Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis

Network-pharmacology-based identification of caveolin-1 as a key target of Oldenlandia diffusa to suppress breast cancer metastasis

(2019) Bowen Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Caveolin-1 enhances metastasis formation in a human model of embryonal rhabdomyosarcoma through Erk signaling cooperation

(2019) Silvia Codenotti et al.   CANCER LETTERS

Tubeimoside V sensitizes human triple negative breast cancer MDA-MB-231 cells to anoikis via regulating caveolin-1-related signaling pathways

(2018) Ke Wang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mechanism of recipient cell-dependent differences in exosome uptake

(2018) Sayo Horibe et al.   BMC CANCER

New Technologies for Analysis of Extracellular Vesicles

(2018) Huilin Shao et al.   CHEMICAL REVIEWS

Caveolin-1 regulates autophagy activity in thyroid follicular cells and is involved in Hashimoto’s thyroiditis disease

(2018) Qingyan Lu et al.   ENDOCRINE JOURNAL

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling

(2018) Frederik Johannes Verweij et al.   JOURNAL OF CELL BIOLOGY

Extracellular vesicles released by herpes simplex virus 1 infected cells block virus replication in recipient cells in a STING-dependent manner.

(2018) Thibaut Deschamps et al.   JOURNAL OF VIROLOGY

Size matters in nanoscale communication

(2018) Andries Zijlstra et al.   NATURE CELL BIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes

(2018) Luisa Statello et al.   PLoS One

CD36-triggered cell invasion and persistent tissue colonization by tumor microvesicles during metastasis

(2018) Susanne Pfeiler et al.   FASEB JOURNAL

Shear stress promotes anoikis resistance of cancer cells via caveolin-1-dependent extrinsic and intrinsic apoptotic pathways

(2018) Shun Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metabolic reprogramming of stromal fibroblasts by melanoma exosome microRNA favours a pre-metastatic microenvironment

(2018) Shin La Shu et al.   Scientific Reports

Interplay between Membrane Curvature and Cholesterol: Role of Palmitoylated Caveolin-1

(2018) Anjali Krishna et al.   BIOPHYSICAL JOURNAL

An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

(2018) Clair Crewe et al.   CELL

Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast cancer cell lines

(2018) America Campos et al.   Nanomedicine

Enhanced expression of caveolin-1 possesses diagnostic and prognostic value and promotes cell migration, invasion and sunitinib resistance in the clear cell renal cell carcinoma

(2017) HaiLong Ruan et al.   EXPERIMENTAL CELL RESEARCH

Inverse expression of caveolin-1 and EGFR in thyroid cancer patients

(2017) Jelena Janković et al.   HUMAN PATHOLOGY

Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis

(2017) Helena Costa Verdera et al.   JOURNAL OF CONTROLLED RELEASE

The metastatic suppressor NDRG1 inhibits EMT, migration and invasion through interaction and promotion of caveolin-1 ubiquitylation in human colorectal cancer cells

(2017) L Mi et al.   ONCOGENE

Caveolin-1 is Markedly Downregulated in Patients with Early-Stage Colorectal Cancer

(2017) Blanca Torrejón et al.   WORLD JOURNAL OF SURGERY

Multicomponent analysis of the tumour microenvironment reveals low CD8 T cell number, low stromal caveolin-1 and high tenascin-C and their combination as significant prognostic markers in non-small cell lung cancer

(2017) David Onion et al.   Oncotarget

Caveolin-1-mediated STAT3 activation determines electrotaxis of human lung cancer cells

(2017) Li Li et al.   Oncotarget

Exosomes in bile as potential pancreatobiliary tumor biomarkers

(2017) Alfredo I. Sagredo et al.   Translational Cancer Research

Macrophage migration inhibitory factor promotes breast cancer metastasis via activation of HMGB1/TLR4/NF kappa B axis

(2016) Wei Lv et al.   CANCER LETTERS

Mechanisms through Which Hypoxia-Induced Caveolin-1 Drives Tumorigenesis and Metastasis in Hepatocellular Carcinoma

(2016) Xiaowen Mao et al.   CANCER RESEARCH

PIKfyve inhibition increases exosome release and induces secretory autophagy

(2016) Nina Pettersen Hessvik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Analysis of caveolin-1 and phosphoinositol-3 kinase expression in primary uveal melanomas

(2016) Miriam Stenzel et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

The Ankrd13 Family of Ubiquitin-interacting Motif-bearing Proteins Regulates Valosin-containing Protein/p97 Protein-mediated Lysosomal Trafficking of Caveolin 1

(2016) Daocharad Burana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

(2016) Wolf Heusermann et al.   JOURNAL OF CELL BIOLOGY

Exosome-Mediated Metastasis: From Epithelial–Mesenchymal Transition to Escape from Immunosurveillance

(2016) Nicholas Syn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Caveolin-1 promotes tumor growth and metastasis via autophagy inhibition in hepatocellular carcinoma

(2016) Wei-Ren Liu et al.   Clinics and Research in Hepatology and Gastroenterology

Barriers to horizontal cell transformation by extracellular vesicles containing oncogenic H-ras

(2016) Tae Hoon Lee et al.   Oncotarget

The matricellular protein CYR61 promotes breast cancer lung metastasis by facilitating tumor cell extravasation and suppressing anoikis

(2016) Yu-Ting Huang et al.   Oncotarget

Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway

(2016) Laura Lagares-Tena et al.   Oncotarget

Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis

(2016) Rina Ortiz et al.   Oncotarget

S100A9 expressed in ER−PgR− breast cancers induces inflammatory cytokines and is associated with an impaired overall survival

(2015) Caroline Bergenfelz et al.   BRITISH JOURNAL OF CANCER

Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs

(2015) Mian He et al.   CARCINOGENESIS

Caveolin-1 Mediates Inflammatory Breast Cancer Cell Invasion via the Akt1 Pathway and RhoC GTPase

(2015) Madhura Joglekar et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Expression of caveolin-1 is correlated with lung adenocarcinoma proliferation, migration, and invasion

(2015) Tian-Yan Luan et al.   MEDICAL ONCOLOGY

Caveolin-1 is Associated with Tumor Progression and Confers a Multi-Modality Resistance Phenotype in Pancreatic Cancer

(2015) Moumita Chatterjee et al.   Scientific Reports

Exosomes Released from Breast Cancer Carcinomas Stimulate Cell Movement

(2015) Dinari A. Harris et al.   PLoS One

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Interactions of caveolin-1 scaffolding and intramembrane regions containing a CRAC motif with cholesterol in lipid bilayers

(2014) Guanhua Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Probing the U-Shaped Conformation of Caveolin-1 in a Bilayer

(2014) Huan Rui et al.   BIOPHYSICAL JOURNAL

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

(2014) Sonia A. Melo et al.   CANCER CELL

Caveolin-1 in Cell Migration and Metastasis

(2014) S. Nunez-Wehinger et al.   CURRENT MOLECULAR MEDICINE

Regulation of exosome release by glycosphingolipids and flotillins

(2014) Santosh Phuyal et al.   FEBS Journal

Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion

(2014) J. Diaz et al.   JOURNAL OF CELL SCIENCE

Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models

(2014) Lorena Lobos-Gonzalez et al.   MELANOMA RESEARCH

Caveolin-1 regulates metastatic behaviors of anoikis resistant lung cancer cells

(2014) Pithi Chanvorachote et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription

(2014) Jaime G Fernández et al.   Molecular Cancer

Caveolin 1 knockdown inhibits the proliferation, migration and invasion of human breast cancer BT474 cells

(2014) RUI WANG et al.   Molecular Medicine Reports

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Caveolin-1 Is Up-Regulated by GLI1 and Contributes to GLI1-Driven EMT in Hepatocellular Carcinoma

(2014) Xiaohong Gai et al.   PLoS One

Cyr61/CTGF/Nov family proteins in gastric carcinogenesis

(2014) Tsu-Yao Cheng   WORLD JOURNAL OF GASTROENTEROLOGY

Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide

(2013) Kevin Quann et al.   CELL CYCLE

The Caveolin-1 Connection to Cell Death and Survival

(2013) A. G. Quest et al.   CURRENT MOLECULAR MEDICINE

Ubiquitination of the N-terminal Region of Caveolin-1 Regulates Endosomal Sorting by the VCP/p97 AAA-ATPase

(2013) Philipp Kirchner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Caveolin-1 as a promoter of tumour spreading: when, how, where and why

(2013) Rebecca Senetta et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exosomes in tumor microenvironment influence cancer progression and metastasis

(2013) Christoph Kahlert et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Exosomes Derived from Epstein-Barr Virus-Infected Cells Are Internalized via Caveola-Dependent Endocytosis and Promote Phenotypic Modulation in Target Cells

(2013) A. Nanbo et al.   JOURNAL OF VIROLOGY

Biochemical and biological characterization of exosomes containing prominin-1/CD133

(2013) Germana Rappa et al.   Molecular Cancer

E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells

(2013) Lorena Lobos-González et al.   Pigment Cell & Melanoma Research

RAC1P29S is a spontaneously activating cancer-associated GTPase

(2013) M. J. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

(2013) P. Kucharzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

(2013) Taketoshi Kajimoto et al.   Nature Communications

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Caveolin-1 Protects B6129 Mice against Helicobacter pylori Gastritis

(2013) Ivana Hitkova et al.   PLoS Pathogens

Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing

(2013) Piroon Jenjaroenpun et al.   PeerJ

Large Oncosomes in Human Prostate Cancer Tissues and in the Circulation of Mice with Metastatic Disease

(2012) Dolores Di Vizio et al.   AMERICAN JOURNAL OF PATHOLOGY

Caveolin-1 Increases Aerobic Glycolysis in Colorectal Cancers by Stimulating HMGA1-MediatedGLUT3Transcription

(2012) Tae-Kyu Ha et al.   CANCER RESEARCH

Multiparametric image analysis reveals role of Caveolin1 in endosomal progression rather than internalization of EGFR

(2012) Hannah Schmidt-Glenewinkel et al.   FEBS LETTERS

Caveolin targeting to late endosome/lysosomal membranes is induced by perturbations of lysosomal pH and cholesterol content

(2012) Dorothy I. Mundy et al.   MOLECULAR BIOLOGY OF THE CELL

Caveolin-1-Enhanced Motility and Focal Adhesion Turnover Require Tyrosine-14 but Not Accumulation to the Rear in Metastatic Cancer Cells

(2012) Hery Urra et al.   PLoS One

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

A Novel FoxM1-Caveolin Signaling Pathway Promotes Pancreatic Cancer Invasion and Metastasis

(2011) C. Huang et al.   CANCER RESEARCH

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Caveolin-1 Deficiency Causes Cholesterol-Dependent Mitochondrial Dysfunction and Apoptotic Susceptibility

(2011) Marta Bosch et al.   CURRENT BIOLOGY

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Caveolin-1, cellular senescence and age-related diseases

(2011) Huafei Zou et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations

(2011) Danilo Ritz et al.   NATURE CELL BIOLOGY

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

Mitochondrial Cholesterol: A Connection Between Caveolin, Metabolism, and Disease

(2011) Marta Bosch et al.   TRAFFIC

Src and Caveolin-1 Reciprocally Regulate Metastasis via a Common Downstream Signaling Pathway in Bladder Cancer

(2010) S. Thomas et al.   CANCER RESEARCH

Caveolin-1 mutants P132L and Y14F are dominant negative regulators of invasion, migration and aggregation in H1299 lung cancer cells

(2010) Maria Shatz et al.   EXPERIMENTAL CELL RESEARCH

Revisiting caveolin trafficking: the end of the caveosome: Figure 1.

(2010) Robert G. Parton et al.   JOURNAL OF CELL BIOLOGY

Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation

(2010) Arnold Hayer et al.   JOURNAL OF CELL BIOLOGY

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

(2010) Arthit Chairoungdua et al.   JOURNAL OF CELL BIOLOGY

Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy

(2010) Tian Tian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages

(2009) C. Barres et al.   BLOOD

Caveolin-1 tumor-promoting role in human melanoma

(2009) Federica Felicetti et al.   INTERNATIONAL JOURNAL OF CANCER

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caveolae Mediate Growth Factor-induced Disassembly of Adherens Junctions to Support Tumor Cell Dissociation

(2009) Lidiya Orlichenko et al.   MOLECULAR BIOLOGY OF THE CELL

Caveolin-1–mediated Suppression of Cyclooxygenase-2 via a β-catenin-Tcf/Lef–dependent Transcriptional Mechanism Reduced Prostaglandin E2 Production and Survivin Expression

(2009) Diego A. Rodriguez et al.   MOLECULAR BIOLOGY OF THE CELL

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients

(2009) Mariantonia Logozzi et al.   PLoS One

Identification of extracellular δ-catenin accumulation for prostate cancer detection

(2009) Qun Lu et al.   PROSTATE

MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell-Induced Exosomes Via Distinct Multivesicular Body Pathways

(2009) Sonja I. Buschow et al.   TRAFFIC

Phosphorylated Caveolin-1 Regulates Rho/ROCK-Dependent Focal Adhesion Dynamics and Tumor Cell Migration and Invasion

(2008) B. Joshi et al.   CANCER RESEARCH

PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and Function

(2008) Michelle M. Hill et al.   CELL

Caveolin-1 in cell polarization and directional migration

(2008) A GRANDEGARCIA et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Caveolin-1 regulates the secretion and cytoprotection of Cyr61 in hyperoxic cell death

(2008) Yang Jin et al.   FASEB JOURNAL

Caveolin-1 Up-regulation during Epithelial to Mesenchymal Transition Is Mediated by Focal Adhesion Kinase

(2008) Kelly M. Bailey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1

(2008) Jacky G. Goetz et al.   JOURNAL OF CELL BIOLOGY

Caveolin-1-dependent  1 integrin endocytosis is a critical regulator of fibronectin turnover

(2008) F. Shi et al.   JOURNAL OF CELL SCIENCE

Caveolin-1: an ambiguous partner in cell signalling and cancer

(2008) Andrew F. G. Quest et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Identification of VEGF-regulated genes associated with increased lung metastatic potential: functional involvement of tenascin-C in tumor growth and lung metastasis

(2008) A Calvo et al.   ONCOGENE

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

The CCN family of proteins: structure–function relationships

(2008) Kenneth P. Holbourn et al.   TRENDS IN BIOCHEMICAL SCIENCES