A broad analysis of resistance development in the malaria parasite

High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission

(2016) David M. Plouffe et al.   Cell Host & Microbe

Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

(2015)   LANCET

Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay

(2015) María Linares et al.   MALARIA JOURNAL

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs

(2015) Jonathan D. Herman et al.   Science Translational Medicine

Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials

(2014) Erika L. Flannery et al.   ACS Chemical Biology

KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission

(2014) Kelli L. Kuhen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of pathogen genomic variants through an integrated pipeline

(2014) Micah J Manary et al.   BMC BIOINFORMATICS

In VitroResistance Selections forPlasmodium falciparumDihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Growth

(2014) Leila S. Ross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diversity-Oriented Synthesis Probe TargetsPlasmodium falciparumCytochrome b Ubiquinone Reduction Site and Synergizes With Oxidation Site Inhibitors

(2014) Amanda K. Lukens et al.   JOURNAL OF INFECTIOUS DISEASES

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dihydroartemisinin–Piperaquine Failure in Cambodia

(2014) David L. Saunders et al.   NEW ENGLAND JOURNAL OF MEDICINE

Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance

(2014) A. K. Lukens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance ofPlasmodium

(2014) María Belén Jiménez-Díaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antimalarial drug discovery — approaches and progress towards new medicines

(2013) Erika L. Flannery et al.   NATURE REVIEWS MICROBIOLOGY

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

(2013) Thomas Spangenberg et al.   PLoS One

Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families

(2013) Selina E. R. Bopp et al.   PLoS Genetics

P. falciparum In Vitro Killing Rates Allow to Discriminate between Different Antimalarial Mode-of-Action

(2012) Laura M. Sanz et al.   PLoS One

Identification and Validation of Tetracyclic Benzothiazepines as Plasmodium falciparum Cytochrome bc1 Inhibitors

(2011) Carolyn K. Dong et al.   CHEMISTRY & BIOLOGY

Extended-Connectivity Fingerprints

(2010) David Rogers et al.   Journal of Chemical Information and Modeling

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE

In silicoactivity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

(2008) David Plouffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA