Primary HIV-1 Strains Use Nef To Downmodulate HLA-E Surface Expression

Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection

(2019) Marion Pardons et al.   PLoS Pathogens

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

(2019) Simon Langer et al.   eLife

A genome-wide survey of mutations in the Jurkat cell line

(2018) Louis Gioia et al.   BMC GENOMICS

Killer cell immunoglobulin–like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1

(2018) Maureen P. Martin et al.   JOURNAL OF CLINICAL INVESTIGATION

HLA Class I Downregulation by HIV-1 Variants from Subtype C Transmission Pairs

(2018) Zachary Ende et al.   JOURNAL OF VIROLOGY

ElevatedHLA-Aexpression impairs HIV control through inhibition of NKG2A-expressing cells

(2018) Veron Ramsuran et al.   SCIENCE

Tracking KLRC2 (NKG2C)+ memory-like NK cells in SIV+ and rhCMV+ rhesus macaques

(2018) Daniel R. Ram et al.   PLoS Pathogens

Identification of novel HIV-1-derived HLA-E-binding peptides

(2018) Zara Hannoun et al.   IMMUNOLOGY LETTERS

HLA-C downregulation by HIV-1 adapts to host HLA genotype

(2018) Nathaniel D. Bachtel et al.   PLoS Pathogens

Bortezomib sensitizes multiple myeloma to NK cells via ER-stress-induced suppression of HLA-E and upregulation of DR5

(2018) Mattias Carlsten et al.   OncoImmunology

The Role of MHC-E in T Cell Immunity Is Conserved among Humans, Rhesus Macaques, and Cynomolgus Macaques

(2017) Helen L. Wu et al.   JOURNAL OF IMMUNOLOGY

Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3

(2017) Santiago Manrique et al.   Nature Communications

Peptide-specific engagement of the activating NK cell receptor KIR2DS1

(2017) Anaïs Chapel et al.   Scientific Reports

Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation

(2017) Dominik Hotter et al.   PLoS Pathogens

The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild

(2016) Anke Heigele et al.   Cell Host & Microbe

HIV-1 Vpu Mediates HLA-C Downregulation

(2016) Richard Apps et al.   Cell Host & Microbe

Sequence variations in HCV core-derived epitopes alter binding of KIR2DL3 to HLA-C∗03:04 and modulate NK cell function

(2016) Sebastian Lunemann et al.   JOURNAL OF HEPATOLOGY

Kinetics of HIV-1 Latency Reversal Quantified on the Single-Cell Level Using a Novel Flow-Based Technique

(2016) G. Martrus et al.   JOURNAL OF VIROLOGY

Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

(2016) S. G. Hansen et al.   SCIENCE

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences

(2016) Macdonald Mahiti et al.   mBio

Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance

(2016) Dorota Kmiec et al.   mBio

A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells

(2016) Zachary B. Davis et al.   PLoS Pathogens

Role of HLA Adaptation in HIV Evolution

(2016) Henrik N. Kløverpris et al.   Frontiers in Immunology

Relative Expression Levels of the HLA Class-I Proteins in Normal and HIV-Infected Cells

(2015) Richard Apps et al.   JOURNAL OF IMMUNOLOGY

A Higher Frequency of NKG2A+than of NKG2A−NK Cells Responds to Autologous HIV-Infected CD4 Cells irrespective of Whether or Not They Coexpress KIR3DL1

(2015) Irene Lisovsky et al.   JOURNAL OF VIROLOGY

HIV infection and antiretroviral therapy lead to unfolded protein response activation

(2015) Mariana Borsa et al.   Virology Journal

Genetic determinants of Nef-mediated CD4 and HLA class I down-regulation differences between HIV-1 subtypes B and C

(2015) Jaclyn K. Mann et al.   Virology Journal

Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa

(2015) Angelique Hölzemer et al.   PLOS MEDICINE

Sequence variations in HIV-1 p24 Gag-derived epitopes can alter binding of KIR2DL2 to HLA-C*03

(2014) Nienke H. van Teijlingen et al.   AIDS

Nef Proteins of Epidemic HIV-1 Group O Strains Antagonize Human Tetherin

(2014) Silvia F. Kluge et al.   Cell Host & Microbe

Phenotypic properties of transmitted founder HIV-1

(2013) N. F. Parrish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes

(2013) Jaclyn K Mann et al.   Retrovirology

Relative resistance of HIV-1 founder viruses to control by interferon-alpha

(2013) Angharad E Fenton-May et al.   Retrovirology

The Human Immunodeficiency Virus Type 1 Nef and Vpu Proteins Downregulate the Natural Killer Cell-Activating Ligand PVR

(2012) Giulia Matusali et al.   JOURNAL OF VIROLOGY

Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef

(2012) Xiaofei Jia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human Leukocyte Antigen Genotype and Risk of HIV Disease Progression before and after Initiation of Antiretroviral Therapy

(2011) M. H. Kuniholm et al.   JOURNAL OF VIROLOGY

Generation of Transmitted/Founder HIV-1 Infectious Molecular Clones and Characterization of Their Replication Capacity in CD4 T Lymphocytes and Monocyte-Derived Macrophages

(2011) C. Ochsenbauer et al.   JOURNAL OF VIROLOGY

The Natural Killer Cell Cytotoxic Function Is Modulated by HIV-1 Accessory Proteins

(2011) Bharatwaj Sowrirajan et al.   Viruses-Basel

Copy Number Variation of KIR Genes Influences HIV-1 Control

(2011) Kimberly Pelak et al.   PLOS BIOLOGY

Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments

(2010) M. Moll et al.   BLOOD

C-C chemokine receptor type 5 (CCR5) utilization of transmitted and early founder human immunodeficiency virus type 1 envelopes and sensitivity to small-molecule CCR5 inhibitors

(2010) Q. Hu et al.   JOURNAL OF GENERAL VIROLOGY

The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation

(2010)   SCIENCE

TCR triggering transcriptionally downregulates CCR5 expression on rhesus macaque CD4+ T-cells with no measurable effect on susceptibility to SIV infection

(2010) Jacob T. Minang et al.   VIROLOGY

Tetherin-Driven Adaptation of Vpu and Nef Function and the Evolution of Pandemic and Nonpandemic HIV-1 Strains

(2009) Daniel Sauter et al.   Cell Host & Microbe

The HLA‐ER/HLA‐ERGenotype Affects the Natural Course of Hepatitis C Virus (HCV) Infection and Is Associated with HLA‐E–Restricted Recognition of an HCV‐Derived Peptide by Interferon‐γ–Secreting Human CD8+T Cells

(2009) Daniela Schulte et al.   JOURNAL OF INFECTIOUS DISEASES

A Multicolor Panel of Novel Lentiviral “Gene Ontology” (LeGO) Vectors for Functional Gene Analysis

(2008) Kristoffer Weber et al.   MOLECULAR THERAPY

HIV-1 Nef Targets MHC-I and CD4 for Degradation Via a Final Common β-COP–Dependent Pathway in T Cells

(2008) Malinda R. Schaefer et al.   PLoS Pathogens

Lysis of Endogenously Infected CD4+ T Cell Blasts by rIL-2 Activated Autologous Natural Killer Cells from HIV-Infected Viremic Individuals

(2008) Manuela Fogli et al.   PLoS Pathogens

Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses

(2007) Anke Specht et al.   VIROLOGY