The safety of nanostructured synthetic amorphous silica (SAS) as a food additive (E 551)

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

(2016) Cynthia Ju et al.   Cellular & Molecular Immunology

Comprehensive European dietary exposure model (CEDEM) for food additives

(2016) David R. Tennant   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Multimethod approach for the detection and characterisation of food-grade synthetic amorphous silica nanoparticles

(2016) Francisco Barahona et al.   JOURNAL OF CHROMATOGRAPHY A

How reliably can a material be classified as a nanomaterial? Available particle-sizing techniques at work

(2016) Frank Babick et al.   JOURNAL OF NANOPARTICLE RESEARCH

Characterization of in vitro genotoxic, cytotoxic and transcriptomic responses following exposures to amorphous silica of different sizes

(2016) Nathalie Decan et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Survey of food-grade silica dioxide nanomaterial occurrence, characterization, human gut impacts and fate across its lifecycle

(2016) Yu Yang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Critical assessment of toxicological effects of ingested nanoparticles

(2016) Christie McCracken et al.   Environmental Science-Nano

Physicochemical and toxicological evaluation of silica nanoparticles suitable for food and consumer products collected by following the EC recommendation

(2015) Catia Contado et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Physical boundaries within aggregates - differences between amorphous, para-crystalline, and crystalline Structures

(2015) Peter Albers et al.   CRYSTAL RESEARCH AND TECHNOLOGY

In vivo genotoxic effects of four different nano-sizes forms of silica nanoparticles in Drosophila melanogaster

(2015) Eşref Demir et al.   JOURNAL OF HAZARDOUS MATERIALS

Integrated probabilistic risk assessment for nanoparticles: the case of nanosilica in food

(2015) Rianne Jacobs et al.   JOURNAL OF NANOPARTICLE RESEARCH

In vitro and in vivo genotoxicity investigations of differently sized amorphous SiO2 nanomaterials

(2015) Elena Maser et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Toxicity of silica nanoparticles depends on size, dose, and cell type

(2015) In-Yong Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

NanoTEST in a Nutshell

(2015) Maria Dusinska et al.   Nanotoxicology

Positive association between serum silicon levels and bone mineral density in female rats following oral silicon supplementation with monomethylsilanetriol

(2015) R. Jugdaohsingh et al.   OSTEOPOROSIS INTERNATIONAL

Regulatory aspects of nanotechnology in the agri/feed/food sector in EU and non-EU countries

(2015) Valeria Amenta et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Oral two-generation reproduction toxicity study with NM-200 synthetic amorphous silica in Wistar rats

(2015) André Wolterbeek et al.   REPRODUCTIVE TOXICOLOGY

Prenatal toxicity of synthetic amorphous silica nanomaterial in rats

(2015) Thomas Hofmann et al.   REPRODUCTIVE TOXICOLOGY

Mechanistic Investigation of the Biological Effects of SiO2, TiO2, and ZnO Nanoparticles on Intestinal Cells

(2015) Magdiel I. Setyawati et al.   Small

Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells

(2015) Luisana Di Cristo et al.   TOXICOLOGICAL SCIENCES

Toxicity, genotoxicity and proinflammatory effects of amorphous nanosilica in the human intestinal Caco-2 cell line

(2015) Adeline Tarantini et al.   TOXICOLOGY IN VITRO

Comprehensive In Vitro Toxicity Testing of a Panel of Representative Oxide Nanomaterials: First Steps towards an Intelligent Testing Strategy

(2015) Lucian Farcal et al.   PLoS One

Effects of SiO2, ZrO2, and BaSO4 nanomaterials with or without surface functionalization upon 28-day oral exposure to rats

(2014) Roland Buesen et al.   ARCHIVES OF TOXICOLOGY

Silica nanoparticles induce oxidative stress and inflammation of human peripheral blood mononuclear cells

(2014) Alvaro Mendoza et al.   CELL STRESS & CHAPERONES

Measurement Methods to Detect, Characterize, and Quantify Engineered Nanomaterials in Foods

(2014) Gurmit Singh et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure. Part 1: Oral route

(2014) Adeline Tarantini et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure, part 2: Intratracheal instillation and intravenous injection

(2014) Yves Guichard et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Toxicity of colloidal silica nanoparticles administered orally for 90 days in rats

(2014) Seong Soo A. An et al.   International Journal of Nanomedicine

Undetactable levels of genotoxicity of SiO2 nanoparticles in in vitro and in vivo tests

(2014) Seong Soo A. An et al.   International Journal of Nanomedicine

Novel insights into the risk assessment of the nanomaterial synthetic amorphous silica, additive E551, in food

(2014) Petra C. E. van Kesteren et al.   Nanotoxicology

Sub-chronic toxicity study in rats orally exposed to nanostructured silica

(2014) Meike van der Zande et al.   Particle and Fibre Toxicology

The Uptake of Soluble and Particulate Antigens by Epithelial Cells in the Mouse Small Intestine

(2014) Savannah E. Howe et al.   PLoS One

Surface area of the digestive tract – revisited

(2014) Herbert F Helander et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Physicochemical properties and in vitro intestinal permeability properties and intestinal cell toxicity of silica particles, performed in simulated gastrointestinal fluids

(2013) Kumiko Sakai-Kato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Minimal Intestinal Epithelial Cell Toxicity in Response to Short- and Long-Term Food-Relevant Inorganic Nanoparticle Exposure

(2013) Christie McCracken et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Kupffer cell-mediated hepatic injury induced by silica nanoparticles in vitro and in vivo

(2013) Jiao Sun et al.   International Journal of Nanomedicine

Evaluation of the toxicity of food additive silica nanoparticles on gastrointestinal cells

(2013) Yi-Xin Yang et al.   JOURNAL OF APPLIED TOXICOLOGY

Kinetics of silica nanoparticles in the human placenta

(2013) Marie Sønnegaard Poulsen et al.   Nanotoxicology

Co-assessment of cell cycle and micronucleus frequencies demonstrates the influence of serum on thein vitrogenotoxic response to amorphous monodisperse silica nanoparticles of varying sizes

(2013) Laetitia Gonzalez et al.   Nanotoxicology

Biological and therapeutic effects of ortho-silicic acid and some ortho-silicic acid-releasing compounds: New perspectives for therapy

(2013) Lela Munjas Jurkić et al.   Nutrition & Metabolism

Reciprocal Response of Human Oral Epithelial Cells to Internalized Silica Nanoparticles

(2013) Chor Yong Tay et al.   PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

Toxic Effect of Silica Nanoparticles on Endothelial Cells through DNA Damage Response via Chk1-Dependent G2/M Checkpoint

(2013) Junchao Duan et al.   PLoS One

Genotoxicity evaluation of nanosized titanium dioxide, synthetic amorphous silica and multi-walled carbon nanotubes in human lymphocytes

(2013) Ana M. Tavares et al.   TOXICOLOGY IN VITRO

An In vitro Model to Study Heterogeneity of Human Macrophage Differentiation and Polarization

(2013) Christian Erbel et al.   Jove-Journal of Visualized Experiments

Presence of Nano-Sized Silica during In Vitro Digestion of Foods Containing Silica as a Food Additive

(2012) Ruud Peters et al.   ACS Nano

Investigating agglomeration and dissolution of silica nanoparticles in aqueous suspensions by dynamic reaction cell inductively coupled plasma-mass spectrometry in time resolved mode

(2012) Federica Aureli et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Processing Pathway Dependence of Amorphous Silica Nanoparticle Toxicity: Colloidal vs Pyrolytic

(2012) Haiyuan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silica nanoparticles administered at the maximum tolerated dose induce genotoxic effects through an inflammatory reaction while gold nanoparticles do not

(2012) Thomas R. Downs et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Mechanisms of toxicity induced by SiO2nanoparticles ofin vitrohuman alveolar barrier: effects on cytokine production, oxidative stress induction, surfactant proteins A mRNA expression and nanoparticles uptake

(2012) Lucian Romeo Farcal et al.   Nanotoxicology

Influence of simulated gastrointestinal conditions on particle-induced cytotoxicity and interleukin-8 regulation in differentiated and undifferentiated Caco-2 cells

(2012) Kirsten Gerloff et al.   Nanotoxicology

In vitrotoxicity of amorphous silica nanoparticles in human colon carcinoma cells

(2012) Helge Gehrke et al.   Nanotoxicology

Mechanism of cellular uptake of genotoxic silica nanoparticles

(2012) Qingshan Mu et al.   Particle and Fibre Toxicology

Physicochemical Determinants in the Cellular Responses to Nanostructured Amorphous Silicas

(2012) Elena Gazzano et al.   TOXICOLOGICAL SCIENCES

The toxicological mode of action and the safety of synthetic amorphous silica—A nanostructured material

(2012) Claudia Fruijtier-Pölloth   TOXICOLOGY

Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2

(2012) Javed Ahmad et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In Vivo Toxicity of Intravenously Administered Silica and Silicon Nanoparticles

(2012) Sergey Ivanov et al.   Materials

Impact of Silica Nanoparticle Design on Cellular Toxicity and Hemolytic Activity

(2011) Tian Yu et al.   ACS Nano

Toxicity of amorphous silica nanoparticles on eukaryotic cell model is determined by particle agglomeration and serum protein adsorption effects

(2011) Daniela Drescher et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

In vitro cytotoxicity and induction of apoptosis by silica nanoparticles in human HepG2 hepatoma cells

(2011) Yuan Yuan et al.   International Journal of Nanomedicine

Amorphous silica nanoparticles do not induce cytotoxicity, cell transformation or genotoxicity in Balb/3T3 mouse fibroblasts

(2011) Chiara Uboldi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Silica and titanium dioxide nanoparticles cause pregnancy complications in mice

(2011) Kohei Yamashita et al.   Nature Nanotechnology

Models for oral uptake of nanoparticles in consumer products

(2011) Eleonore Fröhlich et al.   TOXICOLOGY

The cytotoxic activity of amorphous silica nanoparticles is mainly influenced by surface area and not by aggregation

(2011) Virginie Rabolli et al.   TOXICOLOGY LETTERS

Silicon in beer and brewing

(2010) Troy R Casey et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by silica nanomaterials in human neuronal cell line

(2010) Youn-Jung Kim et al.   Molecular & Cellular Toxicology

Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmidlacZgene mutation assay

(2010) Margriet V. D. Z. Park et al.   Nanotoxicology

Exploring the aneugenic and clastogenic potential in the nanosize range: A549 human lung carcinoma cells and amorphous monodisperse silica nanoparticles as models

(2010) Laetitia Gonzalez et al.   Nanotoxicology

Activation of the inflammasome by amorphous silica and TiO2nanoparticles in murine dendritic cells

(2010) Meike Winter et al.   Nanotoxicology

Presence and risks of nanosilica in food products

(2010) Susan Dekkers et al.   Nanotoxicology

Nano-SiO2 induces apoptosis via activation of p53 and Bax mediated by oxidative stress in human hepatic cell line

(2010) Yiyi Ye et al.   TOXICOLOGY IN VITRO

In vitro toxicity of silica nanoparticles in myocardial cells

(2009) Yiyi Ye et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Changing the dose metric for inhalation toxicity studies: Short-term study in rats with engineered aerosolized amorphous silica nanoparticles

(2009) Christie M. Sayes et al.   INHALATION TOXICOLOGY

Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells

(2009) Kirsten Gerloff et al.   Nanotoxicology

The modified outflow funnel — A device to assess the flow characteristics of powders

(2009) Joanna Ruppel et al.   POWDER TECHNOLOGY

Dietary silicon intake in Belgium: Sources, availability from foods, and human serum levels

(2009) Harry Robberecht et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Size-Dependent Cytotoxicity of Monodisperse Silica Nanoparticles in Human Endothelial Cells

(2009) Dorota Napierska et al.   Small

In vitro developmental toxicity test detects inhibition of stem cell differentiation by silica nanoparticles

(2009) Margriet V.D.Z. Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells

(2009) Fen Wang et al.   TOXICOLOGY IN VITRO

Precipitated silica as flow regulator

(2008) Anne-Kathrin Müller et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Nanoparticulate-induced toxicity and related mechanism in vitro and in vivo

(2008) Hye Won Kim et al.   JOURNAL OF NANOPARTICLE RESEARCH

Reproducible Comet Assay of Amorphous Silica Nanoparticles Detects No Genotoxicity

(2008) Clifford A. Barnes et al.   NANO LETTERS

Mesoporous Silica Nanoparticles for Reducing Hemolytic Activity Towards Mammalian Red Blood Cells

(2008) Igor I. Slowing et al.   Small

Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro

(2008) Eun-Jung Park et al.   TOXICOLOGY LETTERS