Integration of biophysical and biological approaches to validate fragment-like compounds targeting l,d-transpeptidases from Mycobacterium tuberculosis
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Integration of biophysical and biological approaches to validate fragment-like compounds targeting l,d-transpeptidases from Mycobacterium tuberculosis
Authors
Keywords
-
Journal
BIOORGANIC CHEMISTRY
Volume -, Issue -, Pages 106960
Publisher
Elsevier BV
Online
2023-11-05
DOI
10.1016/j.bioorg.2023.106960
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mycobacterium smegmatis: The Vanguard of Mycobacterial Research
- (2023) Ian L. Sparks et al. JOURNAL OF BACTERIOLOGY
- Investigating β-Lactam Drug Targets in Mycobacterium tuberculosis Using Chemical Probes
- (2021) Samantha R. Levine et al. ACS Infectious Diseases
- A Mycobacterial Systems Resource for the Research Community
- (2021) J. A. Judd et al. mBio
- Drug resistance, fitness and compensatory mutations in Mycobacterium tuberculosis
- (2021) Amel Kevin Alame Emane et al. TUBERCULOSIS
- Application of Mycobacterium smegmatis as a surrogate to evaluate drug leads against Mycobacterium tuberculosis
- (2020) Nada Lelovic et al. JOURNAL OF ANTIBIOTICS
- Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors
- (2020) Mohamad Sabbah et al. JOURNAL OF MEDICINAL CHEMISTRY
- The relationship between the structure and toxicity of aminoglycoside antibiotics
- (2020) Moriah Jospe-Kaufman et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification
- (2020) Sherine E Thomas et al. NUCLEIC ACIDS RESEARCH
- Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis
- (2020) João A. Ribeiro et al. ACS Infectious Diseases
- The 1-β-methyl group confers a lower affinity of l,d-transpeptidase LdtMt2 for ertapenem than for imipenem
- (2019) Fen Zhao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches
- (2019) Andrew J. Whitehouse et al. JOURNAL OF MEDICINAL CHEMISTRY
- Identification of potent L,D-transpeptidase 5 inhibitors for Mycobacterium tuberculosis as potential anti-TB leads: virtual screening and molecular dynamics simulations
- (2019) Victor T. Sabe et al. JOURNAL OF MOLECULAR MODELING
- Structural and biochemical analyses of the LdtMt2-panipenem adduct provide new insights into the effect of the 1-β-methyl group on carbapenems
- (2019) Xiaoyan Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Bedaquiline and delamanid in the treatment of multidrug‐resistant tuberculosis: Promising but challenging
- (2018) Yang Li et al. DRUG DEVELOPMENT RESEARCH
- Structural Basis for the Interaction and Processing of β-Lactam Antibiotics by l,d-Transpeptidase 3 (LdtMt3) from Mycobacterium tuberculosis
- (2018) Gerardo Andrés Libreros-Zúñiga et al. ACS Infectious Diseases
- Binding and processing of β-lactam antibiotics by the transpeptidase LdtMt2fromMycobacterium tuberculosis
- (2017) Eva Maria Steiner et al. FEBS Journal
- Non-classical transpeptidases yield insight into new antibacterials
- (2016) Pankaj Kumar et al. Nature Chemical Biology
- Twenty years on: the impact of fragments on drug discovery
- (2016) Daniel A. Erlanson et al. NATURE REVIEWS DRUG DISCOVERY
- Loss of a Functionally and Structurally Distinct ld-Transpeptidase, LdtMt5, Compromises Cell Wall Integrity inMycobacterium tuberculosis
- (2015) Leighanne A. Brammer Basta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Use of Mycobacterium smegmatis Deficient in ADP-Ribosyltransferase as Surrogate for Mycobacterium tuberculosis in Drug Testing and Mutation Analysis
- (2015) Priyanka Agrawal et al. PLoS One
- Nonclassical Transpeptidases of Mycobacterium tuberculosis Alter Cell Size, Morphology, the Cytosolic Matrix, Protein Localization, Virulence, and Resistance to -Lactams
- (2014) M. K. Schoonmaker et al. JOURNAL OF BACTERIOLOGY
- Genetic characterization of mycobacterial L,D-transpeptidases
- (2014) A. N. Sanders et al. MICROBIOLOGY-SGM
- Structure of LdtMt2, anL,D-transpeptidase fromMycobacterium tuberculosis
- (2013) Dominic Böth et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Structural basis for the inhibition ofMycobacterium tuberculosisL,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains
- (2013) Hyoun Sook Kim et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Structures of free and inhibited forms of theL,D-transpeptidase LdtMt1fromMycobacterium tuberculosis
- (2013) Stefania Correale et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- In VitroCross-Linking of Mycobacterium tuberculosis Peptidoglycan by l,d-Transpeptidases and Inactivation of These Enzymes by Carbapenems
- (2013) Mathilde Cordillot et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Meropenem-Clavulanic Acid Shows Activity against Mycobacterium tuberculosis In Vivo
- (2012) Kathleen England et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Inactivation of Mycobacterium tuberculosis l,d-Transpeptidase LdtMt1by Carbapenems and Cephalosporins
- (2012) Vincent Dubée et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Targeting the Cell Wall of Mycobacterium tuberculosis: Structure and Mechanism of L,D-Transpeptidase 2
- (2012) Sabri B. Erdemli et al. STRUCTURE
- Inactivation Kinetics of a New Target of β-Lactam Antibiotics
- (2011) Sébastien Triboulet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin
- (2010) Radhika Gupta et al. NATURE MEDICINE
- Beta-lactam antibiotics: from antibiosis to resistance and bacteriology
- (2009) KOK-FAI KONG et al. APMIS
- Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis
- (2009) J.-E. Hugonnet et al. SCIENCE
- The Peptidoglycan of Stationary-Phase Mycobacterium tuberculosis Predominantly Contains Cross-Links Generated by L,D-Transpeptidation
- (2008) M. Lavollay et al. JOURNAL OF BACTERIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search