Dicarbonyl proteome and genome damage in metabolic and vascular disease

Knockdown of Glyoxalase 1 Mimics Diabetic Nephropathy in Nondiabetic Mice

(2013) F. Giacco et al.   DIABETES

Transduced Tat-glyoxalase protein attenuates streptozotocin-induced diabetes in a mouse model

(2012) Mi Jin Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation

(2011) Mingzhan Xue et al.   BIOCHEMICAL JOURNAL

Glycation of LDL by Methylglyoxal Increases Arterial Atherogenicity: A Possible Contributor to Increased Risk of Cardiovascular Disease in Diabetes

(2011) N. Rabbani et al.   DIABETES

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome

(2010) Naila Rabbani et al.   AMINO ACIDS

Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress

(2010) Alexander Kurz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Increased Glycation and Oxidative Damage to Apolipoprotein B100 of LDL Cholesterol in Patients With Type 2 Diabetes and Effect of Metformin

(2010) N. Rabbani et al.   DIABETES

Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes

(2010) N. Karachalias et al.   DIABETOLOGIA

Protein damage in diabetes and uremia—identifying hotspots of proteome damage where minimal modification is amplified to marked pathophysiological effect

(2010) Paul J. Thornalley et al.   FREE RADICAL RESEARCH

Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance

(2010) Paul J. Thornalley et al.   NUCLEIC ACIDS RESEARCH

Advanced Glycation End Products in Extracellular Matrix Proteins Contribute to the Failure of Sensory Nerve Regeneration in Diabetes

(2009) Beatriz Duran-Jimenez et al.   DIABETES

Quantitative measurement of specific biomarkers for protein oxidation, nitration and glycation in Arabidopsis leaves

(2009) Ulrike Bechtold et al.   PLANT JOURNAL

Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans

(2008) Michael Morcos et al.   AGING CELL

Protein glycationin vivo: functional and structural effects on yeast enolase

(2008) Ricardo A. Gomes et al.   BIOCHEMICAL JOURNAL

Glyoxalase II does not support methylglyoxal detoxification but serves as a general trypanothione thioesterase in African trypanosomes

(2008) Alexandra Wendler et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY