Stereoselective Ag-Catalyzed 1,3-Dipolar Cycloaddition of Activated Trifluoromethyl-Substituted Azomethine Ylides

Diastereo- and Enantioselective Synthesis of Chiral Pyrrolidine-Fused SpirooxindolesviaOrganocatalytic [3+2] 1,3-Dipolar Cycloaddition of Azomethine Ylides with Maleimides

(2015) Hong-Wu Zhao et al.   ADVANCED SYNTHESIS & CATALYSIS

The Squaramide-Catalyzed 1,3-Dipolar Cycloaddition of Nitroalkenes withN-2,2,2-Trifluoroethylisatin Ketimines: An Approach for the Synthesis of 5′-Trifluoromethyl-spiro[pyrrolidin-3,2′-oxindoles]

(2015) Quantao Sun et al.   ADVANCED SYNTHESIS & CATALYSIS

A CuII-N,P Oxazolinylferrocene Ligand Complex for the Asymmetric [3+2] 1,3-Dipolar Cycloaddition of Azomethine Ylide with Malonates

(2015) Li Dai et al.   ChemCatChem

The asymmetric synthesis of CF3-containing spiro[pyrrolidin-3,2′-oxindole] through the organocatalytic 1,3-dipolar cycloaddition reaction

(2015) Mingxia Ma et al.   CHEMICAL COMMUNICATIONS

Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Takuya Hashimoto et al.   CHEMICAL REVIEWS

Catalytic Aerobic Oxidation and Tandem Enantioselective Cycloaddition in Cascade Multicomponent Synthesis

(2015) Marco Potowski et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Selective Copper-Catalyzed Asymmetric [3+2] Cycloaddition of Azomethine Ylides with Acyclic 1,3-Dienes

(2015) María González-Esguevillas et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Progress toward the Introduction of Functionalized Difluoromethylated Building Blocks onto C(sp2) and C(sp) Centers

(2015) Marie-Charlotte Belhomme et al.   CHEMISTRY-A EUROPEAN JOURNAL

Privileged Structures Meet Human T-Cell Leukemia Virus-1 (HTLV-1): C2-Symmetric 3,4-Disubstituted Pyrrolidines as Nonpeptidic HTLV-1 Protease Inhibitors

(2015) Maren Kuhnert et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Small 3-Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry

(2015) Indrawan McAlpine et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Highly Functionalized Chiral Benzopyrano[3,4-c]pyrrolidines Bearing Five Contiguous Stereogenic Centers

(2015) Toru Sato et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereo- and Enantioselective Construction of 3,3′-Pyrrolidinyldispirooxindole Framework via Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Wei Dai et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Construction of 3,4-Diamino Pyrrolidines via Chiral N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with β-Phthalimidonitroethene

(2015) Fu-Sheng He et al.   ORGANIC LETTERS

Brucine Diol–Copper-Catalyzed Asymmetric Synthesis of endo-Pyrrolidines: The Mechanistic Dichotomy of Imino Esters

(2015) Jian-Yuan Li et al.   ORGANIC LETTERS

Asymmetric Construction of Spirocyclic Pyrrolidine-thia(oxa)zolidinediones via N,O-Ligand/Cu(I) Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with 5-Alkylidene Thia(oxa)zolidine-2,4-diones

(2015) Wu-Lin Yang et al.   ORGANIC LETTERS

Silver(I)–Ferrophox Catalyzed Enantioselective Desymmetrization of Cyclopentenedione: Synthesis of Highly Substituted Bicyclic Pyrrolidines

(2015) Tapas Das et al.   ORGANIC LETTERS

Enantioselective Synthesis of exo-4-Nitroprolinates from Nitro­alkenes and Azomethine Ylides Catalyzed by Chiral Phosphor­amidite·Silver(I) or Copper(II) Complexes

(2015) José Sansano et al.   SYNTHESIS-STUTTGART

Aromatic-Amide-Derived Nonbiaryl Atropisomer as Highly Efficient Ligand for Asymmetric Silver-Catalyzed [3 + 2] Cycloaddition

(2015) Xing-Feng Bai et al.   ACS Catalysis

Efficient Diastereo- and Enantioselective Synthesis ofexo-Nitroprolinates by 1,3-Dipolar Cycloadditions Catalyzed by Chiral Phosphoramidite⋅Silver(I) Complexes

(2014) Luis M. Castelló et al.   ADVANCED SYNTHESIS & CATALYSIS

PyBidine-Cu(OTf)2-Catalyzed Asymmetric [3+2] Cycloaddition with Imino Esters: Harmony of Cu-Lewis Acid and Imidazolidine-NH Hydrogen Bonding in Concerto Catalysis

(2014) Takayoshi Arai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides

(2014) Javier Adrio et al.   CHEMICAL COMMUNICATIONS

Trisubstituted 2-Trifluoromethyl Pyrrolidines via Catalytic Asymmetric Michael Addition/Reductive Cyclization

(2014) Michael T. Corbett et al.   ORGANIC LETTERS

Enantioselective Synthesis of α-Heteroarylpyrrolidines by Copper-Catalyzed 1,3-Dipolar Cycloaddition of α-Silylimines

(2014) Ana Pascual-Escudero et al.   ORGANIC LETTERS

Cu(I)-Catalyzed Highly Enantioselective [3 + 3] Cycloaddition between Two Different 1,3-Dipoles, Phthalazinium Dicyanomethanides and Iminoester-Derived Azomethine Ylides

(2014) Chunhao Yuan et al.   ORGANIC LETTERS

Construction of Optically Active Quaternary Propargyl Amines by Highly Enantioselective Zinc/BINOL-Catalyzed Alkynylation of Ketoimines

(2013) Gaochao Huang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Stereoselective Synthesis of Trifluoromethyl Analogues of Polyhydroxypyrrolidines

(2013) Rama K. Khangarot et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis and Use of a Trifluoromethylated Azomethine Ylide Precursor

(2012) Gaël Tran et al.   JOURNAL OF ORGANIC CHEMISTRY

A New Reagent for Direct Difluoromethylation

(2012) Yuta Fujiwara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Serine-Proline Turn: A Novel Hydrogen-Bonded Template for Designing Peptidomimetics

(2012) Benben Song et al.   ORGANIC LETTERS

Diastereoselective Synthesis of CF3-Substituted, Epoxide-Fused Heterocycles with β-(Trifluoromethyl)vinylsulfonium Salts

(2012) Sven P. Fritz et al.   ORGANIC LETTERS

Cu(I)/DTBM-BIPHEP-catalyzed exo-selective 1,3-dipolar cycloaddition of azomethine ylides with cis-trifluorocrotonate for asymmetric construction of trifluoromethylated pyrrolidines

(2012) Qing-Hua Li et al.   TETRAHEDRON LETTERS

Asymmetric construction of trifluoromethylated pyrrolidines via Cu(i)-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with 4,4,4-trifluorocrotonates

(2011) Qing-Hua Li et al.   CHEMICAL COMMUNICATIONS

Novel dipolarophiles and dipoles in the metal-catalyzed enantioselective 1,3-dipolar cycloaddition of azomethine ylides

(2011) Javier Adrio et al.   CHEMICAL COMMUNICATIONS

(5S)-5-(Trifluoromethyl)pyrrolidin-2-one as a Promising Building Block for Fluoroorganic Chemistry

(2011) Andrii V. Bezdudny et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

(2011) Stephen D. Roughley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Validation of a β-Turn Mimetic Library Targeting Protein–Protein and Peptide–Receptor Interactions

(2011) Landon R. Whitby et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of 2-Trifluoromethyl-1,3-oxazolidines as Hydrolytically Stable Pseudoprolines

(2010) Grégory Chaume et al.   JOURNAL OF ORGANIC CHEMISTRY

N-(2-Pyridylmethyl)imines as Azomethine Precursors in Catalytic Asymmetric [3 + 2] Cycloadditions

(2010) Silvia Padilla et al.   ORGANIC LETTERS

Enantioselective Copper-Catalyzed 1,3-Dipolar Cycloadditions

(2008) Levi M. Stanley et al.   CHEMICAL REVIEWS

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS

Indolizidine and quinolizidine alkaloids

(2007) Joseph P. Michael   NATURAL PRODUCT REPORTS