brain Injury

(2012) Kaj Blennow et al.   NEURON

CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial

(2012) Yashbir Dewan et al.   Trials

Altered Bidirectional Plasticity and Reduced Implicit Motor Learning in Concussed Athletes

(2011) L. De Beaumont et al.   CEREBRAL CORTEX

Selective CDK Inhibitor Limits Neuroinflammation and Progressive Neurodegeneration after Brain Trauma

(2011) Shruti V Kabadi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Progesterone in the treatment of acute traumatic brain injury: a clinical perspective and update

(2011) D.G. Stein   NEUROSCIENCE

CR8, a Selective and Potent CDK Inhibitor, Provides Neuroprotection in Experimental Traumatic Brain Injury

(2011) Shruti V. Kabadi et al.   Neurotherapeutics

Progesterone in the clinical treatment of acute traumatic brain injury

(2010) Donald G Stein et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Clinical trials in traumatic brain injury: Past experience and current developments

(2010) Andrew I. R. Maas et al.   Neurotherapeutics

Statins in traumatic brain injury

(2010) Elissa F. Wible et al.   Neurotherapeutics

Role of microglia in neurotrauma

(2010) David J. Loane et al.   Neurotherapeutics

IMPACT recommendations for improving the design and analysis of clinical trials in moderate to severe traumatic brain injury

(2010) Andrew I. R. Maas et al.   Neurotherapeutics

Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies

(2010) David J. Loane et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Severe traumatic brain injury: is there a gender difference in mortality?

(2009) Marcus Ottochian et al.   AMERICAN JOURNAL OF SURGERY

Is there a gender difference in concussion incidence and outcomes?

(2009) R W Dick   BRITISH JOURNAL OF SPORTS MEDICINE

Simvastatin reduces secondary brain injury caused by cortical contusion in rats: Possible involvement of TLR4/NF-κB pathway

(2009) Gang Chen et al.   EXPERIMENTAL NEUROLOGY

Activation of Metabotropic Glutamate Receptor 5 Modulates Microglial Reactivity and Neurotoxicity by Inhibiting NADPH Oxidase

(2009) David J. Loane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substance P is Associated with the Development of Brain Edema and Functional Deficits after Traumatic Brain Injury

(2009) James J Donkin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Key Role of Sulfonylurea Receptor 1 in Progressive Secondary Hemorrhage after Brain Contusion

(2009) J. Marc Simard et al.   JOURNAL OF NEUROTRAUMA

Combination Therapies for Traumatic Brain Injury: Prospective Considerations

(2009) Susan Margulies et al.   JOURNAL OF NEUROTRAUMA

Brain metabolic and hemodynamic effects of cyclosporin A after human severe traumatic brain injury: a microdialysis study

(2008) Anna Teresa Mazzeo et al.   ACTA NEUROCHIRURGICA

Roscovitine Reduces Neuronal Loss, Glial Activation, and Neurologic Deficits after Brain Trauma

(2008) Genell D Hilton et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Comparative Neuroprotective Effects of Cyclosporin a and NIM811, a Nonimmunosuppressive Cyclosporin a Analog, following Traumatic Brain Injury

(2008) Lamin Han Mbye et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Efficacy of Progesterone following a Moderate Unilateral Cortical Contusion Injury

(2008) Lesley K. Gilmer et al.   JOURNAL OF NEUROTRAUMA

Effect of Rosuvastatin on Amnesia and Disorientation after Traumatic Brain Injury (NCT00329758)

(2008) J. Humberto Tapia-Perez et al.   JOURNAL OF NEUROTRAUMA

Classification of Traumatic Brain Injury for Targeted Therapies

(2008) Kathryn E. Saatman et al.   JOURNAL OF NEUROTRAUMA

Moderate and severe traumatic brain injury in adults

(2008) Andrew IR Maas et al.   LANCET NEUROLOGY

Mild Traumatic Brain Injury in U.S. Soldiers Returning from Iraq

(2008) Charles W. Hoge et al.   NEW ENGLAND JOURNAL OF MEDICINE

CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases

(2008) K Bettayeb et al.   ONCOGENE

Adaptive design methods in clinical trials – a review

(2008) Shein-Chung Chow et al.   Orphanet Journal of Rare Diseases

Progesterone for the treatment of experimental brain injury; a systematic review

(2007) C. L. Gibson et al.   BRAIN

Drugs acting on SUR1 to treat CNS ischemia and trauma

(2007) J SIMARD et al.   CURRENT OPINION IN PHARMACOLOGY

Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog

(2007) L.H. Mbye et al.   EXPERIMENTAL NEUROLOGY