An Internal Disulfide Locks a Misfolded Aggregation-prone Intermediate in Cataract-linked Mutants of Human γD-Crystallin

Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ

(2016) Pierre Maisonneuve et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations

(2016) Florian Buhr et al.   MOLECULAR CELL

Aggregation of Trp > Glu point mutants of human gamma-D crystallin provides a model for hereditary or UV-induced cataract

(2016) Eugene Serebryany et al.   PROTEIN SCIENCE

Highly Charged Proteins: The Achilles' Heel of Aging Proteomes

(2016) Adam M.R. de Graff et al.   STRUCTURE

Copper and Zinc Ions Specifically Promote Nonamyloid Aggregation of the Highly Stable Human γ-D Crystallin

(2015) Liliana Quintanar et al.   ACS Chemical Biology

Single-molecule Force Spectroscopy Predicts a Misfolded, Domain-swapped Conformation in human γD-Crystallin Protein

(2015) Sergi Garcia-Manyes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wild-type Human γD-crystallin Promotes Aggregation of Its Oxidation-mimicking, Misfolding-prone W42Q Mutant

(2015) Eugene Serebryany et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence of Highly Conserved β-Crystallin Disulfidome that Can be Mimicked byIn VitroOxidation in Age-related Human Cataract and Glutathione Depleted Mouse Lens

(2015) Xingjun Fan et al.   MOLECULAR & CELLULAR PROTEOMICS

Lanosterol reverses protein aggregation in cataracts

(2015) Ling Zhao et al.   NATURE

Transient misfolding dominates multidomain protein folding

(2015) Alessandro Borgia et al.   Nature Communications

Thermal Stabilization of Dihydrofolate Reductase Using Monte Carlo Unfolding Simulations and Its Functional Consequences

(2015) Jian Tian et al.   PLoS Computational Biology

The Mitochondrial Intermembrane Space Oxireductase Mia40 Funnels the Oxidative Folding Pathway of the CytochromecOxidase Assembly Protein Cox19

(2014) Hugo Fraga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Characterization of a Disulfide-Locked C2-Symmetric Defensin Peptide

(2014) Andrew J. Wommack et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualization of Transient Protein-Protein Interactions that Promote or Inhibit Amyloid Assembly

(2014) Theodoros K. Karamanos et al.   MOLECULAR CELL

Structural and thermodynamic consequences of burial of an artificial ion pair in the hydrophobic interior of a protein

(2014) A. C. Robinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The βγ-crystallins: Native state stability and pathways to aggregation

(2014) Eugene Serebryany et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Lens β-crystallins: The role of deamidation and related modifications in aging and cataract

(2014) Kirsten J. Lampi et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Amyloid Fiber Formation in Human γD-Crystallin Induced by UV–B Photodamage

(2013) Sean D. Moran et al.   BIOCHEMISTRY

A Mechanistic Model for Amorphous Protein Aggregation of Immunoglobulin-like Domains

(2013) Madeleine B. Borgia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tryptophan Cluster Protects Human γD-Crystallin from Ultraviolet Radiation-Induced PhotoaggregationIn Vitro

(2013) Nathaniel Schafheimer et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Frustration in the energy landscapes of multidomain protein misfolding

(2013) W. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disulfide bonds: protein folding and subcellular protein trafficking

(2012) Mahesh Narayan   FEBS Journal

The Human W42R γD-Crystallin Mutant Structure Provides a Link between Congenital and Age-related Cataracts

(2012) Fangling Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disulfide Scrambling Describes the Oligomer Formation of Superoxide Dismutase (SOD1) Proteins in the Familial Form of Amyotrophic Lateral Sclerosis

(2012) Keisuke Toichi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein misfolding and aggregation in cataract disease and prospects for prevention

(2012) Kate L. Moreau et al.   TRENDS IN MOLECULAR MEDICINE

Somatic mutations in aging, cancer and neurodegeneration

(2011) Scott R. Kennedy et al.   MECHANISMS OF AGEING AND DEVELOPMENT

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

The ageing lens and cataract: a model of normal and pathological ageing

(2011) R. Michael et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Lens fibre cell differentiation and organelle loss: many paths lead to clarity

(2011) M. A. Wride   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Aggregation of  -crystallins associated with human cataracts via domain swapping at the C-terminal  -strands

(2011) P. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ensemble folding kinetics of the FBP28 WW domain revealed by an all-atom Monte Carlo simulation in a knowledge-based potential

(2011) Jiabin Xu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Mysterious oligomerization of the amyloidogenic proteins

(2010) Vladimir N. Uversky   FEBS Journal

Characterization of a Transient Unfolding Intermediate in a Core Mutant of γS-Crystallin

(2010) Bryon Mahler et al.   JOURNAL OF MOLECULAR BIOLOGY

Charges in the hydrophobic interior of proteins

(2010) D. G. Isom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of Preformed Asp23−Lys28 Salt Bridge on the Conformational Fluctuations of Monomers and Dimers of Aβ Peptides with Implications for Rates of Fibril Formation

(2009) Govardhan Reddy et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Prions: Protein Aggregation and Infectious Diseases

(2009) Adriano Aguzzi et al.   PHYSIOLOGICAL REVIEWS

Proteomic analysis of the oxidation of cysteine residues in human age-related nuclear cataract lenses

(2008) Peter G. Hains et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Effect of Interdomain Linker Length on an Antagonistic Folding–Unfolding Equilibrium between Two Protein Domains

(2008) Thomas A. Cutler et al.   JOURNAL OF MOLECULAR BIOLOGY

Amyloid formation by globular proteins under native conditions

(2008) Fabrizio Chiti et al.   Nature Chemical Biology

Universality and diversity of folding mechanics for three-helix bundle proteins

(2008) J. S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamical roles of metal ions and the disulfide bond in Cu, Zn superoxide dismutase folding and aggregation

(2008) F. Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deamidation destabilizes and triggers aggregation of a lens protein, βA3-crystallin

(2008) Takumi Takata et al.   PROTEIN SCIENCE

Analysis of nuclear fiber cell cytoplasmic texture in advanced cataractous lenses from Indian subjects using Debye–Bueche theory

(2007) S. Metlapally et al.   EXPERIMENTAL EYE RESEARCH