Article
Immunology
Huifeng Fan, Bingtai Lu, Can Cao, Hui Li, Diyuan Yang, Li Huang, Tao Ding, Minhao Wu, Gen Lu
Summary: In pediatric HAdV pneumonia, TNFSF/TNFRSF members function as key molecules in local and systemic inflammatory network, and the plasma TNFSF13B and TNFSF14 may be the potential local and systemic inflammatory indicators of severe HAdV pneumonia in pediatric patients. The levels of these inflammatory cytokines are positively correlated with the severity of the disease and lung lesions in children with HAdV pneumonia.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emmanuel Ugochukwu Okoro
Summary: TNF alpha increases cellular cholesterol content by up to 2 folds, resistant to ACAT inhibition. This increase is associated with elevated I-125-LDL surface binding and a massive increase in Dil-LDL accumulation. TNF alpha promotes LDLR functions and reduces SR-B1 through lysosome inhibition. The effect is dose-dependently inhibited by the antioxidant tetramethythiourea.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Kirstin Kucka, Isabell Lang, Tengyu Zhang, Daniela Siegmund, Juliane Medler, Harald Wajant
Summary: In the early 1990s, it was described that LT alpha and LT beta could form different heterotrimers that bind to TNFR1 and TNFR2. Despite the previous neglect, the interaction between LT alpha (2)beta and TNFR1 was demonstrated, as well as the ability of membrane-bound LT alpha (2)beta to stimulate signaling through TNFR1 and TNFR2. Etanercept, an approved drug for rheumatoid arthritis, can also inhibit LT alpha (2)beta due to its interaction with TNFR2.
CELL DEATH & DISEASE
(2021)
Review
Gastroenterology & Hepatology
Roberta Figueiroa Souza, Marcos Antonio Ferreira Caetano, Henrique Inhauser Riceti Magalhaes, Patricia Castelucci
Summary: Ulcerative colitis (UC) and Crohn's disease (CD) are types of Inflammatory Bowel Diseases (IBD) characterized by bowel necrosis and the involvement of enteric neurons and glial cells. The main inflammatory mediator is tumor necrosis factor-alpha (TNF-alpha), which is also associated with the production of other cytokines like interleukins (IL). TNF-alpha acts through two receptors, TNFR1 and TNFR2, which have been detected in IBD and their expression correlates with disease activity. Biologic agents targeting TNF-alpha have revolutionized IBD treatment by inducing and maintaining disease remission in a majority of patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, Research & Experimental
Chang Lu, Qiuyang Zhang, Huiying Zhang, Xiumiao Li, Qin Jiang, Jin Yao
Summary: Anlotinib has shown promise in inhibiting ocular neovascularization by reducing avascular areas and pathological neovascular tufts in animal models, suggesting its potential as a therapeutic candidate for eye diseases in the future.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Wenwen Lin, Feng Huang, Yin Yuan, Qiaowei Li, Zhong Lin, Wenqing Zhu, Binbin Lin, Pengli Zhu
Summary: This study aims to investigate the effect of inflamed endothelial exosomes (exo-T) on macrophage function. The results showed that exposure to exo-T for 24 hours skewed macrophages towards the M1 subtype, exacerbated lipid deposition, and promoted macrophage apoptosis. However, it did not significantly affect macrophage migration. Furthermore, the study identified differentially expressed microRNAs (DE-miRNAs) in exo/exo-T and demonstrated that exo-T intervention improves the phosphorylation of MAPK/NF-κB-related proteins.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ping Li, Yang Yang, Xinyu Yang, Yifei Wang, Chon-Kit Chou, Mengmeng Jiang, Jingbin Zheng, Fengyang Chen, Xin Chen
Summary: The study found that TNF receptor type II (TNFR2) is expressed in a wide range of tumor cells. Knocking out TNFR2 in mouse colon cancer cells MC38 and CT26 using CRISPR/Cas9 technology inhibited in vitro proliferation and colony formation of cancer cells through inhibition of AKT phosphorylation and promotion of autophagy-induced cell death. In addition, TNFR2 deficiency significantly impaired the in vivo growth of MC38 or CT26 tumors in mice, accompanied by a decrease in soluble TNFR2 levels in the circulation and an increase in the number of tumor-infiltrating IFN gamma+ CD8 cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Liangpan Shi, Yibin Su, Zhihua Zheng, Jinyu Qi, Weidong Wang, Cunchuan Wang
Summary: This study revealed that miR-146b-5p promotes the initiation and tumorigenesis of colorectal cancer (CRC) by targeting TRAF6. miR-146b-5p is highly expressed while TRAF6 is lowly expressed in CRC tissue and cells. Overexpression of miR-146b-5p enhances proliferation, migration, and invasion of CRC cells as well as tumor growth, which are counteracted by TRAF6 overexpression. These findings help elucidate the mechanisms underlying CRC development and provide guidance for the development of targeted therapy for CRC.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Medicine, Research & Experimental
Ajay Dixit, Aaron Sarver, Jon Zettervall, Huocong Huang, Kexin Zheng, Rolf A. Brekken, Paolo P. Provenzano
Summary: Pancreatic ductal adenocarcinoma (PDA) is resistant to immune therapies due to its fibrotic and immunosuppressive tumor microenvironments. Excessive accumulation of immunosuppressive macrophages has been found to influence immunotherapy resistance. Intervention studies targeting macrophages in combination with checkpoint blockade show promising results.
Article
Biochemistry & Molecular Biology
Chien-Yi Hsu, Chun-Yao Huang, Chun-Ming Shih, Yi-Wen Lin, Po-Hsun Huang, Shing-Jong Lin, Chen-Wei Liu, Cheng-Yen Lin, Feng-Yen Lin
Summary: Tumor necrosis factor superfamily 14 (TNFSF14), also known as LIGHT, plays a role in various physiological functions including the synthesis of nitric oxide and cytokines. It stimulates angiogenesis in tumors and induces the expression of certain molecules in endothelial cells. However, its effects on angiogenesis after tissue ischemia are unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ke Gong, Gao Guo, Nicole A. Beckley, Xiaoyao Yang, Yue Zhang, David E. Gerber, John D. Minna, Sandeep Burma, Dawen Zhao, Esra A. Akbay, Amyn A. Habib
Summary: The study explored the efficacy of broad versus focused targeting of resistance to EGFR inhibition in NSCLC, finding that a broad inhibitor of inflammation, prednisone, is the most effective in suppressing inflammatory signals and resistance mechanisms.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, Research & Experimental
Farid Ghorbaninezhad, Patrizia Leone, Hajar Alemohammad, Basira Najafzadeh, Niloufar Nourbakhsh, Marcella Prete, Eleonora Malerba, Hossein Saeedi, Neda Tabrizi, Vito Racanelli, Behzad Baradaran
Summary: This study reviews the dual role of tumor necrosis factor-alpha (TNF-alpha) in systemic lupus erythematosus (SLE), as well as the efficacy and safety of anti-TNF-alpha therapies in SLE.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Teresa Tsai, Mohannad Alwees, Mohammad Ali Asaad, Janine Theile, Vinodh Kakkassery, H. Burkhard Dick, Tim Schultz, Stephanie C. Joachim
Summary: This study aimed to elucidate the pathophysiology of diabetic retinopathy by comparing protein alterations in the vitreous of patients at different stages. The results showed up-regulated levels of various proteins in the vitreous of proliferative diabetic retinopathy patients, including VEGF-A, PIGF, Angiopoietin-1, Angiopoietin-2, IL-1β, and IL-8. Correlation analysis revealed a strong positive correlation between Angiopoietin-2 and VEGF-A levels, as well as a positive correlation between Angiopoietin-1 and VEGF-A. These findings contribute to the future detection and treatment of the disease.
Article
Oncology
Di Chen, Dawei Song, Yibin Ma, Weizhao Lu, Jianfeng Qiu, Yi Wang
Summary: This study investigates the role of USP22 in PA-induced keratitis. The silencing of USP22 attenuates disease progression, downregulates the NF-kappa B pathway, and suppresses the expression of pro-inflammatory cytokines.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Fisheries
Yaojia Zhou, Ping Ouyang, Yu Tao, Lizi Yin, Kaiyu Wang, Yi Geng, Weiming Lai, Defang Chen, Hongrui Guo, Jing Fang, Zhengli Chen, Li Tang, Xiaoli Huang
Summary: This study revealed the regulatory role of CyHV-3 vTNFRs in host immune response and cell apoptosis, indicating that vTNFRs participate in virus invasion by up-regulating the expression levels of certain immune-related factors and inducing cell apoptosis.
AQUACULTURE REPORTS
(2021)
Article
Surgery
John R. Bradley, Jun Wang, Victoria Bardsley, Verena Broecker, Sathia Thiru, Jordan S. Pober, Rafia S. Al-Lamki
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Biochemistry & Molecular Biology
Cristiana Angelucci, Alessio D'Alessio, Silvia Sorrentino, Filippo Biamonte, Umberto Moscato, Annunziato Mangiola, Gigliola Sica, Fortunata Iacopino
Summary: Glioblastoma (GBM) is the most commonly occurring primary tumor within the central nervous system, characterized by high invasiveness and poor prognosis. This study suggests that the expression of specific molecules in the peritumoral tissue may impact the development and chemoresistance of GBM, with MGMT expression in peritumoral tissue potentially serving as a prognostic factor for patient survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Dami A. Collier, Anna De Marco, Isabella A. T. M. Ferreira, Bo Meng, Rawlings P. Datir, Alexandra C. Walls, Steven A. Kemp, Jessica Bassi, Dora Pinto, Chiara Silacci-Fregni, Siro Bianchi, M. Alejandra Tortorici, John Bowen, Katja Culap, Stefano Jaconi, Elisabetta Cameroni, Gyorgy Snell, Matteo S. Pizzuto, Alessandra Franzetti Pellanda, Christian Garzoni, Agostino Riva, Anne Elmer, Nathalie Kingston, Barbara Graves, Laura E. Mccoy, Kenneth G. C. Smith, John R. Bradley, Nigel Temperton, Lourdes Ceron-Gutierrez, Gabriela Barcenas-Morales, William Harvey, Herbert W. Virgin, Antonio Lanzavecchia, Luca Piccoli, Rainer Doffinger, Mark Wills, David Veesler, Davide Corti, Ravindra K. Gupta
Summary: The B.1.1.7 variant of SARS-CoV-2 exhibited reduced neutralization by vaccines and antibodies from recovered COVID-19 patients, with a more substantial loss seen when introducing the E484K mutation. This mutation poses a threat to the efficacy of the BNT162b2 vaccine.
Article
Multidisciplinary Sciences
Steven A. Kemp, Dami A. Collier, Rawlings P. Datir, Isabella A. T. M. Ferreira, Salma Gayed, Aminu Jahun, Myra Hosmillo, Chloe Rees-Spear, Petra Mlcochova, Ines Ushiro Lumb, David J. Roberts, Anita Chandra, Nigel Temperton, Katherine Sharrocks, Elizabeth Blane, Yorgo Modis, Kendra E. Leigh, John A. G. Briggs, Marit J. van Gils, Kenneth G. C. Smith, John R. Bradley, Chris Smith, Rainer Doffinger, Lourdes Ceron-Gutierrez, Gabriela Barcenas-Morales, David D. Pollock, Richard A. Goldstein, Anna Smielewska, Jordan P. Skittrall, Theodore Gouliouris, Ian G. Goodfellow, Effrossyni Gkrania-Klotsas, Christopher J. R. Illingworth, Laura E. McCoy, Ravindra K. Gupta
Summary: Chronic infection with SARS-CoV-2 can lead to viral evolution and increased resistance to neutralizing antibodies in immunosuppressed individuals treated with convalescent plasma. During convalescent plasma therapy, there were significant shifts in the viral population structure and sensitivity, suggesting strong selection pressure on the virus during treatment.
Article
Biochemistry & Molecular Biology
Emily Stephenson, Gary Reynolds, Rachel A. Botting, Fernando J. Calero-Nieto, Michael D. Morgan, Zewen Kelvin Tuong, Karsten Bach, Waradon Sungnak, Kaylee B. Worlock, Masahiro Yoshida, Natsuhiko Kumasaka, Katarzyna Kania, Justin Engelbert, Bayan Olabi, Jarmila Stremenova Spegarova, Nicola K. Wilson, Nicole Mende, Laura Jardine, Louis C. S. Gardner, Issac Goh, Dave Horsfall, Jim McGrath, Simone Webb, Michael W. Mather, Rik G. H. Lindeboom, Emma Dann, Ni Huang, Krzysztof Polanski, Elena Prigmore, Florian Gothe, Jonathan Scott, Rebecca P. Payne, Kenneth F. Baker, Aidan T. Hanrath, Ina C. D. Schim van der Loeff, Andrew S. Barr, Amada Sanchez-Gonzalez, Laura Bergamaschi, Federica Mescia, Josephine L. Barnes, Eliz Kilich, Angus de Wilton, Anita Saigal, Aarash Saleh, Sam M. Janes, Claire M. Smith, Nusayhah Gopee, Caroline Wilson, Paul Coupland, Jonathan M. Coxhead, Vladimir Yu Kiselev, Stijn van Dongen, Jaume Bacardit, Hamish W. King, Anthony J. Rostron, A. John Simpson, Sophie Hambleton, Elisa Laurenti, Paul A. Lyons, Kerstin B. Meyer, Marko Z. Nikolic, Christopher J. A. Duncan, Kenneth G. C. Smith, Sarah A. Teichmann, Menna R. Clatworthy, John C. Marioni, Berthold Gottgens, Muzlifah Haniffa
Summary: Transcriptomic and proteomic profiling of blood samples from individuals with COVID-19 reveals immune cell and hematopoietic progenitor cell alterations that are differentially associated with disease severity.
Article
Biology
Nick K. Jones, Lucy Rivett, Shaun Seaman, Richard J. Samworth, Ben Warne, Chris Workman, Mark Ferris, Jo Wright, Natalie Quinnell, Ashley Shaw, Ian G. Goodfellow, Paul J. Lehner, Rob Howes, Giles Wright, Nicholas J. Matheson, Michael P. Weekes
Summary: Research shows that there is a fourfold reduction in asymptomatic infection among healthcare workers post-vaccination with the first dose of the BNT162b2 vaccine. This indicates that a single dose of the vaccine can provide short-term protection against asymptomatic SARS-CoV-2 infection, reducing virus transmission and the burden of COVID-19 disease.
Article
Neurosciences
Filippo Biamonte, Gigliola Sica, Antonio Filippini, Alessio D'Alessio
Summary: Glioblastoma (GBM) is a highly aggressive form of brain cancer with cancer stem cells (CSCs) playing a role in resistance against common treatments. Reelin, a large secreted glycoprotein, is found to be highly expressed in GBM and may potentially regulate the behavior of GBM cancer stem cells, making it a potential target for GBM treatment.
Article
Pathology
Rafia S. Al-Lamki, Jun Wang, Jordan S. Pober, John R. Bradley
Summary: The interaction between death receptor 3 (DR3) and E-selectin plays an important role in the progression of clear cell renal cell carcinoma (ccRCC).
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Review
Oncology
Claudia Palazzo, Alessio D'Alessio, Luca Tamagnone
Summary: Extracellular vesicles (EVs) play an important role in the communication mechanisms between cancer and endothelial cells, and may have potential implications in the treatment of vascular pathologies. EVs are able to transport a variety of cell constituents and regulate the functions of endothelial cells. Cancer cell-derived EVs have been found to have a controlling effect on endothelial cell functions and are involved in tumor angiogenesis and cancer progression.
Review
Oncology
Antonio Filippini, Luca Tamagnone, Alessio D'Alessio
Summary: Recent findings suggest that targeting endothelial cell metabolism may be an alternative strategy for antiangiogenic therapy and a novel approach for treating cardiovascular diseases. Understanding how endothelial cells adapt their metabolic status in response to changes in the tissue microenvironment could help develop innovative treatments to counteract abnormal blood vessel growth.
Article
Psychiatry
Christopher Rayner, Jonathan R. Coleman, Megan Skelton, Cherie Armour, John Bradley, Joshua E. J. Buckman, Molly R. Davies, Colette R. Hirsch, Matthew Hotopf, Christopher Hubel, Ian R. Jones, Gursharan Kalsi, Nathalie Kingston, Georgina Krebs, Yuhao Lin, Dina Monssen, Andrew M. McIntosh, Jessica R. Mundy, Alicia J. Peel, Katharine A. Rimes, Henry C. Rogers, Daniel J. Smith, Abigail R. Ter Kuile, Katherine N. Thompson, David Veale, Janet Wingrove, James T. R. Walters, Gerome Breen, Thalia C. Eley
Summary: Background: To achieve stratified care for anxiety and depression, new predictors need to be identified. This study collected retrospectively self-reported therapeutic outcome data in adults who received psychological therapy in the UK over the past ten years. The aim was to replicate factors associated with traditional treatment outcome measures reported in the literature. Methods: Participants were from the Genetic Links to Anxiety and Depression (GLAD) Study, a UK-based volunteer cohort study. Associations between retrospectively self-reported therapy outcomes and sociodemographic, clinical, and therapy-related factors were investigated using ordinal logistic regression models (n = 2890). Results: Four factors were associated with therapy outcomes. Having a university-level education was associated with favorable outcomes. Greater number of reported illness episodes and higher levels of personality disorder symptoms were associated with less favorable outcomes. Regular use of additional therapeutic activities was associated with favorable outcomes. Conclusion: Retrospectively self-reported therapy outcomes can be collected quickly and inexpensively in large observational cohorts. These outcomes were associated with four factors previously reported in the literature. Collecting similar data in larger observational cohorts may lead to the discovery of novel associations with therapy outcomes and generate new hypotheses for prospective studies.
Editorial Material
Oncology
Alessio D'Alessio
Article
Psychology, Clinical
Dina Monssen, Helena L. Davies, Saakshi Kakar, Shannon Bristow, Susannah C. B. Curzons, Molly R. Davies, Emily J. Kelly, Zain Ahmad, John R. Bradley, Steven Bright, Jonathan R. I. Coleman, Kiran Glen, Matthew Hotopf, Abigail R. Ter Kuile, Chelsea Mika Malouf, Gursharan Kalsi, Nathalie Kingston, Monika McAtarsney-Kovacs, Jessica Mundy, Alicia J. Peel, Alish B. Palmos, Henry C. Rogers, Megan Skelton, Brett N. Adey, Sang Hyuck Lee, Hope Virgo, Tom Quinn, Tom Price, Johan Zvrskovec, Thalia C. Eley, Janet Treasure, Christopher Hubel, Gerome Breen
Summary: The United Kingdom Eating Disorders Genetics Initiative (EDGI UK) aims to investigate the environmental and genetic causes of eating disorders. EDGI UK launched in 2020 and is partnered with the charity Beat. This article provides a detailed description of the study protocol and initial sample demographics, diagnoses, and comorbidities.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Article
Biology
Rafia S. Al-Lamki, Nicholas J. Hudson, John R. Bradley, Anne Y. Warren, Tim Eisen, Sarah J. Welsh, Antony C. P. Riddick, Fiach C. O'Mahony, Arran Turnbull, Thomas Powles, Antonio Reverter, David J. Harrison, Grant D. Stewart
Article
Biochemistry & Molecular Biology
John R. Bradley, Jun Wang, Simon Pacey, Anne Y. Warren, Jordan S. Pober, Rafia S. Al-Lamki