Article
Medicine, Research & Experimental
Steve Harakeh, Rajaa Al-Raddadi, Turki Alamri, Soad Al-Jaouni, Mohammed Qari, Yousef Qari, Ajay Kumar, Hanaa M. Tashkandi, Mohammed Moulay, Alia M. Aldahlawi, Petr Slama, Shafiul Haque
Summary: In this study, the antiproliferative activities of trans-Anethole towards human liver cancer (HepG2), cervical cancer (HeLa) and breast cancer (MCF-7) cells were explored. The results showed that trans-Anethole exhibited strong antiproliferative potential towards HepG2 cells and induced apoptosis by upregulating the protein expressions of p53, Caspase-3, and Caspase-9.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Bishal Nepal, Jay K. Bhattarai, Kapur B. Dhami, Michael R. Nichols, Keith J. Stine
Summary: This article investigates the use of mesoporous silica nanoparticles to overcome the hemolytic nature of glycoalkaloids and successfully load tomatine. The drug delivery system exhibits high toxicity towards cancer cells at low concentrations but lower toxicity towards normal cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sun Young Lee, In Young Kim, Min Beom Heo, Jeong Hee Moon, Jin Gyeong Son, Tae Geol Lee
Summary: The study found that exposure to SiO2 NPs affects protein expression even if cell morphology remains unchanged. Long-term exposure to SiO2 NPs leads to changes in reactive oxygen species levels, eventually inducing HepG2 cell death.
Article
Pharmacology & Pharmacy
Yaqi Peng, Xiaoqiang Li, Peixian Gu, Wanting Cheng, Ruifen Zhang, Kun Hu
Summary: Curcumin is a natural plant component with significant in vitro anticancer effects. However, its bioavailability is limited. This study investigates the transportation mechanism of Curcumin-loaded zein-pectin core/shell nanoparticles (En-CUR) into Caco-2 cells and the inhibitory effects of En-CUR on HepG2 cell proliferation. The results show that En-CUR is taken up by Caco-2 cells through multiple endocytic pathways. En-CUR treatment leads to increased apoptosis, cell cycle arrest, and mitochondrial dysfunction in HepG2 cells. These findings suggest that En-CUR is a promising delivery system for Curcumin and exhibits superior anticancer effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rafal Kretowski, Agata Jablonska-Trypuc, Marzanna Cechowska-Pasko
Summary: This study evaluated the anti-cancer effect and mechanism of action of SiNPs in breast cancer cell lines. The results showed that 5-15 nm SiNPs induced dose-dependent cytotoxicity in MDA-MB-231 and ZR-75-1 cells, and also induced apoptosis through decreasing mitochondrial membrane potential and increasing the activity of caspase-9 and caspase-3. Additionally, these nanoparticles caused an increase in selected oxidative stress parameters in breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Shiwen Hu, Pan Wang, Yongchun Chen, Gang Kuang, Cun Wang, Jing Luo, Shaocheng Chen
Summary: The study found that Peucedanum praeruptorum Dunn extract (PPDE) has a significant inhibitory effect on the proliferation of HepG2 human hepatoma cells, while having little effect on normal liver cells. PPDE inhibits intracellular oxidative stress in cancer cells by increasing antioxidant enzyme activity and regulating gene expression.
JOURNAL OF FOOD QUALITY
(2023)
Article
Environmental Sciences
Susu Wang, Yang Zhang, Jufang Gao, Jingdi Zhang, Liming Tao, Wenping Xu
Summary: Acetochlor, a widely used chiral herbicide, can induce toxicity in human liver cells primarily through its S configuration, leading to cell apoptosis. The study provides a theoretical basis for reducing the impact on human health through the production of single pesticides.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Food Science & Technology
Cristina Fuentes, Maria Ruiz-Rico, Ana Fuentes, Jose Manuel Barat, Maria Jose Ruiz
Summary: The study evaluated the cytotoxic effect of different EOCs-functionalised silica particles on HepG2 cells, showing that the functionalised particles had a stronger cytotoxic effect compared to traditional silica particles. Differences in cytotoxicity between functionalised particles may be attributed to the density of the functional components on their surface.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Heba K. Nabih, Ahmed R. Hamed, Shaymaa M. M. Yahya
Summary: Melatonin has anti-proliferative and anti-inflammatory effects on hepatocellular carcinoma cells, by arresting cell cycle at G0/G1 phase and increasing the expression of P53 gene. However, caution should be taken to avoid the development of drug resistance.
SCIENTIFIC REPORTS
(2023)
Article
Food Science & Technology
Tienthanh Nguyen, Ruiyin Guo, Jinwei Chai, Jiena Wu, Junfang Liu, Xin Chen, Mohamed A. Abdel-Rahman, Hu Xia, Xueqing Xu
Summary: Scorpion-venom-derived peptide Smp24 exhibits inhibitory effects on liver cancer cells HepG2 through endocytosis, pore formation, interaction with mitochondrial membrane, mitochondrial dysfunction, apoptosis, and alteration of autophagy-related signaling pathways. Smp24 also shows protective activity in a liver cancer mouse model.
Article
Environmental Sciences
Lakshmi Thangavelu, Royapuram Veeraragavan Geetha, Ezhilarasan Devaraj, Kamal Dua, Dinesh Kumar Chellappan, Sri Renukadevi Balusamy
Summary: The study evaluates the cytotoxic potentials of Acacia catechu ethanolic seed extract in human hepatocellular carcinoma cells, finding that it induces cytotoxicity through increased ROS production, oxidative stress regulation, and apoptosis pathways.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jinling Zhang, Wenbao Wang, Yanzhao Tian, Liwei Ma, Lin Zhou, Hao Sun, Yukun Ma, Huiling Hou, Xiaoli Wang, Jin Ye, Xiaobo Wang
Summary: The study hybridised natural diosgenin with a benzoic acid mustard pharmacophore, resulting in the synthesis of compounds with potent anti-proliferative activity against HepG2 cells, while exhibiting weak cytotoxicity against normal GES-1 cells. Compound 14f showed promising anti-hepatoma potential by inducing cell cycle arrest and apoptosis in HepG2 cells through the regulation of cell cycle and apoptosis pathway-related proteins.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Chiara Argentati, Francesco Morena, Chiara Fontana, Ilaria Tortorella, Carla Emiliani, Loredana Latterini, Giulia Zampini, Sabata Martino
Summary: The study investigated the effects of chemically functionalized nanoparticles on human stem cells, finding that the stem cells exhibited similar growth and viability levels on all types of nanoparticles with morphological changes observed. Gold nanoseeds nanoparticles showed slight genotoxic effects on stem cells but did not impact their behavior.
Article
Biochemistry & Molecular Biology
Ganesh Kumar Raut, Genji Sukumar, Moumita Chakrabarti, Jolly Janette Mendonza, Srihari Pabbaraja, B. Jagan Mohan Reddy, Ramakrishna Sistla, Sai Balaji Andugulapati, Manika Pal Bhadra
Summary: Polyphenols are natural compounds with anti-tumorigenic effects. This study designed and synthesized a compound that interferes with the cell cycle progression in aggressive prostate cancer. Further experiments showed that the compound inhibits the viability of prostate cancer cells and induces apoptosis through oxidative stress. In a mouse model, the compound showed no toxicity and reduced the tumor burden.
Article
Toxicology
Naji Said Aboud Hadi, Ezgi Eyluel Bankoglu, Helga Stopper
Summary: This study investigated the effects of pyrrolizidine alkaloids (PAs) on non-metabolically active neighbor cells using a co-culture model. The results showed that PAs were activated by HepG2 cells and the metabolites induced genomic damage in co-cultured HeLa cells.
ARCHIVES OF TOXICOLOGY
(2023)
