SLC26A3 (DRA) prevents TNF-alpha-induced barrier dysfunction and dextran sulfate sodium-induced acute colitis

Activation of Nuclear Factor−κB by Tumor Necrosis Factor in Intestinal Epithelial Cells and Mouse Intestinal Epithelia Reduces Expression of the Chloride Transporter SLC26A3

(2017) Anoop Kumar et al.   GASTROENTEROLOGY

SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms

(2016) Y. D. Bhutia et al.   BIOCHEMICAL JOURNAL

Neutralization of IL-6 and TNF-α ameliorates intestinal permeability in DSS-induced colitis

(2016) Yong-Tao Xiao et al.   CYTOKINE

ZO-1 interactions with F-actin and occludin direct epithelial polarization and single lumen specification in 3D culture

(2016) Matthew A. Odenwald et al.   JOURNAL OF CELL SCIENCE

Claudins and barrier dysfunction in intestinal inflammation: cause or consequence?

(2015) Alastair J M Watson   GUT

Mechanisms Underlying Dysregulation of Electrolyte Absorption in Inflammatory Bowel Disease–Associated Diarrhea

(2015) Shubha Priyamvada et al.   INFLAMMATORY BOWEL DISEASES

PHD3 Stabilizes the Tight Junction Protein Occludin and Protects Intestinal Epithelial Barrier Function

(2015) Ying Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microangiopathy triggers and inducible nitric oxide synthase exacerbates dextran sulfate sodium-induced colitis

(2015) Hiroki Saijo et al.   LABORATORY INVESTIGATION

Recombinant human MFG-E8 ameliorates colon damage in DSS- and TNBS-induced colitis in mice

(2015) Yinzhong Zhang et al.   LABORATORY INVESTIGATION

Claudin-related intestinal diseases

(2015) Christian Barmeyer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

HCO3−secretion by SLC26A3 and mucosal defence in the colon

(2014) H. Ishiguro   Acta Physiologica

Multifunctional Activity of a Small Tellurium Redox Immunomodulator Compound, AS101, on Dextran Sodium Sulfate-induced Murine Colitis

(2014) Gilad Halpert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for a causal link between adaptor protein PDZK1 downregulation and Na+/H+ exchanger NHE3 dysfunction in human and murine colitis

(2014) Sunil Yeruva et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Slc26a3 deficiency is associated with loss of colonic HCO3−secretion, absence of a firm mucus layer and barrier impairment in mice

(2013) F. Xiao et al.   Acta Physiologica

Adalimumab prevents barrier dysfunction and antagonizes distinct effects of TNF-α on tight junction proteins and signaling pathways in intestinal epithelial cells

(2013) Andreas Fischer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Locally injected Infliximab ameliorates murine DSS colitis: Differences in serum and intestinal levels of drug between healthy and colitic mice

(2013) Loris Riccardo Lopetuso et al.   DIGESTIVE AND LIVER DISEASE

Increased Epithelial Permeability Is the Primary Cause for Bicarbonate Loss in Inflamed Murine Colon

(2013) Marina Juric et al.   INFLAMMATORY BOWEL DISEASES

The distinct roles of anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1) in fluid and electrolyte absorption in the murine small intestine

(2013) Weiliang Xia et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Central Role of the Gut Epithelial Barrier in the Pathogenesis of Chronic Intestinal Inflammation: Lessons Learned from Animal Models and Human Genetics

(2013) Luca Pastorelli et al.   Frontiers in Immunology

Role of NF-κB in epithelial biology

(2012) Manolis Pasparakis   IMMUNOLOGICAL REVIEWS

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Loss of downregulated in adenoma (DRA) impairs mucosal HCO3− secretion in murine ileocolonic inflammation

(2011) Fang Xiao et al.   INFLAMMATORY BOWEL DISEASES

A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice

(2011) Tohru Funakoshi et al.   Journal of Crohns & Colitis

Functional activity of Pat-1 (Slc26a6) Cl−/HCO3− exchange in the lower villus epithelium of murine duodenum

(2010) N. M. Walker et al.   Acta Physiologica

Segregation of Na/H exchanger-3 and Cl/HCO3 exchanger SLC26A3 (DRA) in rodent cecum and colon

(2010) Colleen Talbot et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

New therapeutic targets in ulcerative colitis: The importance of ion transporters in the human colon

(2010) Klaudia Farkas et al.   INFLAMMATORY BOWEL DISEASES

Balsalazine decreases intestinal mucosal permeability of dextran sulfate sodium-induced colitis in mice

(2009) Xiao-chang Liu et al.   ACTA PHARMACOLOGICA SINICA

Mechanisms of transcriptional modulation of the human anion exchanger SLC26A3 gene expression by IFN-γ

(2009) Seema Saksena et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Roles of ZO-1 and ZO-2 in Establishment of the Belt-like Adherens and Tight Junctions with Paracellular Permselective Barrier Function

(2009) Sachiko Tsukita et al.   Annals of the New York Academy of Sciences

Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse

(2008) M C Arrieta et al.   GUT

Distinct Cytokine Patterns Identified from Multiplex Profiles of Murine DSS and TNBS-Induced Colitis

(2008) Philip Alex et al.   INFLAMMATORY BOWEL DISEASES