Targeting Granulocyte-Monocyte Colony-Stimulating Factor Signaling in Rheumatoid Arthritis: Future Prospects

Challenges in the treatment of Rheumatoid Arthritis

(2019) Paola Conigliaro et al.   AUTOIMMUNITY REVIEWS

GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation

(2019) Michael Dougan et al.   IMMUNITY

Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis

(2018) Keiji Hirota et al.   IMMUNITY

How advances in personalized medicine will change rheumatology

(2018) Carlo Selmi et al.   Personalized Medicine

OUP accepted manuscript

(2018)   RHEUMATOLOGY

Mavrilimumab, a Fully Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Monoclonal Antibody

(2018) Gerd R. Burmester et al.   Arthritis & Rheumatology

Increased Frequency of Peripheral B and T Cells Expressing Granulocyte Monocyte Colony-Stimulating Factor in Rheumatoid Arthritis Patients

(2018) Anastasia Makris et al.   Frontiers in Immunology

Pharmacodynamic biomarkers and differential effects of TNF- and GM-CSF-targeting biologics in rheumatoid arthritis

(2018) Xiang Guo et al.   International Journal of Rheumatic Diseases

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

(2017) Daniella M. Schwartz et al.   NATURE REVIEWS DRUG DISCOVERY

Blockade of GM-CSF pathway induced sustained suppression of myeloid and T cell activities in rheumatoid arthritis

(2017) Xiang Guo et al.   RHEUMATOLOGY

OUP accepted manuscript

(2017)   RHEUMATOLOGY

Second-line biologic therapy optimization in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis

(2017) Fabrizio Cantini et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date

(2017) Chiara Crotti et al.   Drug Design Development and Therapy

A Randomized Phase IIb Study of Mavrilimumab and Golimumab in Rheumatoid Arthritis

(2017) Michael E. Weinblatt et al.   Arthritis & Rheumatology

Drug survival of adalimumab in patients with rheumatoid arthritis over 10 years in the real-world settings: high rate remission together with normal function ability

(2016) Florenzo Iannone et al.   CLINICAL RHEUMATOLOGY

Tailored first-line biologic therapy in patients with rheumatoid arthritis, spondyloarthritis, and psoriatic arthritis

(2016) Fabrizio Cantini et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Twelve-Year Retention Rate of First-Line Tumor Necrosis Factor Inhibitors in Rheumatoid Arthritis: Real-Life Data From a Local Registry

(2016) Ennio Giulio Favalli et al.   ARTHRITIS CARE & RESEARCH

The βc receptor family – Structural insights and their functional implications

(2015) Sophie E. Broughton et al.   CYTOKINE

Pivotal Roles of GM-CSF in Autoimmunity and Inflammation

(2015) Aoi Shiomi et al.   MEDIATORS OF INFLAMMATION

Targeting GM-CSF in inflammatory diseases

(2015) Ian P. Wicks et al.   Nature Reviews Rheumatology

Systematic review and meta-analysis of serious infections with tofacitinib and biologic disease-modifying antirheumatic drug treatment in rheumatoid arthritis clinical trials

(2015) Vibeke Strand et al.   ARTHRITIS RESEARCH & THERAPY

2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis

(2015) Jasvinder A. Singh et al.   Arthritis & Rheumatology

MOR103, a human monoclonal antibody to granulocyte–macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trial

(2014) Frank Behrens et al.   ANNALS OF THE RHEUMATIC DISEASES

Preclinical characterisation of the GM-CSF receptor as a therapeutic target in rheumatoid arthritis

(2014) D E A Greven et al.   ANNALS OF THE RHEUMATIC DISEASES

Methotrexate for the treatment of rheumatoid arthritis in the biologic era: Still an “anchor” drug?

(2014) Ennio Giulio Favalli et al.   AUTOIMMUNITY REVIEWS

Ten-Year Drug Survival of Anti-TNF Agents in the Treatment of Inflammatory Arthritides

(2014) Martina Biggioggero et al.   DRUG DEVELOPMENT RESEARCH

Efficacy and safety of mavrilimumab in Japanese subjects with rheumatoid arthritis: Findings from a Phase IIa study

(2014) Tsutomu Takeuchi et al.   Modern Rheumatology

Survival on treatment with second-line biologic therapy: a cohort study comparing cycling and swap strategies

(2014) E. G. Favalli et al.   RHEUMATOLOGY

Nonclinical safety of mavrilimumab, an anti-GMCSF receptor alpha monoclonal antibody, in cynomolgus monkeys: Relevance for human safety

(2014) Patricia C. Ryan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The disease formerly known as rheumatoid arthritis

(2014) Gary S Firestein   ARTHRITIS RESEARCH & THERAPY

Treatment Comparison in Rheumatoid Arthritis: Head-to-Head Trials and Innovative Study Designs

(2014) Ennio Giulio Favalli et al.   Biomed Research International

Novel Mechanisms of Action of the Biologicals in Rheumatic Diseases

(2013) Cecilia Beatrice Chighizola et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Signalling by the βc family of cytokines

(2013) Timothy R. Hercus et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Predictors of response to anti-TNF therapy in RA patients with moderate or high DAS28 scores

(2013) Fabiola Atzeni et al.   JOINT BONE SPINE

Transcriptional Mechanisms Underlying Sensitization of Peripheral Sensory Neurons by Granulocyte-/Granulocyte-Macrophage Colony Stimulating Factors

(2013) Kiran Kumar Bali et al.   Molecular Pain

The Colony-Stimulating Factors and Cancer

(2013) D. Metcalf   Cancer Immunology Research

Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis

(2012) Gerd R Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

The inflammatory cytokine, GM-CSF, alters the developmental outcome of murine dendritic cells

(2012) Yifan Zhan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mavrilimumab, a human monoclonal GM-CSF receptor-α antibody for the management of rheumatoid arthritis: a novel approach to therapy

(2012) Jagdish R Nair et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Inflammasome-Derived IL-1  Regulates the Production of GM-CSF by CD4+ T Cells and    T Cells

(2012) J. R. Lukens et al.   JOURNAL OF IMMUNOLOGY

GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia

(2012) Bijay Parajuli et al.   Journal of Neuroinflammation

Colony stimulating factors and myeloid cell biology in health and disease

(2012) John A. Hamilton et al.   TRENDS IN IMMUNOLOGY

Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development

(2012) Andrew D Cook et al.   ARTHRITIS RESEARCH & THERAPY

Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor- , in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study

(2011) G. R. Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Does polymorphysm of genes coding for pro-inflammatory mediators predict the clinical response to tnf alpha blocking agents? A review analysis of the literature

(2011) Francesca Ingegnoli et al.   AUTOIMMUNITY REVIEWS

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy

(2011) H. L. Wright et al.   RHEUMATOLOGY

Hematopoietic colony-stimulating factors: new players in tumor–nerve interactions

(2010) Sebastian Stösser et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages

(2009) Bruce C Trapnell et al.   CURRENT OPINION IN IMMUNOLOGY

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

(2009) Stephanie Lefèvre et al.   NATURE MEDICINE

G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis

(2009) Ann L. Cornish et al.   Nature Reviews Rheumatology

Use of nonbiologic disease-modifying antirheumatic drugs and risk of infection in patients with rheumatoid arthritis

(2008) Diane Lacaille et al.   ARTHRITIS AND RHEUMATISM

Risk of cardiovascular mortality in patients with rheumatoid arthritis: A meta-analysis of observational studies

(2008) J. Antonio Aviña-Zubieta et al.   ARTHRITIS AND RHEUMATISM

The Structure of the GM-CSF Receptor Complex Reveals a Distinct Mode of Cytokine Receptor Activation

(2008) Guido Hansen et al.   CELL