Evaluation of drug-induced injury and human response in precision-cut tissue slices

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Galectin-3 in Acetaminophen-Induced Hepatotoxicity and Inflammatory Mediator Production

(2012) Ana-Cristina Dragomir et al.   TOXICOLOGICAL SCIENCES

Thyroid organotypic rat and human cultures used to investigate drug effects on thyroid function, hormone synthesis and release pathways

(2012) Alison E.M. Vickers et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Calcium and cell death mechanisms: A perspective from the cell death community

(2011) Boris Zhivotovsky et al.   CELL CALCIUM

Mitochondrial glutathione transferases involving a new function for membrane permeability transition pore regulation

(2011) Yoko Aniya et al.   DRUG METABOLISM REVIEWS

Apoptosis-Inducing Factor Modulates Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity

(2011) Mary Lynn Bajt et al.   TOXICOLOGICAL SCIENCES

Cyclosporine A–Induced Oxidative Stress in Human Renal Mesangial Cells: A Role for ERK 1/2 MAPK Signaling

(2011) Séin O’Connell et al.   TOXICOLOGICAL SCIENCES

Repair pathways evident in human liver organ slices

(2011) Alison E.M. Vickers et al.   TOXICOLOGY IN VITRO

Oxidative stress caused by mitochondrial calcium overload

(2010) Tsung-I Peng et al.   Annals of the New York Academy of Sciences

The signalling pathway of CaMKII-mediated apoptosis and necrosis in the ischemia/reperfusion injury

(2010) Margarita A. Salas et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inhibition of mitochondrial membrane bound-glutathione transferase by mitochondrial permeability transition inhibitors including cyclosporin A

(2010) Enkhbaatar Ulziikhishig et al.   LIFE SCIENCES

Blood cell oxidative stress precedes hemolysis in whole blood–liver slice co-cultures of rat, dog, and human tissues

(2010) Alison E.M. Vickers et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mechanism of Acetaminophen Oxidation by the Peroxidase-like Activity of Methemoglobin

(2009) María I. González-Sánchez et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Macrophages and Inflammatory Mediators in Chemical Toxicity: A Battle of Forces

(2009) Debra L. Laskin   CHEMICAL RESEARCH IN TOXICOLOGY

Liver tissue engineering in the evaluation of drug safety

(2009) Ajit Dash et al.   Expert Opinion on Drug Metabolism & Toxicology

Characterization of Hepatic Mitochondrial Injury Induced by Fatty Acid Oxidation Inhibitors

(2009) Alison E.M. Vickers   TOXICOLOGIC PATHOLOGY

Extracellular matrix as a biological scaffold material: Structure and function

(2008) S BADYLAK et al.   Acta Biomaterialia

Mitochondrial Protein Targets of Thiol-Reactive Electrophiles

(2008) Hansen L. Wong et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Tissue slices for the evaluation of metabolism-based toxicity with the example of diclofenac

(2008) Alison E.M. Vickers   CHEMICO-BIOLOGICAL INTERACTIONS

3D cell culture opens new dimensions in cell-based assays

(2008) Bradley A. Justice et al.   DRUG DISCOVERY TODAY

Evolving concepts in liver tissue modeling and implications forin vitrotoxicology

(2008) André Guillouzo et al.   Expert Opinion on Drug Metabolism & Toxicology