Glycoform-resolved FcɣRIIIa affinity chromatography–mass spectrometry

Therapeutic monoclonal antibody N-glycosylation – Structure, function and therapeutic potential

(2018) Florian Cymer et al.   BIOLOGICALS

Restricted processing of CD16a/Fc γ receptor IIIaN-glycans from primary human NK cells impacts structure and function

(2018) Kashyap R. Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes

(2018) Huilin Li et al.   Nature Chemistry

Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered FcγReceptor IIIa-Immobilized Column

(2018) Masato Kiyoshi et al.   Scientific Reports

Charge variant native mass spectrometry benefits mass precision and dynamic range of monoclonal antibody intact mass analysis

(2018) Aaron O. Bailey et al.   mAbs

Influence of N-glycosylation on effector functions and thermal stability of glycoengineered IgG1 monoclonal antibody with homogeneous glycoforms

(2018) Ryuta Wada et al.   mAbs

Characterization of endogenous human FcγRIII by mass spectrometry reveals site, allele and sequence specific glycosylation

(2018) Nathaniel Washburn et al.   MOLECULAR & CELLULAR PROTEOMICS

Resolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approaches

(2017) Yang Yang et al.   mAbs

Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities

(2017) Gillian Dekkers et al.   Frontiers in Immunology

Native MS Analysis of Bacteriorhodopsin and an Empty Nanodisc by Orthogonal Acceleration Time-of-Flight, Orbitrap and Ion Cyclotron Resonance

(2016) Iain D. G. Campuzano et al.   ANALYTICAL CHEMISTRY

Effect of high mannose glycan pairing on IgG antibody clearance

(2016) Yaoqing Diana Liu et al.   BIOLOGICALS

Multi-level glyco-engineering techniques to generate IgG with defined Fc-glycans

(2016) Gillian Dekkers et al.   Scientific Reports

Fc glycans of therapeutic antibodies as critical quality attributes

(2015) Dietmar Reusch et al.   GLYCOBIOLOGY

In Vitro Glycoengineering of IgG1 and Its Effect on Fc Receptor Binding and ADCC Activity

(2015) Marco Thomann et al.   PLoS One

Multi-Angle Effector Function Analysis of Human Monoclonal IgG Glycovariants

(2015) Tetyana Dashivets et al.   PLoS One

Detailed mass analysis of structural heterogeneity in monoclonal antibodies using native mass spectrometry

(2014) Sara Rosati et al.   Nature Protocols

Next-generation antibodies

(2014) James B. Evans et al.   NATURE REVIEWS DRUG DISCOVERY

Knobs-into-holes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibody-dependent cellular cytotoxicity

(2013) Whitney Shatz et al.   mAbs

Marketing approval of mogamulizumab

(2012) Alain Beck et al.   mAbs

Production, characterization and pharmacokinetic properties of antibodies with N-linked Mannose-5 glycans

(2012) Marcella Yu et al.   mAbs

Isolation and characterization of IgG1 with asymmetrical Fc glycosylation

(2011) S. Ha et al.   GLYCOBIOLOGY

Cell Type-Specific and Site DirectedN-Glycosylation Pattern of FcγRIIIa

(2011) Anne Zeck et al.   JOURNAL OF PROTEOME RESEARCH

Advances in the assessment and control of the effector functions of therapeutic antibodies

(2011) Xu-Rong Jiang et al.   NATURE REVIEWS DRUG DISCOVERY

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY