A bug’s life in the granuloma

Stress and Host Immunity Amplify Mycobacterium tuberculosis Phenotypic Heterogeneity and Induce Nongrowing Metabolically Active Forms

(2015) Giulia Manina et al.   Cell Host & Microbe

The Oxidative Stress Network of Mycobacterium tuberculosis Reveals Coordination between Radical Detoxification Systems

(2015) Subhalaxmi Nambi et al.   Cell Host & Microbe

DNA methylation in bacteria: from the methyl group to the methylome

(2015) María A Sánchez-Romero et al.   CURRENT OPINION IN MICROBIOLOGY

B cells and antibodies in the defense againstMycobacterium tuberculosisinfection

(2015) Jacqueline M. Achkar et al.   IMMUNOLOGICAL REVIEWS

The Extracellular Matrix Regulates Granuloma Necrosis in Tuberculosis

(2015) Basim Al Shammari et al.   JOURNAL OF INFECTIOUS DISEASES

The association between sterilizing activity and drug distribution into tuberculosis lesions

(2015) Brendan Prideaux et al.   NATURE MEDICINE

Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery

(2015) Meenal Datta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variability in Tuberculosis Granuloma T Cell Responses Exists, but a Balance of Pro- and Anti-inflammatory Cytokines Is Associated with Sterilization

(2015) Hannah Priyadarshini Gideon et al.   PLoS Pathogens

Macrophage Polarization Drives Granuloma Outcome during Mycobacterium tuberculosis Infection

(2014) Simeone Marino et al.   INFECTION AND IMMUNITY

Mycobacterium tuberculosis Keto-Mycolic Acid and Macrophage Nuclear Receptor TR4 Modulate Foamy Biogenesis in Granulomas: A Case of a Heterologous and Noncanonical Ligand-Receptor Pair

(2014) H. K. Dkhar et al.   JOURNAL OF IMMUNOLOGY

Interception of host angiogenic signalling limits mycobacterial growth

(2014) Stefan H. Oehlers et al.   NATURE

In search of a new paradigm for protective immunity to TB

(2014) Cláudio Nunes-Alves et al.   NATURE REVIEWS MICROBIOLOGY

Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival ofMycobacterium tuberculosison fatty acids

(2014) Hyungjin Eoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing

(2013) Yanjia J. Zhang et al.   CELL

IntracellularMycobacterium tuberculosisExploits Host-derived Fatty Acids to Limit Metabolic Stress

(2013) Wonsik Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Programmed Heterogeneity: Epigenetic Mechanisms in Bacteria

(2013) Josep Casadesús et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms

(2013) J. T. Mattila et al.   JOURNAL OF IMMUNOLOGY

Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans

(2013) Iñaki Comas et al.   NATURE GENETICS

A conserved human T cell population targets mycobacterial antigens presented by CD1b

(2013) Ildiko Van Rhijn et al.   NATURE IMMUNOLOGY

Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing

(2013) Philana Ling Lin et al.   NATURE MEDICINE

Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression

(2013) A. Cunningham-Bussel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis

(2013) P. Rath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Methylation Impacts Gene Expression and Ensures Hypoxic Survival of Mycobacterium tuberculosis

(2013) Scarlet S. Shell et al.   PLoS Pathogens

Nutritional immunity: transition metals at the pathogen–host interface

(2012) M. Indriati Hood et al.   NATURE REVIEWS MICROBIOLOGY

Resistance mechanisms of Mycobacterium tuberculosis against phagosomal copper overload

(2012) Jennifer L. Rowland et al.   TUBERCULOSIS

Mycobacterial P1-Type ATPases Mediate Resistance to Zinc Poisoning in Human Macrophages

(2011) Hélène Botella et al.   Cell Host & Microbe

MMP-1 drives immunopathology in human tuberculosis and transgenic mice

(2011) Paul Elkington et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomes Released from M.tuberculosis Infected Cells Can Suppress IFN-γ Mediated Activation of Naïve Macrophages

(2011) Prachi P. Singh et al.   PLoS One

Asymmetry and Aging of Mycobacterial Cells Lead to Variable Growth and Antibiotic Susceptibility

(2011) B. B. Aldridge et al.   SCIENCE

Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism

(2010) Mi-Jeong Kim et al.   EMBO Molecular Medicine

Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model

(2009) P. L. Lin et al.   INFECTION AND IMMUNITY

The Mycobacterium tuberculosis DosR Regulon Assists in Metabolic Homeostasis and Enables Rapid Recovery from Nonrespiring Dormancy

(2009) R. L. Leistikow et al.   JOURNAL OF BACTERIOLOGY

Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium

(2009) H. E. Volkman et al.   SCIENCE

Mycobacterium tuberculosis WhiB3 Maintains Redox Homeostasis by Regulating Virulence Lipid Anabolism to Modulate Macrophage Response

(2009) Amit Singh et al.   PLoS Pathogens

Bistability, Epigenetics, and Bet-Hedging in Bacteria

(2008) Jan-Willem Veening et al.   Annual Review of Microbiology

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

(2008) L. E. Via et al.   INFECTION AND IMMUNITY

Nutrient acquisition by mycobacteria

(2008) M. Niederweis   MICROBIOLOGY-SGM

Positive Feedback and Noise Activate the Stringent Response Regulator Rel in Mycobacteria

(2008) Kamakshi Sureka et al.   PLoS One

Mycobacterial persistence requires the utilization of host cholesterol

(2008) A. K. Pandey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

(2008) Pascale Peyron et al.   PLoS Pathogens