Dicarbonyl Stress at the Crossroads of Healthy and Unhealthy Aging

Methylglyoxal down-regulates the expression of cell cycle associated genes and activates the p53 pathway in human umbilical vein endothelial cells

(2019) Jana D. Braun et al.   Scientific Reports

Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.

(2019) Hainan Li et al.   DIABETES

The receptor for advanced glycation end-products (RAGE) is an important pattern recognition receptor (PRR) for inflammaging

(2019) Thibault Teissier et al.   BIOGERONTOLOGY

The deglycase activity of DJ-1 mitigates α-synuclein glycation and aggregation in dopaminergic cells: Role of oxidative stress mediated downregulation of DJ-1 in Parkinson's disease

(2019) Neelam Sharma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications

(2019) Michele Longo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-Inflammatory Effect of an Apigenin-Maillard Reaction Product in Macrophages and Macrophage-Endothelial Cocultures

(2019) Qian Zhou et al.   Oxidative Medicine and Cellular Longevity

ReactELISA method for quantifying methylglyoxal levels in plasma and cell cultures

(2019) Rasmus Kold-Christensen et al.   Redox Biology

Dicarbonyl stress and glyoxalase enzyme system regulation in human skeletal muscle

(2018) Jacob T. Mey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Glyoxalase 1 Modulation in Obesity and Diabetes

(2018) Naila Rabbani et al.   ANTIOXIDANTS & REDOX SIGNALING

Phytochemicals-induced hormesis protects Caenorhabditis elegans against α-synuclein protein aggregation and stress through modulating HSF-1 and SKN-1/Nrf2 signaling pathways

(2018) Shanmugam Govindan et al.   BIOMEDICINE & PHARMACOTHERAPY

Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis

(2018) Meenakshi Ravichandran et al.   Cell Metabolism

Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes

(2018) Alexandra Moraru et al.   Cell Metabolism

Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease and Mortality in Individuals With Type 2 Diabetes

(2018) Nordin M.J. Hanssen et al.   DIABETES CARE

Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases

(2018) Minee L. Choi et al.   FEBS Journal

Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts

(2018) Kerstin Nowotny et al.   FREE RADICAL BIOLOGY AND MEDICINE

ADAPTIVE HOMEOSTASIS AND THE FREE RADICAL THEORY OF AGEING

(2018) Laura C.D. Pomatto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effects of piceatannol on methylglyoxal-induced cytotoxicity in MC3T3-E1 osteoblastic cells

(2018) Kwang Sik Suh et al.   FREE RADICAL RESEARCH

miR-214-Dependent Increase of PHLPP2 Levels Mediates the Impairment of Insulin-Stimulated Akt Activation in Mouse Aortic Endothelial Cells Exposed to Methylglyoxal

(2018) Cecilia Nigro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

(2018) Darren J. Baker et al.   JOURNAL OF CLINICAL INVESTIGATION

Advanced glycation end products in the pathogenesis of chronic kidney disease

(2018) Naila Rabbani et al.   KIDNEY INTERNATIONAL

Methylglyoxal-derived stress: An emerging biological factor involved in the onset and progression of cancer

(2018) Akeila Bellahcène et al.   SEMINARS IN CANCER BIOLOGY

Trans -resveratrol mitigates type 1 diabetes-induced oxidative DNA damage and accumulation of advanced glycation end products in glomeruli and tubules of rat kidneys

(2018) Heba Al-Hussaini et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oxidative Stress, Apoptosis, and Mitochondrial Function in Diabetic Nephropathy

(2018) Sonia Sifuentes-Franco et al.   International Journal of Endocrinology

Pterostilbene inhibited advanced glycation end products (AGEs)-induced oxidative stress and inflammation by regulation of RAGE/MAPK/NF-κB in RAW264.7 cells

(2018) Wenzhe Yu et al.   Journal of Functional Foods

Novel Facial Cream Containing Carnosine Inhibits Formation of Advanced Glycation End-Products in Human Skin

(2018) Mridvika Narda et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Methylglyoxal accumulation de-regulates HoxA5 expression, thereby impairing angiogenesis in glyoxalase 1 knock-down mouse aortic endothelial cells

(2018) Cecilia Nigro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Methylglyoxal induces retinopathy-type lesions in the absence of hyperglycemia: studies in a rat model

(2018) Andrea Schlotterer et al.   FASEB JOURNAL

Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases

(2018) Hao Chi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

(2018) Bee Ling Tan et al.   Frontiers in Pharmacology

Elevated levels of α-dicarbonyl compounds in the plasma of type II diabetics and their relevance with diabetic nephropathy

(2018) Xin-Jie Wang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

All-Trans Retinoic Acid supplementation prevents cardiac fibrosis and cytokines induced by Methylglyoxal

(2017) Umadevi Subramanian et al.   GLYCOCONJUGATE JOURNAL

Increased Dicarbonyl Stress as a Novel Mechanism of Multi-Organ Failure in Critical Illness

(2017) Bas van Bussel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intracellular Accumulation of Methylglyoxal by Glyoxalase 1 Knock Down Alters Collagen Homoeostasis in L6 Myoblasts

(2017) Bernd Stratmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Methylglyoxal-Glyoxalase 1 Balance: The Root of Vascular Damage

(2017) Cecilia Nigro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Global proteomic analysis of advanced glycation end products in theArabidopsisproteome provides evidence for age-related glycation hot spots

(2017) Tatiana Bilova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dicarbonyls induce senescence of human vascular endothelial cells

(2017) Alexander Navarrete Santos et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Hormetic modulation of hepatic insulin sensitivity by advanced glycation end products

(2017) Nelly T. Fabre et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Comparative Examination of Temporal Glyoxalase 1 Variations Following Perforant Pathway Transection, Excitotoxicity, and Controlled Cortical Impact Injury

(2017) Philipp Pieroh et al.   NEUROTOXICITY RESEARCH

Impact of Atherosclerosis- and Diabetes-Related Dicarbonyls on Vascular Endothelial Permeability: A Comparative Assessment

(2017) Mikhail V. Samsonov et al.   Oxidative Medicine and Cellular Longevity

Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance

(2017) Tiago Rodrigues et al.   Scientific Reports

Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux

(2017) Johanna Zemva et al.   Redox Biology

Vascular dysfunction: At the heart of cardiovascular disease, cognitive impairment and depressive symptoms

(2017) T.T. van Sloten   Artery Research

Flavonoid Enhances the Glyoxalase Pathway in Cerebellar Neurons to Retain Cellular Functions

(2017) Joel Frandsen et al.   Scientific Reports

The glycation of fibronectin by glycolaldehyde and methylglyoxal as a model for aging in Bruch’s membrane

(2016) Mai T. Thao et al.   AMINO ACIDS

Pathologic endoplasmic reticulum stress induced by glucotoxic insults inhibits adipocyte differentiation and induces an inflammatory phenotype

(2016) Michele Longo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments

(2016) N. Rabbani et al.   CLINICAL SCIENCE

Methylglyoxal-Induced Endothelial Cell Loss and Inflammation Contribute to the Development of Diabetic Cardiomyopathy

(2016) Branka Vulesevic et al.   DIABETES

Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation

(2016) Mingzhan Xue et al.   DIABETES

Energy restriction and Roux-en-Y gastric bypass reduce postprandial α-dicarbonyl stress in obese women with type 2 diabetes

(2016) Dionne E. Maessen et al.   DIABETOLOGIA

Methylglyoxal treatment in lactating mothers leads to type 2 diabetes phenotype in male rat offspring at adulthood

(2016) Flávio Andrade Francisco et al.   EUROPEAN JOURNAL OF NUTRITION

Dicarbonyl Stress Mimics Diabetic Neurovascular Damage in the Retina

(2016) M. Kolibabka et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics

(2016) Naila Rabbani et al.   GLYCOCONJUGATE JOURNAL

Glyoxalase-1 overexpression partially prevents diabetes-induced impaired arteriogenesis in a rat hindlimb ligation model

(2016) Olaf Brouwers et al.   GLYCOCONJUGATE JOURNAL

Dicarbonyl stress in clinical obesity

(2016) Jinit Masania et al.   GLYCOCONJUGATE JOURNAL

Protective effect of cyanidin against glucose- and methylglyoxal-induced protein glycation and oxidative DNA damage

(2016) Tanyawan Suantawee et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Methylglyoxal induces cell death through endoplasmic reticulum stress-associated ROS production and mitochondrial dysfunction

(2016) Chi-Ming Chan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease

(2016) Manuela Pennisi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Ferulic acid prevents methylglyoxal-induced protein glycation, DNA damage, and apoptosis in pancreatic β-cells

(2016) Weerachat Sompong et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Reduced glyoxalase 1 activity in carotid artery plaques of nondiabetic patients with increased hemoglobin A1c level

(2016) Andreas S. Peters et al.   JOURNAL OF VASCULAR SURGERY

Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

(2016)   LANCET

Methylglyoxal in Metabolic Disorders: Facts, Myths, and Promises

(2016) Paulo Matafome et al.   MEDICINAL RESEARCH REVIEWS

Methylglyoxal Impairs Insulin Secretion of Pancreaticβ-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs

(2016) Jinshuang Bo et al.   Journal of Diabetes Research

Inflammaging: disturbed interplay between autophagy and inflammasomes

(2016) Antero Salminen et al.   Aging-US

The SUR2B subunit of rat vascular KATP channel is targeted by miR-9a-3p induced by prolonged exposure to methylglyoxal

(2015) Shan-Shan Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Frequency Modulated Translocational Oscillations of Nrf2 Mediate the Antioxidant Response Element Cytoprotective Transcriptional Response

(2015) Mingzhan Xue et al.   ANTIOXIDANTS & REDOX SIGNALING

Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease

(2015) Naila Rabbani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Isoferulic acid prevents methylglyoxal-induced protein glycation and DNA damage by free radical scavenging activity

(2015) Aramsri Meeprom et al.   BMC Complementary and Alternative Medicine

Glycation and Hypoxia: Two Key Factors for Adipose Tissue Dysfunction

(2015) Paulo Matafome et al.   CURRENT MEDICINAL CHEMISTRY

The advanced glycation end product methylglyoxal-derived hydroimidazolone-1 and early signs of atherosclerosis in childhood diabetes

(2015) Martin Heier et al.   Diabetes & Vascular Disease Research

HORMESIS: A Fundamental Concept with Widespread Biological and Biomedical Applications

(2015) Edward J. Calabrese et al.   GERONTOLOGY

Elevated Serum Advanced Glycation Endproducts in Obese Indicate Risk for the Metabolic Syndrome: A Link Between Healthy and Unhealthy Obesity?

(2015) Jaime Uribarri et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effect of diet-derived advanced glycation end products on inflammation

(2015) Nicole J. Kellow et al.   NUTRITION REVIEWS

Methylglyoxal, a reactive glucose metabolite, enhances autophagy flux and suppresses proliferation of human retinal pigment epithelial ARPE-19 cells

(2015) Yo-Chen Chang et al.   TOXICOLOGY IN VITRO

Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo

(2015) An-Sheng Cheng et al.   Nutrients

Increased DNA Dicarbonyl Glycation and Oxidation Markers in Patients with Type 2 Diabetes and Link to Diabetic Nephropathy

(2015) Sahar Waris et al.   Journal of Diabetes Research

The Possible Mechanism of Advanced Glycation End Products (AGEs) for Alzheimer’s Disease

(2015) Shun-Yao Ko et al.   PLoS One

Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation

(2014) Airi Jo-Watanabe et al.   AGING CELL

Methylglyoxal, a Reactive Glucose Metabolite, Increases Renin Angiotensin Aldosterone and Blood Pressure in Male Sprague-Dawley Rats

(2014) Indu Dhar et al.   AMERICAN JOURNAL OF HYPERTENSION

Assay of methylglyoxal-derived protein and nucleotide AGEs

(2014) Naila Rabbani et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dicarbonyl proteome and genome damage in metabolic and vascular disease

(2014) Naila Rabbani et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

(2014) Yun Sok Lee et al.   CELL

Dicarbonyl Stress and Atherosclerosis: Is It All RAGE?

(2014) Ranganath Muniyappa et al.   DIABETES

Dicarbonyl Stress in the Absence of Hyperglycemia Increases Endothelial Inflammation and Atherogenesis Similar to That Observed in Diabetes

(2014) Chris Tikellis et al.   DIABETES

High Tissue Glucose Alters Intersomitic Blood Vessels in Zebrafish via Methylglyoxal Targeting the VEGF Receptor Signaling Cascade

(2014) Kristina Jörgens et al.   DIABETES

Methylglyoxal impairs endothelial insulin sensitivity both in vitro and in vivo

(2014) Cecilia Nigro et al.   DIABETOLOGIA

Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

(2014) Michael Ristow et al.   Dose-Response

Endothelial Dysfunction Plays a Key Role in Increasing Cardiovascular Risk in Type 2 Diabetes

(2014) Thomas T. van Sloten et al.   HYPERTENSION

Temporal Dynamics of Glyoxalase 1 in Secondary Neuronal Injury

(2014) Philipp Pieroh et al.   PLoS One

Resveratrol attenuates methylglyoxal-induced mitochondrial dysfunction and apoptosis by Sestrin2 induction

(2014) Kyuhwa Seo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Acute Exposure to a Precursor of Advanced Glycation End Products Induces a Dual Effect on the Rat Pancreatic Islet Function

(2014) Ghada Elmhiri et al.   International Journal of Endocrinology

Increased plasma levels of the methylglyoxal in patients with newly diagnosed type 2 diabetes 初诊2型糖尿病患者血浆甲基乙二醛水平升高

(2014) Xiang Kong et al.   Journal of Diabetes

Arginine-directed glycation and decreased HDL plasma concentration and functionality

(2014) L Godfrey et al.   Nutrition & Diabetes

Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

(2014) Ville-Petteri Mäkinen et al.   PLoS Genetics

Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival

(2014) Y. Toyoda et al.   Biology Open

Acute exposure of methylglyoxal leads to activation of KATP channels expressed in HEK293 cells

(2013) Yang Yang et al.   ACTA PHARMACOLOGICA SINICA

Oxidative damage of DNA induced by the reaction of methylglyoxal with lysine in the presence of ferritin

(2013) Sung Ho An et al.   BMB Reports

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Increased circulating advanced glycation endproducts (AGEs) in acute trauma patients

(2013) Carl I. Schulman et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Knockdown of Glyoxalase 1 Mimics Diabetic Nephropathy in Nondiabetic Mice

(2013) F. Giacco et al.   DIABETES

Early Progression of Diabetic Nephropathy Correlates With Methylglyoxal-Derived Advanced Glycation End Products

(2013) P. J. Beisswenger et al.   DIABETES CARE

Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes

(2013) Olaf Brouwers et al.   DIABETOLOGIA

Higher levels of advanced glycation endproducts in human carotid atherosclerotic plaques are associated with a rupture-prone phenotype

(2013) Nordin M.J. Hanssen et al.   EUROPEAN HEART JOURNAL

Methylglyoxal induces oxidative stress and mitochondrial dysfunction in osteoblastic MC3T3-E1 cells

(2013) K. S. Suh et al.   FREE RADICAL RESEARCH

Methylglyoxal Impairs GLUT4 Trafficking and Leads to Increased Glucose Uptake in L6 Myoblasts

(2013) B. Engelbrecht et al.   HORMONE AND METABOLIC RESEARCH

Metabolic Transit of Dietary Methylglyoxal

(2013) Julia Degen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Advanced glycation end products and diabetic nephropathy: a comparative study using diabetic and normal rats with methylglyoxal-induced glycation

(2013) Lisa Rodrigues et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Aβ-AGE aggravates cognitive deficit in rats via RAGE pathway

(2013) C. Chen et al.   NEUROSCIENCE

Glycation exacerbates the neuronal toxicity of β-amyloid

(2013) X-H Li et al.   Cell Death & Disease

Restoration of Glyoxalase Enzyme Activity Precludes Cognitive Dysfunction in a Mouse Model of Alzheimer’s Disease

(2012) Swati S. More et al.   ACS Chemical Neuroscience

HIF1  is required for survival maintenance of chronic myeloid leukemia stem cells

(2012) H. Zhang et al.   BLOOD

Accumulation of argpyrimidine, a methylglyoxal-derived advanced glycation end product, increases apoptosis of lens epithelial cells bothin vitroandin vivo

(2012) Junghyun Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Methylglyoxal induces hyperpermeability of the blood–retinal barrier via the loss of tight junction proteins and the activation of matrix metalloproteinases

(2012) Junghyun Kim et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Long-Term Methylglyoxal Treatment Causes Endothelial Dysfunction of Rat Isolated Mesenteric Artery

(2012) Masashi MUKOHDA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Methylglyoxal, Cognitive Function and Cerebral Atrophy in Older People

(2012) Velandai Srikanth et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Methylglyoxal promotes oxidative stress and endothelial dysfunction

(2012) Cristina M. Sena et al.   PHARMACOLOGICAL RESEARCH

Expression of Transient Receptor Potential Ankyrin 1 (TRPA1) and Its Role in Insulin Release from Rat Pancreatic Beta Cells

(2012) De-Shou Cao et al.   PLoS One

Angiogenesis Impairment in Diabetes: Role of Methylglyoxal-Induced Receptor for Advanced Glycation Endproducts, Autophagy and Vascular Endothelial Growth Factor Receptor 2

(2012) Hongtao Liu et al.   PLoS One

Methylglyoxal causes structural and functional alterations in adipose tissue independently of obesity

(2012) P. Matafome et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Glyoxalase I Retards Renal Senescence

(2011) Yoichiro Ikeda et al.   AMERICAN JOURNAL OF PATHOLOGY

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation

(2011) Mingzhan Xue et al.   BIOCHEMICAL JOURNAL

Aging and vascular endothelial function in humans

(2011) Douglas R. Seals et al.   CLINICAL SCIENCE

Glycation of LDL by Methylglyoxal Increases Arterial Atherogenicity: A Possible Contributor to Increased Risk of Cardiovascular Disease in Diabetes

(2011) N. Rabbani et al.   DIABETES

Chronic Methylglyoxal Infusion by Minipump Causes Pancreatic β-Cell Dysfunction and Induces Type 2 Diabetes in Sprague-Dawley Rats

(2011) Arti Dhar et al.   DIABETES

Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E

(2011) F. Fiory et al.   DIABETOLOGIA

Intracellular Glycation of Nuclear DNA, Mitochondrial DNA, and Cytosolic Proteins During Senescence-like Growth Arrest

(2011) Viola Breyer et al.   DNA AND CELL BIOLOGY

Occurrence and distribution of salsolinol-like compound, 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (ADTIQ) in Parkinsonian brains

(2011) Yulin Deng et al.   JOURNAL OF NEURAL TRANSMISSION

Role of the Glyoxalase System in Astrocyte-Mediated Neuroprotection

(2011) M. Belanger et al.   JOURNAL OF NEUROSCIENCE

Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals

(2011) Michal Schnaider Beeri et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Advanced glycation end product level, diabetes, and accelerated cognitive aging

(2011) K. Yaffe et al.   NEUROLOGY

Glyoxalase in ageing

(2011) Mingzhan Xue et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Protein homeostasis and aging: The importance of exquisite quality control

(2010) Hiroshi Koga et al.   AGEING RESEARCH REVIEWS

Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose

(2010) Arti Dhar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Oxidative stress and aging: Is methylglyoxal the hidden enemy?This review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Kaushik M. Desai et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Cytotoxic role of methylglyoxal in rat retinal pericytes: Involvement of a nuclear factor-kappaB and inducible nitric oxide synthase pathway

(2010) Junghyun Kim et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Increased Glycation and Oxidative Damage to Apolipoprotein B100 of LDL Cholesterol in Patients With Type 2 Diabetes and Effect of Metformin

(2010) N. Rabbani et al.   DIABETES

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

(2010) O. Brouwers et al.   DIABETOLOGIA

Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction

(2010) C. F. Bento et al.   EXPERIMENTAL PHYSIOLOGY

Advanced glycation end products enhance amyloid precursor protein expression by inducing reactive oxygen species

(2010) Shun-Yao Ko et al.   FREE RADICAL BIOLOGY AND MEDICINE

Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats

(2010) Olaf Brouwers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance

(2010) Paul J. Thornalley et al.   NUCLEIC ACIDS RESEARCH

Methylglyoxal Alters the Function and Stability of Critical Components of the Protein Quality Control

(2010) Carla Figueira Bento et al.   PLoS One

Aging, proteotoxicity, mitochondria, glycation, NAD+ and carnosine: possible inter-relationships and resolution of the oxygen paradox

(2010) Alan R. Hipkiss   Frontiers in Aging Neuroscience

Methylglyoxal induces cellular damage by increasing argpyrimidine accumulation and oxidative DNA damage in human lens epithelial cells

(2009) Junghyun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Methylglyoxal-induced mitochondrial dysfunction in vascular smooth muscle cells

(2009) Hui Wang et al.   BIOCHEMICAL PHARMACOLOGY

Hyperglycemia Impairs Proteasome Function by Methylglyoxal

(2009) M. A. Queisser et al.   DIABETES

Heat Shock Protein 27 Modification is Increased in the Human Diabetic Failing Heart

(2009) T. Gawlowski et al.   HORMONE AND METABOLIC RESEARCH

The sour side of neurodegenerative disorders: the effects of protein glycation

(2009) Hugo Vicente Miranda et al.   JOURNAL OF PATHOLOGY

Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone

(2008) Dag S. Fosmark et al.   ACTA OPHTHALMOLOGICA

Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans

(2008) Michael Morcos et al.   AGING CELL

Reversal of Hyperglycemia-Induced Angiogenesis Deficit of Human Endothelial Cells by Overexpression of Glyoxalase 1In Vitro

(2008) Usman Ahmed et al.   Annals of the New York Academy of Sciences

Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress

(2008) Naila Rabbani et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Methylglyoxal increase in uremia with special reference to snakebite-mediated acute renal failure

(2008) Soma Mukhopadhyay et al.   CLINICA CHIMICA ACTA

Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes

(2008) A. Soro-Paavonen et al.   DIABETES

In Skeletal Muscle Advanced Glycation End Products (AGEs) Inhibit Insulin Action and Induce the Formation of Multimolecular Complexes Including the Receptor for AGEs

(2008) Angela Cassese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reassessing triglyceride synthesis in adipose tissue

(2008) Colleen Nye et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM