Article
Cardiac & Cardiovascular Systems
Dong-Mei Li, Bin-Xin Li, Li-Jie Yang, Peng Gao, Zhong-Yu Ma, Zhong-Juan Li
Summary: The combination of miR-208a with NT-proBNP may provide a more reliable method for diagnosing HFrEF patients, showing higher AUC, sensitivity, and specificity compared to using NT-proBNP alone.
Article
Biochemistry & Molecular Biology
Xiaoxi Yao, David R. Rushlow, Jonathan W. Inselman, Rozalina G. McCoy, Thomas D. Thacher, Emma M. Behnken, Matthew E. Bernard, Steven L. Rosas, Abdulla Akfaly, Artika Misra, Paul E. Molling, Joseph S. Krien, Randy M. Foss, Barbara A. Barry, Konstantinos C. Siontis, Suraj Kapa, Patricia A. Pellikka, Francisco Lopez-Jimenez, Zachi I. Attia, Nilay D. Shah, Paul A. Friedman, Peter A. Noseworthy
Summary: The study aimed to evaluate whether an AI-powered clinical decision support tool based on ECGs enables early diagnosis of low EF. Results showed that the intervention increased the diagnosis of low EF in primary care settings and among patients with a high likelihood of low EF, indicating the potential of using AI algorithms for early diagnosis in routine care.
Article
Cardiac & Cardiovascular Systems
James L. Januzzi, Xi Tan, Lingfeng Yang, Joanne E. Brady, Mei Yang, Puja Banka, Dominik Lautsch
Summary: The study found that NT-proBNP testing was not frequently performed in patients with heart failure with reduced ejection fraction (HFrEF) in US clinical practice, and the concentrations varied across different data sources and subgroups within HFrEF.
Article
Cardiac & Cardiovascular Systems
Leanne Mooney, Colette E. Jackson, Carly Adamson, Alex McConnachie, Paul Welsh, Rachel C. Myles, John J. V. McMurray, Pardeep S. Jhund, Mark C. Petrie, Ninian N. Lang
Summary: Circulating levels of interleukin-6 may identify patients at greater risk of adverse outcomes following hospitalization with heart failure with preserved ejection fraction.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Kazushi Sakane, Yumiko Kanzaki, Kosuke Tsuda, Daichi Maeda, Koichi Sohmiya, Masaaki Hoshiga
Summary: This study found that different factors were associated with disproportionately low BNP levels in patients with different types of heart failure. High BMI, lower blood pressure, and history of cardiovascular surgery were related to disproportionately low BNP in the HFpEF group, while high BMI and smaller left ventricular end-diastolic volume index were associated with disproportionately low BNP in the HFrEF group.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Toru Kondo, Azmil H. Abdul-Rahim, Atefeh Talebi, William T. Abraham, Akshay S. Desai, Kenneth Dickstein, Silvio E. Inzucchi, Lars Kober, Mikhail N. Kosiborod, Felipe A. Martinez, Milton Packer, Mark Petrie, Piotr Ponikowski, Jean L. Rouleau, Marc S. Sabatine, Karl Swedberg, Michael R. Zile, Scott D. Solomon, Pardeep S. Jhund, John J. McMurray
Summary: A simple risk model can be used to identify HFrEF patients without AF who have a high risk of stroke, allowing for targeted use of prophylactic anticoagulant therapy.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Mingming Yang, Toru Kondo, Jawad H. Butt, William T. Abraham, Inder S. Anand, Akshay S. Desai, Lars Kober, Milton Packer, Marc A. Pfeffer, Jean L. Rouleau, Marc S. Sabatine, Scott D. Solomon, Karl Swedberg, Michael R. Zile, Pardeep S. Jhund, John J. McMurray
Summary: Patients with heart failure who have a history of stroke are at a high risk of subsequent cardiovascular events, regardless of ejection fraction. This study investigated the prevalence of stroke history in patients with heart failure and found that they had more vascular comorbidity and worse heart failure compared to those without stroke history. Targeting underutilization of guideline-recommended treatments might improve outcomes in this high-risk population.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Xiao Liu, Ayiguli Abudukeremu, Peng Yu, Zhengyu Cao, Runlu Sun, Maoxiong Wu, Zhiteng Chen, Jianyong Ma, Wengen Zhu, Yangxin Chen, Yuling Zhang, Jingfeng Wang
Summary: The study found that B-type natriuretic peptide (BNP) is associated with an increased risk of stroke in patients with HFpEF and may be a valuable biomarker for stroke prediction in HFpEF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Melissa A. Daubert, Eric Yow, Huiman X. Barnhart, Ileana L. Pina, Tariq Ahmad, Eric Leifer, Lawton Cooper, Patrice Desvigne-Nickens, Mona Fiuzat, Kirkwood Adams, Justin Ezekowitz, David J. Whellan, James L. Januzzi, Christopher M. O'Connor, G. Michael Felker
Summary: A secondary analysis of a heart failure clinical trial found that despite less intensive HF treatment among women, they had a similar response to NT-proBNP compared to men. However, achieving the NT-proBNP treatment goal early had greater prognostic value for women than men.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Sebastian Rosch, Karl-Patrik Kresoja, Christian Besler, Karl Fengler, Anne Rebecca Schoeber, Maximilian von Roeder, Christian Luecke, Matthias Gutberlet, Karin Klingel, Holger Thiele, Karl-Philipp Rommel, Philipp Lurz
Summary: In this study, patients with heart failure with preserved ejection fraction (HFpEF) were stratified based on left ventricular ejection fraction (LVEF), resulting in distinct morphologic and pathophysiologic subphenotypes. Patients with LVEF ranging from 50% to 60% demonstrated reduced contractility, impaired ventriculo-arterial coupling, and higher extracellular volume fraction, while patients with LVEF >60% exhibited a hypercontractile state with excessive left ventricular afterload and diminished preload reserve.
Article
Cardiac & Cardiovascular Systems
Shervin G. Hoseini, Kiyan Heshmat-Ghahdarijani, Saeid Khosrawi, Mohammad Garakyaraghi, Davood Shafie, Marjan Mansourian, Hamidreza Roohafza, Elham Azizi, Masoumeh Sadeghi
Summary: Oral melatonin can decrease NT-Pro BNP and improve the quality of life in patients with HFrEF, making it a potentially beneficial supplement.
CLINICAL CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
David Chieng, Hariharan Sugumar, Louise Segan, Caleb Tan, Donna Vizi, Shane Nanayakkara, Ahmed Al-Kaisey, Joshua Hawson, Sandeep Prabhu, Aleksandr Voskoboinik, Sue Finch, Joseph B. Morton, Geoffrey Lee, Justin Mariani, Andre La Gerche, Andrew J. Taylor, Erin Howden, Peter M. Kistler, Jonathan M. Kalman, David M. Kaye, Liang-Han Ling
Summary: This study compared the effects of AF ablation and usual medical therapy on patients with heart failure with preserved ejection fraction (HFpEF) and concurrent atrial fibrillation (AF). It found that AF ablation can improve the severity of HFpEF, including exercise hemodynamics, natriuretic peptide levels, and patient symptoms. AF ablation can alleviate symptoms of heart failure, improve exercise capacity, and enhance quality of life.
JACC-HEART FAILURE
(2023)
Review
Physiology
Emmanuel Eroume A. Egom
Summary: HFpEF is a major public health issue with no approved therapies. Phenotyping and studying patients may lead to the development of targeted therapies, with obesity being a potential key factor.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elisa Dal Canto, Marielle Scheffer, Kirsten Kortekaas, Annet Driessen-Waaijer, Walter J. Paulus, Loek van Heerebeek
Summary: In patients with HFpEF, NP levels can be used to identify different stages of LV remodeling and myocardial tissue composition. This study found that HFpEF patients with high NP levels had worse LV stiffness and left atrial function, indicating advanced stage of HFpEF.
Article
Cardiac & Cardiovascular Systems
Josef Fritz, Katrin Belovari, Hanno Ulmer, Marc-Michael Zaruba, Moritz Messner, Maria Ungericht, Uwe Siebert, Frank Ruschitzka, Axel Bauer, Gerhard Poelzl
Summary: Clinical decision making in chronic heart failure is primarily based on LVEF and secondarily on the underlying disease. This study found that LVEF mediates the relationship between disease etiology and mortality. Therefore, it is important to clarify the disease etiology as well as measure LVEF.