Article
Nutrition & Dietetics
Luane Aparecida do Amaral, Taina da Silva Fleming de Almeida, Gabriel Henrique Oliveira de Souza, Adrivanio Baranoski, Rafael Souza Maris, Felipe Francisco Bittencourt Junior, Bruna Paola Murino Rafacho, Antonio Carlos Duenhas Monreal, Candida Aparecida Leite Kassuya, Andreia Conceicao Milan Brochado Antoniolli-Silva, Elisvania Freitas dos Santos, Rodrigo Juliano Oliveira
Summary: The study aimed to formulate a natural fiber-rich food product (NFRFP) for colorectal cancer prevention and evaluate its safety and effects in a preclinical model. Results showed that NFRFP exhibited a chemopreventive effect and reduced the incidence of aberrant crypts in the colon.
Article
Biochemistry & Molecular Biology
Huawei Zeng, Bryan D. Safratowich, Wen-Hsing Cheng, Andrew D. Magnuson, Matthew J. Picklo
Summary: High-fat diet-induced obesity is a risk factor for colon cancer. A study found that mice fed a high-fat diet exhibited different fecal metabolomic profiles after AOM treatment. Accumulation of specific fecal lipid species may alter the overall metabolism during colon tumorigenesis.
Article
Food Science & Technology
Yuko Murase Hetrick, Meseret Fesseha, Mee Young Hong
Summary: This study showed that watermelon powder and L-arginine supplementation can reduce the risk of colorectal cancer by upregulating gene expression of cell cycle regulators, leading to decreased proliferation and inhibition of aberrant crypt foci formation in all anatomical regions of the colon.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Medicine, Research & Experimental
Arpamas Vachiraarunwong, Wirote Tuntiwechapikul, Ariyaphong Wongnoppavich, Puttinan Meepowpan, Rawiwan Wongpoomchai
Summary: Six partially purified fractions and two purified compounds were isolated from the seeds of Cleistocalyx nervosum var. paniala. Among them, 2,4'-dihydroxy-6'methoxy-3',5'-dimethylchalcone (DMC) showed the greatest antimutagenicity and anticancer activity. DMC also inhibited the formation of colonic preneoplastic lesions and enhanced the activity of detoxifying enzyme GST.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Marek Kowalczyk, Lukasz Klepacki, Ewa Zielinski, Waldemar Kurpiewski, Krzysztof Zinkiewicz, Lukasz Dysko, Wieslaw Pesta
Summary: Smoking has a significant influence on the occurrence of precursors and advanced colorectal cancer. Smokers have a greater number of ACFs in the rectum, with the most common type being hyperplastic ACF. As age increases, the likelihood of developing ACFs and colon polyps is higher in smokers than non-smokers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Food Science & Technology
Mariana Araujo Vieira do Carmo, Marina Fidelis, Pollyanna Francielli de Oliveira, Lais Quellen Feitoza, Marcos Jose Marques, Eric Batista Ferreira, Won Young Oh, Fereidoon Shahidi, Jarkko Hellstrom, Leonardo Augusto Almeida, Romulo Dias Novaes, Daniel Granato, Luciana Azevedo
Summary: The study demonstrated that Jabuticaba seed extract (LJE) may provide chemopreventive protection against colon cancer development by reducing inflammation and increasing proapoptotic pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Oncology
Marcio Alencar Barreira, Marcio Wilker Soares Campelo, Conceicao da Silva Martins Reboucas, Antoniella Souza Gomes Duarte, Maria Lucianny Lima Barbosa, Said Goncalves da Cruz Fonseca, Raphaela Ribeiro Queiroz, Erica Uchoa Holanda, Ana Beatriz Aragao de Vasconcelos, Vitoria Jannyne Guimaraes de Sousa Araujo, Gabriel Maia Diniz, Reinaldo Barreto Oria, Paulo Roberto Leitao de Vasconcelos
Summary: The composition of the intestinal microbiota, chronic inflammation, and oxidative stress are related to the onset of colorectal cancer (CRC). Diet is the most relevant environmental factor in the development of non-hereditary CRC. Pterostilbene has potential as an anti-tumor drug for CRC chemoprevention. Probiotics in different combinations, concentrations, and dosages have been studied for cancer prevention. The combination of substances should be stimulated to potentiate the expected effect through action on different targets.
Article
Food Science & Technology
Weerachai Chantana, Rentong Hu, Songphon Buddhasiri, Parameth Thiennimitr, Payungsak Tantipaiboonwong, Teera Chewonarin
Summary: This study investigated the chemoprotective action of perilla frutescens (PF) seed residue crude ethanolic extract (PCE) on the promotion stage of colon carcinogenesis and cell culture models. The results showed that PCE reduced the number of aberrant crypt foci (ACF) and decreased pro-inflammatory cytokines. PCE could also modulate inflammation in macrophage cells and suppress cancer cell proliferation induced by inflammation.
Article
Pathology
Sara Gomes Espirito Santo, Tereza Cristina Da Silva, Bruno Cogliati, Luis Fernando Barbisan, Guilherme Ribeiro Romualdo
Summary: Colorectal cancer is a leading cause of cancer-related deaths globally and is characterized by preneoplastic aberrant crypt foci (ACF) as an early manifestation. The role of Panx1 protein, which forms hemichannels, in colon carcinogenesis has not been explored. This study found that Panx1 knockout increased genotoxicity, oxidative stress, and apoptosis in the colon. Moreover, Panx1 knockout led to an increase in ACF development. Overall, these findings suggest a protective role of Panx1 in preventing the development of preneoplastic ACF during chemically induced colon carcinogenesis.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jingyu Zhang, Yandong Xie, Qingling Fan, Cheng Wang
Summary: Our study demonstrated that karanjin can inhibit ACF formation, reduce colon lesions, enhance antioxidant enzyme activity, and induce apoptosis in colon mucosa cells through modulation of the BAX, Bcl2, and p53 pathways in a DMH-induced rat colon cancer model. These findings suggest that karanjin has potential as a therapeutic agent for colon carcinogenesis.
BIOTECHNIC & HISTOCHEMISTRY
(2021)
Article
Medicine, General & Internal
Marek Kowalczyk, Dawid Sigorski, Lukasz Dysko, Ewa Zielinski, Dana Zupanovich Lucka, Lukasz Klepacki
Summary: The study aimed to evaluate the chemopreventive effect of low dose ASA on ACF and adenoma development. The results showed that patients who took low dose ASA for a long period of time had fewer ACFs and adenomas.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, Research & Experimental
Arpamas Chariyakornkul, Nichanan Inboot, Sirinya Taya, Rawiwan Wongpoomchai
Summary: The dichloromethane extract of Cleistocalyx nervosum seed demonstrated chemopreventive effects on chemically-induced carcinogenesis in both initiation and promotion stages in rats by modulating hepatic detoxifying enzymes and suppressing cell proliferation in the liver and colon.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Charatda Punvittayagul, Arpamas Chariyakornkul, Paweena Sankam, Rawiwan Wongpoomchai
Summary: The acidic methanol extract of purple rice husk showed cancer chemopreventive effects in rats, reducing micronucleated hepatocytes and inhibiting preneoplastic lesions in the liver and colon. The extract was not toxic, clastogenic, or carcinogenic, and its mechanisms of action involved the reduction of cytochrome P450 2E1 expression and induction of detoxifying enzymes in the liver. Anthocyanins and vanillic acid were identified as potential anticarcinogenic compounds in purple rice husk.
Article
Food Science & Technology
Phatthawin Lengkidworraphiphat, Rawiwan Wongpoomchai, Thanaporn Bunmee, Arpamas Chariyakornkul, Niraporn Chaiwang, Sanchai Jaturasitha
Summary: Black-boned chicken is a great nutritional source, while Thai native chickens are flavorful and delicious. Broilers might have a link to lipid metabolism.
FOOD SCIENCE OF ANIMAL RESOURCES
(2021)
Article
Oncology
Anna Kakehashi, Arpamas Chariyakornkul, Shugo Suzuki, Napaporn Khuanphram, Kumiko Tatsumi, Shotaro Yamano, Masaki Fujioka, Min Gi, Rawiwan Wongpoomchai, Hideki Wanibuchi
Summary: In this study, novel early molecular biomarkers of liver neoplasms in non-alcoholic steatohepatitis (NASH) were discovered using the STAM mouse model. The protein CACHD1 was found to be significantly elevated in hepatocellular carcinomas, suggesting its potential as a biomarker and molecular target in NASH-associated hepatocarcinogenesis involving cell proliferation, autophagy, and apoptosis. The research highlights CACHD1 as an early biomarker of liver preneoplastic and neoplastic lesions in the context of NASH, with implications for potential therapeutic targets in diabetes mellitus/NASH-associated hepatocarcinogenesis.
Article
Cell Biology
Warunyoo Phannasorn, Arpamas Chariyakornkul, Phumon Sookwong, Rawiwan Wongpoomchai
Summary: Coloured rice bran oil (CRBO) contains higher levels of vitamin E, phytosterols, carotenoids, and chlorophyll compared to white rice bran oil (WRBO), which can alleviate acetaminophen-induced hepatotoxicity by activating antioxidant systems. These components in CRBO may play a protective role in reducing hepatotoxicity.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Romteera Kittichaiworakul, Sirinya Taya, Arpamas Chariyakornkul, Thanongsak Chaiyaso, Rawiwan Wongpoomchai
Summary: Red yeast extracts exhibit antimutagenicity against aflatoxin-induced mutagenesis, modulate detoxifying enzyme activities, and reduce hepatic micronucleus formation in rats. Components like beta-carotene and lycopene may play a role in the antigenotoxic effects of red yeast.
Article
Biochemistry & Molecular Biology
Arpamas Chariyakornkul, Waristha Juengwiroj, Jetsada Ruangsuriya, Rawiwan Wongpoomchai
Summary: The acidified ethanolic extract of Cleistocalyx nervosum var. paniala (CN) can effectively reduce oxidative stress induced acute hepatotoxicity in overdose acetaminophen-treated rats through the suppression of oxidative stress and the enhancement of the antioxidant system in rat livers.
Article
Oncology
Qijie Zhao, Rawiwan Wongpoomchai, Arpamas Chariyakornkul, Zhangang Xiao, Chalermchai Pilapong
Summary: This study developed and validated a gene set-based signature for early-stage HCC patients and identified a Cluster gene that can potentially segregate eHCC patients from non-tumor. The study also revealed that lower infiltration of specific immune cells, such as CD8 Tem and CTLs, may be responsible for worse prognosis in HCC. Cluster C1 signature presented a high accuracy in predicting immune cells and cancerization, with overexpressed PRKDC associated with higher genetic alteration and poor prognosis in eHCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chi Be Hlaing, Arpamas Chariyakornkul, Chalermchai Pilapong, Charatda Punvittayagul, Somdet Srichairatanakool, Rawiwan Wongpoomchai
Summary: The study assessed the toxicity of Fe-TA NPs and found no obvious signs of toxicity, genotoxicity, and early phase hepatocarcinogenicity in rats.
Article
Food Science & Technology
Huina Guo, Arpamas Chariyakornkul, Warunyoo Phannasorn, Sugunya Mahatheeranont, Rawiwan Wongpoomchai
Summary: Cooked glutinous purple rice contains methanol extracts that are rich in phenolic compounds, flavonoids, and anthocyanins, which exhibit antioxidant, anti-inflammatory, and antimutagenic properties. Cooking decreases certain nutrients but increases the content of certain phenolic acid and tocol. The methanol extract of cooked glutinous purple rice shows potential as a chemopreventive fraction for cancer without genotoxic effects or negative effects on phytochemical-drug interaction.
Article
Chemistry, Multidisciplinary
Thipjutha Phatruengdet, Jannarong Intakhad, Monreudee Tapunya, Arpamas Chariyakornkul, Chi Be Hlaing, Rawiwan Wongpoomchai, Chalermchai Pilapong
