Metal‐Free Synthesis of 5‐Trifluoromethyl‐1,2,4‐Triazoles from Iodine‐Mediated Annulation of Trifluoroacetimidoyl Chlorides and Hydrazones

Palladium-catalyzed tandem cyclization of fluorinated imidoyl chlorides with 2-bromophenylboronic acid: Synthesis of 6-fluoroalkyl-phenanthridines

(2019) Yinwei Bao et al.   TETRAHEDRON

Iodine-Mediated Multicomponent Synthesis of 3-Sulfenylimidazo[1,2-a]pyridines from 2-Aminopyridines, Ketones, and Sulfonyl Hydrazides

(2019) Hongjun Ren et al.   SYNLETT

Synthesis of Multi‐substituted Dihydropyrazoles by Copper‐Mediated [4+1] Cycloaddition Reaction of N ‐Sulfonylhydrazones and Sulfoxonium Ylides

(2019) Sipei Hu et al.   ADVANCED SYNTHESIS & CATALYSIS

Silver-Catalyzed Three-Component Route to Trifluoromethylated 1,2,3-Triazolines Using Aldehydes, Amines, and Trifluorodiazoethane

(2019) Anuj Kumar et al.   ORGANIC LETTERS

Silver-Catalyzed [3 + 3] Dipolar Cycloaddition of Trifluorodiazoethane and Glycine Imines: Access to Highly Functionalized Trifluoromethyl-Substituted Triazines and Pyridines

(2019) Zhen Chen et al.   ACS Catalysis

Redox-Divergent Synthesis of Fluoroalkylated Pyridines and 2-Pyridones through Cu-Catalyzed N−O Cleavage of Oxime Acetates

(2018) Dachang Bai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cu-Catalyzed Synthesis of Fluoroalkylated Isoxazoles from Commercially Available Amines and Alkynes

(2018) Xiao-Wei Zhang et al.   ORGANIC LETTERS

Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction of α-Diazoacetates and β-Trifluoromethyl Enones: A Facile Access to Multisubstituted 4-(Trifluoromethyl)pyrazolines

(2018) Yongfeng Li et al.   ORGANIC LETTERS

Expeditious Synthesis of 6-Fluoroalkyl-Phenanthridines via Palladium-Catalyzed Norbornene-Mediated Dehydrogenative Annulation

(2018) Zhuo Wang et al.   ORGANIC LETTERS

Scalable Synthesis of Trifluoromethylated Imidazo-Fused N-Heterocycles Using TFAA and Trifluoroacetamide as CF3-Reagents

(2017) Gabriel Schäfer et al.   ORGANIC LETTERS

One-Pot Cascade Transformations of Zinc Trifluorodiazoethylide and α,β-Unsaturated Enones: Access to Trifluoromethylated Polycyclic Pyrazolines

(2017) Shuang Qin et al.   ORGANIC LETTERS

Trifluoromethyl nitrogen heterocycles: synthetic aspects and potential biological targets

(2016) F. Meyer   CHEMICAL COMMUNICATIONS

Synthesis of 1,2,4-Triazolo[4,3-a ]pyridines and Related Heterocycles by Sequential Condensation and Iodine-Mediated Oxidative Cyclization

(2016) Ertong Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Stereoselective Ag-Catalyzed 1,3-Dipolar Cycloaddition of Activated Trifluoromethyl-Substituted Azomethine Ylides

(2016) Alberto Ponce et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fluorinated diazoalkanes – a versatile class of reagents for the synthesis of fluorinated compounds

(2016) Lucas Mertens et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

2-(Trifluoromethyl)indoles via Pd(0)-Catalyzed C(sp3)–H Functionalization of Trifluoroacetimidoyl Chlorides

(2016) Julia Pedroni et al.   ORGANIC LETTERS

I2-Catalyzed Oxidative Coupling Reactions of Hydrazones and Amines and the Application in the Synthesis of 1,3,5-Trisubstituted 1,2,4-Triazoles

(2016) Zhengkai Chen et al.   ORGANIC LETTERS

Silver-catalyzed regioselective [3+2] cycloaddition of arene-diazonium salts with 2,2,2-trifluorodiazoethane (CF3CHN2): a facile access to 2-aryl-5-trifluoromethyltetrazoles

(2015) Zhen Chen et al.   CHEMICAL COMMUNICATIONS

The asymmetric synthesis of CF3-containing spiro[pyrrolidin-3,2′-oxindole] through the organocatalytic 1,3-dipolar cycloaddition reaction

(2015) Mingxia Ma et al.   CHEMICAL COMMUNICATIONS

Carbon Trifluoromethylation Reactions of Hydrocarbon Derivatives and Heteroarenes

(2015) Concepción Alonso et al.   CHEMICAL REVIEWS

Catalytic Asymmetric Synthesis of Enantioenriched Heterocycles Bearing a CCF3Stereogenic Center

(2015) Yi-Yong Huang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Silver-catalyzed [3 + 2] cycloaddition of isocyanides with diazo compounds: new regioselective access to 1,4-disubstituted-1,2,3-triazoles

(2015) Shuai Wang et al.   Organic Chemistry Frontiers

Oxidative Trifluoromethylation and Trifluoromethylthiolation Reactions Using (Trifluoromethyl)trimethylsilane as a Nucleophilic CF3 Source

(2014) Lingling Chu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Application of Langlois’ Reagent in Trifluoromethylation Reactions

(2014) Cai Zhang   ADVANCED SYNTHESIS & CATALYSIS

Trifluoromethyltrimethylsilane: Nucleophilic Trifluoromethylation and Beyond

(2014) Xiao Liu et al.   CHEMICAL REVIEWS

Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents

(2014) Julie Charpentier et al.   CHEMICAL REVIEWS

Addition of CF3 across unsaturated moieties: a powerful functionalization tool

(2014) Estíbaliz Merino et al.   CHEMICAL SOCIETY REVIEWS

Microwave-assisted synthesis of 1-aryl-5-(trifluoromethyl)-1H-tetrazoles

(2014) Fariba Rahmani et al.   JOURNAL OF FLUORINE CHEMISTRY

Palladium-catalyzed intramolecular C−H bond functionalization of trifluoroacetimidoyl chloride derivatives: Synthesis of 6-trifluoromethyl-phenanthridines

(2014) Mei Zhu et al.   JOURNAL OF FLUORINE CHEMISTRY

I2-Mediated Oxidative C–N Bond Formation for Metal-Free One-Pot Synthesis of Di-, Tri-, and Tetrasubstituted Pyrazoles from α,β-Unsaturated Aldehydes/Ketones and Hydrazines

(2014) Xinting Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of CF3-Containing 3,3′-Cyclopropyl Spirooxindoles by Sequential [3 + 2] Cycloaddition/Ring Contraction of Ylideneoxindoles with 2,2,2-Trifluorodiazoethane

(2014) Tian-Ren Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Silver-Mediated Cycloaddition of Alkynes with CF3CHN2: Highly Regioselective Synthesis of 3-Trifluoromethylpyrazoles

(2013) Feng Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-Light-Induced Radical Cyclization of Trifluoroacetimidoyl Chlorides with Alkynes: Catalytic Synthesis of 2-Trifluoromethyl Quinolines

(2013) Xichang Dong et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of 6-(Trifluoromethyl)phenanthridines via Palladium-Catalyzed Tandem Suzuki/C–H Arylation Reactions

(2013) Wen-Ying Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Chiral Brønsted acid-catalyzed diastereo- and enantioselective synthesis of CF3-substituted aziridines

(2012) Zhuo Chai et al.   CHEMICAL COMMUNICATIONS

Structural and photophysical studies of europium complexes containing triazole ligands

(2012) Alexey N. Gusev et al.   INORGANICA CHIMICA ACTA

Au(I)-Catalyzed Intramolecular Hydroamination of the Fluorinated N′-Aryl-N-Propargyl Amidines: Mild Conditions for the Synthesis of 2-Fluoroalkyl Imidazole Derivatives

(2012) Shan Li et al.   ORGANIC LETTERS

An efficient method to access 2-fluoroalkylbenzimidazoles by PIDA oxidation of amidines

(2011) Jiangtao Zhu et al.   JOURNAL OF FLUORINE CHEMISTRY

Efficient Synthesis of 2-Fluoromethylated Quinolines via Copper-Catalyzed Alkynylation and Cyclization of Fluorinated Imidoyl Iodides

(2010) Shan Li et al.   ADVANCED SYNTHESIS & CATALYSIS

Palladium catalyzed synthesis of 2-trifluoromethylquinolines through a domino Sonogashira–alkyne carbocyclization process

(2010) Zixian Chen et al.   CHEMICAL COMMUNICATIONS

Synthesis of 3,4,5-Trisubstituted-1,2,4-triazoles

(2010) Aline Moulin et al.   CHEMICAL REVIEWS

Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates

(2010) Jing Nie et al.   CHEMICAL REVIEWS

A Short Synthesis of the Triazolopyrimidine Antibiotic Essramycin

(2010) Ugo Battaglia et al.   JOURNAL OF NATURAL PRODUCTS

Copper-Catalyzed Thiolation Annulations of 1,4-Dihalides with Sulfides Leading to 2-Trifluoromethyl Benzothiophenes and Benzothiazoles

(2010) Chun-Lin Li et al.   JOURNAL OF ORGANIC CHEMISTRY

A General and Straightforward Method for the Synthesis of 2-Trifluoromethylbenzothiazoles

(2010) Jiangtao Zhu et al.   ORGANIC LETTERS

Highly Efficient Phosphorescent Organic Light-Emitting Diodes Hosted by 1,2,4-Triazole-Cored Triphenylamine Derivatives: Relationship between Structure and Optoelectronic Properties

(2009) Youtian Tao et al.   Journal of Physical Chemistry C

Efficient Three-Photon Excited Deep Blue Photoluminescence and Lasing of Diphenylamino and 1,2,4-Triazole Endcapped Oligofluorenes

(2009) Po Lam Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Chloroimination of Imidoyl Chlorides to a Triple Bond: An Intramolecular Reaction Leading to 4-Chloroquinolines

(2008) Akira Isobe et al.   ORGANIC LETTERS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS