Targeting Mitochondrial Function for the Treatment of Acute Spinal Cord Injury

Pretreatment with the ciclosporin derivative NIM811 reduces delayed neuronal death in the hippocampus after transient forebrain ischaemia

(2015) Masaaki Hokari et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Necroptosis as an alternative form of programmed cell death

(2010) Dana E Christofferson et al.   CURRENT OPINION IN CELL BIOLOGY

Mitochondrial Ca2+ sequestration and precipitation revisited

(2010) Christos Chinopoulos et al.   FEBS Journal

Calcium-dependent mitochondrial function and dysfunction in neurons

(2010) Natalia B. Pivovarova et al.   FEBS Journal

Applications of Electron Spin Resonance Spectrometry for Reactive Oxygen Species and Reactive Nitrogen Species Research

(2010) Masahiro Kohno   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation and pharmacology of the mitochondrial permeability transition pore

(2009) D. B. Zorov et al.   CARDIOVASCULAR RESEARCH

Tempol protection of spinal cord mitochondria from peroxynitrite-induced oxidative damage

(2009) Yiqin Xiong et al.   FREE RADICAL RESEARCH

The cyclophilin inhibitor Debio 025 combined with PEG IFNα2a significantly reduces viral load in treatment-naïve hepatitis C patients

(2009) Robert Flisiak et al.   HEPATOLOGY

The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication

(2009) Udayan Chatterji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The novel NMDA receptor antagonist, 2-hydroxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)-benzoic acid, is a gating modifier in cultured mouse cortical neurons

(2009) Jihyun Noh et al.   JOURNAL OF NEUROCHEMISTRY

The Functional and Neuroprotective Actions of Neu2000, a Dual-Acting Pharmacological Agent, in the Treatment of Acute Spinal Cord Injury

(2009) Joe E. Springer et al.   JOURNAL OF NEUROTRAUMA

Major cell death pathways at a glance

(2009) Linde Duprez et al.   MICROBES AND INFECTION

The efficacy of alpha-tocopherol in functional recovery of spinal cord injured rats: an experimental study

(2009) M S I Al Jadid et al.   SPINAL CORD

Debio 025, a Cyclophilin Binding Molecule, Is Highly Efficient in Clearing Hepatitis C Virus (HCV) Replicon-Containing Cells When Used Alone or in Combination with Specifically Targeted Antiviral Therapy for HCV (STAT-C) Inhibitors

(2008) L. Coelmont et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Combinations of Cyclophilin Inhibitor NIM811 with Hepatitis C Virus NS3-4A Protease or NS5B Polymerase Inhibitors Enhance Antiviral Activity and Suppress the Emergence of Resistance

(2008) J. E. Mathy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of Free Radicals and Poly(ADP-Ribose)Polymerase-1 in the Development of Spinal Cord Injury: New Potential Therapeutic Targets

(2008) S. Cuzzocrea et al.   CURRENT MEDICINAL CHEMISTRY

Pharmacological evidence for a role of peroxynitrite in the pathophysiology of spinal cord injury

(2008) Yiqin Xiong et al.   EXPERIMENTAL NEUROLOGY

Comparative Neuroprotective Effects of Cyclosporin a and NIM811, a Nonimmunosuppressive Cyclosporin a Analog, following Traumatic Brain Injury

(2008) Lamin Han Mbye et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants

(2008) P. Cassina et al.   JOURNAL OF NEUROSCIENCE

Differential effects of the mitochondrial uncoupling agent, 2,4-dinitrophenol, or the nitroxide antioxidant, Tempol, on synaptic or nonsynaptic mitochondria after spinal cord injury

(2008) Samir P. Patel et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon

(2008) James W. Rowland et al.   Neurosurgical Focus

Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

(2008) Christophe Piot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog

(2007) L.H. Mbye et al.   EXPERIMENTAL NEUROLOGY