Influence of N-glycosylation on effector functions and thermal stability of glycoengineered IgG1 monoclonal antibody with homogeneous glycoforms

Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies

(2018) Sachin S. Shivatare et al.   CHEMICAL COMMUNICATIONS

Kinetics and Characterization of Non-enzymatic Fragmentation of Monoclonal Antibody Therapeutics

(2018) Sahithi Ravuluri et al.   PHARMACEUTICAL RESEARCH

Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered FcγReceptor IIIa-Immobilized Column

(2018) Masato Kiyoshi et al.   Scientific Reports

Glycosylation of IgG-Fc: a molecular perspective

(2017) Masato Kiyoshi et al.   INTERNATIONAL IMMUNOLOGY

Designer α1,6-Fucosidase Mutants Enable Direct Core Fucosylation of Intact N-Glycopeptides and N-Glycoproteins

(2017) Chao Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of highly concentrated antibody solution - A toolbox for the description of protein long-term solution stability

(2017) Marie-Therese Schermeyer et al.   mAbs

Modulating IgG effector function by Fc glycan engineering

(2017) Tiezheng Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of an FcRn affinity chromatographic method for IgG1-type antibodies and evaluation of IgG variants

(2017) Florian Cymer et al.   Bioanalysis

Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins

(2017) Liming Liu   Protein & Cell

IgG Fc engineering to modulate antibody effector functions

(2017) Xinhua Wang et al.   Protein & Cell

Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities

(2017) Gillian Dekkers et al.   Frontiers in Immunology

Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity

(2017) Benjamin Peschke et al.   Frontiers in Immunology

Crystallizable Fragment Glycoengineering for Therapeutic Antibodies Development

(2017) Wei Li et al.   Frontiers in Immunology

Effect of Fc-Glycan Structure on the Conformational Stability of IgG Revealed by Hydrogen/Deuterium Exchange and Limited Proteolysis

(2016) Jing Fang et al.   BIOCHEMISTRY

Highly efficient transglycosylation of sialo-complex-type oligosaccharide using Coprinopsis cinerea endoglycosidase and sugar oxazoline

(2016) Yujiro Higuchi et al.   BIOTECHNOLOGY LETTERS

Glycosynthase Mutants of Endoglycosidase S2 Show Potent Transglycosylation Activity and Remarkably Relaxed Substrate Specificity for Antibody Glycosylation Remodeling

(2016) Tiezheng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy

(2015) Jonathan T. Sockolosky et al.   ADVANCED DRUG DELIVERY REVIEWS

Mouse and human FcR effector functions

(2015) Pierre Bruhns et al.   IMMUNOLOGICAL REVIEWS

Examination of Thermal Unfolding and Aggregation Profiles of a Series of Developable Therapeutic Monoclonal Antibodies

(2015) Mark L. Brader et al.   MOLECULAR PHARMACEUTICS

A common glycan structure on immunoglobulin G for enhancement of effector functions

(2015) Chin-Wei Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Glycoengineering of IgG1 and Its Effect on Fc Receptor Binding and ADCC Activity

(2015) Marco Thomann et al.   PLoS One

Glycoengineered Monoclonal Antibodies with Homogeneous Glycan (M3, G0, G2, and A2) Using a Chemoenzymatic Approach Have Different Affinities for FcγRIIIa and Variable Antibody-Dependent Cellular Cytotoxicity Activities

(2015) Masaki Kurogochi et al.   PLoS One

Multi-Angle Effector Function Analysis of Human Monoclonal IgG Glycovariants

(2015) Tetyana Dashivets et al.   PLoS One

Influence of glycosylation pattern on the molecular properties of monoclonal antibodies

(2014) Kai Zheng et al.   mAbs

Interactions of IgG1 CH2 and CH3 Domains with FcRn

(2014) Tianlei Ying et al.   Frontiers in Immunology

EndoS2is a unique and conserved enzyme of serotype M49 group AStreptococcusthat hydrolyses N-linked glycans on IgG and α1-acid glycoprotein

(2013) Jonathan Sjögren et al.   BIOCHEMICAL JOURNAL

N-Linked Glycan Structures of the Human Fcγ Receptors Produced in NS0 Cells

(2013) Eoin F. J. Cosgrave et al.   JOURNAL OF PROTEOME RESEARCH

Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies

(2013) Tilman Schlothauer et al.   mAbs

Consequences of glycan truncation on Fc structural integrity

(2013) Patrick M Buck et al.   mAbs

N-Linked Protein Glycosylation in the Endoplasmic Reticulum

(2013) J. Breitling et al.   Cold Spring Harbor Perspectives in Biology

Properties of mouse and human IgG receptors and their contribution to disease models

(2012) P. Bruhns   BLOOD

A Practical One-Step Synthesis of 1,2-Oxazoline Derivatives from Unprotected Sugars and Its Application to Chemoenzymaticβ-N-Acetylglucosaminidation of Disialo-oligosaccharide

(2012) Masato Noguchi et al.   HELVETICA CHIMICA ACTA

Highly Aggregated Antibody Therapeutics Can Enhance thein VitroInnate and Late-stage T-cell Immune Responses

(2012) Marisa K. Joubert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The impact of glycosylation on monoclonal antibody conformation and stability

(2012) Kai Zheng et al.   mAbs

Quantitative evaluation of fucose reducing effects in a humanized antibody on Fcγ receptor binding and antibody-dependent cell-mediated cytotoxicity activities

(2012) Shan Chung et al.   mAbs

Production, characterization and pharmacokinetic properties of antibodies with N-linked Mannose-5 glycans

(2012) Marcella Yu et al.   mAbs

Advances in the assessment and control of the effector functions of therapeutic antibodies

(2011) Xu-Rong Jiang et al.   NATURE REVIEWS DRUG DISCOVERY

Impact of Product-Related Factors on Immunogenicity of Biotherapeutics

(2010) Satish Kumar Singh   JOURNAL OF PHARMACEUTICAL SCIENCES

Post-translational Modifications Differentially Affect IgG1 Conformation and Receptor Binding

(2010) Damian Houde et al.   MOLECULAR & CELLULAR PROTEOMICS

Enhanced antibody half-life improves in vivo activity

(2010) Jonathan Zalevsky et al.   NATURE BIOTECHNOLOGY

Dynamic Fluctuations of Protein-Carbohydrate Interactions Promote Protein Aggregation

(2009) Vladimir Voynov et al.   PLoS One

Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells

(2008) M. Peipp et al.   BLOOD

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

(2008) T Shantha Raju   CURRENT OPINION IN IMMUNOLOGY

Protein quality control in the early secretory pathway

(2008) Tiziana Anelli et al.   EMBO JOURNAL

The N-linked oligosaccharide at Fc RIIIa Asn-45: an inhibitory element for high Fc RIIIa binding affinity to IgG glycoforms lacking core fucosylation

(2008) M. Shibata-Koyama et al.   GLYCOBIOLOGY

Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose

(2008) Christine H. Chung et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Role of Complement in the Mechanism of Action of Rituximab for B-Cell Lymphoma: Implications for Therapy

(2008) X. Zhou et al.   ONCOLOGIST

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE

Contribution of Variable Domains to the Stability of Humanized IgG1 Monoclonal Antibodies

(2007) Roxana M. Ionescu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES