Article
Hematology
Soracha E. Ward, Helen Fogarty, Ellie Karampini, Michelle Lavin, Sonja Schneppenheim, Rita Dittmer, Hannah Morrin, Siobhan Glavey, Cliona Ni Cheallaigh, Colm Bergin, Ignacio Martin-Loeches, Patrick W. Mallon, Gerard F. Curley, Ross Baker, Ulrich Budde, Jamie M. O'Sullivan, James S. O'Donnell
Summary: Elevated plasma VWF and impaired ADAMTS-13 function in COVID-19 patients may contribute to microvascular thrombosis. Further research is needed to explore potential therapeutic interventions.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Biochemistry & Molecular Biology
Eskandar Taghizadeh, Najmeh Farahani, Rajab Mardani, Forough Taheri, Hassan Taghizadeh, Seyed Mohammad Gheibihayat
Summary: Familial combined hyperlipidemia (FCHL) is a common familial lipoprotein disorder with a prevalence ranging from 0.5% to 2% in different populations. The disease's etiology is complex and may be related to genetic variants, environmental factors, and lifestyles.
BIOCHEMICAL GENETICS
(2022)
Article
Multidisciplinary Sciences
Noriko Tagawa, Aya Fujinami, Shigeatsu Natsume, Shigeto Mizuno, Ikuo Kato
Summary: This study found that adiponectin levels are decreased in patients with cerebral infarction, and that low molecular weight adiponectin level is associated with atherothrombotic infarction and may serve as a potential biomarker for it.
Article
Cardiac & Cardiovascular Systems
Rafael Zubiran, Arsenio Vargas-Vazquez, Fabiola Del Razo Olvera, Ivette Cruz-Bautista, Alexandro Martagon-Rosado, Maureen Sampson, Alan T. Remaley, Carlos A. Aguilar-Salinas
Summary: The accuracy of different equations in estimating LDL-C concentration was compared, and it was found that both S-LDL-C and eS-LDL-C performed similarly and better than M-LDL-C and F-LDL-C. In Bland-Altman analysis, eS-LDL-C showed the lowest bias, better performance in HTG, and better concordance with LDL-C treatment goals compared to other formulas.
Article
Hematology
Florian Mourre, Roch Giorgi, Antonio Gallo, Franck Boccara, Eric Bruckert, Alain Carrie, Regis Hankard, Jocelyn Inamo, Sandrine Laboureau, Philippe Moulin, Rene Valero, Sophie Beliard
Summary: Background: Animal studies have shown that fetal exposure to high maternal cholesterol levels during pregnancy increases the risk of aortic atheroma in the offspring. However, little is known about the consequences of this exposure on the development of atherosclerotic cardiovascular disease in humans. This study aimed to investigate whether maternal/paternal inheritance of familial hypercholesterolemia (FH) gene mutation could be associated with subclinical coronary atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mark Trinder, Diana Vikulova, Simon R. Pimstone, G. B. John Mancini, Liam Brunham
Summary: This study reveals that familial combined hyperlipidemia (FCHL) is a polygenic susceptibility disease associated with metabolic abnormalities. The cardiovascular risk associated with FCHL phenotype is similar to monogenic familial hypercholesterolemia, despite being more common.
Article
Biochemistry & Molecular Biology
Arsenio Vargas-Vazquez, Omar Yaxmehen Bello-Chavolla, Neftali Eduardo Antonio-Villa, Roopa Mehta, Ivette Cruz-Bautista, Carlos A. Aguilar-Salinas
Summary: In FCHL, the study compared the performance of three methods for estimating LDL-C and found that Sampson's formula showed higher accuracy and concordance with treatment goals than Friedewald's and Martin's equations. Sampson's formula demonstrated improved correlation and consistency in assessing LDL-C performance and treatment monitoring in FCHL.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Endocrinology & Metabolism
Yi Zhang, Chao Liu, Yijing Xu, Yanlei Wang, Fang Dai, Honglin Hu, Tian Jiang, Yunxia Lu, Qiu Zhang
Summary: Multifactorial interventions targeting blood glucose, blood pressure, and lipid profiles can reduce the risk of cardiovascular complications and mortality in patients with type 2 diabetes. This study found associations between health risk behaviors, exercise and diet interventions, and cardiovascular disease. It also highlighted the importance of multifactorial interventions in promoting cardiovascular health.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Diana N. Vikulova, Mark Trinder, G. B. John Mancini, Simon N. Pimstone, Liam R. Brunham
Summary: This study assessed the prevalence of FH, FCHL, and elevated Lp(a) in patients with premature CAD and their impact on treatment and achievement of lipid targets. The results showed that these conditions are common in patients with premature CAD and have differing impacts on individualized management and achievement of lipid targets.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Samet Yaman, Didem Ozdemir, Busra Tugce Akman, Bekir Cakir, Osman Ersoy
Summary: This study investigated the treatment status and compliance of patients with LDL-C >= 250 mg/dL and FH, revealing a significant portion of patients not taking lipid-lowering drugs. Diagnosis and treatment rates of FH patients were found to be very low, indicating a need for further national studies to increase disease awareness among both physicians and patients.
POSTGRADUATE MEDICINE
(2021)
Article
Engineering, Multidisciplinary
Yanling Li, Yajie Gong, Chunyan Huang
Summary: This paper proposes a bivariate combined drought index based on copula function and uses cross-wavelet transform to study the relationship of drought and identify lags in the propagation process. Results show that the index can characterize hydrological and meteorological drought simultaneously and provide strong support for drought detection and prevention.
ALEXANDRIA ENGINEERING JOURNAL
(2021)
Article
Environmental Studies
Feng Dong, Jingyun Li, Jianheng Huang, Yang Lu, Chang Qin, Xiaoyun Zhang, Bin Lu, Yajie Liu, Yifei Hua
Summary: Under the dual pressure of global ecological degradation and economic downturn, emerging industrialized countries need to balance the connection between economy and environment. Using spatial econometric model, the trend and causes of decoupling CO2 and SO2 from economic growth in China were evaluated. The findings show spatial and temporal heterogeneity in the synergistic effect, with higher effect in the western region compared to the eastern region. The results provide valuable insights for policy-makers in emerging industrialized countries.
ENVIRONMENTAL IMPACT ASSESSMENT REVIEW
(2023)
Article
Cardiac & Cardiovascular Systems
Guijuan Feng, Man Yang, Lingkai Xu, Yaqi Liu, Jia Yu, Yuhan Zang, Suwen Shen, Xiaowei Zheng
Summary: This study evaluated the cumulative effect of hsCRP and TyG index on CVD risk. The results suggest that combining these two markers can better predict the risk of cardiovascular disease and have implications for risk stratification in middle-aged and older Chinese populations.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Theresia A. Ottaru, Gideon P. Kwesigabo, Zeeshan Butt, Adovich S. Rivera, Pilly Chillo, Helen Siril, Lisa R. Hirschhorn, Matthew J. Feinstein, Claudia Hawkins
Summary: This study aimed to assess the distribution and factors associated with cardiovascular health index (CVHI) scores among ageing adults living with HIV (ALHIV) in an urban setting in Tanzania. The study found that most ALHIV had ideal levels of blood glucose and smoking status, but lower levels of BMI, blood pressure, and dietary intake. Older age, employment status, alcohol use, and comorbidities of non-communicable diseases were significantly associated with lower odds of ideal cardiovascular health. Therefore, interventions to improve blood pressure management, provide dietary education for BMI control, and reduce alcohol consumption are important for improving the cardiovascular health of ageing ALHIV.
Article
Cell & Tissue Engineering
Zilong Li, Xue Zhang, Xiaomei Li, Yanan Yang, Hongmei Xin, Xiaomeng Yang, Ning Liu, Zhongtao Gai, Yi Liu
Summary: PBMCs from a boy with familial combined hyperlipidemia were used to generate iPSCs carrying compound heterozygous mutations of the LPL gene, showcasing pluripotent characteristics and normal karyotype.
STEM CELL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Maria A. T. C. van Der Loos, Ilse Hellinga, Mariska C. Vlot, Daniel T. Klink, Martin den Heijer, Chantal M. Wiepjes
Summary: This study investigated changes in bone geometry among transgender adolescents treated with GnRHa and GAH, showing that participants who started treatment during early puberty resembled the target gender's bone morphology, while those who started treatment during mid to late puberty remained within the bone geometry of their gender assigned at birth.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Milou Cecilia Madsen, Dennis van Dijk, Chantal Maria Wiepjes, Elfi Barbara Conemans, Abel Thijs, Martin den Heijer
Summary: This study found a high prevalence of erythrocytosis in trans men using testosterone therapy, with factors such as smoking, injection method, age, body mass index (BMI), and pulmonary conditions being associated with increased risk. Recommendations for care include advising smoking cessation, switching to transdermal administration, and weight loss for those with high BMI.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Hematology
Luuk J. J. Scheres, Nienke L. D. Selier, Nienke M. Nota, Jeske J. K. van Diemen, Suzanne C. Cannegieter, Martin den Heijer
Summary: The study found that transgender women showed a more procoagulant profile after undergoing GAHT treatment, while transgender men did not exhibit significant procoagulant changes. Age and route of administration influenced the changes in coagulation parameters.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Endocrinology & Metabolism
Theresa A. Stangl, Chantal M. Wiepjes, Justine Defreyne, Elfi Conemans, Alessandra D. Fisher, Thomas Schreiner, Guy T'Sjoen, Martin den Heijer
Summary: A multicenter prospective study on 1933 transgender individuals starting hormone therapy between 2010 and 2020 showed a very low incidence of liver injury, indicating that liver enzyme monitoring is not necessary for this population.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Iris de Nie, Joyce Asseler, Andreas Meissner, Ilona A. C. Voorn-de Warem, E. Hanna Kostelijk, Martin den Heijer, Judith Huirne, Norah M. van Mello
Summary: The study found that frequent wearing of tight undergarments and extensive tucking in transgender women may result in lower semen quality. These results will help optimize fertility counseling and guide patients on adjusting their lifestyle before pursuing semen cryopreservation.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
I de Nie, C. L. Mulder, A. Meissner, Y. Schut, E. M. Holleman, W. B. van der sluis, S. E. Hannema, M. den Heijer, J. Huirne, A. M. M. van Pelt, N. M. van Mello
Summary: In the majority of transgender women, there were immature germ cells present in their orchiectomy specimen. However, 4.7% of transgender women who initiated medical treatment in Tanner stage 4 or higher had mature spermatozoa, which could be cryopreserved for fertility preservation.
HUMAN REPRODUCTION
(2022)
Article
Endocrinology & Metabolism
Marieke Tebbens, Annemieke C. Heijboer, Guy T'Sjoen, Peter H. Bisschop, Martin den Heijer
Summary: This study assessed the role of estrone in feminization induced by hormone treatment. The results showed that estrone concentrations were not associated with changes in fat percentage and breast development in trans women. Therefore, measuring estrone concentrations is not necessary for monitoring feminization in trans women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Daan van Velzen, Chantal Wiepjes, Nienke Nota, Daniel van Raalte, Renee de Mutsert, Suat Simsek, Martin den Heijer
Summary: The incidence of type 2 diabetes mellitus in transgender individuals after hormone therapy was not different compared with the general population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Lidewij Sophia Boogers, Chantal Maria Wiepjes, Daniel Tatting Klink, Ilse Hellinga, Adrianus Sarinus Paulus van Trotsenburg, Martin den Heijer, Sabine Elisabeth Hannema
Summary: This study investigates the effects of GnRHa and GAHT on growth and the efficacy of growth-reductive treatment. The results show that GnRHa decelerates growth velocity, while GAHT accelerates it. Adult height after regular-dose treatment is slightly lower than predicted at the start of GnRHa, but not significantly different from target height.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Lieve Anne Willemsen, Lidewij Sophia Boogers, Chantal Maria Wiepjes, Daniel Tatting Klink, Adrianus Sarinus Paulus van Trotsenburg, Martin den Heijer, Sabine Elisabeth Hannema
Summary: This study investigates the impact of puberty suppression and gender-affirming hormone treatment on growth and adult height in transgender boys. The results show that during puberty suppression, growth slows down and bone maturation decelerates, while during gender-affirming hormone treatment, growth accelerates. Despite having similar adult height standard deviation scores compared to baseline, puberty suppression and gender-affirming hormone treatment do not negatively impact adult height in transgender boys and may even result in slightly taller adult height.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Sarah Collet, Noor Gieles, Chantal M. Wiepjes, Annemieke C. Heijboer, Tim Reyns, Tom Fiers, Bruno Lapauw, Martin den Heijer, Guy T'Sjoen
Summary: The study found that testosterone levels in transgender women remain stable after initiating feminizing hormone therapy. Adrenal androgens decrease in the first year of hormone therapy and remain unchanged after gonadectomy. The correlation with clinical symptoms still needs to be elucidated.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Evelien T. M. Boekhout-Berends, Chantal M. Wiepjes, Nienke M. Nota, Hans H. M. Schotman, Annemieke C. Heijboer, Martin den Heijer
Summary: Objective: To determine the appropriate reference category for interpreting laboratory results of transgender individuals on hormone therapy. Methods: A large cohort study of transgender men and women was conducted to analyze various laboratory parameters at different time points. Results: Hemoglobin and hematocrit levels decreased in transgender women, while increased in transgender men after starting hormone therapy. Liver enzymes and creatinine levels increased in both gender groups, but prolactin levels showed opposite changes. Overall, reference intervals of the affirmed gender were found to be appropriate after 1 year on hormone therapy. Conclusions: Generating transgender-specific reference intervals is not necessary, and using reference intervals of the affirmed gender after 1 year on hormone therapy is recommended.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Benthe A. M. Dijkman, Christel J. M. de Blok, Koen M. A. Dreijerink, Martin den Heijer
Summary: A 31-year-old woman with complete androgen insensitivity syndrome (CAIS) experienced fluctuations in breast volume during hormone replacement therapy. 3D breast volume measurements showed a significant difference between estradiol monotherapy and combined estradiol and dydrogesterone treatment. Our findings suggest a correlation between progestogen use and breast volume, possibly caused by fluid retention. Limited reports are available on the effects of progesterone on breast development and volume, and 3D imaging provides an easy-to-use method for quantifying breast volume. In women with CAIS, monotherapy with estrogen or continuous progesterone supplementation may be preferable over cyclic progesterone use.
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2023)
Article
Urology & Nephrology
Sarah A. van Eeghen, Chantal M. Wiepjes, Guy T'Sjoen, Natalie J. Nokoff, Martin den Heijer, Petter Bjornstad, Daniel H. van Raalte
Summary: This study investigated the effect of gender-affirming hormone therapy (GAHT) on kidney function in transgender individuals. The results showed that transgender women experienced a decrease in cystatin C levels and an increase in eGFR, while transgender men showed an increase in cystatin C levels and a decrease in eGFR. Changes in creatinine concentrations were also observed depending on the hormone therapy used.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Endocrinology & Metabolism
Marieke Tebbens, Moya Schutte, Marian A. Troelstra, Eveline Bruinstroop, Renee de Mutsert, Aart J. Nederveen, Martin den Heijer, Peter H. Bisschop
Summary: This study investigated the effects of hormone treatment on liver fat and visceral fat in transgender individuals. The results showed that estrogen treatment reduced liver fat content in trans women, but had no effect on visceral fat. Testosterone treatment, on the other hand, increased both liver fat content and visceral fat volume in trans men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
