Comparing the Metabolic Capabilities of Bacteria in the Mycobacterium tuberculosis Complex

Pathology and molecular epidemiology of Mycobacterium pinnipedii tuberculosis in native New Zealand marine mammals

(2019) Wendi D. Roe et al.   PLoS One

Comprehensive Comparative Analysis of Cholesterol Catabolic Genes/Proteins in Mycobacterial Species

(2019) Rochelle van Wyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The genetic requirements of fatty acid import by Mycobacterium tuberculosis within macrophages

(2019) Evgeniya V Nazarova et al.   eLife

Macrophages and lipid metabolism

(2018) Anneleen Remmerie et al.   CELLULAR IMMUNOLOGY

Unexpected genomic and phenotypic diversity of Mycobacterium africanum Lineage 5 affects drug resistance, protein secretion and immunogenicity

(2018) Louis S Ates et al.   Genome Biology and Evolution

Growth ofMycobacterium tuberculosisin vivo segregates with host macrophage metabolism and ontogeny

(2018) Lu Huang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cholesterol and fatty acids grease the wheels of Mycobacterium tuberculosis pathogenesis

(2018) Kaley M Wilburn et al.   Pathogens and Disease

Tuberculosis and the art of macrophage manipulation

(2018) S Upadhyay et al.   Pathogens and Disease

Alveolar Macrophages Provide an Early Mycobacterium tuberculosis Niche and Initiate Dissemination

(2018) Sara B. Cohen et al.   Cell Host & Microbe

Mononuclear cell dynamics in M. tuberculosis infection provide opportunities for therapeutic intervention

(2018) Brian A. Norris et al.   PLoS Pathogens

Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells

(2018) Bum-Ho Bin et al.   Journal of Immunology Research

Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages

(2017) C.J. Cambier et al.   IMMUNITY

Mycobacterium tuberculosis : Rewiring host cell signaling to promote infection

(2017) Michael D. Stutz et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pathology and genetic findings in a rare case of Mycobacterium caprae infection in a sow

(2017) Benedetta Amato et al.   VETERINARY MICROBIOLOGY

Pathology of the Emerging Mycobacterium tuberculosis Complex Pathogen, Mycobacterium mungi, in the Banded Mongoose (Mungos mungo)

(2017) Kathleen A. Alexander et al.   VETERINARY PATHOLOGY

The Cell Wall Lipid PDIM Contributes to Phagosomal Escape and Host Cell Exit of Mycobacterium tuberculosis

(2017) Jeff Quigley et al.   mBio

Lactate oxidation facilitates growth of Mycobacterium tuberculosis in human macrophages

(2017) Sandra Billig et al.   Scientific Reports

Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation

(2017) Florence Levillain et al.   PLoS Pathogens

Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence

(2017) Amy K. Barczak et al.   PLoS Pathogens

Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis

(2017) Evgeniya V Nazarova et al.   eLife

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

CsoR Is Essential for Maintaining Copper Homeostasis in Mycobacterium tuberculosis

(2016) Sarah A. Marcus et al.   PLoS One

Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria

(2016) Eva C. Boritsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuberculosis Caused by Mycobacterium orygis in Dairy Cattle and Captured Monkeys in Bangladesh: a New Scenario of Tuberculosis in South Asia

(2016) Z. Rahim et al.   Transboundary and Emerging Diseases

Delineation of Steroid-Degrading Microorganisms through Comparative Genomic Analysis

(2016) Lee H. Bergstrand et al.   mBio

Whole Genome Sequencing of Mycobacterium africanum Strains from Mali Provides Insights into the Mechanisms of Geographic Restriction

(2016) Kathryn Winglee et al.   PLoS Neglected Tropical Diseases

Within Host Evolution Selects for a Dominant Genotype of Mycobacterium tuberculosis while T Cells Increase Pathogen Genetic Diversity

(2016) Richard Copin et al.   PLoS Pathogens

Macrophage form, function, and phenotype in mycobacterial infection: lessons from tuberculosis and other diseases

(2016) Colleen M. McClean et al.   Pathogens and Disease

Tuberculosis

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M. tuberculosis T Cell Epitope Analysis Reveals Paucity of Antigenic Variation and Identifies Rare Variable TB Antigens

(2015) Mireia Coscolla et al.   Cell Host & Microbe

Characterization of ThreeMycobacteriumspp. with Potential Use in Bioremediation by Genome Sequencing and Comparative Genomics

(2015) Sarbashis Das et al.   Genome Biology and Evolution

Mycobacteria, metals, and the macrophage

(2015) Olivier Neyrolles et al.   IMMUNOLOGICAL REVIEWS

The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens

(2015) Karrera Y. Djoko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Amino acid auxotrophy as a system of immunological control nodes

(2015) Peter J Murray   NATURE IMMUNOLOGY

A bug’s life in the granuloma

(2015) Constance J. Martin et al.   Seminars in Immunopathology

Whole genome sequence analysis of Mycobacterium suricattae

(2015) Anzaan Dippenaar et al.   TUBERCULOSIS

Iron acquisition strategies in mycobacteria

(2015) Zhuo Fang et al.   TUBERCULOSIS

Evolutionary Landscape of the Mycobacterium tuberculosis Complex from the Viewpoint of PhoPR: Implications for Virulence Regulation and Application to Vaccine Development

(2015) Esther Broset et al.   mBio

Mycolic Acids: Structures, Biosynthesis, and Beyond

(2014) Hedia Marrakchi et al.   CHEMISTRY & BIOLOGY

Biosynthesis of mycobacterial lipids by polyketide synthases and beyond

(2014) Luis E. N. Quadri   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Pathogen roid rage: Cholesterol utilization byMycobacterium tuberculosis

(2014) Matthew F. Wipperman et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Amino acid capture and utilization within theMycobacterium tuberculosisphagosome

(2014) Alexandre Gouzy et al.   Future Microbiology

Mycobacterium tuberculosis Strains Lacking Surface Lipid Phthiocerol Dimycocerosate Are Susceptible to Killing by an Early Innate Host Response

(2014) Tracey A. Day et al.   INFECTION AND IMMUNITY

bis-Molybdopterin Guanine Dinucleotide Is Required for Persistence of Mycobacterium tuberculosis in Guinea Pigs

(2014) Monique J. Williams et al.   INFECTION AND IMMUNITY

Slow growth ofMycobacterium tuberculosisat acidic pH is regulated byphoPRand host-associated carbon sources

(2014) Jacob J. Baker et al.   MOLECULAR MICROBIOLOGY

A glimpse into the past and predictions for the future: the molecular evolution of the tuberculosis agent

(2014) Eva C. Boritsch et al.   MOLECULAR MICROBIOLOGY

Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival ofMycobacterium tuberculosison fatty acids

(2014) Hyungjin Eoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator

(2014) J. Gonzalo-Asensio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Triosephosphate Isomerase Is Dispensable In Vitro yet Essential for Mycobacterium tuberculosis To Establish Infection

(2014) C. Trujillo et al.   mBio

Role of Endosomes and Lysosomes in Human Disease

(2014) F. R. Maxfield   Cold Spring Harbor Perspectives in Biology

Mycobacterium tuberculosis Exploits Asparagine to Assimilate Nitrogen and Resist Acid Stress during Infection

(2014) Alexandre Gouzy et al.   PLoS Pathogens

The Immune Response in Tuberculosis

(2013) Anne O'Garra et al.   Annual Review of Immunology

Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing

(2013) Yanjia J. Zhang et al.   CELL

13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosis

(2013) Dany J.V. Beste et al.   CHEMISTRY & BIOLOGY

Molybdenum cofactor: A key component ofMycobacterium tuberculosispathogenesis?

(2013) Monique Williams et al.   CRITICAL REVIEWS IN MICROBIOLOGY

The evolutionary pressures that have molded Mycobacterium tuberculosis into an infectious adjuvant

(2013) David G Russell   CURRENT OPINION IN MICROBIOLOGY

The Intracellular Environment of Human Macrophages That Produce Nitric Oxide Promotes Growth of Mycobacteria

(2013) Joo-Yong Jung et al.   INFECTION AND IMMUNITY

IntracellularMycobacterium tuberculosisExploits Host-derived Fatty Acids to Limit Metabolic Stress

(2013) Wonsik Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism and Regulation of Mycobactin Fatty Acyl-AMP Ligase FadD33

(2013) Olivia Vergnolle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Molybdenum Cofactor

(2013) Ralf R. Mendel   JOURNAL OF BIOLOGICAL CHEMISTRY

Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms

(2013) J. T. Mattila et al.   JOURNAL OF IMMUNOLOGY

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids

(2013) C. J. Cambier et al.   NATURE

Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate

(2013) Alexandre Gouzy et al.   Nature Chemical Biology

Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression

(2013) A. Cunningham-Bussel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacterium microti Tuberculosis in Its Maintenance Host, the Field Vole (Microtus agrestis)

(2013) A. Kipar et al.   VETERINARY PATHOLOGY

A vitamin B12 transporter in Mycobacterium tuberculosis

(2013) K. Gopinath et al.   Open Biology

Correction: The Role of Selection in Shaping Diversity of Natural M. tuberculosis Populations

(2013) Caitlin S. Pepperell et al.   PLoS Pathogens

Glucose Phosphorylation Is Required for Mycobacterium tuberculosis Persistence in Mice

(2013) Joeli Marrero et al.   PLoS Pathogens

Vitamin B12 absorption: Mammalian physiology and acquired and inherited disorders

(2012) Renata Kozyraki et al.   BIOCHIMIE

Comparative analysis of mycobacterium and related actinomycetes yields insight into the evolution of mycobacterium tuberculosis pathogenesis

(2012) Abigail McGuire et al.   BMC GENOMICS

Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations

(2012) Jennifer E. Griffin et al.   CHEMISTRY & BIOLOGY

M. tuberculosis Induces Potent Activation of IDO-1, but This Is Not Essential for the Immunological Control of Infection

(2012) Antje Blumenthal et al.   PLoS One

Linking the Transcriptional Profiles and the Physiological States of Mycobacterium tuberculosis during an Extended Intracellular Infection

(2012) Kyle H. Rohde et al.   PLoS Pathogens

Adventures in Rhodococcus — from steroids to explosivesThis article is based on a presentation by Dr. Lindsay Eltis at the 60th Annual Meeting of the Canadian Society of Microbiologists in Hamilton, Ontario, 14  June 2010. Dr. Eltis was the recipient of the 2010 Norgen Biotek Corporation / CSM Award, an annual award sponsored by Norgen Biotek and the Canadian Society of Microbiologists intended to recognize outstanding scientific work in microbiology by a Canadian researcher.

(2011) Katherine C. Yam et al.   CANADIAN JOURNAL OF MICROBIOLOGY

Mycobacterial P1-Type ATPases Mediate Resistance to Zinc Poisoning in Human Macrophages

(2011) Hélène Botella et al.   Cell Host & Microbe

Spontaneous Phthiocerol Dimycocerosate-Deficient Variants of Mycobacterium tuberculosis Are Susceptible to Gamma Interferon-Mediated Immunity

(2011) Meghan A. Kirksey et al.   INFECTION AND IMMUNITY

Mammalian cell entry gene family of Mycobacterium tuberculosis

(2011) Fan Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

aprABC: a Mycobacterium tuberculosis complex-specific locus that modulates pH-driven adaptation to the macrophage phagosome

(2011) Robert B. Abramovitch et al.   MOLECULAR MICROBIOLOGY

Discovery and characterization of a unique mycobacterial heme acquisition system

(2011) M. V. Tullius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper resistance is essential for virulence of Mycobacterium tuberculosis

(2011) F. Wolschendorf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier

(2011) Kyu Y. Rhee et al.   TRENDS IN MICROBIOLOGY

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

(2011) Jennifer E. Griffin et al.   PLoS Pathogens

Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages

(2011) Jaiyanth Daniel et al.   PLoS Pathogens

Mycobacterium tuberculosis Wears What It Eats

(2010) David G. Russell et al.   Cell Host & Microbe

Metabolomics of Mycobacterium tuberculosis Reveals Compartmentalized Co-Catabolism of Carbon Substrates

(2010) Luiz Pedro S. de Carvalho et al.   CHEMISTRY & BIOLOGY

Functional Analysis of Molybdopterin Biosynthesis in Mycobacteria Identifies a Fused Molybdopterin Synthase in Mycobacterium tuberculosis

(2010) M. J. Williams et al.   JOURNAL OF BACTERIOLOGY

Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved

(2010) Iñaki Comas et al.   NATURE GENETICS

Nitrate Respiration Protects Hypoxic Mycobacterium tuberculosis Against Acid- and Reactive Nitrogen Species Stresses

(2010) Mai Ping Tan et al.   PLoS One

Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

(2010) J. Marrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacterium africanum—Review of an Important Cause of Human Tuberculosis in West Africa

(2010) Bouke C. de Jong et al.   PLoS Neglected Tropical Diseases

Functional Genetic Diversity among Mycobacterium tuberculosis Complex Clinical Isolates: Delineation of Conserved Core and Lineage-Specific Transcriptomes during Intracellular Survival

(2010) Susanne Homolka et al.   PLoS Pathogens

Cholesterol Metabolism Increases the Metabolic Pool of Propionate inMycobacterium tuberculosis

(2009) Xinxin Yang et al.   BIOCHEMISTRY

Phylogenetic detection of horizontal gene transfer during the step-wise genesis of Mycobacterium tuberculosis

(2009) Frédéric Veyrier et al.   BMC EVOLUTIONARY BIOLOGY

A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity

(2009) Carine White et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione Provides a Source of Cysteine Essential for Intracellular Multiplication of Francisella tularensis

(2009) Khaled Alkhuder et al.   PLoS Pathogens

Phthiocerol Dimycocerosates of M. tuberculosis Participate in Macrophage Invasion by Inducing Changes in the Organization of Plasma Membrane Lipids

(2009) Catherine Astarie-Dequeker et al.   PLoS Pathogens

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

(2008) T. P. Stinear et al.   GENOME RESEARCH

Functional Characterization of a Vitamin B12-Dependent Methylmalonyl Pathway in Mycobacterium tuberculosis: Implications for Propionate Metabolism during Growth on Fatty Acids

(2008) S. Savvi et al.   JOURNAL OF BACTERIOLOGY

Deciphering the Genetic Bases of the Structural Diversity of Phenolic Glycolipids in Strains of theMycobacterium tuberculosisComplex

(2008) Wladimir Malaga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathology of Mycobacterium bovis Infection in Wild Meerkats (Suricata suricatta)

(2008) J.A. Drewe et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Identification of a copper-binding metallothionein in pathogenic mycobacteria

(2008) Ben Gold et al.   Nature Chemical Biology

Control of M. tuberculosis ESAT-6 Secretion and Specific T Cell Recognition by PhoP

(2008) Wafa Frigui et al.   PLoS Pathogens

Mycobacterial persistence requires the utilization of host cholesterol

(2008) A. K. Pandey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacterium pinnipedii: Transmission from South American sea lion (Otaria byronia) to Bactrian camel (Camelus bactrianus bactrianus) and Malayan tapirs (Tapirus indicus)

(2007) I. Moser et al.   VETERINARY MICROBIOLOGY