Uhrf1 regulates germinal center B cell expansion and affinity maturation to control viral infection

Lis1 Regulates Germinal Center B Cell Antigen Acquisition and Affinity Maturation

(2017) Jingjing Chen et al.   JOURNAL OF IMMUNOLOGY

CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation

(2017) Arantxa Pérez-García et al.   Nature Communications

UHRF1 is required for basal stem cell proliferation in response to airway injury

(2017) Handan Xiang et al.   Cell Discovery

UHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development

(2016) Brandon Kent et al.   DEVELOPMENTAL BIOLOGY

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses

(2016) Chun Chou et al.   IMMUNITY

Regulation of germinal center B-cell differentiation

(2016) Yang Zhang et al.   IMMUNOLOGICAL REVIEWS

Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses

(2016) Oliver Bannard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes

(2016) Jingyao Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice

(2016) Haoxing Zhang et al.   Nature Communications

Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis

(2016) Yu Cui et al.   Cell Reports

Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer

(2016) Yuanhui Jia et al.   Cell Discovery

T cell help controls the speed of the cell cycle in germinal center B cells

(2015) A. D. Gitlin et al.   SCIENCE

UHRF1 Is a Sensor for DNA Interstrand Crosslinks and Recruits FANCD2 to Initiate the Fanconi Anemia Pathway

(2015) Chih-Chao Liang et al.   Cell Reports

UHRF1 Contributes to DNA Damage Repair as a Lesion Recognition Factor and Nuclease Scaffold

(2015) Yanyan Tian et al.   Cell Reports

Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma

(2014) Jagan R. Muppidi et al.   NATURE

Clonal selection in the germinal centre by regulated proliferation and hypermutation

(2014) Alexander D. Gitlin et al.   NATURE

The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells

(2014) Yuuki Obata et al.   NATURE IMMUNOLOGY

The UHRF1 Protein Stimulates the Activity and Specificity of the Maintenance DNA Methyltransferase DNMT1 by an Allosteric Mechanism

(2013) Pavel Bashtrykov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AP4 is a mediator of epithelial–mesenchymal transition and metastasis in colorectal cancer

(2013) Rene Jackstadt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication

(2013) Atsuya Nishiyama et al.   NATURE

UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9

(2013) Xiaoli Liu et al.   Nature Communications

Affinity-based selection and the germinal center response

(2012) Tyani D. Chan et al.   IMMUNOLOGICAL REVIEWS

The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry

(2012) David Dominguez-Sola et al.   NATURE IMMUNOLOGY

The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers

(2012) Dinis Pedro Calado et al.   NATURE IMMUNOLOGY

DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation

(2011) R. Shaknovich et al.   BLOOD

Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context

(2011) Jesús Espada et al.   NUCLEIC ACIDS RESEARCH

Late Interleukin-6 Escalates T Follicular Helper Cell Responses and Controls a Chronic Viral Infection

(2011) J. A. Harker et al.   SCIENCE

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence

(2010) Michael Berger et al.   NATURE IMMUNOLOGY

Impaired Antibody Response Causes Persistence of Prototypic T Cell–Contained Virus

(2009) Andreas Bergthaler et al.   PLOS BIOLOGY

Instructive Role of the Transcription Factor E2A in Early B Lymphopoiesis and Germinal Center B Cell Development

(2008) Kyongrim Kwon et al.   IMMUNITY

AP4 encodes a c-MYC-inducible repressor of p21

(2008) P. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo

(2007) Megan M. McCausland et al.   JOURNAL OF VIROLOGICAL METHODS