Emerging molecular therapeutic targets for spinal cord injury

Knockdown of fidgetin improves regeneration of injured axons by a microtubule-based mechanism

(2019) Andrew J. Matamoros et al.   JOURNAL OF NEUROSCIENCE

Neuropilin-1-mediated pruning of corticospinal tract fibers is required for motor recovery after spinal cord injury

(2019) Toru Nakanishi et al.   Cell Death & Disease

Melatonin Treatment Alleviates Spinal Cord Injury-Induced Gut Dysbiosis in Mice

(2019) Yingli Jing et al.   JOURNAL OF NEUROTRAUMA

Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition

(2019) Ashley L. Kalinski et al.   JOURNAL OF CELL BIOLOGY

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

(2019) Thomas H. Hutson et al.   Science Translational Medicine

Emerging targets for reprograming the immune response to promote repair and recovery of function after spinal cord injury

(2018) Faith H. Brennan et al.   CURRENT OPINION IN NEUROLOGY

Nerve injury-induced chronic pain is associated with persistent DNA methylation reprogramming in dorsal root ganglion

(2018) Judit Garriga et al.   JOURNAL OF NEUROSCIENCE

Blocking Autophagy in Oligodendrocytes Limits Functional Recovery after Spinal Cord Injury

(2018) Sujata Saraswat Ohri et al.   JOURNAL OF NEUROSCIENCE

Effects of Mitochondrial Transplantation on Bioenergetics, Cellular Incorporation, and Functional Recovery after Spinal Cord Injury

(2018) Jenna L. Gollihue et al.   JOURNAL OF NEUROTRAUMA

Adult rat myelin enhances axonal outgrowth from neural stem cells

(2018) Gunnar H. D. Poplawski et al.   Science Translational Medicine

Lysosomal damage after spinal cord injury causes accumulation of RIPK1 and RIPK3 proteins and potentiation of necroptosis

(2018) Shuo Liu et al.   Cell Death & Disease

Class I histone deacetylase (HDAC) inhibitor CI-994 promotes functional recovery following spinal cord injury

(2018) Suxiang Zhang et al.   Cell Death & Disease

Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration

(2018) Yuichi Sekine et al.   Cell Reports

Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations

(2018) Bo Chen et al.   CELL

Required growth facilitators propel axon regeneration across complete spinal cord injury

(2018) Mark A. Anderson et al.   NATURE

Melatonin for the treatment of spinal cord injury

(2018) Yun Guan et al.   Neural Regeneration Research

Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration

(2018) Xue-Wei Wang et al.   Cell Reports

Remodeling of lumbar motor circuitry remote to a thoracic spinal cord injury promotes locomotor recovery

(2018) Ying Wang et al.   eLife

Pharmacological Stimulation of Mitochondrial Biogenesis Using the Food and Drug Administration-Approved β2-Adrenoreceptor Agonist Formoterol for the Treatment of Spinal Cord Injury

(2018) Natalie E. Scholpa et al.   JOURNAL OF NEUROTRAUMA

Promoting Axon Regeneration in Adult CNS by Targeting Liver Kinase B1

(2018) Yosuke Ohtake et al.   MOLECULAR THERAPY

Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration

(2018) Young Mi Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis

(2018) Fucheng Luo et al.   Nature Communications

E6020, a synthetic TLR4 agonist, accelerates myelin debris clearance, Schwann cell infiltration, and remyelination in the rat spinal cord

(2017) Jamie S. Church et al.   GLIA

Neuregulin-1 positively modulates glial response and improves neurological recovery following traumatic spinal cord injury

(2017) Arsalan Alizadeh et al.   GLIA

The Temporal Pattern, Flux, and Function of Autophagy in Spinal Cord Injury

(2017) Kailiang Zhou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cell biology of spinal cord injury and repair

(2017) Timothy M. O’Shea et al.   JOURNAL OF CLINICAL INVESTIGATION

Design and optimization of PLGA microparticles for controlled and local delivery of Neuregulin-1 in traumatic spinal cord injury

(2017) Kallivalappil T. Santhosh et al.   JOURNAL OF CONTROLLED RELEASE

LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway

(2017) Zhaohui Shao et al.   JOURNAL OF NEUROSCIENCE

Chd7 Collaborates with Sox2 to Regulate Activation of Oligodendrocyte Precursor Cells after Spinal Cord Injury

(2017) Toru Doi et al.   JOURNAL OF NEUROSCIENCE

The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury

(2017) Hassan Al-Ali et al.   JOURNAL OF NEUROSCIENCE

Systemic Neutrophil Depletion Modulates the Migration and Fate of Transplanted Human Neural Stem Cells to Rescue Functional Repair

(2017) Hal X. Nguyen et al.   JOURNAL OF NEUROSCIENCE

An Image-Based miRNA Screen Identifies miRNA-135s As Regulators of CNS Axon Growth and Regeneration by Targeting Krüppel-like Factor 4

(2017) Eljo Y. van Battum et al.   JOURNAL OF NEUROSCIENCE

Maresin 1 Promotes Inflammatory Resolution, Neuroprotection, and Functional Neurological Recovery After Spinal Cord Injury

(2017) Isaac Francos-Quijorna et al.   JOURNAL OF NEUROSCIENCE

Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin–N-cadherin pathway after spinal cord injury

(2017) Masamitsu Hara et al.   NATURE MEDICINE

Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others

(2017) Michael W. Norsworthy et al.   NEURON

An Intrinsic Epigenetic Barrier for Functional Axon Regeneration

(2017) Yi-Lan Weng et al.   NEURON

A green tea polyphenol epigallocatechin-3-gallate enhances neuroregeneration after spinal cord injury by altering levels of inflammatory cytokines

(2017) Lucia Machova Urdzikova et al.   NEUROPHARMACOLOGY

Ketogenic Metabolism Inhibits Histone Deacetylase (HDAC) and Reduces Oxidative Stress After Spinal Cord Injury in Rats

(2017) Xiaomeng Wang et al.   NEUROSCIENCE

Gut Microbiota Are Disease-Modifying Factors After Traumatic Spinal Cord Injury

(2017) Kristina A. Kigerl et al.   Neurotherapeutics

The Brain Is Needed to Cure Spinal Cord Injury

(2017) Tadashi Isa   TRENDS IN NEUROSCIENCES

Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury

(2017) Kathren L. Fink et al.   Cell Reports

HDAC3 inhibition ameliorates spinal cord injury by immunomodulation

(2017) Tomoharu Kuboyama et al.   Scientific Reports

Restoration of Visual Function by Enhancing Conduction in Regenerated Axons

(2016) Fengfeng Bei et al.   CELL

Brg1 directly regulates Olig2 transcription and is required for oligodendrocyte progenitor cell specification

(2016) Steven Matsumoto et al.   DEVELOPMENTAL BIOLOGY

Gut dysbiosis impairs recovery after spinal cord injury

(2016) Kristina A. Kigerl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miR-155 Deletion in Mice Overcomes Neuron-Intrinsic and Neuron-Extrinsic Barriers to Spinal Cord Repair

(2016) A. D. Gaudet et al.   JOURNAL OF NEUROSCIENCE

Remyelinating Oligodendrocyte Precursor Cell miRNAs from the Sfmbt2 Cluster Promote Cell Cycle Arrest and Differentiation

(2016) Nicholas J. Kuypers et al.   JOURNAL OF NEUROSCIENCE

Chitosan polyplex mediated delivery of miRNA-124 reduces activation of microglial cells in vitro and in rat models of spinal cord injury

(2016) Andrew M. Louw et al.   Nanomedicine-Nanotechnology Biology and Medicine

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

(2016) Hi-Jai R. Shin et al.   NATURE

Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination

(2016) Danyang He et al.   NATURE NEUROSCIENCE

Ryk controls remapping of motor cortex during functional recovery after spinal cord injury

(2016) Edmund R Hollis et al.   NATURE NEUROSCIENCE

Autophagy in acute brain injury

(2016) Lorenzo Galluzzi et al.   NATURE REVIEWS NEUROSCIENCE

Time representation of mitochondrial morphology and function after acute spinal cord injury

(2016) Gang Lv et al.   Neural Regeneration Research

The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration

(2016) Romain Cartoni et al.   NEURON

The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS

(2016) Andrea Tedeschi et al.   NEURON

Role of autophagy in the bimodal stage after spinal cord ischemia reperfusion injury in rats

(2016) Bo Fang et al.   NEUROSCIENCE

Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System

(2016) Xueting Luo et al.   Cell Reports

An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK

(2016) Yan Hao et al.   eLife

IVIg attenuates complement and improves spinal cord injury outcomes in mice

(2016) Faith H. Brennan et al.   Annals of Clinical and Translational Neurology

Adoptive transfer of M2 macrophages promotes locomotor recovery in adult rats after spinal cord injury

(2015) Shan-Feng Ma et al.   BRAIN BEHAVIOR AND IMMUNITY

Azithromycin drives alternative macrophage activation and improves recovery and tissue sparing in contusion spinal cord injury

(2015) Bei Zhang et al.   Journal of Neuroinflammation

A Single Bolus of Docosahexaenoic Acid Promotes Neuroplastic Changes in the Innervation of Spinal Cord Interneurons and Motor Neurons and Improves Functional Recovery after Spinal Cord Injury

(2015) Z.-H. Liu et al.   JOURNAL OF NEUROSCIENCE

Overexpression of Sox11 Promotes Corticospinal Tract Regeneration after Spinal Injury While Interfering with Functional Recovery

(2015) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

G-CSF promotes autophagy and reduces neural tissue damage after spinal cord injury in mice

(2015) Yuji Guo et al.   LABORATORY INVESTIGATION

Loss of microRNA-124 expression in neurons in the peri-lesion area in mice with spinal cord injury

(2015) Gong Ju et al.   Neural Regeneration Research

PTEN inhibition and axon regeneration and neural repair

(2015) Shuxin Li et al.   Neural Regeneration Research

Structural and functional reorganization of propriospinal connections promotes functional recovery after spinal cord injury

(2015) Linard Filli et al.   Neural Regeneration Research

Mitochondrial Division Inhibitor 1 Ameliorates Mitochondrial Injury, Apoptosis, and Motor Dysfunction After Acute Spinal Cord Injury in Rats

(2015) Gang Li et al.   NEUROCHEMICAL RESEARCH

Injury-Induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics

(2015) Stephane Belin et al.   NEURON

Subtype-Specific Regeneration of Retinal Ganglion Cells following Axotomy: Effects of Osteopontin and mTOR Signaling

(2015) Xin Duan et al.   NEURON

Acetyl-l-carnitineamelioratesmitochondrial damage and apoptosis following spinal cord injury in rats

(2015) Zhen-yu Zhang et al.   NEUROSCIENCE LETTERS

Neuroinflammation triggered by β-glucan/dectin-1 signaling enables CNS axon regeneration

(2015) Katherine T. Baldwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-26a supports mammalian axon regeneration in vivo by suppressing GSK3β expression

(2015) J-J Jiang et al.   Cell Death & Disease

Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death

(2015) S Liu et al.   Cell Death & Disease

Stimulation of autophagy promotes functional recovery in diabetic rats with spinal cord injury

(2015) Kai-liang Zhou et al.   Scientific Reports

The effect of systemic PTEN antagonist peptides on axon growth and functional recovery after spinal cord injury

(2014) Yosuke Ohtake et al.   BIOMATERIALS

Nogo limits neural plasticity and recovery from injury

(2014) Martin E Schwab et al.   CURRENT OPINION IN NEUROBIOLOGY

BMP signaling in axon regeneration

(2014) Jian Zhong et al.   CURRENT OPINION IN NEUROBIOLOGY

N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma

(2014) Samir P. Patel et al.   EXPERIMENTAL NEUROLOGY

Functional regeneration beyond the glial scar

(2014) Jared M. Cregg et al.   EXPERIMENTAL NEUROLOGY

CCR5 Blockade Promotes M2 Macrophage Activation and Improves Locomotor Recovery After Spinal Cord Injury in Mice

(2014) Fengtao Li et al.   INFLAMMATION

Higenamine promotes M2 macrophage activation and reduces Hmgb1 production through HO-1 induction in a murine model of spinal cord injury

(2014) Zhenyu Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Progesterone Reduces Secondary Damage, Preserves White Matter, and Improves Locomotor Outcome after Spinal Cord Contusion

(2014) Daniel Garcia-Ovejero et al.   JOURNAL OF NEUROTRAUMA

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2014) Antje Kroner et al.   NEURON

Ketogenic Diet in Neuromuscular and Neurodegenerative Diseases

(2014) Antonio Paoli et al.   Biomed Research International

Glutathione and mitochondria

(2014) Vicent Ribas et al.   Frontiers in Pharmacology

Immunohistochemical Analysis of the Ubiquitin Proteasome System and Autophagy Lysosome System Induced After Traumatic Intracranial Injury

(2013) Kentaro Sakai et al.   AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY

Mitochondrial fusion and fission after spinal sacord injury in rats

(2013) Yang Cao et al.   BRAIN RESEARCH

Progesterone reduces the expression of spinal cyclooxygenase-2 and inducible nitric oxide synthase and prevents allodynia in a rat model of central neuropathic pain

(2013) M.F. Coronel et al.   EUROPEAN JOURNAL OF PAIN

Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury

(2013) Xueting Luo et al.   EXPERIMENTAL NEUROLOGY

Systemic iron chelation results in limited functional and histological recovery after traumatic spinal cord injury in rats

(2013) Andrew Sauerbeck et al.   EXPERIMENTAL NEUROLOGY

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

(2013) Ravid Shechter et al.   IMMUNITY

Autophagy Reduces Neuronal Damage and Promotes Locomotor Recovery via Inhibition of Apoptosis After Spinal Cord Injury in Rats

(2013) Peifu Tang et al.   MOLECULAR NEUROBIOLOGY

Liposomal Targeting of Prednisolone Phosphate to Synovial Lining Macrophages during Experimental Arthritis Inhibits M1 Activation but Does Not Favor M2 Differentiation

(2013) Wouter Hofkens et al.   PLoS One

Developmental Decline in Neuronal Regeneration by the Progressive Change of Two Intrinsic Timers

(2013) Y. Zou et al.   SCIENCE

Genome Regulation by Long Noncoding RNAs

(2012) John L. Rinn et al.   Annual Review of Biochemistry

Late blocking of peripheral TNF-α is ineffective after spinal cord injury in mice

(2012) Pía M. Vidal et al.   IMMUNOBIOLOGY

Reactive Astrogliosis after Spinal Cord Injury—Beneficial and Detrimental Effects

(2012) Soheila Karimi-Abdolrezaee et al.   MOLECULAR NEUROBIOLOGY

NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans

(2012) Travis L Dickendesher et al.   NATURE NEUROSCIENCE

Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors

(2012) S. de Lima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders

(2012) Carl E. Stafstrom et al.   Frontiers in Pharmacology

Multiple transcription factor families regulate axon growth and regeneration

(2011) Darcie L. Moore et al.   Developmental Neurobiology

Progesterone attenuates astro- and microgliosis and enhances oligodendrocyte differentiation following spinal cord injury

(2011) Florencia Labombarda et al.   EXPERIMENTAL NEUROLOGY

Leukocyte Common Antigen-Related Phosphatase Is a Functional Receptor for Chondroitin Sulfate Proteoglycan Axon Growth Inhibitors

(2011) D. Fisher et al.   JOURNAL OF NEUROSCIENCE

A Phase I/IIa Clinical Trial of a Recombinant Rho Protein Antagonist in Acute Spinal Cord Injury

(2011) Michael G. Fehlings et al.   JOURNAL OF NEUROTRAUMA

Functional regeneration of respiratory pathways after spinal cord injury

(2011) Warren J. Alilain et al.   NATURE

Targeting Mitochondrial Function for the Treatment of Acute Spinal Cord Injury

(2011) Melanie L. McEwen et al.   Neurotherapeutics

Engineering neuronal growth cones to promote axon regeneration over inhibitory molecules

(2011) E.-M. Hur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficacy and safety of lithium carbonate treatment of chronic spinal cord injuries: a double-blind, randomized, placebo-controlled clinical trial

(2011) M L Yang et al.   SPINAL CORD

Beneficial effects of secretory leukocyte protease inhibitor after spinal cord injury

(2010) Nader Ghasemlou et al.   BRAIN

Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation

(2010) Masahiko Mukaino et al.   EXPERIMENTAL NEUROLOGY

Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease

(2010) Daniel J. Ho et al.   EXPERIMENTAL NEUROLOGY

The molecular identity of the mitochondrial Ca2+ sequestration system

(2010) Anatoly A. Starkov   FEBS Journal

Calcium-dependent mitochondrial function and dysfunction in neurons

(2010) Natalia B. Pivovarova et al.   FEBS Journal

Long-Distance Axon Regeneration in the Mature Optic Nerve: Contributions of Oncomodulin, cAMP, and pten Gene Deletion

(2010) T. Kurimoto et al.   JOURNAL OF NEUROSCIENCE

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Altered microRNA expression following traumatic spinal cord injury

(2009) Nai-Kui Liu et al.   EXPERIMENTAL NEUROLOGY

Effect of cyclosporin A on functional recovery in the spinal cord following contusion injury

(2009) Siobhan S. McMahon et al.   JOURNAL OF ANATOMY

Neuroprotective and Axon Growth-Promoting Effects following Inflammatory Stimulation on Mature Retinal Ganglion Cells in Mice Depend on Ciliary Neurotrophic Factor and Leukemia Inhibitory Factor

(2009) M. Leibinger et al.   JOURNAL OF NEUROSCIENCE

Significant recovery of motor function in a patient with complete T7 paraplegia receiving etanercept

(2009) M Dinomais et al.   JOURNAL OF REHABILITATION MEDICINE

PTP  Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

(2009) Y. Shen et al.   SCIENCE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

Involvement of mitochondrial signaling pathways in the mechanism of Fas-mediated apoptosis after spinal cord injury

(2008) Wen Ru Yu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Inactivation of Glycogen Synthase Kinase 3 Promotes Axonal Growth and Recovery in the CNS

(2008) J. Dill et al.   JOURNAL OF NEUROSCIENCE