Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days

Network analysis and cross species comparison of protein–protein interaction networks of human, mouse and rat cytochrome P450 proteins that degrade xenobiotics

(2016) Bagavathy Shanmugam Karthikeyan et al.   Molecular BioSystems

Highly Synchronized Expression of Lineage-Specific Genes duringIn VitroHepatic Differentiation of Human Pluripotent Stem Cell Lines

(2016) Nidal Ghosheh et al.   Stem Cells International

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Viability, function and morphological integrity of precision-cut liver slices during prolonged incubation: Effects of culture medium

(2015) Viktoriia Starokozhko et al.   TOXICOLOGY IN VITRO

Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices

(2014) Marlon J.A. Jetten et al.   TOXICOLOGY

Precision-cut liver slices from diet-induced obese rats exposed to ethanol are susceptible to oxidative stress and increased fatty acid synthesis

(2013) Michael J. Duryee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Precision-cut liver slices: A tool to model the liver ex vivo

(2013) Peter Olinga et al.   JOURNAL OF HEPATOLOGY

User-friendly solutions for microarray quality control and pre-processing on ArrayAnalysis.org

(2013) Lars M. T. Eijssen et al.   NUCLEIC ACIDS RESEARCH

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

(2013) Radina Kostadinova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs

(2013) Inge M. Westra et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver

(2012) Mackenzie Hadi et al.   ARCHIVES OF TOXICOLOGY

Species differences in drug transporters and implications for translating preclinical findings to humans

(2012) Xiaoyan Chu et al.   Expert Opinion on Drug Metabolism & Toxicology

Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices

(2012) Brian G. Lake et al.   XENOBIOTICA

Evaluation of drug-induced injury and human response in precision-cut tissue slices

(2012) Alison E. M. Vickers et al.   XENOBIOTICA

Up-regulation of cytochrome P450 and phase II enzymes by xenobiotics in precision-cut tissue slices

(2012) Costas Ioannides   XENOBIOTICA

In vitro models for liver toxicity testing

(2012) Valerie Y. Soldatow et al.   Toxicology Research

Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes

(2011) M.G.L. Elferink et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Repair pathways evident in human liver organ slices

(2011) Alison E.M. Vickers et al.   TOXICOLOGY IN VITRO

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

(2010) Inge A M de Graaf et al.   Nature Protocols

Coordinated induction of drug transporters and phase I and II metabolism in human liver slices

(2008) P. Olinga et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity

(2008) M ELFERINK et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Liver slices as a model to study fibrogenesis and test the effects of anti-fibrotic drugs on fibrogenic cells in human liver

(2008) M. van de Bovenkamp et al.   TOXICOLOGY IN VITRO