Article
Biochemistry & Molecular Biology
Michela Cantiello, Monica Carletti, Mery Giantin, Giulia Gardini, Francesca Capolongo, Paolo Cascio, Marianna Pauletto, Flavia Girolami, Mauro Dacasto, Carlo Nebbia
Summary: This study provides a comprehensive characterization of phenobarbital's (PB) effects on drug-metabolizing enzyme (DME) catalytic activities in cattle liver. The findings show that PB increases the protein amounts and enzyme activities of certain target enzymes, but has contradictory effects on others. The study also reveals an increase in 26S proteasome activity, suggesting a potential role in cattle DME regulation. The results further confirm species differences in DME expression and activity between cattle, humans, and rodents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Julen Sanz-Serrano, Roncesvalles Garayoa, Ana Isabel Vitas, Amaya Azqueta, Adela Lopez de Cerain
Summary: The study found that none of the ten fried meat-based food extracts induced gene mutations in Salmonella typhimurium TA98, but five of them induced chromosomal aberrations in TK6 cells after 24 hours without metabolic activation. Further studies are needed to validate the biological relevance of these in vitro findings.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Ronan Adler Tavella, Caroline Lopes Feijo Fernandes, Lucia Emanueli Schimith, Lisiane Martins Volcao, Marina dos Santos, Flavio Manoel Rodrigues da Silva Junior
Summary: Socioeconomic and demographic factors, lifestyle, and cultural characteristics may have an important impact on genetic damage. This study analyzed the association between a set of factors and genetic damage by studying populations in southern Brazil. The results showed that age had a weak association with genetic damage, while factors such as skin color, occupational exposure, drug use, exposure to radiation, and the cultural habit of consuming chimarrao were found to be associated with genetic damage. Yerba mate consumption was identified as a confounding factor in cytogenetic studies in the southern region of South America.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Beatriz Alvarez-Gonzalez, Patricia Porras-Quesada, Veronica Arenas-Rodriguez, Alba Tamayo-Gomez, Fernando Vazquez-Alonso, Luis Javier Martinez-Gonzalez, Antonio F. Hernandez, Maria Jesus Alvarez-Cubero
Summary: The development and progression of prostate cancer are influenced by the interaction between genetic, environmental, and dietary factors. Chemical exposures and genetic polymorphisms in genes encoding xenobiotic metabolizing enzymes, antioxidant enzymes, and DNA repair enzymes play a major role in cancer development. Understanding the causal risk factors for prostate cancer can help identify high-risk individuals and develop effective detection and prevention methods.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Romteera Kittichaiworakul, Sirinya Taya, Arpamas Chariyakornkul, Thanongsak Chaiyaso, Rawiwan Wongpoomchai
Summary: Red yeast extracts exhibit antimutagenicity against aflatoxin-induced mutagenesis, modulate detoxifying enzyme activities, and reduce hepatic micronucleus formation in rats. Components like beta-carotene and lycopene may play a role in the antigenotoxic effects of red yeast.
Article
Food Science & Technology
Peng Li, Shaoying Wang, Bo Lv, Manman Zhang, Changrui Xing, Xinyang Sun, Yong Fang
Summary: A renewable and effective biomass-derived adsorbent, magnetic rice husk-based biochar (MRHB), was developed for the removal of AFB1 from peanut oil. The adsorption capacity of MRHB was as high as 951.1 μg/g, with over 95% removal of AFB1. MRHB showed negligible cytotoxicity and had no negative effects on the nutritional quality of the oil. Therefore, MRHB is a promising adsorbent for the removal of AFB1 from oils due to its low cost, high efficiency, and high safety.
Article
Food Science & Technology
Ya-Chun Chou, Yu-Hsuan Lin, Pin-Hsuan Lin, Yen-Chen Tung, Chi-Tang Ho, Min-Hsiung Pan
Summary: The study found that 5-demethylnobiletin exerts a significant inhibitory effect on colon cancer induced by benzo[a]pyrene, through the regulation of inflammation and xenobiotic-metabolizing enzymes. Experimental results demonstrate that 5-demethylnobiletin enhances detoxification enzyme activity and inhibits harmful enzyme activity, thereby reducing the occurrence of colon cancer.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Marek Drozdzik, Joanna Lapczuk-Romanska, Christoph Wenzel, Sylwia Szelag-Pieniek, Mariola Post, Lukasz Skalski, Mateusz Kurzawski, Stefan Oswald
Summary: The study found that the protein abundance of hepatic drug metabolizing enzymes is affected by both the type of liver pathology and the functional state of the organ. CYP2E1 is the most vulnerable enzyme, while the protein levels of CYP1A1, CYP2B6, CYP2C19, CYP2D6 as well as UGT1A1, UGT1A3 and UGT2B15 remain relatively stable during liver function deterioration.
Article
Food Science & Technology
Julen Sanz-Serrano, Ariane Vettorazzi, Damian Muruzabal, Amaya Azqueta, Adela Lopez de Cerain
Summary: This article provides a complete in vitro genotoxicity assessment of three nutrients widely used in the European market, demonstrating that they did not show genotoxicity in any of the conditions tested. This study contributes to the limited evidence available and complements EFSA recommendations for in vitro genotoxicity testing of nutrients.
Article
Food Science & Technology
Ya'nan Li, Ren Wang, Xiaohu Luo, Zhengxing Chen, Li Wang, Yunyu Zhou, Weizhi Liu, Miaomiao Cheng, Chen Zhang
Summary: This study focuses on the synthesis of rice husk-based mesoporous silica (MCM-41) for the removal of aflatoxin B-1 (AFB(1)) from peanut oil. The results show that MCM-41 has high specific surface area and good adsorption performance. This study provides important insights with economic value.
Correction
Cell Biology
Sivagami Gunasekaran, Karthikkumar Venkatachalam, Kabalimoorthy Jeyavel, Nalini Namasivayam
Summary: The correction to this paper has been published.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Chemistry, Applied
Ya'nan Li, Yunyu Zhou, Ren Wang, Zhengxing Chen, Xiaohu Luo, Li Wang, Xiuping Zhao, Chen Zhang, Peibin Yu
Summary: This study developed a facile approach to prepare amino-grafted magnetic mesoporous silica (NMMS) from rice husk, which exhibited high adsorption capacity and removal rate for AFB(1) in aqueous solutions. The NMMS showed good recyclability with a maintained high removal rate after multiple cycles.
Article
Medicine, Research & Experimental
Eman El-Khateeb, Brahim Achour, Zubida M. Al-Majdoub, Jill Barber, Amin Rostami-Hodjegan
Summary: Liver cirrhosis affects the abundance of drug-metabolizing enzymes and transporters, leading to non-uniform reductions in levels that necessitate the use of PBPK models for precise drug dosing.
MOLECULAR PHARMACEUTICS
(2021)
Article
Toxicology
Naima Chamlal, Djamel Eddine Benouareth, Messaouda Khallef, Sophie Simar-Mentieres, Fabrice Nesslany
Summary: This study evaluated the mutagenicity and genotoxicity of industrially processed meat products sold in popular supermarkets in Algeria. The results showed that all extracts analyzed did not induce mutagenic activity, but one extract did cause a significant increase in the number of micronucleated cells. This highlights the importance of genetic damage detection in reducing exposure to harmful contaminants and the need for further research on genotoxic effects of processed meat globally.
TOXICOLOGY IN VITRO
(2021)
Article
Polymer Science
Heng Wang, Jianyong Pang, Yihua Xu
Summary: The mechanical properties of rice husk ash-rubber-fiber concrete (RRFC) under hygrothermal environment were studied by selecting the optimal group through orthogonal tests. The mass loss, relative dynamic elastic modulus analysis, strength analysis, degradation degree analysis after cyclic loading, and internal microstructure analysis of the optimal group of RRFC samples were compared and analyzed. The results show that the large specific surface area of rice husk ash optimizes the particle size distribution of RRFC specimens and enhances the compactness of concrete. The presence of rubber particles and PVA fibers effectively improves the mechanical properties and fatigue resistance of RRFC. Compressive strength generally increases and then decreases after dry-wet cycles, reaching a peak at the seventh cycle, with a greater decrease in compressive strength under chloride salt solution compared to clear water solution. The RRFC materials provide new options for the construction of highways and tunnels in coastal areas, and exploring energy conservation and emission reduction is of great practical significance.
Article
Chemistry, Multidisciplinary
Charatda Punvittayagul, Arpamas Chariyakornkul, Teera Chewonarin, Kanokwan Jarukamjorn, Rawiwan Wongpoomchai
DRUG AND CHEMICAL TOXICOLOGY
(2019)
Article
Medicine, Research & Experimental
Arpamas Chariyakornkul, Nichanan Inboot, Sirinya Taya, Rawiwan Wongpoomchai
Summary: The dichloromethane extract of Cleistocalyx nervosum seed demonstrated chemopreventive effects on chemically-induced carcinogenesis in both initiation and promotion stages in rats by modulating hepatic detoxifying enzymes and suppressing cell proliferation in the liver and colon.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Charatda Punvittayagul, Arpamas Chariyakornkul, Paweena Sankam, Rawiwan Wongpoomchai
Summary: The acidic methanol extract of purple rice husk showed cancer chemopreventive effects in rats, reducing micronucleated hepatocytes and inhibiting preneoplastic lesions in the liver and colon. The extract was not toxic, clastogenic, or carcinogenic, and its mechanisms of action involved the reduction of cytochrome P450 2E1 expression and induction of detoxifying enzymes in the liver. Anthocyanins and vanillic acid were identified as potential anticarcinogenic compounds in purple rice husk.
Article
Food Science & Technology
Phatthawin Lengkidworraphiphat, Rawiwan Wongpoomchai, Thanaporn Bunmee, Arpamas Chariyakornkul, Niraporn Chaiwang, Sanchai Jaturasitha
Summary: Black-boned chicken is a great nutritional source, while Thai native chickens are flavorful and delicious. Broilers might have a link to lipid metabolism.
FOOD SCIENCE OF ANIMAL RESOURCES
(2021)
Article
Oncology
Anna Kakehashi, Arpamas Chariyakornkul, Shugo Suzuki, Napaporn Khuanphram, Kumiko Tatsumi, Shotaro Yamano, Masaki Fujioka, Min Gi, Rawiwan Wongpoomchai, Hideki Wanibuchi
Summary: In this study, novel early molecular biomarkers of liver neoplasms in non-alcoholic steatohepatitis (NASH) were discovered using the STAM mouse model. The protein CACHD1 was found to be significantly elevated in hepatocellular carcinomas, suggesting its potential as a biomarker and molecular target in NASH-associated hepatocarcinogenesis involving cell proliferation, autophagy, and apoptosis. The research highlights CACHD1 as an early biomarker of liver preneoplastic and neoplastic lesions in the context of NASH, with implications for potential therapeutic targets in diabetes mellitus/NASH-associated hepatocarcinogenesis.
Article
Biochemistry & Molecular Biology
Charatda Punvittayagul, Arpamas Chariyakornkul, Kanokwan Jarukamjorn, Rawiwan Wongpoomchai
Summary: The study found that vanillic acid exhibited significant protection against diethylnitrosamine- and 1,2-dimethylhydrazine-induced hepatocarcinogenesis by inducing detoxifying enzymes, reducing proliferation, and inducing apoptosis.
Article
Cell Biology
Warunyoo Phannasorn, Arpamas Chariyakornkul, Phumon Sookwong, Rawiwan Wongpoomchai
Summary: Coloured rice bran oil (CRBO) contains higher levels of vitamin E, phytosterols, carotenoids, and chlorophyll compared to white rice bran oil (WRBO), which can alleviate acetaminophen-induced hepatotoxicity by activating antioxidant systems. These components in CRBO may play a protective role in reducing hepatotoxicity.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Romteera Kittichaiworakul, Sirinya Taya, Arpamas Chariyakornkul, Thanongsak Chaiyaso, Rawiwan Wongpoomchai
Summary: Red yeast extracts exhibit antimutagenicity against aflatoxin-induced mutagenesis, modulate detoxifying enzyme activities, and reduce hepatic micronucleus formation in rats. Components like beta-carotene and lycopene may play a role in the antigenotoxic effects of red yeast.
Article
Biochemistry & Molecular Biology
Arpamas Chariyakornkul, Waristha Juengwiroj, Jetsada Ruangsuriya, Rawiwan Wongpoomchai
Summary: The acidified ethanolic extract of Cleistocalyx nervosum var. paniala (CN) can effectively reduce oxidative stress induced acute hepatotoxicity in overdose acetaminophen-treated rats through the suppression of oxidative stress and the enhancement of the antioxidant system in rat livers.
Article
Oncology
Qijie Zhao, Rawiwan Wongpoomchai, Arpamas Chariyakornkul, Zhangang Xiao, Chalermchai Pilapong
Summary: This study developed and validated a gene set-based signature for early-stage HCC patients and identified a Cluster gene that can potentially segregate eHCC patients from non-tumor. The study also revealed that lower infiltration of specific immune cells, such as CD8 Tem and CTLs, may be responsible for worse prognosis in HCC. Cluster C1 signature presented a high accuracy in predicting immune cells and cancerization, with overexpressed PRKDC associated with higher genetic alteration and poor prognosis in eHCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chi Be Hlaing, Arpamas Chariyakornkul, Chalermchai Pilapong, Charatda Punvittayagul, Somdet Srichairatanakool, Rawiwan Wongpoomchai
Summary: The study assessed the toxicity of Fe-TA NPs and found no obvious signs of toxicity, genotoxicity, and early phase hepatocarcinogenicity in rats.
Article
Food Science & Technology
Huina Guo, Arpamas Chariyakornkul, Warunyoo Phannasorn, Sugunya Mahatheeranont, Rawiwan Wongpoomchai
Summary: Cooked glutinous purple rice contains methanol extracts that are rich in phenolic compounds, flavonoids, and anthocyanins, which exhibit antioxidant, anti-inflammatory, and antimutagenic properties. Cooking decreases certain nutrients but increases the content of certain phenolic acid and tocol. The methanol extract of cooked glutinous purple rice shows potential as a chemopreventive fraction for cancer without genotoxic effects or negative effects on phytochemical-drug interaction.
Article
Chemistry, Multidisciplinary
Thipjutha Phatruengdet, Jannarong Intakhad, Monreudee Tapunya, Arpamas Chariyakornkul, Chi Be Hlaing, Rawiwan Wongpoomchai, Chalermchai Pilapong
Article
Oncology
Orapin Insuan, Arpamas Chariyakornkul, Yuwada Rungrote, Rawiwan Wongpoomchai
JOURNAL OF CANCER PREVENTION
(2017)
