Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor

Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control

(2018) Markus Schmid et al.   Nature Communications

Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages

(2017) Mareike D. Maler et al.   mBio

Immunity duration of a recombinant adenovirus type-5 vector-based Ebola vaccine and a homologous prime-boost immunisation in healthy adults in China: final report of a randomised, double-blind, placebo-controlled, phase 1 trial

(2017) Jing-Xin Li et al.   Lancet Global Health

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors

(2016) M. Richter et al.   BLOOD

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations

(2016) Hélène Quach et al.   CELL

Safety and Immunogenicity of Novel Adenovirus Type 26– and Modified Vaccinia Ankara–Vectored Ebola Vaccines

(2016) Iain D. Milligan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity

(2016) Daniela Anghelina et al.   JOURNAL OF VIROLOGY

Virus and Host Mechanics Support Membrane Penetration and Cell Entry

(2016) Urs F. Greber   JOURNAL OF VIROLOGY

Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5–based Constructs

(2016) Julio Alonso-Padilla et al.   MOLECULAR THERAPY

New insights into the multidimensional concept of macrophage ontogeny, activation and function

(2016) Florent Ginhoux et al.   NATURE IMMUNOLOGY

Principles of Virus Uncoating: Cues and the Snooker Ball

(2016) Yohei Yamauchi et al.   TRAFFIC

Co-option of Membrane Wounding Enables Virus Penetration into Cells

(2015) Stefania Luisoni et al.   Cell Host & Microbe

Vaccinia Virus Binds to the Scavenger Receptor MARCO on the Surface of Keratinocytes

(2015) Daniel T. MacLeod et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

(2014) T. Lion   CLINICAL MICROBIOLOGY REVIEWS

Adenovirus Vectors for Gene Therapy, Vaccination and Cancer Gene Therapy

(2014) William Wold et al.   CURRENT GENE THERAPY

Innate Immunity to Adenovirus

(2014) Rodinde Hendrickx et al.   HUMAN GENE THERAPY

The Macrophage Paradox

(2014) Jordan V. Price et al.   IMMUNITY

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

The Scavenger Receptor MARCO Modulates TLR-Induced Responses in Dendritic Cells

(2014) Haydn T. Kissick et al.   PLoS One

IL-1α and Complement Cooperate in Triggering Local Neutrophilic Inflammation in Response to Adenovirus and Eliminating Virus-Containing Cells

(2014) Nelson C. Di Paolo et al.   PLoS Pathogens

Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population

(2013) Dawn ME Bowdish et al.   BMC Medical Genetics

Tracking Viral Genomes in Host Cells at Single-Molecule Resolution

(2013) I-Hsuan Wang et al.   Cell Host & Microbe

Adenoviruses Types, Cell Receptors and Local Innate Cytokines in Adenovirus Infection

(2013) Rong-Fu Chen et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

A Direct and Versatile Assay Measuring Membrane Penetration of Adenovirus in Single Cells

(2013) M. Suomalainen et al.   JOURNAL OF VIROLOGY

SR-A and SREC-I Are Kupffer and Endothelial Cell Receptors for Helper-dependent Adenoviral Vectors

(2013) Pasquale Piccolo et al.   MOLECULAR THERAPY

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Virus interactions with endocytic pathways in macrophages and dendritic cells

(2013) Jason Mercer et al.   TRENDS IN MICROBIOLOGY

HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection

(2013) Daniel T. MacLeod et al.   Nature Communications

Uncoating of non-enveloped viruses

(2013) Maarit Suomalainen et al.   Current Opinion in Virology

Adenovirus signalling in entry

(2012) Nina Wolfrum et al.   CELLULAR MICROBIOLOGY

Adenovirus Serotype 26 Utilizes CD46 as a Primary Cellular Receptor and Only Transiently Activates T Lymphocytes following Vaccination of Rhesus Monkeys

(2012) H. Li et al.   JOURNAL OF VIROLOGY

Ad5:Ad48 Hexon Hypervariable Region Substitutions Lead to Toxicity and Increased Inflammatory Responses Following Intravenous Delivery

(2012) Lynda Coughlan et al.   MOLECULAR THERAPY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

C911: A Bench-Level Control for Sequence Specific siRNA Off-Target Effects

(2012) Eugen Buehler et al.   PLoS One

MARCO Regulates Early Inflammatory Responses against Influenza

(2011) Sanjukta Ghosh et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Kinesin-1-Mediated Capsid Disassembly and Disruption of the Nuclear Pore Complex Promote Virus Infection

(2011) Sten Strunze et al.   Cell Host & Microbe

Drifting Motions of the Adenovirus Receptor CAR and Immobile Integrins Initiate Virus Uncoating and Membrane Lytic Protein Exposure

(2011) Christoph J. Burckhardt et al.   Cell Host & Microbe

Adenoviral Vector Immunity: Its Implications and Circumvention Strategies

(2011) Yadvinder S. Ahi et al.   CURRENT GENE THERAPY

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Identification of Adenovirus Serotype 5 Hexon Regions That Interact with Scavenger Receptors

(2011) R. Khare et al.   JOURNAL OF VIROLOGY

Functional Genetic and Biophysical Analyses of Membrane Disruption by Human Adenovirus

(2011) C. L. Moyer et al.   JOURNAL OF VIROLOGY

Avidity Binding of Human Adenovirus Serotypes 3 and 7 to the Membrane Cofactor CD46 Triggers Infection

(2011) H. V. Trinh et al.   JOURNAL OF VIROLOGY

Genetic Variants in MARCO Are Associated with the Susceptibility to Pulmonary Tuberculosis in Chinese Han Population

(2011) Mai-Juan Ma et al.   PLoS One

Chemotactic antiviral cytokines promote infectious apical entry of human adenovirus into polarized epithelial cells

(2011) Verena Lütschg et al.   Nature Communications

Viral attachment strategies: the many faces of adenoviruses

(2011) Karolina Cupelli et al.   Current Opinion in Virology

Virus Entry by Endocytosis

(2010) Jason Mercer et al.   Annual Review of Biochemistry

SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens

(2010) S. Mukhopadhyay et al.   BLOOD

Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14

(2010) Hongjie Wang et al.   NATURE MEDICINE

Crystal Structure of Human Adenovirus at 3.5 A Resolution

(2010) V. S. Reddy et al.   SCIENCE

Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein Networks

(2010) H. Liu et al.   SCIENCE

Scavenger receptors: role in innate immunity and microbial pathogenesis

(2009) Thomas Areschoug et al.   CELLULAR MICROBIOLOGY

Virus Binding to a Plasma Membrane Receptor Triggers Interleukin-1α-Mediated Proinflammatory Macrophage Response In Vivo

(2009) Nelson C. Di Paolo et al.   IMMUNITY

Cryo-Electron Microscopy Structure of an Adenovirus-Integrin Complex Indicates Conformational Changes in both Penton Base and Integrin

(2009) S. Lindert et al.   JOURNAL OF VIROLOGY

Scavenger Receptor A: A New Route for Adenovirus 5

(2009) Hidde J. Haisma et al.   MOLECULAR PHARMACEUTICS

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

(2009) Roman Barbalat et al.   NATURE IMMUNOLOGY

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One

MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis

(2009) Dawn M. E. Bowdish et al.   PLoS Pathogens

Key Role of Splenic Myeloid DCs in the IFN-αβ Response to Adenoviruses In Vivo

(2008) György Fejer et al.   PLoS Pathogens