Progranulin Decreases Susceptibility to Streptococcus pneumoniae in Influenza and Protects against Lethal Coinfection

Protective effects of Progranulin against focal cerebral ischemia-reperfusion injury in rats by suppressing endoplasmic reticulum stress and NF-κB activation in reactive astrocytes

(2018) Qing Shu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Progranulin aggravates pulmonary immunopathology during influenza virus infection

(2018) Qin Luo et al.   THORAX

Alveolar Macrophages in the Resolution of Inflammation, Tissue Repair, and Tolerance to Infection

(2018) Benoit Allard et al.   Frontiers in Immunology

HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress

(2017) Maolin Ge et al.   JOURNAL OF IMMUNOLOGY

Contribution of Progranulin to Protective Lung Immunity During Bacterial Pneumonia

(2017) Shan Zou et al.   JOURNAL OF INFECTIOUS DISEASES

Innate Sensing of Influenza A Virus Hemagglutinin Glycoproteins by the Host Endoplasmic Reticulum (ER) Stress Pathway Triggers a Potent Antiviral Response via ER-Associated Protein Degradation

(2017) Dylan A. Frabutt et al.   JOURNAL OF VIROLOGY

Progranulin and its biological effects in cancer

(2017) Fabian Arechavaleta-Velasco et al.   MEDICAL ONCOLOGY

Novel protective mechanism for interleukin-33 at the mucosal barrier during influenza-associated bacterial superinfection

(2017) K M Robinson et al.   Mucosal Immunology

Host-directed therapies for bacterial and viral infections

(2017) Stefan H. E. Kaufmann et al.   NATURE REVIEWS DRUG DISCOVERY

Progranulin protects lung epithelial cells from cigarette smoking-induced apoptosis

(2017) Kyoung Young Lee et al.   RESPIROLOGY

With Friends Like These: The Complex Role of Neutrophils in the Progression of Severe Pneumonia

(2017) Roger D. Pechous   Frontiers in Cellular and Infection Microbiology

Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality

(2016) Dalit Talmi-Frank et al.   Cell Host & Microbe

Inflammatory mechanisms in patients with chronic obstructive pulmonary disease

(2016) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Progranulin Controls Sepsis via C/EBPα-RegulatedIl10Transcription and Ubiquitin Ligase/Proteasome-Mediated Protein Degradation

(2016) Wenjun Yan et al.   JOURNAL OF IMMUNOLOGY

Astragaloside IV protects against polymicrobial sepsis through inhibiting inflammatory response and apoptosis of lymphocytes

(2016) Ren Liu et al.   JOURNAL OF SURGICAL RESEARCH

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Macrolide Resistance in Streptococcus pneumoniae

(2016) Max R. Schroeder et al.   Frontiers in Cellular and Infection Microbiology

Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease

(2016) Jinlong Jian et al.   EBioMedicine

Association Between Progranulin and Gaucher Disease

(2016) Jinlong Jian et al.   EBioMedicine

Progranulin is preferentially expressed in patients with psoriasis vulgaris and protects mice from psoriasis-like skin inflammation

(2015) Kun Huang et al.   IMMUNOLOGY

1918 pandemic influenza virus andStreptococcus pneumoniaeco-infection results in activation of coagulation and widespread pulmonary thrombosis in mice and humans

(2015) Kathie-Anne Walters et al.   JOURNAL OF PATHOLOGY

Progranulin protects against renal ischemia/reperfusion injury in mice

(2015) Meng Zhou et al.   KIDNEY INTERNATIONAL

Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity

(2015) Naphak Modhiran et al.   Science Translational Medicine

Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway

(2015) Eike R. Hrincius et al.   Cell Reports

Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling

(2014) Yun-peng Zhao et al.   ANNALS OF THE RHEUMATIC DISEASES

Progranulin is required for proper ER stress response and inhibits ER stress-mediated apoptosis through TNFR2

(2014) Meiling Li et al.   CELLULAR SIGNALLING

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

(2014) Katrin D. Mayer-Barber et al.   NATURE

The co-pathogenesis of influenza viruses with bacteria in the lung

(2014) Jonathan A. McCullers   NATURE REVIEWS MICROBIOLOGY

Coronavirus infection, ER stress, apoptosis and innate immunity

(2014) To S. Fung et al.   Frontiers in Microbiology

Immunomodulatory adjuvant therapy in severe community-acquired pneumonia

(2014) Ben Morton et al.   Expert Review of Respiratory Medicine

A Systems Analysis Identifies a Feedforward Inflammatory Circuit Leading to Lethal Influenza Infection

(2013) Marlène Brandes et al.   CELL

Bacterial Coinfection in Influenza

(2013) Daniel S. Chertow et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Depletion of Alveolar Macrophages during Influenza Infection Facilitates Bacterial Superinfections

(2013) H. E. Ghoneim et al.   JOURNAL OF IMMUNOLOGY

Oseltamivir resistance during treatment of H7N9 infection

(2013) Alan J Hay et al.   LANCET

Insights into the role of progranulin in immunity, infection, and inflammation

(2012) J. Jian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Prevention of LPS-Induced Acute Lung Injury in Mice by Progranulin

(2012) Zhongliang Guo et al.   MEDIATORS OF INFLAMMATION

Influenza Induces Endoplasmic Reticulum Stress, Caspase-12–Dependent Apoptosis, and c-Jun N-Terminal Kinase–Mediated Transforming Growth Factor–β Release in Lung Epithelial Cells

(2011) Elle C. Roberson et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Protein N-glycosylation, protein folding, and protein quality control

(2011) Jürgen Roth et al.   MOLECULES AND CELLS

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling

(2011) Jindong Xu et al.   NEUROBIOLOGY OF AGING

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Lethal Synergism of 2009 Pandemic H1N1 Influenza Virus and Streptococcus pneumoniae Coinfection Is Associated with Loss of Murine Lung Repair Responses

(2011) J. C. Kash et al.   mBio

Caveolin-1 Protects against Sepsis by Modulating Inflammatory Response, Alleviating Bacterial Burden, and Suppressing Thymocyte Apoptosis

(2010) Hong Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza Infection

(2009) M. D. Tate et al.   JOURNAL OF IMMUNOLOGY

Lethal Influenza Virus Infection in Macaques Is Associated with Early Dysregulation of Inflammatory Related Genes

(2009) Cristian Cillóniz et al.   PLoS Pathogens

Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness

(2008) David M. Morens et al.   JOURNAL OF INFECTIOUS DISEASES

H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

(2008) Lucy A. Perrone et al.   PLoS Pathogens