Journal
FUTURE MEDICINAL CHEMISTRY
Volume 8, Issue 18, Pages 2177-2183Publisher
FUTURE SCI LTD
DOI: 10.4155/fmc-2016-0192
Keywords
heart; heart failure; heat shock proteins; HSP70; stress; therapy
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Heat shock proteins are a family of proteins that are produced by cells in response to exposure to stressful conditions. The best studied heat shock protein is HSP70, which is known to act as a molecular chaperone to maintain cellular homeostasis and inhibit protein aggregation in response to stress. While early animal studies suggested that increasing HSP70 in the heart (using a transgenic, gene transfer or pharmacological approach) provided cardiac protection against acute cardiac stress, recent studies have found no benefit of increasing HSP70 in mouse models of chronic cardiac stress. As HSP70 has been considered a potential therapeutic target, it is important to comprehensively assess HSP70 therapies in preclinical models of acute and chronic cardiac disease.
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