Preclinical characterisation of the GM-CSF receptor as a therapeutic target in rheumatoid arthritis

MOR103, a human monoclonal antibody to granulocyte–macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trial

(2014) Frank Behrens et al.   ANNALS OF THE RHEUMATIC DISEASES

GM-CSF as a therapeutic target in inflammatory diseases

(2013) Annemarie van Nieuwenhuijze et al.   MOLECULAR IMMUNOLOGY

Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis

(2012) Gerd R Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Protein engineering and preclinical development of a GM-CSF receptor antibody for the treatment of rheumatoid arthritis

(2012) RR Minter et al.   BRITISH JOURNAL OF PHARMACOLOGY

The GM-CSF receptor family: Mechanism of activation and implications for disease

(2012) Timothy R. Hercus et al.   GROWTH FACTORS

Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor- , in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study

(2011) G. R. Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of systemic and local myeloid cell subpopulations by bone marrow cell-derived granulocyte-macrophage colony-stimulating factor in experimental inflammatory arthritis

(2011) Andrew D. Cook et al.   ARTHRITIS AND RHEUMATISM

Granulocyte-macrophage colony-stimulating factor (GM-CSF): a chemoattractive agent for murine leukocytes in vivo

(2011) Maitham Khajah et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy

(2011) H. L. Wright et al.   RHEUMATOLOGY

Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials

(2010) M. G. H. van de Sande et al.   ANNALS OF THE RHEUMATIC DISEASES

In vivo kinetics of 111Indium-labelled autologous granulocytes following i.v. administration of granulocyte-macrophage colony-stimulating factor (GM-CSF)

(2010) D. Hovgaard et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases

(2009) John A. Hamilton et al.   ARTHRITIS AND RHEUMATISM

G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis

(2009) Ann L. Cornish et al.   Nature Reviews Rheumatology