Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1

Esculetin induces death of human colon cancer cells via the reactive oxygen species-mediated mitochondrial apoptosis pathway

(2015) Areum Daseul Kim et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Structural basis of Keap1 interactions with Nrf2

(2015) Peter Canning et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting cancer cell metabolism in pancreatic adenocarcinoma

(2015) Romain Cohen et al.   Oncotarget

Nrf2 activation as target to implement therapeutic treatments

(2015) Velio Bocci et al.   Frontiers in Chemistry

Esculetin Downregulates the Expression of AML1-ETO and C-Kit in Kasumi-1 Cell Line by Decreasing Half-Life of mRNA

(2015) Sharad Sawney et al.   Journal of Oncology

RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity

(2015) Brandon L. Probst et al.   PLoS One

Esculetin, a coumarin derivative, exerts in vitro and in vivo antiproliferative activity against hepatocellular carcinoma by initiating a mitochondrial-dependent apoptosis pathway

(2014) J. Wang et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Human acute promyelocytic leukemia NB4 cells are sensitive to esculetin through induction of an apoptotic mechanism

(2014) Virginia Rubio et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation

(2014) Antonio Cuadrado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Potent Keap1–Nrf2 Protein–Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis

(2014) Zheng-Yu Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preclinical evidences toward the use of triterpenoid CDDO-Me for solid cancer prevention and treatment

(2014) Yan-Yang Wang et al.   Molecular Cancer

Molecular and Chemical Regulation of the Keap1-Nrf2 Signaling Pathway

(2014) Young-Sam Keum et al.   MOLECULES

Targeting Nrf2-Mediated Gene Transcription by Triterpenoids and Their Derivatives

(2013) Agnieszka Loboda et al.   Biomolecules & Therapeutics

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

(2013) Douglas Marcotte et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Esculetin Suppresses Proliferation of Human Colon Cancer Cells by Directly Targeting  -Catenin

(2013) S.-Y. Lee et al.   Cancer Prevention Research

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

(2012) Sadagopan Magesh et al.   MEDICINAL RESEARCH REVIEWS

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

(2011) Subash C. Gupta et al.   ANTIOXIDANTS & REDOX SIGNALING

Anti-carcinogenic action of curcumin by activation of antioxidant defence system and inhibition of NF-κB signalling in lymphoma-bearing mice

(2011) Laxmidhar Das et al.   BIOSCIENCE REPORTS

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

(2011) Adam Lister et al.   Molecular Cancer

p38 MAPK activation is required for esculetin-induced inhibition of vascular smooth muscle cells proliferation

(2011) Eun-Sun Yun et al.   TOXICOLOGY IN VITRO

Small molecule modulators of antioxidant response pathway

(2010) Wooyoung Hur et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Aesculetin-induced apoptosis through a ROS-mediated mitochondrial dysfunction pathway in human cervical cancer cells

(2010) Jin Yang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways

(2010) Constance Saw et al.   Chinese Medicine

Targeting NRF2 signaling for cancer chemoprevention

(2009) Mi-Kyoung Kwak et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Induction of apoptosis by esculetin in human leukemia U937 cells: Roles of Bcl-2 and extracellular-regulated kinase signaling

(2009) Cheol Park et al.   TOXICOLOGY IN VITRO

Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

(2008) Wenge Li et al.   BIOCHEMICAL PHARMACOLOGY

Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis

(2008) S Nair et al.   BRITISH JOURNAL OF CANCER

Sodium arsenite induces ROS generation, DNA oxidative damage, HO-1 and c-Myc proteins, NF-κB activation and cell proliferation in human breast cancer MCF-7 cells

(2008) Ruben Ruiz-Ramos et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Induction of apoptosis by esculetin in human leukemia U937 cells through activation of JNK and ERK

(2007) Cheol Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY