Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration

Modest enhancement of sensory axon regeneration in the sciatic nerve with conditional co-deletion of PTEN and SOCS3 in the dorsal root ganglia of adult mice

(2018) Zachary R. Gallaher et al.   EXPERIMENTAL NEUROLOGY

Nerve injury-induced chronic pain is associated with persistent DNA methylation reprogramming in dorsal root ganglion

(2018) Judit Garriga et al.   JOURNAL OF NEUROSCIENCE

Intrinsic mechanisms of neuronal axon regeneration

(2018) Marcus Mahar et al.   NATURE REVIEWS NEUROSCIENCE

Selecting optimal combinations of transcription factors to promote axon regeneration: Why mechanisms matter

(2017) Ishwariya Venkatesh et al.   NEUROSCIENCE LETTERS

Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration

(2016) Vidya Ramesh et al.   GENES & DEVELOPMENT

Epigenetic mechanisms in neurogenesis

(2016) Bing Yao et al.   NATURE REVIEWS NEUROSCIENCE

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program

(2016) Vijayendran Chandran et al.   NEURON

The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS

(2016) Andrea Tedeschi et al.   NEURON

Intrinsic Control of Axon Regeneration

(2016) Zhigang He et al.   NEURON

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

Activating Injury-Responsive Genes with Hypoxia Enhances Axon Regeneration through Neuronal HIF-1α

(2015) Yongcheol Cho et al.   NEURON

TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

(2015) Arshan Perera et al.   Cell Reports

An RNA Binding Protein Promotes Axonal Integrity in Peripheral Neurons by Destabilizing REST

(2014) F. Cargnin et al.   JOURNAL OF NEUROSCIENCE

A Comparison of RNA-Seq and Exon Arrays for Whole Genome Transcription Profiling of the L5 Spinal Nerve Transection Model of Neuropathic Pain in the Rat

(2014) James R Perkins et al.   Molecular Pain

REST and stress resistance in ageing and Alzheimer’s disease

(2014) Tao Lu et al.   NATURE

The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells

(2014) Yuuki Obata et al.   NATURE IMMUNOLOGY

Spinal Cord Injury and the Neuron-Intrinsic Regeneration-Associated Gene Program

(2014) Nitish D. Fagoe et al.   NEUROMOLECULAR MEDICINE

PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system

(2014) Radhika Puttagunta et al.   Nature Communications

MicroRNA-9 controls dendritic development by targeting REST

(2014) Sebastian A Giusti et al.   eLife

Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis

(2013) Christian Bronner et al.   BIOCHEMICAL PHARMACOLOGY

Injury-Induced HDAC5 Nuclear Export Is Essential for Axon Regeneration

(2013) Yongcheol Cho et al.   CELL

MicroRNAs: regulators of neuronal fate

(2013) Alfred X Sun et al.   CURRENT OPINION IN CELL BIOLOGY

Dynamic regulation of SCG10 in regenerating axons after injury

(2013) Jung Eun Shin et al.   EXPERIMENTAL NEUROLOGY

The DNA Methyltransferase Dnmt1 Directly Interacts with the SET and RING Finger-associated (SRA) Domain of the Multifunctional Protein Uhrf1 to Facilitate Accession of the Catalytic Center to Hemi-methylated DNA

(2013) Ahmet Can Berkyurek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTEN Inhibition to Facilitate Intrinsic Regenerative Outgrowth of Adult Peripheral Axons

(2013) K. J. Christie et al.   JOURNAL OF NEUROSCIENCE

A Critical Role for Macrophages Near Axotomized Neuronal Cell Bodies in Stimulating Nerve Regeneration

(2013) J. P. Niemi et al.   JOURNAL OF NEUROSCIENCE

Epigenetic Regulation of Sensory Axon Regeneration after Spinal Cord Injury

(2013) M. J. Finelli et al.   JOURNAL OF NEUROSCIENCE

The Small Cell Lung Cancer-Specific Isoform of RE1-Silencing Transcription Factor (REST) Is Regulated By Neural-Specific Ser/Arg Repeat-Related Protein of 100 kDa (nSR100)

(2013) Masahito Shimojo et al.   MOLECULAR CANCER RESEARCH

Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication

(2013) Atsuya Nishiyama et al.   NATURE

DNA methylation: roles in mammalian development

(2013) Zachary D. Smith et al.   NATURE REVIEWS GENETICS

Axon–soma communication in neuronal injury

(2013) Ida Rishal et al.   NATURE REVIEWS NEUROSCIENCE

Epigenetic Regulation of Axon Outgrowth and Regeneration in CNS Injury: The First Steps Forward

(2013) Ricco Lindner et al.   Neurotherapeutics

UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9

(2013) Xiaoli Liu et al.   Nature Communications

Waking up the sleepers: shared transcriptional pathways in axonal regeneration and neurogenesis

(2012) Giorgia Quadrato et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

HDAC5 is a novel injury-regulated tubulin deacetylase controlling axon regeneration

(2012) Yongcheol Cho et al.   EMBO JOURNAL

microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons

(2012) Federico Dajas-Bailador et al.   NATURE NEUROSCIENCE

REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors

(2012) Alma Rodenas-Ruano et al.   NATURE NEUROSCIENCE

Assembly of a new growth cone after axotomy: the precursor to axon regeneration

(2012) Frank Bradke et al.   NATURE REVIEWS NEUROSCIENCE

Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation

(2012) Scott B Rothbart et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1

(2012) K. Arita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal Intrinsic Mechanisms of Axon Regeneration

(2011) Kai Liu et al.   Annual Review of Neuroscience

The histone acetyltransferase p300 promotes intrinsic axonal regeneration

(2011) Perrine Gaub et al.   BRAIN

CpG islands and the regulation of transcription

(2011) A. M. Deaton et al.   GENES & DEVELOPMENT

Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury

(2011) Kirstin Rose et al.   PAIN

Epigenetic Regulation of Gene Expression in Physiological and Pathological Brain Processes

(2011) Johannes Gräff et al.   PHYSIOLOGICAL REVIEWS

Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation

(2010) Eric Hervouet et al.   Epigenetics

Mammalian Target of Rapamycin (mTOR) Activation Increases Axonal Growth Capacity of Injured Peripheral Nerves

(2010) Namiko Abe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation

(2010) Bermans J. Iskandar et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetic Gene Silencing Underlies C-Fiber Dysfunctions in Neuropathic Pain

(2010) H. Uchida et al.   JOURNAL OF NEUROSCIENCE

Cortical DNA methylation maintains remote memory

(2010) Courtney A Miller et al.   NATURE NEUROSCIENCE

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

(2010) Kai Liu et al.   NATURE NEUROSCIENCE

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens

(2010) Quincey LaPlant et al.   NATURE NEUROSCIENCE

Regulation of the NRSF/REST gene by methylation and CREB affects the cellular phenotype of small-cell lung cancer

(2010) A Kreisler et al.   ONCOGENE

Signaling to Transcription Networks in the Neuronal Retrograde Injury Response

(2010) I. Michaelevski et al.   Science Signaling

Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells

(2009) Daniela Meilinger et al.   EMBO REPORTS

Molecular targets for axon regeneration: focus on the intrinsic pathways

(2009) Simone Di Giovanni   EXPERT OPINION ON THERAPEUTIC TARGETS

The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease

(2009) A. N. Packer et al.   JOURNAL OF NEUROSCIENCE

Neuron-restrictive silencer factor causes epigenetic silencing of Kv4.3 gene after peripheral nerve injury

(2009) H. Uchida et al.   NEUROSCIENCE

Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

(2008) Kyohei Arita et al.   NATURE

UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells

(2008) Jong Kyong Kim et al.   NUCLEIC ACIDS RESEARCH

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE