Recent advances of thiazole hybrids in biological applications

Synthesis, cytotoxicity and anti-metastatic properties of new pyridyl-thiazole arene ruthenium(II) complexes

(2018) Li Wang et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives

(2018) Zafer Sahin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-based optimization of free fatty acid receptor 1 agonists bearing thiazole scaffold

(2018) Zheng Li et al.   BIOORGANIC CHEMISTRY

Synthesis, biological evaluation, and docking studies of novel 5,6-diaryl-1,2,4-triazine thiazole derivatives as a new class of α -glucosidase inhibitors

(2018) Guangcheng Wang et al.   BIOORGANIC CHEMISTRY

Effects of antioxidants on apoptosis induced by dasatinib and nilotinib in K562 cells

(2018) Sara Damiano et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

New (arene)ruthenium(II) complexes of 4‑aryl‑4 H ‑naphthopyrans with anticancer and anti-vascular activities

(2018) Florian Schmitt et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation

(2018) Brian T. O’Neill et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, molecular docking, ctDNA interaction, DFT calculation and evaluation of antiproliferative and anti-Toxoplasma gondii activities of 2,4-diaminotriazine-thiazole derivatives

(2018) Krzysztof Z. Łączkowski et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and evaluation of some new 5-(hetaryl)thiazoles as potential antimicrobial agents

(2018) Samir Bondock et al.   SYNTHETIC COMMUNICATIONS

Design, synthesis and antimycobacterial activity of hybrid molecules combining pyrazinamide with a 4-phenylthiazol-2-amine scaffold

(2018) Jan Zitko et al.   MedChemComm

Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer’s Disease Drug Discovery

(2018) Xue-Yang Jiang et al.   ACS Medicinal Chemistry Letters

Synthesis, antitumor activity and CDK1 inhibiton of new thiazole nortopsentin analogues

(2017) Barbara Parrino et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biological Potential of Thiazole Derivatives of Synthetic Origin

(2017) Raghav Mishra et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Conformation-Based Design and Synthesis of Apratoxin A Mimetics Modified at the α,β-Unsaturated Thiazoline Moiety

(2017) Yuichi Onda et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, structure characterization, in vitro and in silico biological evaluation of a new series of thiazole nucleus integrated with pyrazoline scaffolds

(2017) Rajitha Sadashiva et al.   JOURNAL OF MOLECULAR STRUCTURE

Cyclotheonellazoles A–C, Potent Protease Inhibitors from the Marine Sponge Theonella aff. swinhoei

(2017) Michal Issac et al.   JOURNAL OF NATURAL PRODUCTS

Understanding drug resistance will improve the treatment of bacterial infections

(2017) Laura J. V. Piddock   NATURE REVIEWS MICROBIOLOGY

Synthesis and biological evaluation of new 2-aryl-4-((4-aryl-1H-1,2,3-triazol-1-yl)methyl)thiazole derivatives

(2017) Vikas Shinde et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties

(2016) Stephen O. Pember et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Coumarins as cholinesterase inhibitors: A review

(2016) Luana G. de Souza et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review

(2016) Xiao Xiao et al.   CHEMISTRY & BIODIVERSITY

Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis

(2016) Mehmet Gümus et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Thiazole: A Review on Chemistry, Synthesis and Therapeutic Importance of its Derivatives

(2016) Mahesh T. Chhabria et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Strategies for meloxicam delivery to and across the skin: a review

(2016) Jianmin Chen et al.   DRUG DELIVERY

Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer’s Agents: Synthesis and Biological Evaluation

(2016) Mahesh Shidore et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antiproliferative activity evaluation of new thiazole–benzimidazole derivatives using real-time cell analysis (RTCA DP)

(2016) Yusuf Özkay et al.   MEDICINAL CHEMISTRY RESEARCH

Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61

(2016) Kuan-Chun Huang et al.   MOLECULAR CANCER THERAPEUTICS

Synthesis of New 3-Heteroarylindoles as Potential Anticancer Agents

(2016) Abdou Abdelhamid et al.   MOLECULES

Overview on the recently developed thiazolyl heterocycles as useful therapeutic agents

(2016) Nosrat O. Mahmoodi et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Ionic liquid-promoted one-pot synthesis of thiazole–imidazo[2,1-b][1,3,4]thiadiazole hybrids and their antitubercular activity

(2016) Jurupula Ramprasad et al.   MedChemComm

Sulfonamide-1,3,5-triazine–thiazoles: discovery of a novel class of antidiabetic agents via inhibition of DPP-4

(2016) Hai-De Gao et al.   RSC Advances

A Novel Approach to Inhibit Heat Shock Response as Anticancer Strategy by Coumarine Compounds Containing Thiazole Skeleton

(2015) İrfan Koca et al.   Anti-Cancer Agents in Medicinal Chemistry

One-Pot Multi-Component Synthesis of 1,4-Dihydropyridines Using Zn2+@KSF and Evaluating Their Antibacterial and Antioxidant Activities

(2015) Nosrat O. Mahmoodi et al.   ARCHIV DER PHARMAZIE

2-(3′-Indolyl)-N-arylthiazole-4-carboxamides: Synthesis and evaluation of antibacterial and anticancer activities

(2015) Mukund P. Tantak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel thiazole–thiophene conjugates as adenosine receptor antagonists: Synthesis, biological evaluation and docking studies

(2015) Dhaivat H. Pandya et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, antioxidant and anticholinesterase activities of novel coumarylthiazole derivatives

(2015) Belma Zengin Kurt et al.   BIOORGANIC CHEMISTRY

Synthesis of novel thiazole-based 8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepines as potential antitumor and antifungal agents

(2015) Juan Ramírez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bioactive thiazole and benzothiazole derivatives

(2015) Abdul Rouf et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potential of aryl–urea–benzofuranylthiazoles hybrids as multitasking agents in Alzheimer's disease

(2015) Belma Zengin Kurt et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Some New Benzimidazole-Thiazole Derivatives as Anticancer Agents

(2014) Zienab M. Nofal et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis, Characterization, and Biological Evaluation of Some Tri-Substituted Imidazole/thiazole Derivatives

(2014) H. B'Bhatt et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis and evaluation of anti-inflammatory and analgesic activity of some substituted thiazolyl and thaizolidinonyl tetrahydronapthalene derivatives

(2014) Mogedda E. Haiba et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and anti-inflammatory evaluation of new pyrazoles bearing biodynamic thiazole and thiazolidinone scaffolds

(2014) Lalit D. Khillare et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis and synthetic chemistry of pleuromutilin

(2014) Neal J. Fazakerley et al.   TETRAHEDRON

Thiazole-based aminopyrimidines and N-phenylpyrazolines as potent antimicrobial agents: synthesis and biological evaluation

(2014) Konstantinos Liaras et al.   MedChemComm

New anti-inflammatory thiazolyl-carbonyl-thiosemicarbazides and thiazolyl-azoles with antioxidant properties as potential iNOS inhibitors

(2013) Brînduşa Tiperciuc et al.   ARCHIVES OF PHARMACAL RESEARCH

Synthesis of some new 2-(3-pyridyl)-4,5-disubstituted thiazoles as potent antimicrobial agents

(2013) Samir Bondock et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of some novel thiazole compounds as potential anti-inflammatory agents

(2013) M.H.M. Helal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thiazole–aminopiperidine hybrid analogues: Design and synthesis of novel Mycobacterium tuberculosis GyrB inhibitors

(2013) Variam Ullas Jeankumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dual evaluation of some novel 2-amino-substituted coumarinylthiazoles as anti-inflammatory–antimicrobial agents and their docking studies with COX-1/COX-2 active sites

(2013) Navneet Chandak et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and pharmacological evaluation of some novel 4-isopropyl thiazole-based sulfonyl derivatives as potent antimicrobial and antitubercular agents

(2013) G. V. Suresh Kumar et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis, anti-inflammatory evaluation, and docking studies of some new thiazole derivatives

(2013) Pran Kishore Deb et al.   MEDICINAL CHEMISTRY RESEARCH

Novel pleuromutilin derivatives as antibacterial agents: Synthesis, biological evaluation and molecular docking studies

(2012) Xinyang Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

4-Hydroxy-2-methyl-N-(2-thiazole)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide (EX15) and its Cu(II) Complex as New Oxicam Selective Cyclooxygenase-2 Inhibitors

(2012) Yousery El-Sayed Sherif et al.   CROATICA CHEMICA ACTA

Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring

(2012) A.K. Mohammed Iqbal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization, and biological evaluation of novel thiazole and pyrazole derivatives of quinoline-4-carboxylic acid as potential antimicrobial agents

(2012) Abha Bishnoi et al.   MEDICINAL CHEMISTRY RESEARCH

Docking, synthesis, and pharmacological investigation of novel substituted thiazole derivatives as non-carboxylic, anti-inflammatory, and analgesic agents

(2012) S. N. Thore et al.   MEDICINAL CHEMISTRY RESEARCH

A review on various heterocyclic moieties and their antitubercular activity

(2011) S. Sharma et al.   BIOMEDICINE & PHARMACOTHERAPY

Design, synthesis and SAR exploration of hybrid 4-chlorophenylthiazolyl-s-triazine as potential antimicrobial agents

(2011) Prashant Gahtori et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatory–antibacterial agents

(2011) Pawan Kumar et al.   MEDICINAL CHEMISTRY RESEARCH

Thiazoles: having diverse biological activities

(2011) Shiv Jee Kashyap et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis, antimicrobial, antioxidant, anti-inflammatory, and analgesic activities of some new 3-(2′-thienyl)pyrazole-based heterocycles

(2011) Bakr F. Abdel-Wahab et al.   MEDICINAL CHEMISTRY RESEARCH

Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)propanamides as glucokinase activators

(2010) Fuying Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities

(2010) Haifeng Tang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS