Article
Cell Biology
Ping Han, Yu Lei, Jingmei Liu, Jiqiao Liu, Huanjun Huang, Dean Tian, Wei Yan
Summary: The suppression of BVES in HCC enhances tumor cell extrusion, thus promoting HCC metastasis. This study contributes to a more comprehensive understanding of tumor metastasis and provides clues for developing novel HCC therapy strategies.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Yanhong Wang, Na Li, Yanping Zheng, Anqing Wang, Chunlei Yu, Zhenbo Song, Shuyue Wang, Ying Sun, Lihua Zheng, Guannan Wang, Lei Liu, Jingwen Yi, Yanxin Huang, Muqing Zhang, Yongli Bao, Luguo Sun
Summary: KIAA1217 plays a crucial role in hepatocellular carcinoma (HCC) metastasis by promoting cell migration and invasion through inducing epithelial-mesenchymal transition (EMT), and activating JAK1/2 and STAT3. It interacts with the Notch and Wnt/β-catenin pathways to facilitate HCC metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yang-ling Li, Man-man Zhang, Lin-wen Wu, Ye-han Liu, Zuo-yan Zhang, Ling-hui Zeng, Neng-ming Lin, Chong Zhang
Summary: The study found that DYRK1A is upregulated in HCC tissues, promoting invasion and migration abilities of HCC cells, and is associated with poor prognosis in patients. DYRK1A enhances HCC cell metastasis by promoting epithelial-mesenchymal transition (EMT) and interacting with components of the TGF-beta/SMAD and STAT3 signaling pathways.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Juan Kong, Di Li, Shidong Zhang, Huixia Zhang, Yuanyuan Fu, Bo Qian, Chunhua Bei, Shengkui Tan, Xiaonian Zhu
Summary: Okadaic acid (OA) has been found to promote the epithelial-mesenchymal transition (EMT) process of hepatocellular carcinoma cells, enhancing their invasion and migration abilities while decreasing the activity of protein phosphatase 2A (PP2A). This indicates that OA plays a role in promoting metastasis of HCC.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Yun Liang, Xiao Chen, Zhu Tao, Meng Ma, Dickson Adah, Xiaofen Li, Lingling Dai, Wenting Ding, Songwe Fanuel, Siting Zhao, Li Qin, Xiaoping Chen, Xiaowen Zhang
Summary: The study found that Plasmodium infection significantly suppressed the progression, recurrence, and metastasis of HCC in two mouse models. Additionally, Plasmodium infection inhibited EMT by downregulating CCR10-mediated PI3K/Akt/GSK-3 beta/Snail signaling pathway, thus preventing tumor recurrence and metastasis.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cell Biology
Fei Ling, Huan Zhang, Yunliang Sun, Jinyi Meng, Jaceline Gislaine Pires Sanches, He Huang, Qingqing Zhang, Xiao Yu, Bo Wang, Li Hou, Jun Zhang
Summary: The study found that the interaction between ANXA7 and SRI regulates EMT and affects migration, invasion, and proliferation in HCC cells, ultimately promoting aggressiveness in HCC. This provides a novel potential therapeutic target for preventing recurrence and metastasis in HCC.
CELL DEATH & DISEASE
(2021)
Article
Biotechnology & Applied Microbiology
Huiming Zhang, Shuang Liu, Liqiang Chen, Yanliang Sheng, Wenzhe Luo, Gang Zhao
Summary: miR-509-3p inhibits the proliferation, migration, invasion, and EMT of HCC cells by negatively regulating Twist, thereby suppressing HCC development and metastasis.
Review
Biochemistry & Molecular Biology
Sharad Khare, Tripti Khare, Raghu Ramanathan, Jamal A. Ibdah
Summary: This review discusses the role and involvement of microRNAs (miRs) in the heterogeneity and metastasis of hepatocellular carcinoma, with a special emphasis on their potential as diagnostic and prognostic tools in the risk prediction, early detection, and treatment of hepatocellular carcinoma.
Article
Environmental Sciences
Bisha Ding, Weiyang Lou, Weimin Fan, Jie Pan
Summary: The study found that miR-374c-5p was downregulated in HCC and associated with favorable prognosis. Exosomes derived from BMSCs could deliver miR-374c-5p and suppress migration, invasion, and proliferation of HCC cells. Additionally, miR-374c-5p inhibited EMT by targeting the LIMK1-Wnt/β-catenin axis. These findings suggest that miR-374c-5p could serve as a potential target for HCC treatment.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Medicine, Research & Experimental
Enjun Lv, Jiaqi Sheng, Chengpeng Yu, Dean Rao, Wenjie Huang
Summary: Long noncoding RNAs (lncRNAs) have gained widespread attention as new and crucial molecules involved in biological function regulation, particularly in tumor metastasis such as hepatocellular carcinoma; despite the incomplete understanding of their mechanisms, lncRNAs have been shown to be closely associated with various stages of tumor growth, invasion, and metastasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Weiyingqi Cui, Aravindh Subramani, Pedro Fonseca, Yumeng Zhang, Le Tong, Yuanyuan Zhang, Lars Egevad, Andreas Lundqvist, Lars Holmgren
Summary: Preserving an accurate cell count is crucial for maintaining homeostasis. Apical extrusion, a process in which redundant cells are eliminated by neighboring cells, plays a key role in this regard. Recent studies have revealed that apical extrusion can also be triggered in cells transformed by oncogenes, suggesting it may be a mechanism through which tumor cells escape their microenvironment.
Review
Immunology
Defa Huang, Dingyu Rao, Qing Jin, Mi Lai, Jiali Zhang, Zhonghong Lai, Haibin Shen, Tianyu Zhong
Summary: Hepatocellular carcinoma (HCC) is a common liver cancer with a poor prognosis. CD147, a glycoprotein, plays a crucial role in HCC invasion, metastasis, and angiogenesis. This review discusses the molecular structure of CD147 and its potential as a diagnostic and therapeutic target for HCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Zixin Wu, Guishuai Lv, Fuxue Xing, Wei Xiang, Yue Ma, Qiyu Feng, Wen Yang, Hongyang Wang
Summary: Copper is a crucial cofactor that plays a dual role in promoting and inhibiting tumor development. Imbalanced copper homeostasis can have detrimental effects on the liver, especially in hepatocellular carcinoma (HCC), a highly aggressive and difficult-to-treat liver cancer. This review discusses the molecular mechanisms of copper in HCC pathogenesis, progression, and potential therapeutics, introducing the concepts of cuproplasia and cuproptosis.
Review
Cell Biology
Shiwen Ma, Yao Mawulikplimi Adzavon, Xiaohu Wen, Pengxiang Zhao, Fei Xie, Mengyu Liu, Xuemei Ma
Summary: Ferroptosis is a newly defined programmed cell death process that differs from other types of programmed cell death. It can be regulated by antioxidants and iron-chelating agents, and it affects cancer progression by influencing iron ion deposition and lipid peroxidation. Significant progress has been made in understanding the molecular mechanism of ferroptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xinyang Hu, Shijin Yuan, Sining Zhou, Ting Sun, Chaoqun Wang, Shilong Ying, Heping Zhu, Jingfeng Luo, Hongchuan Jin, Yiming Liu
Summary: This study found that GP73 interacts with vimentin, promoting the dephosphorylation of vimentin at S56 by PP1A, and facilitating vimentin polymerization, which prevents vimentin degradation via the TRIM56-mediated ubiquitin/proteasome pathway. Clinical trials demonstrated that the 5-hydroxytryptamine receptor agonist Clomipramine can inhibit GP73-mediated vimentin polymerization, effectively suppressing metastasis of HCC with high GP73 expression. This study reveals the process of GP73-mediated vimentin polymerization and provides Clomipramine as a potential drug targeting vimentin in metastatic HCC patients with high sGP73 levels.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Xiangming Ding, Dongxiao Li, Mengke Li, Han Wang, Qin He, Yunwu Wang, Hongbing Yu, Dean Tian, Qin Yu
LABORATORY INVESTIGATION
(2018)
Article
Biochemistry & Molecular Biology
Gang Chi, Xin-Xia Feng, Ying-Xia Ru, Ting Xiong, Yuan Gao, Han Wang, Zhen-Long Luo, Ran Mo, Fang Guo, Yong-Pei He, Gui-Mei Zhang, De-An Tian, Zuo-Hua Feng
MOLECULAR IMMUNOLOGY
(2018)
Article
Immunology
Xin-Xia Feng, Gang Chi, Han Wang, Yuan Gao, Qian Chen, Ying-Xia Ru, Zhen-Long Luo, Wei Yan, Pei-Yuan Li, Mei Liu, Zuo-Hua Feng, De-An Tian
INTERNATIONAL IMMUNOPHARMACOLOGY
(2019)
Article
Oncology
Han Wang, Xinxia Feng, Ping Han, Yu Lei, Yujia Xia, Dean Tian, Wei Yan
MOLECULAR MEDICINE REPORTS
(2019)
Article
Medicine, Research & Experimental
Han Wang, Wei Yan, Zuohua Feng, Yuan Gao, Liu Zhang, Xinxia Feng, Dean Tian
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Ran Mo, Xin-Xia Feng, Ya-Nan Wu, Han Wang, Yong-Pei He, Huan-Huan Sun, Fang Guo, Qian Chen, Wei Yan, Pei-Yuan Li, Mei Liu, Gui-Mei Zhang, De-An Tian, Zuo-Hua Feng
MOLECULAR IMMUNOLOGY
(2020)
Article
Oncology
Yujia Xia, Jiayi He, Hongji Zhang, Han Wang, George Tetz, Casey A. Maguire, Yu Wang, Amblessed Onuma, Dmitry Genkin, Victor Tetz, Alexey Stepanov, Stanislav Terekhov, Valeria Ukrainskaya, Hai Huang, Allan Tsung
MOLECULAR ONCOLOGY
(2020)
Review
Immunology
Han Wang, Xinxia Feng, Wei Yan, Dean Tian
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Gastroenterology & Hepatology
Han Wang, Hongji Zhang, Yu Wang, Zachary J. Brown, Yujia Xia, Zheng Huang, Chengli Shen, Zhiwei Hu, Joal Beane, Ephraim A. Ansa-Addo, Hai Huang, Dean Tian, Allan Tsung
Summary: The study shows an increased number of Tregs in NASH-HCC, and depleting Tregs can inhibit the initiation and progression of HCC. There is a positive correlation between increased NETs and hepatic Tregs levels, and NETs promote Treg activity through metabolic reprogramming, linking innate and adaptive immunity. Therapies targeting NETs and Treg interactions may offer a potential strategy for preventing HCC in NASH patients.
JOURNAL OF HEPATOLOGY
(2021)
Article
Oncology
Lili Li, Yujia Xia, Xiaoyu Ji, Han Wang, Zerui Zhang, Panpan Lu, Qiang Ding, Deqiong Wang, Mei Liu
Summary: This study found that MIG/CXCL9 plays an important role in the Treg/Th17 imbalance in MAFLD, as inhibiting MIG/CXCL9 can alleviate MASH and increase the Treg/Th17 ratio. MIG/CXCL9 promotes Th17 cell proliferation and affects the status of Treg and Th17 cells by modulating the JNK signaling pathway.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Hongji Zhang, Yu Wang, Amblessed Onuma, Jiayi He, Han Wang, Yujia Xia, Rhea Lal, Xiang Cheng, Gyulnara Kasumova, Zhiwei Hu, Meihong Deng, Joal D. Beane, Alex C. Kim, Hai Huang, Allan Tsung
Summary: Despite significant advances in immune checkpoint blockade therapy for advanced cancer, targeting the tumor immune microenvironment remains a critical approach to improve efficacy. Combination therapy using DNase I and PD-1 antibody shows superior efficacy over single-agent treatment in colorectal cancer. The resistance to anti-PD-1 blockade can be reversed by targeting neutrophil extracellular traps with DNase I, indicating a novel strategy for overcoming immunotherapy resistance in advanced cancer.
Article
Oncology
Yu Lei, Ping Han, Yu Chen, Han Wang, Shuhui Wang, Muru Wang, Jingmei Liu, Wei Yan, Dean Tian, Mei Liu
Summary: PRMT3 is upregulated in HCC, and its overexpression promotes HCC cell proliferation, glycolysis, and tumor growth. PRMT3 interacts with LDHA and mediates ADMA modification at the R112 site.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Hongji Zhang, Tianmeng Chen, Jinghua Ren, Yujia Xia, Amblessed Onuma, Yu Wang, Jiayi He, Junru Wu, Han Wang, Ahmad Hamad, Chengli Shen, Jinxiang Zhang, John M. Asara, Gregory K. Behbehani, Haitao Wen, Meihong Deng, Allan Tsung, Hai Huang
Summary: The research demonstrates that pre-operative exercise protects against liver injury by driving Kupffer cells towards an anti-inflammatory phenotype through itaconate metabolism.