☆ 4.7 Article

Holothuria Leucospilota Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Journal

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Volume 20, Issue 19, Pages -

Publisher

MDPI

DOI: 10.3390/ijms20194738

Keywords

Holothuria leucospilota; polysaccharides; hyperlipidemia; high-fat diet; short-chain fatty acids; lipid metabolism; gut microbiota

Categories

Biochemistry & Molecular Biology Chemistry, Multidisciplinary

Funding

Project of Haikou Ocean and Fisheries Bureau [HHCL201804]
Key Project of Science and Technology of Haikou [2017051]
Scientific Research Foundation of Hainan University [KYQD1609]

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Abstract

Holothuria leucospilota polysaccharides (HLP) are expected to become potential resources for the treatment of hyperlipidemia because of their various bioactivities. In the study, the treatment of HLP on improving hyperlipidemia in rats was explored. Oral administration of HLP at 100 or 200 mg/kg body weight effectively alleviated serum lipid levels and liver histological abnormalities in high-fat-diet rats. HLP regulated abnormal mRNA, lipogenesis-related hormones and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6 and interleukin-12) levels. HLP improved the ability of gut microbiota to produce short-chain fatty acids (SCFAs). SCFAs have been found to ameliorate liver lesions. Therefore, HLP alleviated hyperlipidemia by improving the levels of SCFAs to regulate lipid metabolism. These results indicated that HLP could be used as beneficial polysaccharides to alleviate hyperlipidemia.

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