NCAM1 Polysialylation

Polysialylation and lipopolysaccharide-induced shedding of E-selectin ligand-1 and neuropilin-2 by microglia and THP-1 macrophages

(2016) Sebastian Werneburg et al.   GLIA

Sequence Requirements for Neuropilin-2 Recognition by ST8SiaIV and Polysialylation of ItsO-Glycans

(2016) Gaurang P. Bhide et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strictly co-isogenic C57BL/6J-Prnp−/−mice: A rigorous resource for prion science

(2016) Mario Nuvolone et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Polysialic acid enters the cell nucleus attached to a fragment of the neural cell adhesion molecule NCAM to regulate the circadian rhythm in mouse brain

(2016) Nina Westphal et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Prion Protein Deficiency Causes Diverse Proteome Shifts in Cell Models That Escape Detection in Brain Tissue

(2016) Mohadeseh Mehrabian et al.   PLoS One

ST8SIA4-Dependent Polysialylation is Part of a Developmental Program Required for Germ Layer Formation from Human Pluripotent Stem Cells

(2016) Ryan P. Berger et al.   STEM CELLS

Prion Protein and Copper Cooperatively Protect Neurons by Modulating NMDA Receptor Through S-nitrosylation

(2015) Lisa Gasperini et al.   ANTIOXIDANTS & REDOX SIGNALING

Deficits of olfactory interneurons in polysialyltransferase- and NCAM-deficient mice

(2015) Iris Röckle et al.   Developmental Neurobiology

Polysialic acid on SynCAM 1 in NG2 cells and on neuropilin-2 in microglia is confined to intracellular pools that are rapidly depleted upon stimulation

(2015) Sebastian Werneburg et al.   GLIA

Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice

(2015) Tom Vanden Berghe et al.   IMMUNITY

In vivo stimulation of early peripheral axon regeneration by N-propionylmannosamine in the presence of polysialyltransferase ST8SIA2

(2015) Georgios Koulaxouzidis et al.   JOURNAL OF NEURAL TRANSMISSION

The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis

(2015) Mohadeseh Mehrabian et al.   PLoS One

Polysialylation controls dendritic cell trafficking by regulating chemokine recognition

(2015) E. Kiermaier et al.   SCIENCE

Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages

(2015) Anahita Shahraz et al.   Scientific Reports

A crucial role for polysialic acid in developmental interneuron migration and the establishment of interneuron densities in the mouse prefrontal cortex

(2014) T. Krocher et al.   DEVELOPMENT

Changes in polysialic acid expression on myeloid cells during differentiation and recruitment to sites of inflammation: Role in phagocytosis

(2014) Nicholas M Stamatos et al.   GLYCOBIOLOGY

Polysialic Acid, a Glycan with Highly Restricted Expression, Is Found on Human and Murine Leukocytes and Modulates Immune Responses

(2014) P. M. Drake et al.   JOURNAL OF IMMUNOLOGY

Sialic Acids in the Brain: Gangliosides and Polysialic Acid in Nervous System Development, Stability, Disease, and Regeneration

(2014) Ronald L. Schnaar et al.   PHYSIOLOGICAL REVIEWS

Functional Cross-Talk Between the Cellular Prion Protein and the Neural Cell Adhesion Molecule is Critical for Neuronal Differentiation of Neural Stem/Precursor Cells

(2014) Kanella Prodromidou et al.   STEM CELLS

The Polysialyltransferases Interact with Sequences in Two Domains of the Neural Cell Adhesion Molecule to Allow Its Polysialylation

(2013) Matthew G. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polysialic Acid on Neuropilin-2 Is Exclusively Synthesized by the Polysialyltransferase ST8SiaIV and Attached to Mucin-typeO-Glycans Located between the b2 and c Domain

(2013) Manuela Rollenhagen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells

(2013) Mario Nuvolone et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition–like mechanism

(2013) Yasuhiro Itoh et al.   NATURE NEUROSCIENCE

Targeted mutation of the gene encoding prion protein in zebrafish reveals a conserved role in neuron excitability

(2013) Valerie C. Fleisch et al.   NEUROBIOLOGY OF DISEASE

Polysialic Acid: Versatile Modification of NCAM, SynCAM 1 and Neuropilin-2

(2013) Martina Mühlenhoff et al.   NEUROCHEMICAL RESEARCH

Lack of influence of prion protein gene expression on kainate-induced seizures in mice: Studies using congenic, coisogenic and transgenic strains

(2013) J.F. Striebel et al.   NEUROSCIENCE

Copper chelation and exogenous copper affect circadian clock phase resetting in the suprachiasmatic nucleus in vitro

(2013) Y. Yamada et al.   NEUROSCIENCE

The ZIP5 Ectodomain Co-Localizes with PrP and May Acquire a PrP-Like Fold That Assembles into a Dimer

(2013) Cosmin L. Pocanschi et al.   PLoS One

Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases

(2013) Walker S. Jackson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic analysis of prion diseases: Creating clarity or causing confusion?

(2012) Richard Rubenstein   ELECTROPHORESIS

PSA–NCAM: Synaptic functions mediated by its interactions with proteoglycans and glutamate receptors

(2012) Oleg Senkov et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Unraveling the neuroprotective mechanisms of PrPCin excitotoxicity

(2012) Franc Llorens et al.   Prion

A  neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors

(2012) H. You et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion protein facilitates uptake of zinc into neuronal cells

(2012) Nicole T. Watt et al.   Nature Communications

Homeostatic regulation of NCAM polysialylation is critical for correct synaptic targeting

(2011) Johannes Vogt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Polysialyltransferase overexpression in Schwann cells mediates different effects during peripheral nerve regeneration

(2011) J. Jungnickel et al.   GLYCOBIOLOGY

Polysialic acid is required for neuropilin-2a/b-mediated control of CCL21-driven chemotaxis of mature dendritic cells and for their migration in vivo

(2011) Angela Rey-Gallardo et al.   GLYCOBIOLOGY

Sequences Prior to Conserved Catalytic Motifs of Polysialyltransferase ST8Sia IV Are Required for Substrate Recognition

(2011) Joseph L. Zapater et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Characterization of Human ZIP13 Protein

(2011) Bum-Ho Bin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polysialic acid controls NCAM signals at cell-cell contacts to regulate focal adhesion independent from FGF receptor activity

(2011) K. Eggers et al.   JOURNAL OF CELL SCIENCE

Neuroprotective role of PrPC against kainate-induced epileptic seizures and cell death depends on the modulation of JNK3 activation by GluR6/7–PSD-95 binding

(2011) Patricia Carulla et al.   MOLECULAR BIOLOGY OF THE CELL

The Injured and Regenerating Nervous System

(2011) Andrey Irintchev et al.   NEUROSCIENTIST

The Zinc Transporter SLC39A14/ZIP14 Controls G-Protein Coupled Receptor-Mediated Signaling Required for Systemic Growth

(2011) Shintaro Hojyo et al.   PLoS One

Evidence for Retrogene Origins of the Prion Gene Family

(2011) Sepehr Ehsani et al.   PLoS One

Prion protein at the crossroads of physiology and disease

(2011) Emiliano Biasini et al.   TRENDS IN NEUROSCIENCES

Prion protein and Aβ-related synaptic toxicity impairment

(2010) Anna Maria Calella et al.   EMBO Molecular Medicine

Polysialylated neuropilin-2 enhances human dendritic cell migration through the basic C-terminal region of CCL21

(2010) A. Rey-Gallardo et al.   GLYCOBIOLOGY

Neural Cell Adhesion Molecule-Associated Polysialic Acid Regulates Synaptic Plasticity and Learning by Restraining the Signaling through GluN2B-Containing NMDA Receptors

(2010) G. Kochlamazashvili et al.   JOURNAL OF NEUROSCIENCE

APC/CFzr/Cdh1-dependent regulation of cell adhesion controls glial migration in the Drosophila PNS

(2010) Marion Silies et al.   NATURE NEUROSCIENCE

Axonal prion protein is required for peripheral myelin maintenance

(2010) Juliane Bremer et al.   NATURE NEUROSCIENCE

Divergent impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid expression in immature neurons and interneurons of the adult cerebral cortex

(2010) J. Nacher et al.   NEUROSCIENCE

Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells

(2010) D. Evseenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic cell adhesion molecule SynCAM 1 is a target for polysialylation in postnatal mouse brain

(2010) S. P. Galuska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Family reunion – The ZIP/prion gene family

(2010) Sepehr Ehsani et al.   PROGRESS IN NEUROBIOLOGY

Imbalance of neural cell adhesion molecule and polysialyltransferase alleles causes defective brain connectivity

(2009) Herbert Hildebrandt et al.   BRAIN

Transcriptional regulation of PSA-NCAM expression by NMDA receptor activation in RA-differentiated C6 glioma cultures

(2009) Jaspreet Singh et al.   BRAIN RESEARCH BULLETIN

Identification of Sequences in the Polysialyltransferases ST8Sia II and ST8Sia IV That Are Required for the Protein-specific Polysialylation of the Neural Cell Adhesion Molecule, NCAM

(2009) Deirdre A. Foley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NCAM and polysialyltransferase profiles match dopaminergic marker gene expression but polysialic acid is dispensable for development of the midbrain dopamine system

(2009) Miriam Schiff et al.   JOURNAL OF NEUROCHEMISTRY

Characterization of prion protein-enriched domains, isolated from rat cerebellar granule cells in culture

(2009) Francesca Farina et al.   JOURNAL OF NEUROCHEMISTRY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

The Comprehensive Native Interactome of a Fully Functional Tagged Prion Protein

(2009) Dorothea Rutishauser et al.   PLoS One

Evolutionary Descent of Prion Genes from the ZIP Family of Metal Ion Transporters

(2009) Gerold Schmitt-Ulms et al.   PLoS One

Regulation of GABAA and Glutamate Receptor Expression, Synaptic Facilitation and Long-Term Potentiation in the Hippocampus of Prion Mutant Mice

(2009) Alejandra Rangel et al.   PLoS One

Polysialic acid governs T-cell development by regulating progenitor access to the thymus

(2009) P. M. Drake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Embryonic Cell Adhesion by the Prion Protein

(2009) Edward Málaga-Trillo et al.   PLOS BIOLOGY

Interactome Analyses Identify Ties of PrPC and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones

(2009) Joel C. Watts et al.   PLoS Pathogens

The Prion's Elusive Reason for Being

(2008) Adriano Aguzzi et al.   Annual Review of Neuroscience

Evolutionary history of the alpha2,8-sialyltransferase (ST8Sia) gene family: Tandem duplications in early deuterostomes explain most of the diversity found in the vertebrate ST8Sia genes

(2008) Anne Harduin-Lepers et al.   BMC EVOLUTIONARY BIOLOGY

NCAM Is at the Heart of Reciprocal Regulation of E-Cadherin- and Integrin-Mediated Adhesions via Signaling Modulation

(2008) Margaret C. Frame et al.   DEVELOPMENTAL CELL

Polysialic acid controls NCAM-induced differentiation of neuronal precursors into calretinin-positive olfactory bulb interneurons

(2008) Iris Röckle et al.   Developmental Neurobiology

NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin

(2008) Francois Lehembre et al.   EMBO JOURNAL

Disruption of laminin in the peripheral nervous system impedes nonmyelinating Schwann cell development and impairs nociceptive sensory function

(2008) Wei-Ming Yu et al.   GLIA

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors

(2008) Houman Khosravani et al.   JOURNAL OF CELL BIOLOGY

Olfactory behavior and physiology are disrupted in prion protein knockout mice

(2008) Claire E Le Pichon et al.   NATURE NEUROSCIENCE

The Zinc Transporter SLC39A13/ZIP13 Is Required for Connective Tissue Development; Its Involvement in BMP/TGF-β Signaling Pathways

(2008) Toshiyuki Fukada et al.   PLoS One

Polysialic acid in the plasticity of the developing and adult vertebrate nervous system

(2007) Urs Rutishauser   NATURE REVIEWS NEUROSCIENCE