Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms

Remuscularization of the failing heart

(2017) Wolfram-Hubertus Zimmermann   JOURNAL OF PHYSIOLOGY-LONDON

Human Embryonic Stem Cell-Derived Cardiomyocytes Self-Arrange with Areas of Different Subtypes During Differentiation

(2017) Maj Linea Vestergaard et al.   STEM CELLS AND DEVELOPMENT

Large-scale production of human pluripotent stem cell derived cardiomyocytes

(2016) Henning Kempf et al.   ADVANCED DRUG DELIVERY REVIEWS

Stiff matrix induces switch to pure β-cardiac myosin heavy chain expression in human ESC-derived cardiomyocytes

(2016) Natalie Weber et al.   BASIC RESEARCH IN CARDIOLOGY

Clinical and Mechanistic Insights Into the Genetics of Cardiomyopathy

(2016) Michael A. Burke et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

(2016) Paul W Burridge et al.   NATURE MEDICINE

Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells

(2016) Henning Kempf et al.   Nature Communications

Postnatal Development of Right Ventricular Myofibrillar Biomechanics in Relation to the Sarcomeric Protein Phenotype in Pediatric Patients with Conotruncal Heart Defects

(2016) Fatiha Elhamine et al.   Journal of the American Heart Association

Isolation and Mechanical Measurements of Myofibrils from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2016) Josè Manuel Pioner et al.   Stem Cell Reports

Pluripotent stem cell derived cardiovascular progenitors – A developmental perspective

(2015) Matthew J. Birket et al.   DEVELOPMENTAL BIOLOGY

Cardiomyopathy in a Dish: Using Human Inducible Pluripotent Stem Cells to Model Inherited Cardiomyopathies

(2015) Forum Kamdar et al.   JOURNAL OF CARDIAC FAILURE

Contractile properties of developing human fetal cardiac muscle

(2015) Alice W. Racca et al.   JOURNAL OF PHYSIOLOGY-LONDON

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

(2015) J. T. Hinson et al.   SCIENCE

Engineering Adolescence

(2014) Xiulan Yang et al.   CIRCULATION RESEARCH

Tri-iodo-l-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells

(2014) Xiulan Yang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Factors Associated With in Utero Demise of Fetuses That Have Underlying Cardiac Pathologies

(2014) Christine E. MacColl et al.   PEDIATRIC CARDIOLOGY

Structure, sarcomeric organization, and thin filament binding of cardiac myosin-binding protein-C

(2014) Roger Craig et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Genetics and Disease of Ventricular Muscle

(2014) D. Fatkin et al.   Cold Spring Harbor Perspectives in Medicine

Familial hypertrophic cardiomyopathy: functional variance among individual cardiomyocytes as a trigger of FHC-phenotype development

(2014) Bernhard Brenner et al.   Frontiers in Physiology

Acquisition of a Quantitative, Stoichiometrically Conserved Ratiometric Marker of Maturation Status in Stem Cell-Derived Cardiac Myocytes

(2014) Fikru B. Bedada et al.   Stem Cell Reports

Controlling Expansion and Cardiomyogenic Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture

(2014) Henning Kempf et al.   Stem Cell Reports

Familial hypertrophic cardiomyopathy: Functional effects of myosin mutation R723G in cardiomyocytes

(2013) Theresia Kraft et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tropomyosin isoform expression and phosphorylation in the human heart in health and disease

(2013) Steven B. Marston et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutations

(2013) Sabine J. van Dijk et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Myosin light chain 2-based selection of human iPSC-derived early ventricular cardiac myocytes

(2013) Alexandra Bizy et al.   Stem Cell Research

Pluripotent Stem Cell Models of Human Heart Disease

(2013) A. Moretti et al.   Cold Spring Harbor Perspectives in Medicine

Diagnosis and Prognosis of Fetal Cardiomyopathies: A Review

(2012) Maurizio Mongiovi et al.   CURRENT PHARMACEUTICAL DESIGN

Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro

(2012) George Kensah et al.   EUROPEAN HEART JOURNAL

The Functional Properties of Human Slow Skeletal Troponin T Isoforms in Cardiac Muscle Regulation

(2012) Jose Renato Pinto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase A changes calcium sensitivity but not crossbridge kinetics in human cardiac myofibrils

(2011) John S. Walker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Distinct regulation of mitogen-activated protein kinase activities is coupled with enhanced cardiac differentiation of human embryonic stem cells

(2011) Henning Kempf et al.   Stem Cell Research

Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function

(2010) Bin Wei et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Molecular and Functional Characterization of a Novel Cardiac-Specific Human Tropomyosin Isoform

(2010) Sudarsan Rajan et al.   CIRCULATION

Protein kinase A–induced myofilament desensitization to Ca2+as a result of phosphorylation of cardiac myosin–binding protein C

(2010) Peter P. Chen et al.   JOURNAL OF GENERAL PHYSIOLOGY

Kinetics of cardiac sarcomeric processes and rate-limiting steps in contraction and relaxation

(2010) Robert Stehle et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity

(2010) Ganapathy Jagatheesan et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Titin-based mechanical signalling in normal and failing myocardium

(2009) Martina Krüger et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Insights into the kinetics of Ca2+-regulated contraction and relaxation from myofibril studies

(2009) Robert Stehle et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Global Expression Profile of Highly Enriched Cardiomyocytes Derived from Human Embryonic Stem Cells

(2009) Xiu Qin Xu et al.   STEM CELLS

Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development

(2008) Charles E. Murry et al.   CELL