Methylglyoxal Impairs Insulin Secretion of Pancreaticβ-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs

The global implications of diabetes and cancer

(2014) Yuankai Shi et al.   LANCET

Mulberry Fruit Extract Protects Pancreatic β-Cells against Hydrogen Peroxide-Induced Apoptosis via Antioxidative Activity

(2014) Jong Lee et al.   MOLECULES

P38 Plays an Important Role in Glucolipotoxicity-Induced Apoptosis in INS-1 Cells

(2014) Lingli Zhou et al.   Journal of Diabetes Research

The chemistry and biological activities of N-acetylcysteine

(2013) Yuval Samuni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Methylglyoxal induces oxidative stress and mitochondrial dysfunction in osteoblastic MC3T3-E1 cells

(2013) K. S. Suh et al.   FREE RADICAL RESEARCH

Reduction of Methylglyoxal-Induced Glycation by Pyridoxamine Improves Adipose Tissue Microvascular Lesions

(2013) Tiago Rodrigues et al.   Journal of Diabetes Research

The Role of Uncoupling Proteins in Diabetes Mellitus

(2013) Jing Liu et al.   Journal of Diabetes Research

Methylglyoxal promotes oxidative stress and endothelial dysfunction

(2012) Cristina M. Sena et al.   PHARMACOLOGICAL RESEARCH

Chronic Methylglyoxal Infusion by Minipump Causes Pancreatic β-Cell Dysfunction and Induces Type 2 Diabetes in Sprague-Dawley Rats

(2011) Arti Dhar et al.   DIABETES

Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E

(2011) F. Fiory et al.   DIABETOLOGIA

Mitogen-Activated Protein Kinases in Mammalian Oxidative Stress Responses

(2010) Christopher Runchel et al.   ANTIOXIDANTS & REDOX SIGNALING

Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose

(2010) Arti Dhar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy

(2010) Jianxin Lu et al.   CLINICAL BIOCHEMISTRY

Regulation of insulin secretion: role of mitochondrial signalling

(2010) S. Jitrapakdee et al.   DIABETOLOGIA

Methylglyoxal-induced mitochondrial dysfunction in vascular smooth muscle cells

(2009) Hui Wang et al.   BIOCHEMICAL PHARMACOLOGY

Reactive Oxygen Species-Mediated Pancreatic β-Cell Death Is Regulated by Interactions between Stress-Activated Protein Kinases, p38 and c-Jun N-Terminal Kinase, and Mitogen-Activated Protein Kinase Phosphatases

(2008) Ni Hou et al.   ENDOCRINOLOGY

Modulation of methylglyoxal and glutathione by soybean isoflavones in mild streptozotocin-induced diabetic rats

(2008) Mei-Ping Lu et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES