Article
Oncology
Tohru Yoneyama, Shingo Hatakeyama, Mihoko Sutoh-Yoneyama, Taku Yoshiya, Tsuyoshi Uemura, Takehiro Ishizu, Minoru Suzuki, Shingo Hachinohe, Shintaro Ishiyama, Motohiro Nonaka, Michiko N. Fukuda, Chikara Ohyama
Summary: The study demonstrates that IF7 can serve as an efficient delivery vehicle for B-10 by targeting tumor tissues via the tumor vasculature, which could be relevant for BNCT drugs. Multiple treatments at ultralow doses of IF7-B-10 significantly suppressed tumor growth in mouse models of human bladder cancer, suggesting its potential for clinical applications in the future.
Article
Chemistry, Multidisciplinary
Takahiro Nomoto, Ying Yao, Yukiya Inoue, Minoru Suzuki, Kaito Kanamori, Hiroyasu Takemoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama
Summary: In this study, a boron delivery system PEG-P[Lys/Lys(fructose)]-BPA was developed for selective accumulation within the tumor and quick clearance from normal organs and blood. The system showed efficient tumor accumulation and retention in tumor cells, with high accumulation contrast between the tumor and normal tissues. Upon thermal neutron irradiation, PEG-P[Lys/Lys(fructose)]-BPA significantly inhibited tumor growth in mice, suggesting its potential as a promising boron delivery system for BNCT.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Multidisciplinary
Wenlu Yan, Tianqun Lang, Runqi Zhu, Xiao Zhu, Yu Li, Ting Wu, Qi Yin, Yaping Li
Summary: This review summarizes the latest research progress on improving cancer therapy using anti-hypoxia nanosized drug delivery systems (NDDSs), including mechanisms such as increasing oxygen supply, reducing oxygen consumption, and inhibiting hypoxia-related signaling pathways.
Article
Chemistry, Multidisciplinary
Chencheng Xue, Hui Zhang, Xuan Wang, Haoyu Du, Lu Lu, Yang Fei, Yanan Li, Yuchen Zhang, Menghuan Li, Zhong Luo
Summary: This study presents a bio-inspired protein nanocomplex that efficiently eliminates tumors through enhanced ferroptosis therapy. The complex induces pronounced ferroptosis in tumor cells and targets tumor cell membrane for enhanced uptake, demonstrating superior antitumor effects with no obvious adverse effects.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Hiroyuki Michiue, Mizuki Kitamatsu, Asami Fukunaga, Nobushige Tsuboi, Atsushi Fujimura, Hiroaki Matsushita, Kazuyo Igawa, Tomonari Kasai, Natsuko Kondo, Hideki Matsui, Shuichi Furuya
Summary: This study explored the use of self-assembling A6K peptide nanotubes as boron carriers for tumor selective therapy, improving the limitations of BSH in intracellular transduction and non-specific drug delivery. By varying the A6K peptide and BSH mixture ratio, materials with different morphologies were produced, leading to increased intracellular boron uptake efficiency. The findings suggest that A6K peptide offers a unique and simple strategy for enhancing the effectiveness of BNCT drugs.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Oncology
Song Wang, Zhengchao Zhang, Lele Miao, Yumin Li
Summary: Boron neutron capture therapy (BNCT) is an emerging therapy that selectively kills tumor cells by using boron delivery agents to release alpha and lithium particles through neutron-triggered fission. It has been developed for the treatment of various cancers and requires further research on efficient delivery agents and accurate dose measurement systems.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Biomedical
Ahram Kim, Yuya Suzuki, Yukio Nagasaki
Summary: Boronic acids have potential for biomedical applications, but are limited by rapid excretion and off-target effects. By employing a polymeric carrier, stable encapsulation of boronic acid-containing drugs can be achieved with improved pharmacokinetics and on-target drug release capability. Enhancements in antitumor efficacy and reduction in hepatotoxicity can be achieved through this approach.
ACTA BIOMATERIALIA
(2021)
Article
Pharmacology & Pharmacy
Yan Ting Liu, Shreya Goel, Megumi Kai, Jose Alberto Moran Guerrero, Thao Nguyen, Junhua Mai, Haifa Shen, Arturas Ziemys, Kenji Yokoi
Summary: Our study showed that tumors derived from different seed and soil sources exhibited varying responses to immunotherapy, with differences in PD-L1 expression, therapeutic delivery, immune cell accumulation, and tumor coagulation. This highlights the importance of understanding organ-specific heterogeneity in the delivery and response to immunotherapy in polyclonal tumors.
Review
Biochemistry & Molecular Biology
Mohsen Karami Fath, Kimiya Babakhaniyan, Maryam Zokaei, Azadeh Yaghoubian, Sadaf Akbari, Mahdieh Khorsandi, Asma Soofi, Mohsen Nabi-Afjadi, Hamidreza Zalpoor, Fateme Jalalifar, Ali Azargoonjahromi, Zahra Payandeh, Armina Alagheband Bahrami
Summary: This study reviews the applications of therapeutic peptides and targeting ligands in cancer therapy. Therapeutic peptides show promise as targeted drug delivery systems due to their specificity and modifiability.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Review
Biotechnology & Applied Microbiology
Xiufeng Cong, Jun Chen, Ran Xu
Summary: Spatially- and/or temporally-controlled drug release is the goal of drug delivery systems to achieve optimal therapeutic effects. The abnormal characteristics of the tumor microenvironment provide opportunities for stimulus-responsive drug delivery systems to better deliver drugs and combat tumors. By responding to these signals, responsive drug delivery systems can achieve more precise drug release and reduce systemic toxicity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jelena Matovic, Katayun Bahrami, Philipp Stockmann, Iris K. . Sokka, You Cheng Khng, Mirkka Sarparanta, Evamarie Hey-Hawkins, Jarkko Rautio, Filip S. Ekholm
Summary: Boron neutron capture therapy (BNCT) is a cancer treatment that uses boron delivery agents to selectively eradicate tumor cells. In this study, we focus on a GLUT1-targeting strategy to BNCT and synthesize carborane-bearing D-galactose, D-mannose, and D-allose as potential delivery agents. We find that these agents exhibit significantly improved boron delivery capacity compared to clinically approved agents in vitro, laying the groundwork for future preclinical assessment studies.
MOLECULAR PHARMACEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Parisa Maleki Dana, Jamal Hallajzadeh, Zatollah Asemi, Mohammad Ali Mansournia, Bahman Yousefi
Summary: Melanoma, a less common type of skin cancer, has the highest mortality rate. Although there have been advances in melanoma treatment, it still faces challenges such as systemic toxicity, water insolubility, and inadequate cellular penetration. Chitosan-based delivery platforms have shown significant success in overcoming these challenges.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Song Wang, Zhengchao Zhang, Lele Miao, Jiaxing Zhang, Futian Tang, Muzhou Teng, Yumin Li
Summary: Boron Neutron Capture Therapy (BNCT) is a new binary radiation therapy that uses neutron capture reaction to kill tumor cells. It has been included in the clinical backup program for the treatment of glioma, melanoma, and other diseases. However, the key challenge of BNCT lies in developing more efficient boron delivery agents to improve targeting and selectivity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biophysics
Xin Huang, Husheng Yan
Summary: A branched arginine-rich polymer co-administered with doxorubicin overcame barriers in conventional chemotherapy, significantly enhancing anticancer efficacy and reducing the doxorubicin dose. The guanidinium groups in the polymer may play a pivotal role in its mechanism of action.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Riku Kawasaki, Hidetoshi Hirano, Keita Yamana, Hinata Isozaki, Shogo Kawamura, Yu Sanada, Kaori Bando, Anri Tabata, Kouhei Yoshikawa, Hideki Azuma, Takushi Takata, Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki, Naoki Tarutani, Kiyofumi Katagiri, Shin-ichi Sawada, Yoshihiro Sasaki, Kazunari Akiyoshi, Takeshi Nagasaki, Atsushi Ikeda
Summary: Boron neutron capture therapy (BNCT) is a promising cancer treatment, but delivering effective boron agents is challenging. We developed hybrid nanoparticles called HBNGs that can efficiently deliver highly concentrated boron agents, surpassing the effectiveness of clinically used boron agent L-BPA/fructose complex in vitro. HBNGs accumulate in tumors and show high tumor selectivity, allowing for successful BNCT without tumor regrowth. The therapeutic efficacy of HBNGs is superior to L-BPA/fructose complex, making it a promising approach to cancer therapeutics.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Analytical
Jing-yan Kang, Yu-jie Zhang, Xing Li, Chen Dong, Hong-yu Liu, Li-jing Miao, Paul J. Low, Zhi-xian Gao, Narayan S. Hosmane, Ai-guo Wu
ANALYTICAL METHODS
(2018)
Article
Chemistry, Multidisciplinary
Xinmei Zhao, Leyong Zeng, Narayan Hosmane, Yan Gong, Aiguo Wu
CHINESE CHEMICAL LETTERS
(2019)
Review
Chemistry, Inorganic & Nuclear
Yinghuai Zhu, Shanmin Gao, Narayan S. Hosmane
INORGANICA CHIMICA ACTA
(2018)
Article
Chemistry, Inorganic & Nuclear
Yinghuai Zhu, Zhiyu Bai, Wen Chuen Phuan, Fatima Abi Ghaida, Narayan S. Hosmane, Jun Ding
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2018)
Article
Materials Science, Biomaterials
Okan Icten, Dursun Ali Kose, Stephan J. Matissek, Jason A. Misurelli, Sherine F. Elsawa, Narayan S. Hosmane, Birgul Zumreoglu-Karan
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2018)
Article
Chemistry, Multidisciplinary
Yinghuai Zhu, Narayan S. Hosmane
PURE AND APPLIED CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Marlon R. Lutz, Sebastian Flieger, Andre Colorina, John Wozny, Narayan S. Hosmane, Daniel P. Becker
Article
Chemistry, Multidisciplinary
Yinghuai Zhu, Parichat Prommana, Narayan S. Hosmane, Paolo Coghi, Chairat Uthaipibull, Yingjun Zhang
Summary: Boron nanoparticles with hydroxyl groups were synthesized in situ and characterized using various analytical techniques. These nanoparticles exhibited good antimalarial activity against Plasmodium falciparum, while showing low toxicity to various cell lines.
Review
Biochemistry & Molecular Biology
Bhaskar C. Das, Nitesh K. Nandwana, Sasmita Das, Varsha Nandwana, Mohammed Adil Shareef, Yogarupa Das, Mariko Saito, Louis M. Weiss, Frankis Almaguel, Narayan S. Hosmane, Todd Evans
Summary: This review introduces current boron-containing drug candidates, including boron-based compounds for the treatment of different diseases. It also describes their synthesis, structure-activity relationship, and associated biological activities.
Article
Biochemistry & Molecular Biology
Martha L. Jimenez-Gonzalez, Juan Pablo F. Rebolledo-Chavez, Marisela Cruz-Ramirez, Rene Antano, Angel Mendoza, Narayan S. Hosmane, Lena Ruiz-Azuara, Jose Luis Hernandez-Lopez, Luis Ortiz-Frade
Summary: In this work, an electrochemical study of the Boron cage monomercaptoundecahydro-closo-dodecaborate [B12H11SH](2-) in solution and in a self-assembled monolayer over a gold electrode was conducted. The study revealed the interaction between the boron cage and the gold surface, formation of a self-assembled monolayer, and the reduction of active sites on the gold surface due to the presence of the boron cage. Bulkier thiols were found to enhance charge accumulation at the electrode-solution interface.
Review
Biochemistry & Molecular Biology
Varsha Nandwana, Nitesh K. Nandwana, Yogarupa Das, Mariko Saito, Tanisha Panda, Sasmita Das, Frankis Almaguel, Narayan S. Hosmane, Bhaskar C. Das
Summary: This review article summarizes the importance of gut microbiota in neurodevelopment and neurodegenerative disorders and discusses breakthroughs in using probiotics, prebiotics, and synbiotics for treating neurological illnesses. It also explores the role of a boron-based diet in memory and neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Sebastian Flieger, Mao Takagaki, Natsuko Kondo, Marlon R. Lutz, Yash Gupta, Hiroki Ueda, Yoshinori Sakurai, Graham Moran, Prakasha Kempaiah, Narayan Hosmane, Minoru Suzuki, Daniel P. Becker
Summary: New carborane-bearing hydroxamate matrix metalloproteinase (MMP) ligands with nanomolar potency against MMP-2, -9 and -13 have been synthesized for boron neutron capture therapy (BNCT). In vitro studies showed that these new MMP ligands had high tumoricidal effects in the BNCT assay. This study highlights the importance of targeting MMP enzymes overexpressed on the surface of tumor cells for BNCT efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Yinghuai Zhu, Jianghong Cai, Narayan S. Hosmane, Minoru Suzuki, Kazuko Uno, Yingjun Zhang, Mao Takagaki
Summary: Carboxyboranylamino ethanol was prepared with a 75.0% yield through an amine-exchange reaction. It showed lower cytotoxicity and higher anti-tumor efficacy in vitro compared to 4-borono-l-phenylalanine (BPA) and methyl 2-hydroxyl-5-(1'-ortho-carbonylmethyl-1',2',3'-triazol-4'-yl)-benzonate (2). The bio-enhancement was explained using molecular docking calculations.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Hongyu Liu, Zhuangwei Zhou, Yujie Zhang, Ningyi Chen, Jingyan Kang, Guijian Liu, Narayan S. Hosmane, Aiguo Wu
NANOSCALE ADVANCES
(2019)
Correction
Biochemistry & Molecular Biology
Mohamed Marzouk, Shimaa M. Khalifa, Amal H. Ahmed, Ahmed M. Metwaly, Hala Sh. Mohammed, Hanan A. A. Taie
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Gerardo Andres Libreros-Zuniga, Danilo Pava e Pavao, Vinicius de Morais Barroso, Nathalya Cristina de Moraes Roso Mesquita, Saulo Fehelberg Pinto Braga, Glaucius Oliva, Rafaela Salgado Ferreira, Kelly Ishida, Marcio Vinicius Bertacine Dias
Summary: Tuberculosis is a major global cause of death, and the emergence of drug-resistant strains has increased the burden of this disease. New alternative therapies are constantly needed, and recent research has identified small molecules as potential inhibitors of Ldts in M. tuberculosis, which have antimycobacterial activity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiao-Dong Wang, Yong-Si Liu, Ming-Hao Hu
Summary: In this study, a selffolded fluorescent probe was designed to selectively illuminate G4s by unfolding its intramolecular aggregation mediated by G4 binding. This probe showed more controllable background emission and promising ability to track G4 forming dynamics compared to previous disaggregation-induced emission (DIE) probes.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Xiang, Zhuo Yuan, Qichuan Deng, Linshen Xie, Dongke Yu, Jianyou Shi
Summary: This review provides a brief description of the diagnosis, pathogenesis, and potential therapeutic inhibitors for renal fibrosis. Currently, there are no clear therapeutic targets or drugs for renal fibrosis; however, some natural products may have potential efficacy for treating renal fibrosis.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Simone Giovannuzzi, Anna Nikitjuka, Bruna Rafaela Pereira Resende, Michael Smietana, Alessio Nocentini, Claudiu T. Supuran, Jean-Yves Winum
Summary: Boron-based compounds have been extensively studied in medicinal chemistry, playing a crucial role in designing small molecule drugs for various diseases. Boron is particularly valuable in developing inhibitors for metalloenzymes carbonic anhydrases, and it can modulate ligand recognition ability and selectivity. Recent advancements have led to the discovery of novel boron-based inhibitors that can inhibit carbonic anhydrases through a Lewis acid-base mechanism. Further research is needed to fully explore the potential of boron-based inhibitors and advance their clinical applications.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinxin Liu, Lei Chen, Ze Chen
Summary: This study developed a nanostructured photosensitizer loaded with oxygen-throttling drug and demonstrated its enhanced cytotoxicity against tumor cells under hypoxic conditions. Animal experiments showed the enhanced tumor targeting capability of the photosensitizer and its inhibitory effect on tumor growth.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuai Jiang, Wen-Yan Li, Zai-Feng Yuan, Qin-Shi Zhao
Summary: This study isolated two new dimeric Lycopodium alkaloids and twelve previously undescribed Lycopodium alkaloids from Lycopodiastrum casuarinoides. The structures of these compounds were determined and their inhibitory activities on the Cav3.1 channel were evaluated.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yan Yang, Dong-Xiao Yan, Rui-Xue Rong, Bing-Ye Shi, Man Zhang, Jing Liu, Jie Xin, Tao Xu, Wen-Jie Ma, Xiao-Liu Li, Ke-Rang Wang
Summary: In this study, a series of nucleolar fluorescent probes based on naphthalimide derivatives were designed and synthesized, which could achieve clear nucleolar staining in living cells. The results showed that these probes exhibited good targeting to the cell nucleolus and could bind to RNA and enhance fluorescence. This has positive implications for the diagnosis and treatment of nucleolus-related diseases.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yongxi Dong, Fang Wang, Jinlan Wen, Yongqing Mao, Shanhui Zhang, Tiemei Long, Zhangxiang Yang, Lei Li, Jiquan Zhang, Li Dong, Gang Liu, Jianwei Xu
Summary: The hybrid molecules of Scutellarein and Tertramethylpyrazine show excellent neuroprotective and antiplatelet effects in the treatment of ischemic stroke. Compound 1e is particularly effective, enhancing cell membrane permeability and inhibiting cell uptake, as well as significantly reducing cerebral infarction volume.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yu Chen, Yuanyuan Ying, Jonathan Lalsiamthara, Yuheng Zhao, Saber Imani, Xin Li, Sijing Liu, Qingjing Wang
Summary: This paper examines the role and metabolic regulation of NAD+ in bacteria, highlighting its impact on physiology and virulence. It explores enzymes associated with NAD+ metabolism as potential targets for antibacterial drugs and vaccine candidates. Additionally, it scrutinizes the medical potential of NAD+ and provides insights for its application in biomedicine.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jon Macicior, Daniel Fernandez, Silvia Ortega-Gutierrez
Summary: Hutchinson-Gilford progeria syndrome (HGPS), also known as progeria, is a rare genetic disease that causes premature aging and significantly reduces life expectancy. Currently, there is only one approved drug for treating progeria, but its efficacy is limited. Progerin levels are believed to be the most important biomarker related to disease severity.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Fuko Hirano, Naoya Kondo, Yusuke Murata, Aya Sudani, Takashi Temma
Summary: Fluorinated alpha-methyl 3BPA derivatives showed improved water solubility, tumor targetability, and biodistribution compared to 3BPA and BPA, resulting in significantly improved tumor-to-normal tissue ratios.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ying Shi, Jiaqin Tang, Shumeng Zhi, Ruiqi Jiang, Qing Huang, Lei Sun, Zhizhong Wang, Yanran Wu
Summary: Necroptosis is a type of cell death associated with various diseases. In this study, we identified a small molecule inhibitor, SY-1, that effectively blocks necroptosis by inhibiting the phosphorylation of RIP1/RIP3/MLKL pathway. SY-1 also showed protective effects against TNF-induced hypothermia and improved survival in mice with SIRS. These findings highlight the potential therapeutic applications of SY-1.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Andrea Bagan, Sonia Abas, Judith Pala-Pujadas, Alba Irisarri, Christian Grinan-Ferre, Merce Pallas, Itziar Muneta-Arrate, Carolina Muguruza, Luis F. Callado, Belen Perez, Elies Molins, Jose A. Morales-Garcia, Carmen Escolano
Summary: Recent studies have identified the modulation of imidazoline I-2 receptors (I-2-IR) by selective ligands as a potential strategy for treating neurodegenerative diseases. This study reports a family of bicyclic alpha-iminophosphonates that show high affinity and selectivity for I-2-IR and demonstrates their neuroprotective and anti-inflammatory effects in in vitro and in vivo models. The findings emphasize the importance of exploring structurally novel I-2-IR ligands for therapeutic strategies in neurodegeneration.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qiuping Xiang, Tianbang Wu, Cheng Zhang, Chao Wang, Hongrui Xu, Qingqing Hu, Jiankang Hu, Guolong Luo, Xiaoxi Zhuang, Xishan Wu, Yan Zhang, Yong Xu
Summary: This study reports the discovery of a 1-(indolizin-3-yl)ethan-1-one derivative as a potent and selective CBP bromodomain inhibitor for AML drug development.
BIOORGANIC CHEMISTRY
(2024)
