Article
Clinical Neurology
Alexander P. Murphy, Anna Johnson, Volker Straub, Alison Heads-Baister, Stephen Lord, John P. Bourke
Summary: The study aimed to audit the change in measures of left ventricular function in DMD patients before and after ACEi/BB therapy, showing a slower decline in left ventricular function after therapy initiation, supporting the international DMD recommendations.
Article
Cardiac & Cardiovascular Systems
Alireza Oraii, Jeff S. Healey, Alexander P. Benz, Arjun K. Pandey, Jorge A. Wong, Sylvanus Fonguh, Jia Wang, David Conen, Hertzel C. Gerstein, Stuart J. Connolly, William F. McIntyre
Summary: Most patients with atrial fibrillation do not have indications for SGLT2 inhibitors, but they still have a substantial risk of cardiovascular events. Future research should evaluate the efficacy of SGLT2 inhibitors in patients with atrial fibrillation.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Gad Cotter, Beth A. Davison, Alexandre Mebazaa, Koji Takagi, Maria Novosadova, Yonathan Freund, Alain Cohen-Solal
Summary: There are multiple medication options for patients with heart failure and reduced ejection fraction, with RAASbs and BBs being the cornerstone of treatment. ARNis have shown to further reduce adverse effects, while other medications can be considered as adjunct therapies for symptom relief. Comparing the efficacy of these medications and prioritizing certain ones over others is important due to their similar side effects.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Suzanne V. Arnold, Daniel N. Silverman, Kensey Gosch, Michael E. Nassif, Margaret Infeld, Sheldon Litwin, Markus Meyer, Timothy J. Fendler
Summary: This study examines the association of beta-blockers with heart failure (HF) hospitalization and death in patients with HF and EF >= 40%. The results show that beta-blockers are associated with a higher risk of HF hospitalization as EF increases, with potential benefit in patients with HFmrEF and potential risk in patients with higher EF (particularly >60%).
JACC-HEART FAILURE
(2023)
Article
Medicine, General & Internal
Essraa Bayoumi, Phillip H. Lam, Robert Enders, Cherinne Arundel, Helen M. Sheriff, Vijaywant Brar, Corrine Y. Jurgens, Prakash Deedwania, Charles Faselis, Richard M. Allman, Gregg C. Fonarow, Ali Ahmed
Summary: This study found that the use of beta-blockers in older patients with HFrEF is associated with a lower risk of all-cause mortality, but not with a lower risk of heart failure readmission. This association is similar for patients admitted from nursing homes and those not admitted.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Fadel Bahouth, Adi Elias, Itai Ghersin, Emad Khoury, Omer Bar, Haitham Sholy, Johad Khoury, Zaher S. Azzam
Summary: This study found that in patients with acute decompensated heart failure (ADHF), the heart rate at discharge has significant prognostic value on 1-year mortality, with patients having a heart rate <90 beats per minute showing significantly lower mortality rates.
Review
Pharmacology & Pharmacy
Lukasz Wolowiec, Grzegorz Grzesk, Joanna Osiak, Aleksandra Wijata, Martyna Medlewska, Patryk Gaborek, Joanna Banach, Anna Wolowiec, Mariola Glowacka
Summary: Beta-blockers are a diverse group of antiarrhythmic drugs that have different pharmacokinetic and chemical properties. Some selectively block beta-adrenergic receptors while others are non-selective. They reduce the influence of the sympathetic nervous system on the heart, resulting in negative effects on inotropy, chronotropy, bathmotropy, and dromotropy. Despite being used in medicine since the 1960s, they still play a crucial role in the treatment of cardiac arrhythmias. Propranolol, the oldest beta-adrenergic antagonist, has additional applications due to its unique properties.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Chan Soon Park, Jin Joo Park, Alexandre Mebazaa, Hae-Young Lee, Kye Hun Kim, Byung-Su Yoo, Seok-Min Kang, Sang Hong Baek, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho, Shung Chull Chae, Byung-Hee Oh, Dong-Ju Choi
Summary: The study investigated the impact of beta-blockers based on NP levels and HF phenotypes. Results showed that beta-blockers benefit HFrEF patients in terms of survival, have no effect on HFmrEF patients, and reduce mortality in HFpEF patients with high NP levels.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Run-Zhen Chen, Chen Liu, Peng Zhou, Jian-Nan Li, Jin-Ying Zhou, Ying Wang, Xiao-Xiao Zhao, Yi Chen, Li Song, Han-Jun Zhao, Hong-Bing Yan
Summary: This study showed that the use of beta-blockers in ACS patients without HF undergoing PCI was associated with a significant reduction in long-term mortality.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Pediatrics
Rachele Adorisio, Nicoletta Cantarutti, Marco Ciabattini, Antonio Amodeo, Fabrizio Drago
Summary: This study found that high dosage carvedilol therapy significantly improves cardiac outcomes, including heart rate reduction and ejection fraction improvement, in children with dilated cardiomyopathy and chronic heart failure.
FRONTIERS IN PEDIATRICS
(2022)
Article
Health Care Sciences & Services
Lauren Gilstrap, Andrea M. Austin, A. James O'Malley, Barbara Gladders, Amber E. Barnato, Anna Tosteson, Jonathan Skinner
Summary: The demographics of heart failure are changing with a growing older population. Elderly heart failure patients are often underrepresented in clinical trials, but this study found that receiving a beta-blocker after discharge is associated with lower 90-day mortality and readmission rates even among those aged 75 and older.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Vincenzo Arcoraci, Francesco Squadrito, Michelangelo Rottura, Maria Antonietta Barbieri, Giovanni Pallio, Natasha Irrera, Alessandro Nobili, Giuseppe Natoli, Christiano Argano, Giovanni Squadrito, Salvatore Corrao
Summary: In older patients with heart failure and chronic obstructive pulmonary disease, the use of beta-blockers is lower than recommended, especially in those with COPD. There is a significant underuse of beta-blockers post-hospital discharge, with physicians often rejecting beta-blockers in COPD patients instead of opting for selective beta 1-blockers. Multidisciplinary collaboration is necessary for better drug management and adherence to guideline recommendations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Jeffrey Triska, Juan Tamargo, Biykem Bozkurt, Uri Elkayam, Addison Taylor, Yochai Birnbaum
Summary: The 2021 European Society of Cardiology guidelines recommend avoiding NDCC in patients with HF and reduced ejection fraction, and initiating beta-blockers only in stable patients. However, NDCC and beta-blockers are still commonly used in patients with AF and acute decompensated HF. The safety and efficacy of these therapies in this setting are unclear.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Public, Environmental & Occupational Health
In-Sun Oh, Yeon-Hee Baek, Han Eol Jeong, Kristian B. Filion, Ju-Young Shin
Summary: This study aimed to compare the ability of different methodological approaches to minimize immeasurable time bias in pharmacoepidemiological studies, specifically looking at the use of beta-blockers and all-cause mortality in heart failure patients. The results showed that adjusting for hospitalization as a time-varying variable successfully minimized the bias.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Geriatrics & Gerontology
Lauren Gilstrap, Andrew Cohen, Gregory M. Ouellet, Parag Goyal, Barbara Gladders, Danette Flint, Jonathan Skinner
Summary: The use of beta-blockers in patients with heart failure with reduced ejection fraction (HFrEF) and Alzheimer's disease and related dementias (ADRD) is associated with lower mortality rates.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Medicine, General & Internal
Niels Adriaenssens, Beatrice Scholtes, Robin Bruyndonckx, Jan Y. Verbakel, An De Sutter, Stefan Heytens, Ann van den Bruel, Isabelle Desombere, Pierre van Damme, Herman Goossens, Laetitia Buret, Els Duysburgh, Samuel Coenen
Summary: This study aims to investigate the seroprevalence of SARS-CoV-2 antibodies among primary healthcare providers in Belgium, including infection rates, clinical manifestations, risk factors, effectiveness of preventive measures, and accuracy of primary care testing methods. Data will be collected and analyzed using a prospective cohort study design, and the results will be disseminated and published.
Article
Public, Environmental & Occupational Health
Janneke D. M. Verberk, Marieke L. A. de Hoog, Ilse Westerhof, Sam van Goethem, Christine Lammens, Greet Ieven, Erwin de Bruin, Dirk Eggink, Julia A. Bielicki, Samuel Coenen, Janko van Beek, Marc J. M. Bonten, Herman Goossens, Patricia C. J. L. Bruijning-Verhagen
Summary: This remote prospective household study quantified the transmission of SARS-CoV-2 and investigated the effects of various factors on transmission. The study found that a majority of transmissions occurred early after the introduction of SARS-CoV-2 into households, and household infection control measures had no significant impact on transmission.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Immunology
Zhuxin Mao, Xiao Li, Koos Korsten, Louis Bont, Christopher Butler, Joanne Wildenbeest, Samuel Coenen, Niel Hens, Joke Bilcke, Philippe Beutels
Summary: The study aimed to estimate the average costs and health-related quality of life (HRQoL) in older adults with respiratory syncytial virus (RSV) and influenza infection. The results showed that the direct costs per nonhospitalized RSV episode were estimated to be 26.4 euros, with indirect costs of 4.4 euros. For nonhospitalized influenza episodes, the direct costs were estimated to be 42.5 euros, with indirect costs of 32.1 euros. The study also found a decrease in HRQoL during RSV and influenza infections.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Pharmacology & Pharmacy
Katoo M. M. Muylle, Sven van Laere, Luigi Pannone, Samuel Coenen, Carlo de Asmundis, Alain G. G. Dupont, Pieter Cornu
Summary: By developing and validating a risk prediction model considering patient- and drug-related factors, the QT-DDI alerting was significantly improved, leading to more appropriate stratification with increased accuracy and precision.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Economics
Xiao Li, Joke Bilcke, Alike W. van der Velden, Robin Bruyndonckx, Samuel Coenen, Emily Bongard, Muirrean de Paor, Slawomir Chlabicz, Maciek Godycki-Cwirko, Nick Francis, Rune Aabenhus, Heiner C. Bucher, Annelies Colliers, An De Sutter, Ana Garcia-Sangenis, Dominik Glinz, Nicolay J. Harbin, Katarzyna Kosiek, Morten Lindbaek, Christos Lionis, Carl Llor, Reka Miko-Pauer, Ruta Radzeviciene Jurgute, Bohumil Seifert, Par-Daniel Sundvall, Pia Touboul Lundgren, Nikolaos Tsakountakis, Theo J. Verheij, Herman Goossens, Christopher C. Butler, Philippe Beutels
Summary: This study aimed to evaluate the cost-effectiveness of adding oseltamivir to primary care in Europe for treating influenza-like illness (ILI) in adults/adolescents and children. The results showed that adding oseltamivir to primary care is likely to be cost-effective from the healthcare payers' perspective, and cost-saving from a societal perspective in adults/adolescents.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Primary Health Care
Eline Meyers, Liselore De Rop, Ellen Deschepper, Els Duysburgh, Tine De Burghgraeve, Pauline Van Ngoc, Marina Digregorio, Simon Delogne, Anja Coen, Nele De Clercq, Laetitia Buret, Samuel Coenen, An De Sutter, Beatrice Scholtes, Jan Y. Verbakel, Piet Cools, Stefan Heytens
Summary: Elderly nursing home residents in Belgium have shown decreased antibody responses after receiving the COVID-19 vaccine, indicating potential insufficient protection. Age, comorbidities, and care dependency are predictive factors for seronegativity in nursing home residents.
EUROPEAN JOURNAL OF GENERAL PRACTICE
(2023)
Article
Primary Health Care
Katarina Hedin, Alike W. van der Velden, Malene Plejdrup Hansen, Anna B. Moberg, Anca Balan, Pascale Bruno, Samuel Coenen, Eskild Johansen, Anna Kowalczyk, Peter Konstantin Kurotschka, Sanne R. van der Linde, Lile Malania, Jorn Rohde, Jan Verbakel, Heike Vornhagen, Akke Vellinga
Summary: This study conducted a long-term follow-up of non-hospitalized patients with COVID-19 and found that 52% of patients developed long-COVID. The most common symptom was fatigue, and these lingering symptoms had an impact on patients' daily activities. Obese patients took longer to recover compared to non-obese patients.
EUROPEAN JOURNAL OF GENERAL PRACTICE
(2023)
Article
Biotechnology & Applied Microbiology
Irina Spacova, Ilke De Boeck, Eline Cauwenberghs, Lize Delanghe, Peter A. Bron, Tim Henkens, Alix Simons, Imane Gamgami, Leentje Persoons, Ingmar Claes, Marianne F. L. van den Broek, Dominique Schols, Peter Delputte, Samuel Coenen, Veronique Verhoeven, Sarah Lebeer
Summary: The study developed a throat spray with live lactobacilli that exhibited several mechanisms of action against respiratory viral infections. Three selected strains showed significant reduction in the cytopathogenic effects of respiratory syncytial virus (RSV), influenza A/H1N1 and B viruses, and HCoV-229E coronavirus in co-culture models. Administration of the throat spray in healthy volunteers confirmed temporary colonization of the throat by metabolically active lactobacilli. The developed spray may be a potential broad-acting live biotherapeutic strategy against respiratory viral diseases.
MICROBIAL BIOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Julie Domen, Jan Yvan Jos Verbakel, Niels Adriaenssens, Beatrice Scholtes, Bart Peeters, Robin Bruyndonckx, An De Sutter, Stefan Heytens, Ann van den Bruel, Isabelle Desombere, Pierre Van Damme, Herman Goossens, Laetitia Buret, Els Duysburgh, Samuel Coenen
Summary: A study validated a rapid serological test for SARS-CoV-2 antibodies in healthcare providers in Belgium. The results showed that the test underestimated or overestimated the true seroprevalence in the population.
Article
Cardiac & Cardiovascular Systems
Andreas B. Gevaert, Birgit Boehm, Haley Hartmann, Inge Goovaerts, Tibor Stoop, Caroline M. Van De Heyning, Paul J. Beckers, Flavia Baldassarri, Stephan Mueller, Renate Oberhoffer, Andre Duvinage, Mark J. Haykowsky, Ulrik Wisloff, Volker Adams, Burkert Pieske, Martin Halle, Emeline M. Van Craenenbroeck
Summary: This study investigated the effects of MICT and HIIT on vascular function and repair in HFpEF. The results showed that these training methods did not change vascular function or cellular endothelial repair. This did not significantly contribute to the improvement of VO2peak in HFpEF patients.
JACC-HEART FAILURE
(2023)
Article
Infectious Diseases
Akke Vellinga, Addiena Luke-Currier, Nathaly Garzon-Orjuela, Rune Aabenhus, Marilena Anastasaki, Anca Balan, Femke Boehmer, Valerija Bralic Lang, Slawomir Chlabicz, Samuel Coenen, Ana Garcia-Sangenis, Anna Kowalczyk, Lile Malania, Angela Tomacinschii, Sanne R. van der Linde, Emily Bongard, Christopher C. Butler, Herman Goossens, Alike W. van der Velden
Summary: This study examined the antibiotic prescribing for respiratory tract infections in general practices across European countries. The findings showed that some countries did not meet the appropriate prescribing standards for certain types of infections, and the antibiotic usage rates differed among countries, with Denmark and Spain having lower rates compared to others.
Article
Allergy
Hayat Bentouhami, Milcah Kahkelam Bungwa, Lidia Casas, Samuel Coenen, Joost Weyler
Summary: This study investigates the relationship between asthma occurrence in children and systemic antibiotic use in the first year of life. The results show that excessive use of antibiotics in the first year may contribute to the development of asthma in children. This association is more pronounced in children who have had lower respiratory tract infections in their first year.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
Paul Little, Nick A. Francis, Beth Stuart, Gilly O'Reilly, Natalie Thompson, Taeko Becque, Alastair Hay, Kay Wang, Michael Sharland, Anthony Harnden, Guiqing Yao, James Raftery, Shihua Zhu, Joseph Little, Charlotte Hookham, Kate Rowley, Joanne Euden, Kim Harman, Samuel Coenen, Robert C. Read, Catherine Woods, Christopher C. Butler, Saul N. Faust, Geraldine Leydon, Mandy Wan, Kerenza Hood, Jane Whitehurst, Samantha Richards-Hall, Peter Smith, Michael Thomas, Michael Moore, Theo Verheij
Summary: This study aims to evaluate the clinical effectiveness and cost-effectiveness of amoxicillin for uncomplicated lower respiratory tract infections in children. The results show that amoxicillin has no significant impact on clinical symptoms and resource utilization. It is suggested that parents and clinicians need better access to information and communication.
HEALTH TECHNOLOGY ASSESSMENT
(2023)
Article
Infectious Diseases
Helene Vermeulen, Niel Hens, Lucy Catteau, Boudewijn Catry, Samuel Coenen
Summary: A significant decrease in community antibiotic consumption in Europe was observed during the COVID-19 pandemic, with a decrease in seasonal variation as well.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Immunology
Bruno Salaun, Jonathan De Smedt, Charlotte Vernhes, Annick Moureau, Deniz Oner, Arangassery Rosemary Bastian, Michel Janssens, Sunita Balla-Jhagjhoorsingh, Jeroen Aerssens, Christophe Lambert, Samuel Coenen, Christopher C. Butler, Simon B. Drysdale, Joanne G. Wildenbeest, Andrew J. Pollard, Peter J. M. Openshaw, Louis Bont, RESCEU Investigators
Summary: Cellular immunity plays a primary role in preventing symptomatic RSV infections in older adults, according to a study. T-cell data were found to be more predictive of RSV infection than functional antibody data.
FRONTIERS IN IMMUNOLOGY
(2023)