Significant Roles of Regulatory T Cells and Myeloid Derived Suppressor Cells in Hepatitis B Virus Persistent Infection and Hepatitis B Virus-Related HCCs

Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma

(2015) Elias J. Sayour et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Clinical relevance of regulatory T cells monitoring in the peripheral blood of ovarian cancer patients

(2015) Tomáš Brtnický et al.   HUMAN IMMUNOLOGY

The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus

(2015) Seiichi Sato et al.   IMMUNITY

Inhibition of Foxp3 in cancer cells induces apoptosis of thyroid cancer cells

(2015) Ryan Chu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival

(2015) Serena Lunardi et al.   Oncotarget

Reduced Toll-like receptor-9 expression on peripheral CD14+ monocytes of chronic hepatitis B patients and its restoration by effective therapy

(2014) Yi-Wen Huang et al.   ANTIVIRAL THERAPY

Expression and Clinical Significance of Myeloid Derived Suppressor Cells in Chronic Hepatitis B Patients

(2014) Li-Rong Lu et al.   Asian Pacific Journal of Cancer Prevention

Adaptive immune contexture at the tumour site and downmodulation of circulating myeloid-derived suppressor cells in the response of solitary fibrous tumour patients to anti-angiogenic therapy

(2014) M Tazzari et al.   BRITISH JOURNAL OF CANCER

FOXP3 and CTLA4 overexpression in multiple myeloma bone marrow as a sign of accumulation of CD4+ T regulatory cells

(2014) Walter Moises Tobias Braga et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth

(2014) Yuan Yin et al.   CELL RESEARCH

Regulatory Role of CD4+CD25+Foxp3+ Regulatory T Cells on IL-17-Secreting T Cells in Chronic Hepatitis B Patients

(2014) Jie Li et al.   DIGESTIVE DISEASES AND SCIENCES

Tumor-Induced CD11b+Gr-1+ Myeloid Cells Suppress T Cell Sensitization in Tumor-Draining Lymph Nodes

(2014) S. Watanabe et al.   JOURNAL OF IMMUNOLOGY

γδT Cells Drive Myeloid-Derived Suppressor Cell–Mediated CD8+T Cell Exhaustion in Hepatitis B Virus–Induced Immunotolerance

(2014) Xiaohui Kong et al.   JOURNAL OF IMMUNOLOGY

A Phase I Study of High-Dose Interleukin-2 With Sorafenib in Patients With Metastatic Renal Cell Carcinoma and Melanoma

(2014) Paul Monk et al.   JOURNAL OF IMMUNOTHERAPY

Myeloid-Derived Suppressor Cells Are Associated with Viral Persistence and Downregulation of TCR ζ Chain Expression on CD8+ T Cells in Chronic Hepatitis C Patients

(2014) Qing-Lei Zeng et al.   MOLECULES AND CELLS

Cyclooxygenase-2 genetic variants influence intratumoral infiltration of Foxp3-positive regulatory T cells in non-small cell lung cancer

(2014) TAKURO YUKAWA et al.   ONCOLOGY REPORTS

Monocytes from Chronic HBV Patients React In Vitro to HBsAg and TLR by Producing Cytokines Irrespective of Stage of Disease

(2014) Arjan Boltjes et al.   PLoS One

CD4+CD25hiCD127low Regulatory T Cells Are Increased in Oral Squamous Cell Carcinoma Patients

(2014) Kue Peng Lim et al.   PLoS One

Dissecting the Regulatory Microenvironment of a Large Animal Model of Non-Hodgkin Lymphoma: Evidence of a Negative Prognostic Impact of FOXP3+ T Cells in Canine B Cell Lymphoma

(2014) Dammy Pinheiro et al.   PLoS One

Expression of PD-1 (CD279) and FoxP3 in diffuse large B-cell lymphoma

(2014) Matthew J. Ahearne et al.   VIRCHOWS ARCHIV

Differently immunogenic cancers in mice induce immature myeloid cells that suppress CTL in vitro but not in vivo following transfer

(2013) K. Schmidt et al.   BLOOD

Higher Frequencies of GARP+CTLA-4+Foxp3+ T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality

(2013) S. Kalathil et al.   CANCER RESEARCH

Human CD14+CTLA-4+regulatory dendritic cells suppress T-cell response by cytotoxic T-lymphocyte antigen-4-dependent IL-10 and indoleamine-2,3-dioxygenase production in hepatocellular carcinoma

(2013) Yanmei Han et al.   HEPATOLOGY

Regulation of accumulation and function of myeloid derived suppressor cells in different murine models of hepatocellular carcinoma

(2013) Tamar Kapanadze et al.   JOURNAL OF HEPATOLOGY

A Clinical Study of HBsAg-Activated Dendritic Cells and Cytokine-Induced Killer Cells During the Treatment for Chronic Hepatitis B

(2013) Y.-J. Ma et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Changes of Treg and Th17 cells balance in the development of acute and chronic hepatitis B virus infection

(2012) Liang Xue-Song et al.   BMC GASTROENTEROLOGY

Expression of CD39 on FoxP3+ T regulatory cells correlates with progression of HBV infection

(2012) Yan Tang et al.   BMC IMMUNOLOGY

TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma

(2012) Pengyuan Yang et al.   CANCER CELL

Altered Functions of Plasmacytoid Dendritic Cells and Reduced Cytolytic Activity of Natural Killer Cells in Patients With Chronic HBV Infection

(2012) Jeremie Martinet et al.   GASTROENTEROLOGY

Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice

(2012) Leonhard Stross et al.   HEPATOLOGY

Modulation of regulatory T-cell activity in combination with interleukin-12 increases hepatic tolerogenicity in woodchucks with chronic hepatitis B

(2012) Itziar Otano et al.   HEPATOLOGY

Impairment of CD4+cytotoxic T cells predicts poor survival and high recurrence rates in patients with hepatocellular carcinoma

(2012) Junliang Fu et al.   HEPATOLOGY

Sequential immunological analysis of HBV/HCV co-infected patients during Peg-IFN/RBV therapy

(2012) Yasuteru Kondo et al.   JOURNAL OF GASTROENTEROLOGY

Sorafenib reduces hepatic infiltrated regulatory T cells in hepatocellular carcinoma patients by suppressing TGF-beta signal

(2012) Quanrongzi Wang et al.   JOURNAL OF SURGICAL ONCOLOGY

Significance of the Balance between Regulatory T (Treg) and T Helper 17 (Th17) Cells during Hepatitis B Virus Related Liver Fibrosis

(2012) Jing Li et al.   PLoS One

HBsAg Inhibits IFN-α Production in Plasmacytoid Dendritic Cells through TNF-α and IL-10 Induction in Monocytes

(2012) Bisheng Shi et al.   PLoS One

Regulatory T cells are the most important determinant factor of hepatitis B infection prognosis: A systematic review and meta-analysis

(2012) Seyed Hossein Aalaei-Andabili et al.   VACCINE

The balance between intrahepatic IL-17+ T cells and Foxp3+ regulatory T cells plays an important role in HBV-related end-stage liver disease

(2011) Yinghua Niu et al.   BMC IMMUNOLOGY

Foxp3+ regulatory T cells and the formation of portal vein tumour thrombus in patients with hepatocellular carcinoma

(2011) Shun Shen   CANADIAN JOURNAL OF SURGERY

Frequency of CD45RO+ subset in CD4+CD25high regulatory T cells associated with progression of hepatocellular carcinoma

(2011) Yoshiko Takata et al.   CANCER LETTERS

Immunosuppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus

(2011) S. Chen et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species

(2011) Robert S. Tacke et al.   HEPATOLOGY

Increased CD4+CD69+CD25- T cells in patients with hepatocellular carcinoma are associated with tumor progression

(2011) Jiankang Zhu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Foxp3+ regulatory T cells are associated with the natural history of chronic hepatitis B and poor prognosis of hepatocellular carcinoma

(2011) Fengmei Wang et al.   LIVER INTERNATIONAL

Lower peripheral blood CD14+ monocyte frequency and higher CD34+ progenitor cell frequency are associated with HBV vaccine induced response in HIV infected individuals

(2011) D.D. Anthony et al.   VACCINE

Toll-Like Receptors Signaling Contributes to Immunopathogenesis of HBV Infection

(2011) Yasuteru Kondo et al.   Gastroenterology Research and Practice

The natural history of chronic HBV infection and geographical differences

(2010) Yun-Fan Liaw et al.   ANTIVIRAL THERAPY

Myeloid-derived suppressor cell heterogeneity and subset definition

(2010) Elisa Peranzoni et al.   CURRENT OPINION IN IMMUNOLOGY

Tolerogenic dendritic cells and myeloid-derived suppressor cells: Potential for regulation and therapy of liver auto- and alloimmunity

(2010) Sudha Natarajan et al.   IMMUNOBIOLOGY

Hepatitis B Virus Replication Could Enhance Regulatory T Cell Activity by Producing Soluble Heat Shock Protein 60 From Hepatocytes

(2010) Yasuteru Kondo et al.   JOURNAL OF INFECTIOUS DISEASES

Regulatory T cells in chronic hepatitis B patients affect the immunopathogenesis of hepatocellular carcinoma by suppressing the anti-tumour immune responses

(2010) H. H. Zhang et al.   JOURNAL OF VIRAL HEPATITIS

Increased Level of both CD4+FOXP3+ Regulatory T Cells and CD14+HLA-DR−/low Myeloid-Derived Suppressor Cells and Decreased Level of Dendritic Cells in Patients with Multiple Myeloma

(2010) M. K. Brimnes et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Circulating CD4+CD25high Regulatory T Cells and Expression of PD-1 and BTLA on CD4+ T Cells in Patients with Chronic Hepatitis B Virus Infection

(2010) Xue-Ping Nan et al.   VIRAL IMMUNOLOGY

The Liver Is a Site for Tumor-Induced Myeloid-Derived Suppressor Cell Accumulation and Immunosuppression

(2009) Dan Ilkovitch et al.   CANCER RESEARCH

Antiviral Intrahepatic T-Cell Responses Can Be Restored by Blocking Programmed Death-1 Pathway in Chronic Hepatitis B

(2009) Paola Fisicaro et al.   GASTROENTEROLOGY

Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor

(2009) Bastian Hoechst et al.   HEPATOLOGY

Population alterations of l-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14−/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer

(2009) Chien-Ying Liu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV

(2009) Debora Franceschini et al.   JOURNAL OF CLINICAL INVESTIGATION

Fine characterization of intrahepatic NK cells expressing natural killer receptors in chronic hepatitis B and C

(2009) Paula Bonorino et al.   JOURNAL OF HEPATOLOGY

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

(2009) S. Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Derived Suppressor Cells Down-Regulate L-Selectin Expression on CD4+ and CD8+ T Cells

(2009) E. M. Hanson et al.   JOURNAL OF IMMUNOLOGY

Overexpression of Toll-like receptor 2/4 on monocytes modulates the activities of CD4+CD25+ regulatory T cells in chronic hepatitis B virus infection

(2009) Ye Zhang et al.   VIROLOGY

Reversal of Myeloid Cell-Mediated Immunosuppression in Patients with Metastatic Renal Cell Carcinoma

(2008) S. Kusmartsev et al.   CLINICAL CANCER RESEARCH

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

(2008) Bastian Hoechst et al.   GASTROENTEROLOGY

Programmed death 1 expression during antiviral treatment of chronic hepatitis B: Impact of hepatitis B e-antigen seroconversion

(2008) Alexander Evans et al.   HEPATOLOGY

Phenotypic and Functional Analysis of Dendritic Cells and Clinical Outcome in Patients With High-Risk Melanoma Treated With Adjuvant Granulocyte Macrophage Colony-Stimulating Factor

(2008) Adil I. Daud et al.   JOURNAL OF CLINICAL ONCOLOGY

Circulating CD4+ CD25+regulatory T cells correlate with chronic hepatitis B infection

(2007) Guoping Peng et al.   IMMUNOLOGY