Molecular Profiling of Inflammatory Bowel Disease: Is It Ready for Use in Clinical Decision-Making?

Mucosal IL13RA2 expression predicts nonresponse to anti-TNF therapy in Crohn's disease

(2019) Bram Verstockt et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Low TREM1 expression in whole blood predicts anti-TNF response in inflammatory bowel disease

(2019) Bram Verstockt et al.   EBioMedicine

Colonic epithelial cell diversity in health and inflammatory bowel disease

(2019) Kaushal Parikh et al.   NATURE

Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease

(2019) Gareth J. Walker et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A blood-based prognostic biomarker in IBD

(2019) Daniele Biasci et al.   GUT

Pharmacogenetics in the Treatment of Cardiovascular Diseases and Its Current Progress Regarding Implementation in the Clinical Routine

(2019) Cristina Lucía Dávila-Fajardo et al.   Genes

Pharmacokinetic Modeling and Simulation of Biologicals in Inflammatory Bowel Disease: The Dawning of a New Era for Personalized Treatment

(2018) Erwin Dreesen et al.   CURRENT DRUG TARGETS

Gene Expression Signature for Prediction of Golimumab Response in a Phase 2a Open-label Trial of Patients With Ulcerative Colitis

(2018) Shannon E. Telesco et al.   GASTROENTEROLOGY

Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn’s disease

(2018) Heike Schmitt et al.   GUT

Cell-centred meta-analysis reveals baseline predictors of anti-TNFα non-response in biopsy and blood of patients with IBD

(2018) Renaud Gaujoux et al.   GUT

TREM-1, the ideal predictive biomarker for endoscopic healing in anti-TNF-treated Crohn’s disease patients?

(2018) Bram Verstockt et al.   GUT

OP013 HLA-DQA1 contributes to the development of antibodies to anti-TNF therapy in Crohn’s disease

(2018) A Sazonovs et al.   Journal of Crohns & Colitis

An Intergenic Variant rs9268877 Between HLA-DRA and HLA-DRB Contributes to the Clinical Course and Long-term Outcome of Ulcerative Colitis

(2018) Ho-Su Lee et al.   Journal of Crohns & Colitis

Genomic and Expression Analyses Identify a Disease-Modifying Variant for Fibrostenotic Crohn’s Disease

(2018) Marijn C Visschedijk et al.   Journal of Crohns & Colitis

Health-Risk Behaviors and Chronic Conditions Among Adults with Inflammatory Bowel Disease — United States, 2015 and 2016

(2018) Fang Xu et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease

(2018) James Kinchen et al.   CELL

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

(2018) Amit V. Khera et al.   NATURE GENETICS

Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn Disease Reveals Tissue-Specific Characteristics and Drug Targets

(2018) Werna T. Uniken Venema et al.   GASTROENTEROLOGY

Multiomics Analyses to Deliver the Most Effective Treatment to Every Patient With Inflammatory Bowel Disease

(2018) Rinse K. Weersma et al.   GASTROENTEROLOGY

Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

(2018) Yael Haberman et al.   Nature Communications

PRedicting Outcomes For Crohn’s dIsease using a moLecular biomarkEr (PROFILE): protocol for a multicentre, randomised, biomarker-stratified trial

(2018) Miles Parkes et al.   BMJ Open

Effects of Epithelial IL-13Rα2 Expression in Inflammatory Bowel Disease

(2018) Bram Verstockt et al.   Frontiers in Immunology

Differences in Clinical Course, Genetics, and the Microbiome Between Familial and Sporadic Inflammatory Bowel Diseases

(2017) Nienke Z Borren et al.   Journal of Crohns & Colitis

OP022 Proximity extension assay based proteins show immune cell specificity and can diagnose and predict outcomes in inflammatory bowel diseases: IBD Character study

(2017) R. Kalla et al.   Journal of Crohns & Colitis

Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study

(2017) Subra Kugathasan et al.   LANCET

Transcriptional risk scores link GWAS to eQTLs and predict complications in Crohn's disease

(2017) Urko M Marigorta et al.   NATURE GENETICS

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease

(2017) James C Lee et al.   NATURE GENETICS

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

(2017) Katrina M de Lange et al.   NATURE GENETICS

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

(2017) Nathaniel R West et al.   NATURE MEDICINE

Precision Diagnosis and Treatment for Advanced Non–Small-Cell Lung Cancer

(2017) Martin Reck et al.   NEW ENGLAND JOURNAL OF MEDICINE

NUDT15 polymorphisms are better than thiopurine S-methyltransferase as predictor of risk for thiopurine-induced leukopenia in Chinese patients with Crohn's disease

(2016) X. Zhu et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Systematic review: genetic biomarkers associated with anti-TNF treatment response in inflammatory bowel diseases

(2016) S. Bek et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Genetic Markers Predict Primary Non-Response and Durable Response To Anti-TNF Biologic Therapies in Crohn’s Disease

(2016) Grant E Barber et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A Genetic Variation in the Neonatal Fc-Receptor Affects Anti-TNF Drug Concentrations in Inflammatory Bowel Disease

(2016) Thomas Billiet et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Association Between Response to Etrolizumab and Expression of Integrin αE and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis

(2016) Gaik W. Tew et al.   GASTROENTEROLOGY

Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency

(2016) Dror S. Shouval et al.   GASTROENTEROLOGY

Effect of vedolizumab (anti-α4β7-integrin) therapy on histological healing and mucosal gene expression in patients with UC

(2016) Ingrid Arijs et al.   GUT

From Genes to Mechanisms

(2016) Holm H. Uhlig et al.   INFLAMMATORY BOWEL DISEASES

Genetic Predictors of Benign Course of Ulcerative Colitis—A North American Inflammatory Bowel Disease Genetics Consortium Study

(2016) Uri Kopylov et al.   INFLAMMATORY BOWEL DISEASES

DOP082. Proximity extension assay immunoassay technology identifies novel serum biomarkers that can diagnose and classify inflammatory bowel diseases: IBD Character Consortium

(2016)   Journal of Crohns & Colitis

Prediction of Short- and Medium-term Efficacy of Biosimilar Infliximab Therapy. Do Trough Levels and Antidrug Antibody Levels or Clinical And Biochemical Markers Play the More Important Role?

(2016) Lorant Gonczi et al.   Journal of Crohns & Colitis

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

(2016) Isabelle Cleynen et al.   LANCET

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity

(2016) Takaya Moriyama et al.   NATURE GENETICS

Familial Risk of Inflammatory Bowel Disease: A Population-Based Cohort Study 1977–2011

(2015) Frederik Trier Moller et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Characteristics of Skin Lesions Associated With Anti–Tumor Necrosis Factor Therapy in Patients With Inflammatory Bowel Disease

(2015) Isabelle Cleynen et al.   ANNALS OF INTERNAL MEDICINE

Factors Associated With Short- and Long-Term Outcomes of Therapy for Crohn’s Disease

(2015) Walter Reinisch et al.   Clinical Gastroenterology and Hepatology

Identification of Risk Loci for Crohn’s Disease Phenotypes Using a Genome-Wide Association Study

(2015) Arnald Alonso et al.   GASTROENTEROLOGY

Immunogenicity to infliximab is associated with HLA-DRB1

(2015) Thomas Billiet et al.   GUT

Pharmacokinetics of anti-TNF monoclonal antibodies in inflammatory bowel disease: Adding value to current practice

(2015) Niels Vande Casteele et al.   JOURNAL OF CLINICAL PHARMACOLOGY

IBD Genetic Risk Profile in Healthy First-Degree Relatives of Crohn’s Disease Patients

(2015) David Kevans et al.   Journal of Crohns & Colitis

A Matrix-based Model Predicts Primary Response to Infliximab in Crohn’s Disease

(2015) Thomas Billiet et al.   Journal of Crohns & Colitis

Clinical Features and HLA Association of 5-Aminosalicylate (5-ASA)-induced Nephrotoxicity in Inflammatory Bowel Disease

(2015) Graham A. Heap et al.   Journal of Crohns & Colitis

NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel disease

(2015) Ayumi Asada et al.   JOURNAL OF GASTROENTEROLOGY

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

Epidemiology and risk factors for IBD

(2015) Ashwin N. Ananthakrishnan   Nature Reviews Gastroenterology & Hepatology

Differential Effect of Genetic Burden on Disease Phenotypes in Crohn's Disease and Ulcerative Colitis: Analysis of a North American Cohort

(2014) Ashwin N Ananthakrishnan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Targeted next-generation sequencing panels for monogenetic disorders in clinical diagnostics: the opportunities and challenges

(2014) Tom J de Koning et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

The Diagnostic Approach to Monogenic Very Early Onset Inflammatory Bowel Disease

(2014) Holm H. Uhlig et al.   GASTROENTEROLOGY

Genetic susceptibility and genotype–phenotype association in 588 Danish children with inflammatory bowel disease

(2014) C. Jakobsen et al.   Journal of Crohns & Colitis

Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial

(2014) Séverine Vermeire et al.   LANCET

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

(2014) Suk-Kyun Yang et al.   NATURE GENETICS

HLA-DQA1–HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants

(2014) Graham A Heap et al.   NATURE GENETICS

Performance of the Montreal classification for inflammatory bowel diseases

(2014) Lieke M Spekhorst   WORLD JOURNAL OF GASTROENTEROLOGY

Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn's and Colitis Epidemiology Study

(2013) Siew C. Ng et al.   GASTROENTEROLOGY

Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment

(2013) Cornelia Tillack et al.   GUT

Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease

(2013) Holm H Uhlig   GUT

Targeted next-generation sequencing: A novel diagnostic tool for primary immunodeficiencies

(2013) Isaac J. Nijman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project

(2012) Isabelle Cleynen et al.   GUT

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Clinical, serological and genetic predictors of inflammatory bowel disease course

(2012) Laurent Beaugerie   WORLD JOURNAL OF GASTROENTEROLOGY

Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis

(2011) James C. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Genomewide Association betweenGLCCI1and Response to Glucocorticoid Therapy in Asthma

(2011) Kelan G. Tantisira et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients

(2011) F Weber et al.   PHARMACOGENOMICS JOURNAL

Predictive value of epithelial gene expression profiles for response to infliximab in Crohnʼs disease‡

(2010) Ingrid Arijs et al.   INFLAMMATORY BOWEL DISEASES

Confirmation of Multiple Crohn's Disease Susceptibility Loci in a Large Dutch–Belgian Cohort

(2009) Rinse K Weersma et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Genetic Risk Profiling and Prediction of Disease Course in Crohn's Disease Patients

(2009) Liesbet Henckaerts et al.   Clinical Gastroenterology and Hepatology

The Signaling Function of the IL-13Rα2 Receptor in the Development of Gastrointestinal Fibrosis and Cancer Surveillance

(2009) Warren Strober et al.   CURRENT MOLECULAR MEDICINE

Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis

(2009) I. Arijs et al.   GUT

Familial aggregation and antimicrobial response dose-dependently affect the risk for Crohnʼs disease

(2009) Marie Joossens et al.   INFLAMMATORY BOWEL DISEASES

Genome wide association (GWA) predictors of anti-TNFα therapeutic responsiveness in pediatric inflammatory bowel disease

(2009) Marla C. Dubinsky et al.   INFLAMMATORY BOWEL DISEASES

Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer

(2009) Eric Van Cutsem et al.   NEW ENGLAND JOURNAL OF MEDICINE