The PI(4)P phosphatase Sac2 controls insulin granule docking and release

Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

(2018) Nikhil R. Gandasi et al.   Cell Metabolism

Control of insulin granule formation and function by the ABC transporters ABCG1 and ABCA1 and by oxysterol binding protein OSBP

(2018) Syed Saad Hussain et al.   MOLECULAR BIOLOGY OF THE CELL

Genetically encoded lipid biosensors

(2018) Rachel C. Wills et al.   MOLECULAR BIOLOGY OF THE CELL

SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes

(2018) James P Zewe et al.   eLife

Development of a Wireless-Controlled LED Array for the Tunable Optogenetic Control of Cellular Activities

(2018) Yuankai Qi et al.   Engineering

Excess cholesterol inhibits glucose-stimulated fusion pore dynamics in insulin exocytosis

(2017) Yingke Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Multiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis

(2017) Roni Levin et al.   MOLECULAR BIOLOGY OF THE CELL

Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa

(2017) Fushun Fan et al.   eLife

Molecular regulation of insulin granule biogenesis and exocytosis

(2016) P. V. Ro der et al.   BIOCHEMICAL JOURNAL

ORP5/ORP8 localize to endoplasmic reticulum–mitochondria contacts and are involved in mitochondrial function

(2016) Romain Galmes et al.   EMBO REPORTS

Characterization of Phospholipids in Insulin Secretory Granules and Mitochondria in Pancreatic Beta Cells and Their Changes with Glucose Stimulation

(2015) Michael J. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling

(2015) FoSheng Hsu et al.   JOURNAL OF CELL BIOLOGY

Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway

(2015) Fubito Nakatsu et al.   JOURNAL OF CELL BIOLOGY

Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis

(2015) Fan Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts

(2015) J. Chung et al.   SCIENCE

Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis

(2015) Nikhil R. Gandasi et al.   PLoS One

A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi

(2014) Gerald R.V. Hammond et al.   JOURNAL OF CELL BIOLOGY

Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature

(2014) Yading Ling et al.   MOLECULAR BIOLOGY OF THE CELL

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

(2014) J. Fadista et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site

(2014) Nikhil R. Gandasi et al.   Nature Communications

Phosphatidylinositol-4-phosphate: The Golgi and beyond

(2013) Maria A. De Matteis et al.   BIOESSAYS

Recruitment of arfaptins to the trans-Golgi network by PI(4)P and their involvement in cargo export

(2013) David Cruz-Garcia et al.   EMBO JOURNAL

Spatial Control of Epac2 Activity by cAMP and Ca2+-Mediated Activation of Ras in Pancreatic   Cells

(2013) O. Idevall-Hagren et al.   Science Signaling

Phosphoinositides Differentially Regulate Protrudin Localization through the FYVE Domain

(2012) Jung-Eun Gil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells

(2012) Manuel Gálvez-Santisteban et al.   NATURE CELL BIOLOGY

Optogenetic control of phosphoinositide metabolism

(2012) O. Idevall-Hagren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol Accumulation Increases Insulin Granule Size and Impairs Membrane Trafficking

(2012) Jonathan S. Bogan et al.   TRAFFIC

Bulk-like endocytosis plays an important role in the recycling of insulin granules in pancreatic beta cells

(2012) Du Wen et al.   Protein & Cell

Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites

(2011) Christopher J. Stefan et al.   CELL

PI4P and Rab Inputs Collaborate in Myosin-V-Dependent Transport of Secretory Compartments in Yeast

(2011) Felipe H. Santiago-Tirado et al.   DEVELOPMENTAL CELL

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

(2011) Maud de Saint-Jean et al.   JOURNAL OF CELL BIOLOGY

An Expanded Palette of Genetically Encoded Ca2+ Indicators

(2011) Y. Zhao et al.   SCIENCE

Rim2α Determines Docking and Priming States in Insulin Granule Exocytosis

(2010) Takao Yasuda et al.   Cell Metabolism

Phosphatidylinositol 4-Phosphate Controls Both Membrane Recruitment and a Regulatory Switch of the Rab GEF Sec2p

(2010) Emi Mizuno-Yamasaki et al.   DEVELOPMENTAL CELL

Class II Phosphoinositide 3-Kinase Regulates Exocytosis of Insulin Granules in Pancreatic β Cells

(2010) Veronica Dominguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinesin-73 Is a Processive Motor That Localizes to Rab5-containing Organelles

(2010) Thomas M. Huckaba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct plasma-membrane PtdIns(4)P and PtdIns(4,5)P2 dynamics in secretagogue-stimulated  -cells

(2010) A. Wuttke et al.   JOURNAL OF CELL SCIENCE

Glucose-Induced Cyclic AMP Oscillations Regulate Pulsatile Insulin Secretion

(2008) Oleg Dyachok et al.   Cell Metabolism

Ca2+-regulated Pool of Phosphatidylinositol-3-phosphate Produced by Phosphatidylinositol 3-Kinase C2α on Neurosecretory Vesicles

(2008) Peter J. Wen et al.   MOLECULAR BIOLOGY OF THE CELL

SAC1 lipid phosphatase and growth control of the secretory pathway

(2008) Anastasia Blagoveshchenskaya et al.   Molecular BioSystems

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE