Non-uniformity of Changes in Drug-Metabolizing Enzymes and Transporters in Liver Cirrhosis: Implications for Drug Dosage Adjustment

Review article: time to revisit Child‐Pugh score as the basis for predicting drug clearance in hepatic impairment

(2021) Eman El‐Khateeb et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Proteomic Quantification of Changes in Abundance of Drug-Metabolizing Enzymes and Drug Transporters in Human Liver Cirrhosis: Different Methods, Similar Outcomes

(2021) Eman El-Khateeb et al.   DRUG METABOLISM AND DISPOSITION

Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight

(2020) Christine Wegler et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Scaling Factors for Clearance in Adult Liver Cirrhosis

(2020) Eman El-Khateeb et al.   DRUG METABOLISM AND DISPOSITION

Physiologically‐Based Pharmacokinetic Modeling in Renal and Hepatic Impairment Populations: A Pharmaceutical Industry Perspective

(2020) Tycho Heimbach et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters

(2020) Brahim Achour et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Quantification of Proteins Involved in Drug Metabolism and Disposition in the Human Liver Using Label-Free Global Proteomics

(2019) Narciso Couto et al.   MOLECULAR PHARMACEUTICS

Potential impact of the joint association of total bilirubin and gamma-glutamyltransferase with metabolic syndrome

(2019) Makoto Shiraishi et al.   Diabetology & Metabolic Syndrome

Proteomic Quantification of Human Blood–Brain Barrier SLC and ABC Transporters in Healthy Individuals and Dementia Patients

(2019) Zubida M. Al-Majdoub et al.   MOLECULAR PHARMACEUTICS

A repository of protein abundance data of drug metabolizing enzymes and transporters for applications in physiologically based pharmacokinetic (PBPK) modelling and simulation

(2019) Mayur K. Ladumor et al.   Scientific Reports

Protein Abundance of Hepatic Drug Transporters in Patients With Different Forms of Liver Damage

(2019) Marek Drozdzik et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Data Generated by Quantitative Liquid Chromatography-Mass Spectrometry Proteomics Are Only the Start and Not the Endpoint: Optimization of Quantitative Concatemer-Based Measurement of Hepatic Uridine-5′-Diphosphate–Glucuronosyltransferase Enzymes with Reference to Catalytic Activity

(2018) Brahim Achour et al.   DRUG METABOLISM AND DISPOSITION

Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study

(2018) Bhagwat Prasad et al.   DRUG METABOLISM AND DISPOSITION

Identification and Quantification of Blood-Brain Barrier Transporters in Isolated Rat Brain Microvessels

(2018) Hajar Al Feteisi et al.   JOURNAL OF NEUROCHEMISTRY

Effect of Hepatic Impairment on the Pharmacokinetics of Alectinib

(2018) Peter N. Morcos et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Effect of Liver Disease on Hepatic Transporter Expression and Function

(2017) Nilay Thakkar et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Metabonomics Research Progress on Liver Diseases

(2017) Mengqian Yu et al.   Canadian Journal of Gastroenterology and Hepatology

Importance of Hepatic Transporters in Clinical Disposition of Drugs and Their Metabolites

(2016) Mitesh Patel et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetic drug interactions in liver disease: An update

(2016) Pietro Palatini   WORLD JOURNAL OF GASTROENTEROLOGY

Molecular changes in hepatic metabolism and transport in cirrhosis and their functional importance

(2016) Christoph G Dietrich   WORLD JOURNAL OF GASTROENTEROLOGY

Cytokine patterns in cancer patients: A review of the correlation between interleukin 6 and prognosis

(2016) Bodo E. Lippitz et al.   OncoImmunology

A proposal for scientific framework enabling specific population drug dosing recommendations

(2015) Pravin R. Jadhav et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Application of an LC–MS/MS method for the simultaneous quantification of human intestinal transporter proteins absolute abundance using a QconCAT technique

(2015) M.D. Harwood et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Proinflammatory Cytokines (IL-1α, IL-6) and Hepatocyte Growth Factor in Patients with Alcoholic Liver Cirrhosis

(2015) Andrzej Prystupa et al.   Gastroenterology Research and Practice

Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis

(2014) Ali A Mokdad et al.   BMC Medicine

The burden of liver disease in Europe: A review of available epidemiological data

(2013) Martin Blachier et al.   JOURNAL OF HEPATOLOGY

Alternative Fusion Protein Strategies to Express Recalcitrant QconCAT Proteins for Quantitative Proteomics of Human Drug Metabolizing Enzymes and Transporters

(2013) Matthew R. Russell et al.   JOURNAL OF PROTEOME RESEARCH

Mechanistic Modeling to Predict the Transporter- and Enzyme-Mediated Drug-Drug Interactions of Repaglinide

(2013) Manthena V. S. Varma et al.   PHARMACEUTICAL RESEARCH

A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance

(2010) Trevor N. Johnson et al.   CLINICAL PHARMACOKINETICS

The Correlation between Increased Serum Concentrations of Interleukin-6 Family Cytokines and Disease Activity in Rheumatoid Arthritis Patients

(2010) Soo-Jin Chung et al.   YONSEI MEDICAL JOURNAL

Quantitative Analysis of UDP-Glucuronosyltransferase (UGT) 1A and UGT2B Expression Levels in Human Livers

(2009) T. Izukawa et al.   DRUG METABOLISM AND DISPOSITION

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

Pharmacokinetics and Pharmacodynamics of Dabigatran Etexilate, an Oral Direct Thrombin Inhibitor, Are Not Affected by Moderate Hepatic Impairment

(2008) Joachim Stangier et al.   JOURNAL OF CLINICAL PHARMACOLOGY