Programming for T-lymphocyte fates: modularity and mechanisms

Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells

(2019) Amélie Montel-Hagen et al.   Cell Stem Cell

Transcriptional and epigenetic regulation of innate-like T lymphocyte development

(2018) Mihalis Verykokakis et al.   CURRENT OPINION IN IMMUNOLOGY

Transformation of Accessible Chromatin and 3D Nucleome Underlies Lineage Commitment of Early T Cells

(2018) Gangqing Hu et al.   IMMUNITY

Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells

(2018) John L. Johnson et al.   IMMUNITY

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding

(2018) Hiroyuki Hosokawa et al.   IMMUNITY

Innate Lymphoid Cell Development: A T Cell Perspective

(2018) Dylan E. Cherrier et al.   IMMUNITY

Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by SPI1 (PU.1)

(2018) Jonas Ungerbäck et al.   GENOME RESEARCH

Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16

(2018) Hiroyuki Hosokawa et al.   NATURE IMMUNOLOGY

TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+CD8+ thymocytes

(2018) Akinola Olumide Emmanuel et al.   NATURE IMMUNOLOGY

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

(2018) Kenneth KH Ng et al.   eLife

The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development

(2017) Masaki Miyazaki et al.   IMMUNITY

Development and differentiation of early innate lymphoid progenitors

(2017) Christelle Harly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: β-Catenin–Interacting Tcf1 Isoforms Are Essential for Thymocyte Survival but Dispensable for Thymic Maturation Transitions

(2017) Zhe Xu et al.   JOURNAL OF IMMUNOLOGY

Downregulation of E Protein Activity Augments an ILC2 Differentiation Program in the Thymus

(2017) Hong-Cheng Wang et al.   JOURNAL OF IMMUNOLOGY

The T-ALL related gene BCL11B regulates the initial stages of human T-cell differentiation

(2017) V L Ha et al.   LEUKEMIA

Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids

(2017) Christopher S Seet et al.   NATURE METHODS

Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network

(2017) William J. R. Longabaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes

(2017) Satoshi Kojo et al.   Nature Communications

Loss of CD44dim Expression from Early Progenitor Cells Marks T-Cell Lineage Commitment in the Human Thymus

(2017) Kirsten Canté-Barrett et al.   Frontiers in Immunology

Distinct requirement of Runx complexes for TCRβ enhancer activation at distinct developmental stages

(2017) Wooseok Seo et al.   Scientific Reports

Distinct Gene Regulatory Pathways for Human Innate versus Adaptive Lymphoid Cells

(2016) Olivia I. Koues et al.   CELL

Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality

(2016) Han-Yu Shih et al.   CELL

Views on helper/cytotoxic lineage choice from a bottom-up approach

(2016) Ichiro Taniuchi   IMMUNOLOGICAL REVIEWS

Hematopoiesis and T-cell specification as a model developmental system

(2016) Ellen V. Rothenberg et al.   IMMUNOLOGICAL REVIEWS

A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors

(2016) Mario Buono et al.   NATURE CELL BIOLOGY

Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment

(2016) Hao Yuan Kueh et al.   NATURE IMMUNOLOGY

Innate-like functions of natural killer T cell subsets result from highly divergent gene programs

(2016) Isaac Engel et al.   NATURE IMMUNOLOGY

Distinct myeloid progenitor–differentiation pathways identified through single-cell RNA sequencing

(2016) Roy Drissen et al.   NATURE IMMUNOLOGY

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

(2016) Inge Van de Walle et al.   Nature Communications

Deciphering the Innate Lymphoid Cell Transcriptional Program

(2016) Cyril Seillet et al.   Cell Reports

Transcriptional Regulation of Innate and Adaptive Lymphocyte Lineages

(2015) Maria Elena De Obaldia et al.   Annual Review of Immunology

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions

(2015) Eric M. Pietras et al.   Cell Stem Cell

Innate lymphoid cells: new insights into function and development

(2015) Victor S. Cortez et al.   CURRENT OPINION IN IMMUNOLOGY

Regulation of early T-lineage gene expression and developmental progression by the progenitor cell transcription factor PU.1

(2015) Ameya Champhekar et al.   GENES & DEVELOPMENT

The E–Id protein axis modulates the activities of the PI3K–AKT–mTORC1–Hif1a and c-myc/p19Arf pathways to suppress innate variant TFHcell development, thymocyte expansion, and lymphomagenesis

(2015) Masaki Miyazaki et al.   GENES & DEVELOPMENT

Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells

(2015) Danielle Califano et al.   IMMUNITY

The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development

(2015) Yong Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bcl11b is essential for group 2 innate lymphoid cell development

(2015) Jennifer A. Walker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcription Factor 7 Limits Regulatory T Cell Generation in the Thymus

(2015) Melanie M. Barra et al.   JOURNAL OF IMMUNOLOGY

Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages

(2015) David Casero et al.   NATURE IMMUNOLOGY

TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow

(2015) Qi Yang et al.   NATURE IMMUNOLOGY

The development of innate lymphoid cells requires TOX-dependent generation of a common innate lymphoid cell progenitor

(2015) Corey R Seehus et al.   NATURE IMMUNOLOGY

Dynamic recruitment of Ets1 to both nucleosome-occupied and -depleted enhancer regions mediates a transcriptional program switch during early T-cell differentiation

(2015) Pierre Cauchy et al.   NUCLEIC ACIDS RESEARCH

Human innate lymphoid cells

(2014) M. D. Hazenberg et al.   BLOOD

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

(2014) Christoph S.N. Klose et al.   CELL

Development, Differentiation, and Diversity of Innate Lymphoid Cells

(2014) Andreas Diefenbach et al.   IMMUNITY

The Transcription Factor GATA3 Is Critical for the Development of All IL-7Rα-Expressing Innate Lymphoid Cells

(2014) Ryoji Yagi et al.   IMMUNITY

Transcriptional and epigenetic networks of helper T and innate lymphoid cells

(2014) Han-Yu Shih et al.   IMMUNOLOGICAL REVIEWS

MEK1/2 Induces STAT5-Mediated Germline Transcription of the TCR  Locus in Response to IL-7R Signaling

(2014) K. Maki et al.   JOURNAL OF IMMUNOLOGY

Neural Crest Origin of Perivascular Mesenchyme in the Adult Thymus

(2014) S. M. Muller et al.   JOURNAL OF IMMUNOLOGY

Contribution of Neural Crest-Derived Cells in the Embryonic and Adult Thymus

(2014) K. Foster et al.   JOURNAL OF IMMUNOLOGY

IFN- -Producing and IL-17-Producing    T Cells Differentiate at Distinct Developmental Stages in Murine Fetal Thymus

(2014) K. Shibata et al.   JOURNAL OF IMMUNOLOGY

GATA-3 Dose-Dependent Checkpoints in Early T Cell Commitment

(2014) Deirdre D. Scripture-Adams et al.   JOURNAL OF IMMUNOLOGY

The Multifaceted Roles of Bcl11b in Thymic and Peripheral T Cells: Impact on Immune Diseases

(2014) Dorina Avram et al.   JOURNAL OF IMMUNOLOGY

A committed precursor to innate lymphoid cells

(2014) Michael G. Constantinides et al.   NATURE

TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4+ T cell fate and interact with Runx3 to silence Cd4 in CD8+ T cells

(2014) Farrah C Steinke et al.   NATURE IMMUNOLOGY

A far downstream enhancer for murine Bcl11b controls its T-cell specific expression

(2013) L. Li et al.   BLOOD

E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment

(2013) W. Xu et al.   BLOOD

GATA-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice

(2013) M. E. Garcia-Ojeda et al.   BLOOD

Architecture of a lymphomyeloid developmental switch controlled by PU.1, Notch and Gata3

(2013) M. M. Del Real et al.   DEVELOPMENT

Functional development of γδ T cells

(2013) Immo Prinz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulators of chromatin state and transcription in CD4 T-cell polarization

(2013) Steven Z. Josefowicz   IMMUNOLOGY

Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength

(2013) Inge Van de Walle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evolutionary implications of a third lymphocyte lineage in lampreys

(2013) Masayuki Hirano et al.   NATURE

Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness

(2013) Melanie Wencker et al.   NATURE IMMUNOLOGY

The transcriptional landscape of αβ T cell differentiation

(2013) Michael Mingueneau et al.   NATURE IMMUNOLOGY

Synergistic, Context-Dependent, and Hierarchical Functions of Epithelial Components in Thymic Microenvironments

(2012) Lesly Calderón et al.   CELL

Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity

(2012) Jingli A. Zhang et al.   CELL

A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis

(2012) Ruth Simon et al.   EMBO JOURNAL

E Protein Transcription Factors Are Required for the Development of CD4+ Lineage T Cells

(2012) Mary Elizabeth Jones-Mason et al.   IMMUNITY

Bcl11a is essential for lymphoid development and negatively regulates p53

(2012) Yong Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

(2012) Nadia R Cohen et al.   NATURE IMMUNOLOGY

Transcription factor RORα is critical for nuocyte development

(2012) See Heng Wong et al.   NATURE IMMUNOLOGY

Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo

(2012) S. Zandi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Lineage Commitment: Identity and Renunciation

(2011) E. V. Rothenberg   JOURNAL OF IMMUNOLOGY

T Cell Factor 1 Regulates Thymocyte Survival via a ROR t-Dependent Pathway

(2011) R. Wang et al.   JOURNAL OF IMMUNOLOGY

A thymus candidate in lampreys

(2011) Baubak Bajoghli et al.   NATURE

A critical role for TCF-1 in T-lineage specification and differentiation

(2011) Brittany Nicole Weber et al.   NATURE

The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets

(2011) Cliff Y Yang et al.   NATURE IMMUNOLOGY

The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells

(2011) Masaki Miyazaki et al.   NATURE IMMUNOLOGY

T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling

(2011) K. Germar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combinatorial Transcriptional Control In Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators

(2010) Nicola K. Wilson et al.   Cell Stem Cell

Bcl11b represses a mature T-cell gene expression program in immature CD4+CD8+ thymocytes

(2010) Philippe Kastner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination

(2010) Yanhong Ji et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fine-Scale Staging of T Cell Lineage Commitment in Adult Mouse Thymus

(2010) M. A. Yui et al.   JOURNAL OF IMMUNOLOGY

Cell-Type-Specific Activation and Repression of PU.1 by a Complex of Discrete, Functionally Specialized cis-Regulatory Elements

(2010) M. A. Zarnegar et al.   MOLECULAR AND CELLULAR BIOLOGY

HEB-Deficient T-Cell Precursors Lose T-Cell Potential and Adopt an Alternative Pathway of Differentiation

(2010) M. Braunstein et al.   MOLECULAR AND CELLULAR BIOLOGY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Decision checkpoints in the thymus

(2010) Andrea C Carpenter et al.   NATURE IMMUNOLOGY

An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells

(2010) Louise M D'Cruz et al.   NATURE IMMUNOLOGY

A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

(2010) Yin C Lin et al.   NATURE IMMUNOLOGY

Reprogramming of T Cells to Natural Killer-Like Cells upon Bcl11b Deletion

(2010) P. Li et al.   SCIENCE

An Early T Cell Lineage Commitment Checkpoint Dependent on the Transcription Factor Bcl11b

(2010) L. Li et al.   SCIENCE

An Essential Developmental Checkpoint for Production of the T Cell Lineage

(2010) T. Ikawa et al.   SCIENCE

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

Evolution of Genetic Networks Underlying the Emergence of Thymopoiesis in Vertebrates

(2009) Baubak Bajoghli et al.   CELL

Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A

(2009) Y. Yashiro-Ohtani et al.   GENES & DEVELOPMENT

Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development

(2009) M. A. Inlay et al.   GENES & DEVELOPMENT

GATA-3 is required for early T lineage progenitor development

(2009) Tomonori Hosoya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specification

(2008) Y. Guo et al.   BLOOD

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

Transcription factor expression dynamics of early T-lymphocyte specification and commitment

(2008) Elizabeth-Sharon David-Fung et al.   DEVELOPMENTAL BIOLOGY

Notch signaling is necessary for GATA3 function in the initiation of T cell development

(2008) Katsuto Hozumi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of Lymphocyte Development by Cell-Type-Specific Interpretation of Notch Signals

(2008) L. Nie et al.   MOLECULAR AND CELLULAR BIOLOGY

Adult T-cell progenitors retain myeloid potential

(2008) Haruka Wada et al.   NATURE

The earliest thymic progenitors for T cells possess myeloid lineage potential

(2008) J. Jeremiah Bell et al.   NATURE

The Immunological Genome Project: networks of gene expression in immune cells

(2008) Tracy S P Heng et al.   NATURE IMMUNOLOGY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology